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| | Patent 4379149: Process for introducing an oxygen-containing functional group into ansamycins |
 | | Thus, such a lower alkoxy group may be substituted by halogen atoms, especially in the 2-position, such as in the 2,2,2-trichloroethoxy, 2-chloroethoxy or 2-iodoethoxy radical, or by lower alkoxy radicals, especially in the 1-position, such as in the 1-butoxyethoxy radical, or in the 2-position, such as in the 2-methoxyethoxy radical. |
 | | An esterified carboxyl group present as substituent in hydrocarbyl is a group in which the hydrogen atom is replaced by one of the above-characterised hydrocarbon radicals, preferably a lower alkyl or phenyl-lower alkyl radical; examples of an esterified carboxyl group are especially the methoxycarbonyl, ethoxycarbonyl, tert.-butoxycarbonyl or benzoyloxycarbonyl groups, and also a lactonised carboxyl group. |
 | | Among preferred functional groups which occur in such substituted carboxylic acids are: hydroxy, methoxy, halogen, especially chlorine, nitro, lower alkoxycarbonyl, especially methoxycarbonyl, and di-lower alkylamino, especially dimethylamino, and in the case of the aromatic groups, also formyl, methylenedioxy and primary amino. |
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