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Topic: Nitric oxide synthase

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Citrulline

Ornithine

Glycine

Amino acid

	Nitric oxide - Wikipedia, the free encyclopedia
		Nitric oxide in the air may later convert to nitric acid which has been implicated in acid rain.
		This underlies the action of nitroglycerin, amyl nitrate and other nitrate derivatives in the treatment of heart disease: the compounds are converted to nitric oxide (by a process that is not completely understood) which in turn dilates the coronary artery (blood vessels around the heart), thereby increasing its blood supply.
		Nitric oxide was named "Molecule of the Year" in 1992 by the journal Science, a Nitric Oxide Society was founded, and a scientific journal devoted entirely to nitric oxide was created.
	en.wikipedia.org /wiki/Nitric_oxide (828 words)

	Reviews on nitric oxide synthases (Site not responding. Last check: 2007-11-03)
		Appleton, I., Tomlinson, A. and Willoughby, D.A. Induction of cyclooxygenase and nitric oxide synthase in inflammation.
		Arnal, J.F., Michel, J.B. and Harrison, D.G. Nitric oxide in the pathogenesis of hypertension.
		Jorens, P.G., Vermeire, P.A. and Herman, A.G. arginine-dependent nitric oxide synthase: A new metabolic pathway in the lung and airways.
	metallo.scripps.edu /PROMISE/NOS_REV.html (6429 words)

	Nitric oxide synthase - Wikipedia, the free encyclopedia
		The nitric oxide synthases (NOS) are a group of enzymes (EC 1.14.13.39) responsible for the synthesis of nitric oxide from the terminal nitrogen atom of
		The originally identified nitric oxide synthase was the NOS isoform identified in neuronal tissue known as nNOS or NOS1 followed by the endothelial NOS called eNOS or NOS3.
		They were originally classified as "constituitvely expressed" and "Ca sensitive" but it is now known that they are present in may different cell types and that expression is regulated under specific physiological conditions.
	en.wikipedia.org /wiki/Nitric_oxide_synthase (486 words)

	Research - Nitric Oxide Synthase (Site not responding. Last check: 2007-11-03)
		The nitric oxide synthases (NOS) are hemoproteins with a cytochrome P450-like active site that catalyze the oxidation of arginine to nitric oxide and citrulline.
		The explosion of research in this area has demonstrated that nitric oxide fulfills a large range of biological functions as both a messenger and a cytotoxic factor.
		There are three basic types of nitric oxide synthases: (a) a soluble constitutive enzyme found in high concentrations in the brain, (b) a constitutive endothelial enzyme that is membrane bound, and (c) an inducible enzyme associated with the cytotoxic function of macrophages.
	www.sacs.ucsf.edu /home/Ortiz/res-nos.htm (283 words)

	ALZET® Bibliography - Administration of Nitric Oxide Synthase Inhibitors
		P4585 Wang,H.H, Lautt,W.W. Evidence of nitric oxide, a flow-dependent factor, being a trigger of liver regeneration in rats..
		P3861 Chatterjee,S., Collins,T.J., Yallampalli,C. Inhibition of nitric oxide facilitates LH release from rat pituitaries.
		P3836 Nakamura,T. Contribution of L-arginine-derived nitric oxide to the structural integrity of coronary artery and cardiac interstitium, and to the regulation of sympathetic nerve activity: assessment using a rat model produced by chronic nitric oxide inhibition.
	www.alzet.com /bibliography/NOSI-Q2-2004/index.php (3602 words)

	Characterization of Inducible Nitric Oxide Synthase Expression in Human Airway Epithelium (Site not responding. Last check: 2007-11-03)
		Nitric oxide is an important mediator of inflammatory responses in the lung and a key regulator of pulmonary vascular and bronchomotor tone.
		Participation of nitric oxide and iron in the oxidation of DNA in asbestos-treated human lung epithelial cells.
		Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation.
	ehp.niehs.nih.gov /members/1998/Suppl-5/1119-1124guo/guo-full.html (5106 words)

	Diabetes: Reduced Sensitivity of Inducible Nitric Oxide S... @ HighBeam Research (Site not responding. Last check: 2007-11-03)
		Nitric oxide (NO), synthesized by the inducible isoform of nitric oxide synthase (iNOS), has been proposed as a mediator of immune-induced [Beta]-cell destruction in type 1 diabetes.
		The radical nitric oxide (NO) is a molecule that regulates complex, physiological functions, such as memory formation, vascular tone, and immunological host-defense reactions (4,5).
		By using pharmacological inhibitors of nitric oxide synthase (NOS), it has been concluded that several of the deleterious actions of cytokines on rodent islet functions in vitro are mediated by NO formation (12).
	highbeam.com /library/doc0.asp?docid=1G1:54551179&refid=ink_tptd_mag (5215 words)

	Reproductive Biology and Endocrinology \| Full text \| Nitric oxide synthase activity in human trophoblast, term placenta ...
		To investigate the possible role of nitric oxide (NO) produced locally or intramurally in the quiescence of the pregnant myometrium, nitric oxide synthase (NOS) activity was measured in samples from first trimester (villous, and non villous-trophoblast), term placenta and pregnant myometrium.
		Nitric oxide (NO) is a multifunctional signal and important modulator of cellular responses in a variety of tissues including those involved in human reproduction.
		Purcell TL, Buhimschi IA, Given R, Chwalisz K, Garfield RE: Inducible nitric oxide synthase is present in the rat placenta at the fetal-maternal interface and decreases prior to labour.
	www.rbej.com /content/1/1/51 (4147 words)

	Nitric oxide synthases
		Giovanelli, J., Campos, K.L. and Kaufman, S. Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.
		Hevel, J.M. and Marletta, M.A. Macrophage nitric oxide synthase: relationship between enzymebound tetrahydrobiopterin and synthase activity.
		Crane, B.R., Arvai, A.S., Ghosh, D.K., Wu, C., Getzoff, E.D., Stuehr, D.J. and Tainer, J.A. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
	metallo.scripps.edu /PROMISE/NOS.html (823 words)

	NITRIC OXIDE (Site not responding. Last check: 2007-11-03)
		La Jolla, CA (October 24, 1997)- A new understanding of the structure of nitric oxide synthase, the enzyme that regulates nitric oxide activity in the body, offers key information useful for developing drugs for everything from high blood pressure to cancer.
		Researchers at the Scripps Research Institute have determined the structure of nitric oxide synthase oxygenase, the enzyme that turns NO on and off.
		Defining the structure of nitric oxide synthase (NOS) will help researchers understand not only how NO is produced in the body but also how NO production is controlled.
	www.accessexcellence.org /WN/SUA11/no1097.html (561 words)

	Induction of Endothelial Nitric Oxide Synthase Expression by Melanoma Sensitizes Endothelial Cells to Tumor Necrosis ...
		Nitric oxide and apoptosis: another paradigm for the double-edged role of nitric oxide.
		Nitric oxide promotes murine mammary tumour growth and metastasis by stimulating tumour cell migration, invasiveness and angiogenesis.
		Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors.
	clincancerres.aacrjournals.org /cgi/content/full/10/20/6879 (5062 words)

	Nitric Oxide Synthase (Site not responding. Last check: 2007-11-03)
		Nitric oxide has been found to play many diverse physiological roles ranging from a neuro transmitter, a vasodilator to a cytotoxic agent.
		The enzyme that catalyzes the formation of NO from oxygen and arginine is nitric oxide synthase, a very complex enzyme containing several cofactors and a heme group which is part of the catalytic site.
		In addition, we are studying a variety of inhibitors of the enzyme to sort between the many mechanisms of inhibition that are possible in nitric oxide synthase.
	www.aecom.yu.edu /home/biophysics/rousseau/nos/nos.htm (181 words)

	XIV. International Union of Pharmacology Nomenclature in Nitric Oxide Research -- Moncada et al. 49 (2): 137 -- ...
		Abbreviations for the Isoenzymes of Nitric Oxide Synthase
		Rand, M. Nitrergic transmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission.
		Williams, R. Nitric oxide in biology: its role as a ligand.
	pharmrev.aspetjournals.org /cgi/content/full/49/2/137 (3368 words)

	Nitric Oxide
		Nitric Oxide Quantitation Kit is faster and easier-to-use than existing methods for measuring the production of NO in biological samples.
		The Nitric Oxide Quantitation Kit can be used with a variety of sample types, including plasma, serum, saliva, urine, cell lysate, tissue homogenate and tissue culture medium.
		The intensity of the color formed is linearly related to the concentration of nitrite, and hence, to the original RSNO concentration.
	www.vincibiochem.it /NOOX.htm (488 words)

	A Neuronal Isoform of Nitric Oxide Synthase Expressed in Pancreatic {beta}-Cells Controls Insulin Secretion -- Lajoix ...
		Alm P, Ekstrom P, Henningsson R, Lundquist I: Morphological evidence for the existence of nitric oxide and carbon monoxide pathways in the rat islets of Langerhans: an immunocytochemical and confocal microscopical study.
		Holmqvist B, Ekström P: Subcellular localization of neuronal nitric oxide synthase in the brain of a teleost: an immunoelectron and confocal microscopical study.
		-hydroxy-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.
	diabetes.diabetesjournals.org /cgi/content/full/50/6/1311 (7411 words)

	Selected references on nitric oxide synthases
		Hurshman, A.R. and Marletta, M.A. Nitric oxide complexes of inducible nitric oxide synthase: spectral characterization and effect on catalytic activity.
		McMillan, K. and Masters, B.S.S. Prokaryotic expression of the heme- and flavin-binding domains of rat neuronal nitric oxide synthase as distinct polypeptides: identification of the heme-binding proximal thiolate ligand as cysteine-415.
		Wolff, D.J., Naddelman, R.A., Lubeskie, A. and Saks, D.A. Inhibition of nitric oxide synthase isoforms by porphyrins.
	www.icgeb.trieste.it /~p450srv/NOS_reviews.html (3727 words)

	Inhibition of Inducible Nitric Oxide Synthase Restores Endothelium-Dependent Relaxations in Proinflammatory ... (Site not responding. Last check: 2007-11-03)
		Mülsch A, Bassenge E, Busse R. Nitric oxide synthesis in endothelial cytosol: evidence for a calcium-dependent and calcium-independent mechanism.
		B is a key mechanism for nitric oxide synthase gene activation in macrophages and smooth muscle cells.
		Busse R, Mülsch A. Calcium-dependent nitric oxide synthase in endothelial cytosol is mediated by calmodulin.
	atvb.ahajournals.org /cgi/content/full/17/9/1746 (6006 words)

	[No title] (Site not responding. Last check: 2007-11-03)
		146 : Q6XS76 0.88 0.92 417 440 80 103 24 0 0 1147 Q6XS76 Inducible nitric oxide synthase (Fragment 147 : Q5W9H7 0.88 0.91 417 440 84 107 24 0 0 1151 Q5W9H7 Nitric oxide synthase 2 (EC 1.14.13.39).
		159 : Q8CJ25 0.62 0.74 28 201 52 224 173 1 1 224 Q8CJ25 Neuronal nitric oxide synthase (Fragment) 160 : Q8CJ25 0.62 0.74 443 616 52 224 173 1 1 224 Q8CJ25 Neuronal nitric oxide synthase (Fragment) 161 : Q6E5V9 0.62 0.73 27 415 38 422 385 1 4 1199 Q6E5V9 Nitric oxide synthase.
		196 : Q8WP07 0.82 0.89 180 201 1 22 22 0 0 22 Q8WP07 Nitiric oxide synthase 2A (Fragment).
	www.infobiogen.fr /db/hssp/3nod.hssp (3003 words)

	Nitric Oxide Website
		Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.
		Xu W, Liu L, Charles IG, Moncada S. Nitric oxide (NO) is a pleiotropic signalling molecule that binds to cytochrome c oxidase (complex IV) reversibly and in competition with oxygen.
		Macrophages can kill tumor cells by releasing high levels of nitric oxide (NO) and related reactive nitrogen species such as nitroxyl and peroxynitrite, after up-regulation of expression of the inducible nitric oxide synthase gene (iNOS).
	www.wxumac.demon.co.uk (586 words)

	Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells -- Rumbo et ... (Site not responding. Last check: 2007-11-03)
		Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells -- Rumbo et al.
		Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells
		Inducible nitric oxide synthase (iNOS) functions as a homodimer.
	content.febsjournal.org /cgi/content/abstract/272/2/444 (196 words)

	MSN Encarta - Search Results - nitric oxide synthase
		Furchgott, Robert F., Ignarro, Louis J. Cell Signaling : nitric oxide and cell signaling research
		Nitric Acid: analysis in an alchemist's laboratory (picture)
		Exclusively for MSN Encarta Premium Subscribers--quickly search thousands of articles from magazines such as Time, Newsweek, The Atlantic Monthly, and Smithsonian.
	ca.encarta.msn.com /nitric_oxide_synthase.html (88 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Background: Nitric oxide (NO) has an important effect on blood pressure, arterial wall, and the basal release of endothelial NO in hypertension (HPN) may be reduced.
		Until now, there is no solid data revealing the potential role of the polymorphism of the nitric oxide synthase gene (NOS) in patients with HPN and microvascular angina.
		Aim: The aim of the present study is to investigate the gene of endothelial nitric oxide synthase (eNOS), as the polymorphism of this gene may be a putative candidate for HPN and initiate the process of atherosclerosis.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=20601289 (463 words)

	Nitric Oxide Synthase \| Glaucoma Research Foundation
		Aminoguanidine works by inhibiting the activity of an enzyme which makes nitric oxide in excess.
		This enzyme, nitric oxide synthase, has been found to be present in the optic nerve tissue of patients with glaucoma.
		This means that there may be some treatment for glaucoma that will protect the optic nerve from damage, even if eye pressure cannot be controlled, or for those people who still have damage when pressure is controlled.
	www.glaucoma.org /research/nitric_oxide_sy.html (354 words)

	Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than ...
		Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than in Control Subjects -- Kingwell et al.
		Higaki Y, Hirshman MF, Fujii N, Goodyear LJ: Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle.
		Radegran G, Saltin B: Nitric oxide in the regulation of vasomotor tone in human skeletal muscle.
	diabetes.diabetesjournals.org /cgi/content/full/51/8/2572 (5978 words)

	Nitric oxide synthase : myelin structure? - www.ezboard.com
		Peroxynitrite inhibits inducible (type 2) nitric oxide synthase in murine lung epithelial cells in vitro.
		Peroxynitrite, formed by nitric oxide (NO) and superoxide, can alter protein function by nitrating amino acids such as tyrosine, cysteine, trytophan, or methionine.
		Interesting study on UA and gives a glow that there is a way of upregulating UA that does not entail eating liver.
	p205.ezboard.com /fmsdiagnosedfrm26.showMessage?topicID=213.topic (1160 words)

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