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Topic: Nimesulide

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	Acute generalized exanthematous pustulosis induced by nimesulide
		Nimesulide is a new nonsteroidal anti-inflammatory (NSAID) drug with antipyretic and analgesic properties.
		We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.
		Nimesulide should be added to the list of agents associated with this serious adverse drug reaction.
	dermatology.cdlib.org /126/case_presentations/agep/teixeira.html (2191 words)

	Indian Pediatrics - Editorial
		In the nimesulide group, 30 children (63.8%) needed admission based on their clinical conditions (others were admitted only for the study) compared to 26 (52%) children in the paracetamol group.
		This was a double blind randomized controlled trial to assess the efficacy of nimesulide and paracetamol in the treatment of fever in children seen at a secondary level hospital in Faridabad District of Haryana.
		In conclu-sion, nimesulide has better antipyretic effect than paracetamol in children in the doses used in the study and appears to be safe for use in them.
	www.indianpediatrics.net /may2002/may-472-477.htm (1910 words)

	Patent 5,998,480
		Nimesulide has demonstrated as having a better therapeutical ratio, less gastrolesivity and, in general, better tolerability with respect to other nonsteroidal anti-inflammatories such as for example, arylalkaloid acids such as acetylsalicylic acid, Ketoprofen, Diclofenac, Naproxen, thanks to the presence of a sulfanilide group in its molecule.
		Since nimesulide, a weak acid from the chemical viewpoint, is scarcely absorbed at low pH values (for example in the gastric tract), a possible initial step is salification with alkaline or alkaline-earth bases.
		In the preparation according to this invention, nimesulide can be present in dispersed form, the phospholipid can be a phosphatidyl acid ester, phosphatidylcholine in particular, and the acid can be an organic or an inorganic acid, preferably chosen from the group that comprises lactic acid, salicylic acid, glycolic acid, citric acid, aqueous hydrochloric acid.
	www.pharmcast.com /Patents/120799OG/5998480_topical120799.htm (758 words)

	Treatment of neurodegenerative conditions with nimesulide - Patent 5985930
		Nimesulide, or a structurally related compound, may be administered so as to provide an effective concentration in the nervous system of the subject being treated.
		In specific, nonlimiting embodiments of the invention, the concentration of nimesulide is at least 1 nanomolar, and preferably at least 1 micromolar in the location of neuronal cells which are desired to be treated.
		Nimesulide or a structurally related compound may be comprised in a suitable pharmaceutic carrier.
	www.freepatentsonline.com /5985930.html (5002 words)

	Wallace Pharmaceuticals (Site not responding. Last check: 2007-10-19)
		SOONIL (Nimesulide) is a new non-steroidal anti-inflammatory analgesic agent which can be given orally on a twice daily basis in a number of painful, inflammatory and fever conditions.
		The pharmacodynmic profile of nimesulide is suggestive of reduced propensity to cause adverse gastrointestinal effects.
		Nimesulide has been well tolerated by the patients with asthama and hypersentivity to aspirin or a history of intolerance to NSAIDs.
	www.wallace.co.in /med_pain_soonildoctor.htm (671 words)

	Sheffield------Rainsford Kim Prof. Dr. med.------United Kingdom------Nimesulide's molecular structure achieves rapid ...
		Nimesulide is available in various galenic forms, such as tablets or sachets with orange flavour (especially good for patients who have problems swallowing).
		George Moore, who developed nimesulide, aimed to produce a drug that controls oxyradicals and this intrinsic chemical characteristics (pKa value of 6.5) are now recognised as being important features of the drug (1).
		Nimesulide is certainly the medication of first choice for patients with acute pain, musculo-skeletal problems, arthritis and sports injuries.
	www.just-medical.com /en/medrep_b.cfm?medb_id=475 (861 words)

	Nimesulide fights breast cancer by targeting key enzyme (Site not responding. Last check: 2007-10-19)
		Nimesulide is a non-steroidal anti-inflammatory drug (NSAID), a drug that controls pain and inflammation.
		Nimesulide has been around since 1985, but was banned from clinical and over-the-counter use in the United States due to rare cases of liver damage and related deaths.
		The researchers took several of these nimesulide analogs and, in laboratory cultures, tested their effects on estrogen-dependent breast cancer cells taken from human breast tissue.
	www.news-medical.net /?id=17368 (786 words)

	BioMed Central \| Full text \| Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates
		Given that the effects of nimesulide reducing oxidative damage in vivo might be attributed to its direct antioxidant properties, the aim of the present study was to determine whether nimesulide could attenuate the oxidative damage seen after the in vitro exposure of disrupted brain cell homogenates to kainate.
		Unlike the in vitro situation, nimesulide treatment afforded a neuroprotective effect against kainate-induced in vivo oxidative stress in the rat hippocampus, probably acting through inhibition of cyclooxygenase-2, which is now considered a key cellular source of free radicals in the injured brain [24].
		Nimesulide was dissolved in absolute ethanol (when added to the brain homogenate, the final alcohol concentration was 1%) and added as one of nine different concentrations (0.1, 0.2, 0.4, 0.6, 0.8, 1, 1.2, 1.4, and 1.6 mM) to the incubation mixture.
	www.biomedcentral.com /1471-2210/3/7 (3191 words)

	Journal of Neuroinflammation \| Full text \| Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction ...
		Recently, we have found a significant neuroprotective effect of nimesulide both in global cerebral ischemia [10,22], a type of injury that mimics the clinical situation of cardio-respiratory arrest, and in a rat model of ischemic stroke induced by the transient (1 h) occlusion of the middle cerebral artery [12].
		In the model of transient focal ischemia, the time window of nimesulide's neuroprotection extends over a 24 h period [12], and in other models of cerebral ischemia, the time window of protection of nimesulide is similarly wide [10,22,51].
		The vascular inaccessibility of nimesulide into the ischemic/infarcted region could be a plausible explanation for these findings considering that, unlike transient ischemia, in permanent ischemic stroke the protective effects of any drug/agent depend, in large part, on the ability of the compound to reach the ischemic areas mainly through passive diffusion.
	www.jneuroinflammation.com /content/2/1/3 (5405 words)

	Nimesulide - Wikipedia, the free encyclopedia
		Nimesulide is a prescription non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties and its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthrosis and primary dysmenorrhoea in adolescents and adults above 12 years old.
		The therapeutic effects of Nimesulide are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
		Like most drugs in NSAID category, nimesulide is known to be hepatotoxic (damaging to the liver) in rare but unpredictable cases and should be taken with care.
	en.wikipedia.org /wiki/Nimesulide (571 words)

	Nimesulide: A `painful' crash
		NIMESULIDE is a pain killer that is categorised as a non-steroidal anti-inflammatory drug (NSAID) in medical terminology.
		The pattern of price movement in Nimesulide is an interesting phenomenon because the crash in price was accompanied by a concurrent rapid growth in the use of the molecule.
		Nimesulide is a relatively newer NSAID that has been eating into the market of older generation NSAIDs such as Ibuprofen and Diclofenac.
	www.thehindubusinessline.com /2000/02/07/stories/080715j1.htm (427 words)

	Pharmalicensing.com: Nimesulide at CPT 2000 in Florence
		From the symposium Nimesulide: a multifactorial approach to inflammation and pain, held on 17 July in Florence (Italy) in occasion of the VII World Conference on Clinical Pharmacology and Therapeutics (CPT 2000) and chaired by Prof.
		The pharmacological basis of this activity and the rationale of the use of Nimesulide in a pathologic condition, like dysmenorrhoea, in which a very quick effect is needed, have been dealt with at the above symposium.
		Nimesulide resulted to be as effective as diclofenac in reducing pain, but its analgesic activity consistently with the data from Sandrini and Pulkkinen presented hereby - was already evident within the first half hour after administration.
	pharmalicensing.com /company/disprelease/969021157_39c216e52c05f (689 words)

	The importance of COX-2 inhibition for aspirin induced asthma -- Bennett 55 (Supplement 2): 54 -- Thorax
		was not inhibited by nimesulide, in contrast to the concentration-related
		Efficacy and tolerability of nimesulide in asthmatic patients intolerant to aspirin.
		Inhibition of the neutrophil oxidative response induced by the oral administration of nimesulide in normal volunteers.
	thorax.bmj.com /cgi/content/full/55/suppl_2/S54 (1444 words)

	Manufacturer and exporter of Pharmaceutical Formulations, Manufacturer of Pharmaceuticals, Exporters of ... (Site not responding. Last check: 2007-10-19)
		Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties and a specific mode of action.
		Nimesulide is proved safe and effective in the symptomatic treatment of a wide range of inflammatory and painful conditions, including osteoarthritis, extra-articular disorders, pain and primary dysmenorrhoea.
		Nimesulide is currently marketed in around 50 countries worldwide under different brand names, and it is among the most prescribed NSAIDs.
	www.astralpharmaceutical.com /NimesulideNCombinations.htm (114 words)

	Bioline International Official Site (site up-dated regularly)
		Nimesulide should not be used as the primary mode of treatment as an antipyretic or analgesic, when better and safer choices are available.
		Nimesulide is not used in the United States, Finland, Spain, Portugal and Israel.
		Numerous studies have shown life-threatening ADRs with nimesulide such as hepatotoxicity,[1] renal toxicity, severe skin reactions, gastrointestinal toxicity, potentiation of seizures and potentiation of colitis in passive cigarette smoking.
	www.bioline.org.br /request?ph04085 (897 words)

	Nimesulide Pro-drug
		Nimesulide is a nonsteroidal antiinflammatory agent that differs from most compounds of this class by the fact that it exhibits an acidic character by virtue of a sulfonamide rather than a carboxylic group.
		This pro-drug is totally safe to use for human consumption as all the components present in the Pro-drug are already established as safe.
		Nimesulide Pro-drug equivalent to Nimesulide 1%w/w in a water miscible cream base.
	www.geocities.com /pharma_research/drug/nimesulide_prodrug.html (363 words)

	Allergy & Asthma Disease Management Center: Ask the Expert
		In particular, nimesulide is selective for COX-2 and displays additional properties in terms of its effects on inflammatory mediator synthesis and release.
		nimesulide and the remaining 75 mg was given 1 hr later.
		The clinical presentations of intolerance to nimesulide were urticaria/angioedema in three patients, mild rhinitis in one patient, and mild dyspnea in one patient.
	www.aaaai.org /aadmc/ate/category.asp?cat=1034 (909 words)

	RedOrbit - Health - Treatment of De Quervain Disease With Triamcinolone Injection With or Without Nimesulide: a ... (Site not responding. Last check: 2007-10-19)
		Nimesulide (Eurodrug Laboratories, The Hague, The Netherlands) is a nonsteroidal anti-inflammatory drug of the sulfonamide class, which is marketed in European and Asian countries.
		Nimesulide has been found to be a selective cyclooxygenase-2 inhibitor in human beings at clinically recommended doses13.
		We also studied the probability of the recurrence of symptoms after triamcinolone injection with or without oral nimesulide and investigated whether factors such as patient age, gender, duration of symptoms, dominant hand involvement, previous steroid injection, and the presence of crepitation were predictive factors for the recurrence of the disease.
	www.redorbit.com /news/display?id=113875 (3320 words)

	U.S. Patent: 5688829 - Therapeutic injectable analgesic composition containing nimesulide and a process for the ...
		The use of nimesulide through intra-muscular administration as an analgesic agent has not been successful because Nimesulide is practically insoluble in water and its formulations in conventional oily bases or as suspensions result in depot formation in the muscular tissues which defies the main objective of quick relief.
		It is an object of the present invention to provide a novel therapeutic injectable analgesic composition containing nimesulide for intra-muscular administration from which the nimesulide is rapidly absorbed and distributed in body fluids.
		______________________________________ Nimesulide 2.5% to 10% w/v and Parenteral absorption 90% to 97.5% w/v.
	www.everypatent.com /comp/pat5688829.html (2002 words)

	BioMed Central \| Full text \| Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ...
		Nimesulide (4-nitro-2-phenoxymethanesulfonanilide), a selective inhibitor of COX-2, belonging to the sulfonamide class [9], is less ulcerogenic than other NSAIDs [10], and suppresses the formation of aberrant crypt foci (ACF), being putative precancerous lesions of the colon cancer, induced by a colon carcinogen, azoxymethane (AOM) in rats [11].
		The suppressive effects of nimesulide, troglitazone and bezafibrate on the development of colonic adenocarcinoma was well correlated with the inhibition of cell proliferation activity, induction of apoptosis, and lowered immunoreactivity of β-catenin, COX-2, iNOS, and nitrotyrosine in the colonic malignancies.
		The estimated daily intakes of nimesulide, troglitazone, and bezafibrate in mice given the diets containing 400 ppm and 500 ppm were approximately 160 mg/kg and 200 mg/kg in the present study.
	www.biomedcentral.com /1471-2407/5/46 (5565 words)

	Physicochemical Characterization and Dissolution Properties of Nimesulide-Cyclodextrin Binary Systems
		The thermal behavior of kneaded nimesulide (KN) and coevaporated nimesulide (CN) is similar to the untreated samples, indicating that their solid-state properties were not substantially affected by the kneading and evaporation processes (
		Nimesulide induced severe hemolytic anemia and acute liver failure leading to liver tranplantation.
		Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide: isolation and characterization of nimesulide-L-lysine-cyclodextrin complexes.
	www.aapspharmscitech.org /view.asp?art=pt040102&pdf=yes (3940 words)

	Indian Pediatrics - Editorial
		Nimesulide was primarily used for its antipyretic (10 trials) or anti-inflammatory and analgesic activity (4 trials).
		Nimesulide (4-nitro-2-phenoxy-methanesulphonamide) is a relatively new NSAID, which can be given orally or rectally on a twice daily basis to reduce fever, pain and inflammatory symptoms in various disease states(2-4).
		The pooled estimates for the hepatic enzyme elevation are based on sample sizes of 177 subjects in the nimesulide group and 189 cases in the paracetamol group (all such studies had paracetamol as the control drug).
	www.indianpediatrics.net /june2003/june-518-531.htm (3843 words)

	Nimesulide labels will now carry warning-Patna-Cities-NEWS-The Times of India (Site not responding. Last check: 2007-10-19)
		PATNA: Drugs controller general (India) Ashwini Kumar has directed the state drugs controllers to ask the manufacturers of Nimesulide formulations for paediatric use to give cautionary note on its label indicating that "co-administration with other potentially hepato-toxico drugs (drugs which could cause damage to liver) should be avoided".
		The matter was examined in the light of the directions of Delhi high court in a PIL filed by a lawyersâ group, Social Jurist, it said.
		The experts said a ban on the use of Nimesulide for children would not be justified.
	timesofindia.indiatimes.com /cms.dll/html/uncomp/articleshow?msid=63261 (331 words)

	What will happen if my child has been given nimesulide? - Drugs - DoctorNDTV (Site not responding. Last check: 2007-10-19)
		Nimesulide is not allowed to be given even to adults in US, UK, Canada, Australia and 150 other countries.
		The use of nimesulide in children is banned even in Bangladesh.
		Furthermore the combination of nimesulide with paracetamol is illegal because it is being manufactured and marketed without approval from the Drugs Controller General, India (DCGI).
	www.doctorndtv.com /FAQ/detailfaq.asp?id=7473 (349 words)

	The Critical Role of Mitochondrial Energetic Impairment in the Toxicity of Nimesulide to Hepatocytes -- Mingatto et al. ...
		hepatocytes by nimesulide in the presence of oligomycin.
		Effects of nimesulide (Nim) or its reduced metabolite (NimH) on succinate-supported oligomycin-induced state 4 respiration of mitochondria in digitonin-permeabilized isolated rat hepatocytes.
		Gandini R and Montalto C (1991) First dose and steady state pharmacokinetics of nimesulide and its 4-hydroxy metabolite in healthy volunteers.
	jpet.aspetjournals.org /cgi/content/full/303/2/601 (3787 words)

	The Hindu Business Line : NPIL to replace nimesulide with `Vah'
		EVEN as the debate goes back and forth on the use of nimesulide, a popular fever drug, Nicholas Piramal India Ltd has decided to phase out its version of the drug, Orthobid and replace it with Vah (Valdecoxib), touted to be a "better drug with less side-effects".
		Nimesulide, a non-steroid anti-inflammatory analgesic, had been put under a scanner by the Drug Controller General of India (DCGI) following concerns raised by the medical community on the safety of the drug, particularly when administered to children.
		That the DCGI is reported to have cleared the use of the drug in adults and paediatric use is something that the medical fraternity is not willing to endorse.
	www.blonnet.com /2003/01/21/stories/2003012101900200.htm (382 words)

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