| | Method for detecting, identifying, and quantitating organisms and viruses - Patent 5288611 (Site not responding. Last check: 2007-10-18) |
 | | Genetic analysis includes, for example, the determination of the numbers of ribosomal RNA genes in various organisms; the determination of the similarity between the multiple ribosomal RNA genes which are present in cells, determination of the rate and extent of synthesis of rRNA in cells and the factors which control them. |
 | | It is known that the ribosomal RNA gene base sequence is at least partially similar in widely different organisms, and that the DNA of E. coli bacterial ribosomal RNA genes hybridizes well with rRNA from plants, mammals, and a wide variety of other bacterial species. |
 | | Hybridization does occur between imperfectly complementary molecules with the result that a certain fraction of the bases in the hybridized region are not paired with the proper complementary base. |
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