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Topic: Neutropenia

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	Neutropenia Symptoms, Causes, Diagnosis, and Treatment on MedicineNet.com
		"Neutropenia" is a condition of an abnormally low number of a type of a particular type of white blood cell called a neutrophil.
		Neutropenia can be present (though it is relatively uncommon) in normal healthy individuals, notably in fls and Yemenite Jews.
		Causes of neutropenia from disease can be categorized as resulting from decreased production of white blood cells, destruction of white blood cells after they are produced, or pooling of white blood cells (accumulation of the white blood cells out of the circulation).
	www.medicinenet.com /neutropenia/article.htm (424 words)

	THE MERCK MANUAL, Sec. 11, Ch. 135, Leukopenia And Lymphocytopenia
		Neutropenia may be classified by the neutrophil count (total WBC × % neutrophils and bands) and the relative risk of infection: mild (1000 to 1500/µL), moderate (500 to 1000/µL), or severe (< 500/µL).
		Neutropenia may be classified by whether it arises secondary to factors extrinsic to marrow myeloid cells or whether an intrinsic defect appears to be present in the myeloid progenitors (see Table 135-1).
		Patients with chronic neutropenia since infancy and a history of recurrent fevers and chronic gingivitis should have WBC counts and differential counts obtained three times/wk for 6 wk to evaluate the periodicity suggestive of cyclic neutropenia.
	www.merck.com /pubs/mmanual/section11/chapter135/135a.htm (2424 words)

	About Neutropenia - Neutropenia Support Association Inc.
		These infections can be life threatening when the patient is persistently severe neutropenic and it is therefore important that if the patient develops any signs or symptoms of an infection, then he or she should be seen by a doctor as soon as possible and treated with medications to fight the infection (such as antibiotics).
		Who distinctive groups of patients with severe congenital neutropenia have a relative abundance of marrow neutrophils with severe reductions in patients with glycogen storage type 1B, maturation of marrow neutrophils appears to be complete, but blood counts are very low and a similar pattern of infections and inflammation occur as in the older congenital neutropenias.
		Congenital neutropenia is distinguished from immunoneutropenia of the newborn by its persistence after the first few weeks to months of life and by specific antibody tests.
	www.neutropenia.ca /about/index.html (1488 words)

	eMedicine - Neutropenia : Article by John E Godwin, MD, MS
		Neutropenia with abnormal immunoglobulins: This disorder is observed in individuals with X-linked agammaglobulinemia, isolated immunoglobulin A (IgA) deficiency, X-linked hyperimmunoglobulin M (XHIGM) syndrome, and dysgammaglobulinemia type I. In XHIGM, which is due to mutations in the CD40 ligand, patients actually can have normal or elevated levels of IgM but markedly decreased serum IgG levels.
		Felty syndrome: This is a syndrome of rheumatoid arthritis, splenomegaly, and neutropenia.
		Splenic sequestration: The degree of neutropenia resulting from this process is proportional to the severity of splenomegaly and the bone marrow's ability to compensate for the reduction in circulating bands and neutrophils.
	www.emedicine.com /med/topic1640.htm (4586 words)

	Neutropenia - Wikipedia, the free encyclopedia
		Neutropenia is a hematological disorder characterized by an abnormally low number of neutrophil granulocytes (a type of white blood cell).
		However, neutropenia is more properly considered a subset of leukopenia as a whole.
		Neutropenia and agranulocytosis can also result from antibody or complement-mediated damage to the stem cells.
	en.wikipedia.org /wiki/Neutropenia (670 words)

	Neutropenia (Site not responding. Last check: 2007-10-17)
		Neutropenia is a severe drop in infection-fighting white blood cells (neutrophils).
		Cancer patients who are at an increased risk of Neutropenia include the elderly, patients with pre-existing Neutropenia, prior chemotherapy or radiation treatment, and co-morbid conditions that leave patients immunocompromised.
		Neulasta was recently approved by the U.S. Food and Drug Administration for decreasing the incidence of infection as manifested by febrile Neutropenia (neutropenia with fever) in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs.
	www.bymyside.com /neutropenia.html (900 words)

	Imaginis - Neutropenia (Site not responding. Last check: 2007-10-17)
		Neutropenia is an abnormal decrease in white blood cells most often resulting from a viral infection or exposure to certain drugs or chemicals.
		Neutropenia is defined as a sharp reduction of neutrophils.
		Neutropenia is most common during or after a patient receives chemotherapy to treat cancer.
	imaginis.com /breasthealth/neutropenia.asp (1100 words)

	Neutropenia Symptoms - Medical Symptoms Pages
		Neutropenia is the abnormally small number of neutrophil cells in the blood.
		Neutropenia can be acute or chronic and clinically is broken up into four levels based on severity.
		Neutropenia is often a silent disease, that being one which is often difficult to see at first.
	www.symptoms101.com /med/archives/2005/07/neutropenia.php (561 words)

	Neutropenia \| AHealthyMe.com
		Neutropenia is sometimes called agranulocytosis or granulocytopenia because neutrophils make up about 60% of WBCs and have granules inside their cell walls.
		The cause of neutropenia is often difficult to establish and depends on a combination of the patient's history, genetic evaluation, bone marrow biopsy, and repeated measurements of the WBC.
		Neutropenia related to pesticide exposure is treated by removing the patient from the contaminated environment.
	www.ahealthyme.com /topic/topic100587216 (662 words)

	Neutropenia: White Blood Cell Disorders: Merck Manual Home Edition
		In chronic neutropenia, the course may be less severe if the number of neutrophils is not extremely low, and the course can occasionally be intermittent (cyclic neutropenia).
		In many cases, the neutropenia is expected and the cause is known, as in those receiving chemotherapy or radiation therapy.
		When neutropenia is caused by another disease (such as tuberculosis or leukemia or other cancers), treatment of the underlying disease may resolve the neutropenia.
	www.merck.com /mmhe/sec14/ch174/ch174b.html (857 words)

	Neutropenia: Patient Information: Arizona Telemedicine Program
		Neutropenia may be accompanied by a fever, easy bruisability, petechiae (small red-purple spots on skin), enlarged glands in the throat, and an enlarged spleen.
		Neutropenia is often accompanied by anemia and thrombocytopenia, causing weakness, pallor, and bleeding.
		Neutropenia is diagnosed by patient history, physical examination for symptoms, and laboratory testing.
	www.telemedicine.arizona.edu /patient_info/benign_disorders/disorders/neutropenia.html (401 words)

	Advances in the Management of Chemotherapy Induced Neutropenia (Site not responding. Last check: 2007-10-17)
		Neutropenia may lead to life-threatening infections and result in hospitalization, intravenous antibiotics or intravenous antifungals resulting in increased medical costs, a decreased quality of life and dose delays or reductions which may ultimately affect survival.
		Neutropenia risk models in different cancers involving specific treatment regimens and particular patient characteristics are being developed so a proactive approach to the management of CIN may be adopted allowing for the safe delivery of optimal chemotherapy.
		Prophylaxis against neutropenia in all patients would not be feasible in terms of resource utilization, as this practice would place a significant financial burden on the medical system due to the use of colony stimulating factors (CSFs) in patients who might not develope neutropenia.
	professional.cancerconsultants.com /current_oncology_2003.aspx?id=79 (3149 words)

	Neutropenia
		The lowering of the white blood cells that fight infections is known as Neutropenia.
		Another approach to treatment of febrile Neutropenia is the use of medicines, which stimulate bone marrow to produce more white blood cells.
		Febrile Neutropenia is fairly easy to treat unless there is a delay in the initiation of treatment.
	www.tirgan.com /leucpnia.htm (352 words)

	Neutropenia (Site not responding. Last check: 2007-10-17)
		Neutropenia confers a substantial risk of life-threatening infection and the magnitude of risk is closely correlated with the severity and duration of neutropenia.
		Patients developing fever during neutropenia require treatment with intravenous antibiotics and occasionally admission to the hospital until the neutrophil blood cells return to sufficient levels in the blood to fight the infection.
		Fortunately, there are strategies for the prevention of chemotherapy-induced neutropenia that have been proven to reduce the incidence of fever, infection and admission to the hospital and help patients receive their treatment on schedule.
	www.411cancer.com /syndication/veContent.jsp?ArticleTypeID=TNPV&ArticleID=supportive_neutropenia&lid=1&clinicid=1 (2060 words)

	Neutropenia definition - Medical Dictionary definitions of popular medical terms
		Neutropenia: Not enough neutrophils, neutrophils being a type of white blood cell (specifically a form of granulocyte) filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis.
		Neutropenia lowers the immunologic barrier to bacterial and fungal infection.
		Neutropenia - "Neutropenia" is a condition of an abnormally low number of a type of a particular type of white blood cell called a neutrophil.
	www.medterms.com /script/main/art.asp?articlekey=4560 (451 words)

	[No title]
		The most common reason that cancer patients experience neutropenia is as a side effect of chemotherapy. Chemotherapy-induced neutropenia increases a patient’s risk of infection and disrupts cancer treatment. Fortunately, neutropenia can be prevented. The prevention of neutropenia allows patients to receive their scheduled treatment and reduces the risk of infection and hospitalization.
		Neutropenia is a condition characterized by abnormally low blood levels of infection-fighting neutrophils, a specific kind of white blood cell. Neutropenia increases your risk of bacterial and fungal infections.
		When discussing the consequences and management of neutropenia, it is important to distinguish between chemotherapy-induced neutropenia and neutropenia resulting from other causes because they may be managed differently.
	patient.cancerconsultants.com /supportive_treatment.aspx?id=993 (2272 words)

	Neutropenia Interferes With Symptom Management
		Neutropenia, one of the most common side effects of chemotherapy, occurs when white blood cells (immune cells) are destroyed by chemotherapy, leaving the immune system unable to fight infections.
		Chemotherapy-induced neutropenia can become a serious condition for several reasons: Many patients who develop neutropenia will require a delay in treatment or a dose reduction, which can prevent them from receiving the greatest benefits of treatment; patients who develop neutropenia may require hospitalization; and even minor infections can become life-threatening.
		The researchers conclude that cancer patients who developed neutropenia did not benefit from a clinical intervention to reduce symptom burden; reasons for this are likely to be complex.
	patient.cancerconsultants.com /news.aspx?id=34820 (430 words)

	Neutropenia (low neutrophils) - MayoClinic.com
		Neutropenia is an abnormally low number of neutrophils — a type of white blood cell — in the blood.
		Neutropenia isn't a specific disease but a sign of an underlying problem.
		Severe neutropenia increases the risk of infection of the lungs, kidneys, blood and skin.
	www.mayoclinic.com /health/neutropenia/HQ01112 (209 words)

	Further Evidence that Neulasta™ is The Most Effective Agent for Reducing Febrile Neutropenia (Site not responding. Last check: 2007-10-17)
		Neutropenia occurs when white blood cells (immune cells) are destroyed by chemotherapy, leaving the immune system unable to fight bacterial, viral and fungal infections.
		Previous clinical trials have indicated that Neulasta™ reduces the incidence and/or severity of neutropenia in patients undergoing treatment for non-myeloid (blood) cancer and further trials are being conducted to determine the true clinical efficacy of treatment with Neulasta™.
		One clinical trial compared the incidence of febrile neutropenia (neutropenia accompanied by a fever) in patients treated with Neulasta™ or Neupogen® while the second clinical trial compared the incidence of febrile neutropenia in patients treated with Neulasta™ or no support therapy for neutropenia.
	www.cancerconsultants.com /syndication/veContent.jsp?ArticleID=suppcare_oct02&clinicid=1&ArticleTypeID=News (555 words)

	Congenital and Acquired Neutropenia -- Berliner et al. 2004 (1): 63 -- Hematology
		Overexpression of ELA2 in Neutropenia Caused by Gfi1 Mutations
		Alloimmune neonatal neutropenia (AINN) is caused by maternal
		K-cell lymphocytosis/neutropenia syndrome: the neutropenia is not caused by autoimmunity.
	www.asheducationbook.org /cgi/content/full/2004/1/63 (7327 words)

	Adult Health Advisor 2005.2: Neutropenia
		Neutropenia is an abnormally low number of white blood cells (neutrophils).
		People with neutropenia tend to develop infections easily because their white blood cell count is too low to fight off germs, such as bacteria.
		For example, neutropenia related to vitamin deficiency usually goes away after 2 weeks of treatment with vitamins.
	www.med.umich.edu /1libr/aha/aha_neutrope_crs.htm (462 words)

	Neutropenia
		Neutropenia (a decrease in neutrophils) can be caused by a problem in the bone marrow that keeps new cells from being formed, or by a condition that prematurely destroys cells in the bloodstream.
		If the neutropenia is caused by a viral infection, it goes away when the infection is cured.
		Congenital neutropenia is sometimes referred to as Kostmann's syndrome.
	www.mayoclinic.org /peds-whitecell-rst/neutropenia.html (250 words)

	Neutropenia Support Association Inc.
		Increasing the understanding of neutropenia by providing information and support for care givers, patients and their families.
		Neutropenia is a blood disorder you don't often hear about, but it can affect anyone.
		Neutropenia affects as many as one in three patients receiving chemotherapy for cancer.
	www.neutropenia.ca (410 words)

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