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Topic: Nitroglycerin

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  Nitrostat (Nitroglycerin) drug description - prescription drugs and medications at RxList
Nitroglycerin injection is a clear, practically colorless additive solution for intravenous infusion after dilution.
Nitroglycerin sublingual tablets contain 0.15 mg (1/400 grain), 0.3 mg (1/200 grain), 0.4 mg (1/150 grain) and 0.6 (1/100 grain) nitroglycerin.
The remainder of nitroglycerin in each system serves as a reservoir and is not delivered in normal use.
www.rxlist.com /cgi/generic/ntg.htm   (525 words)

  RxMed: Pharmaceutical Information - NITROGLYCERIN
Nitroglycerin is rapidly metabolized in the liver by hepatic enzymes to dinitrates and mononitrates.
Nitroglycerin is approximately 60% protein bound while the metabolites 1,2 dinitroglycerol and 1,3 dinitroglycerol are 60 and 30% protein bound, respectively.
Nitroglycerin is excreted by the renal route, primarily as the 2 dinitrometabolites, which have an excretion half-life of approximately 3 to 4 hours.
www.rxmed.com /b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20N)/NITROGLYCERIN.html   (2154 words)

 Nitroglycerin Summary   (Site not responding. Last check: )
Nitroglycerin was discovered by chemist Ascanio Sobrero in 1847, working under TJ Pelouze at the University of Torino.
Solid nitroglycerin is much less sensitive to shock than the liquid, a feature common in explosives and in the past it has often been shipped in the frozen state, but this has resulted in a high number of accidents during the thawing process by the end user just prior to use.
These effects arise because nitroglycerin is converted to nitric oxide in the body (by a mechanism that is not completely understood), and nitric oxide is a natural vasodilator.
www.bookrags.com /Nitroglycerin   (1803 words)

Before a worker is placed in a job with a potential for exposure to nitroglycerin, a licensed health care professional should evaluate and document the worker's baseline health status with thorough medical, environmental, and occupational histories, a physical examination, and physiologic and laboratory tests appropriate for the anticipated occupational risks.
Nitroglycerin should be stored in a cool, dry, well-ventilated area in tightly sealed containers that are labeled in accordance with OSHA's Hazard Communication Standard [29 CFR 1910.1200].
Nitroglycerin is not subject to EPA emergency planning requirements under the Superfund Amendments and Reauthorization Act (SARA) (Title III) in 42 USC 11022.
www.osha.gov /SLTC/healthguidelines/nitroglycerin/recognition.html   (3618 words)

 Nitroglycerin Tablets, Capsules, And Spray
Nitroglycerin relaxes the blood vessels to the heart, thereby increasing the supply of blood and oxygen.
Nitroglycerin is available in sublingual (under the tongue) tablets, buccal (between the cheek and gum) tablets, controlled-release (long-acting) tablets or capsules, and as a spray to be used orally.
Nitroglycerin sublingual tablets and nitroglycerin spray are used to relieve chest pain during attacks and to prevent pain before activities known to provoke attacks (such as climbing stairs, sexual activity, walking uphill, and being outside in cold weather).
www.clevelandclinic.org /health/health-info/docs/0700/0723.asp?index=4899   (1319 words)

 Nitroglycerin (Transdermal Patch) - RxList Generic Information
The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter.
The dinitrates are less effective vasodilators than nitroglycerin, but they are longer-lived in the serum, and their net contribution to the overall effect of chronic nitroglycerin regimens is not known.
In one well-controlled clinical trial, subjects receiving nitroglycerin appeared to exhibit a rebound or withdrawal effect, so that their exercise tolerance at the end of the daily drug-free interval was Less than that exhibited by the parallel group receiving placebo.
www.peru.k12.in.us /pjhs/teacher/jsites/top200/ntgtd.htm   (2075 words)

 Nitroglycerin, Nitro-Bid, Nitro-Dur, Nitrolingual Spray, Nitrostat Tablets, Transderm-Nitro, side effects, drug ...
Nitroglycerin is thought to improve oxygen flow by relaxing the walls of arteries and veins, thus allowing them to dilate.
Nitroglycerin may cause severe low blood pressure (possibly marked by dizziness or light-headedness), especially if you are in an upright position or have just gotten up from sitting or lying down.
Since nitroglycerin is available in many forms, it is crucial for you to follow your doctor's directions for taking the type of nitroglycerin prescribed for you.
www.pdrhealth.com /drug_info/rxdrugprofiles/drugs/nit1296.shtml   (1413 words)

 Using Nitroglycerin for Sudden Chest Pain-Topic Overview
Nitroglycerin is a vasodilator, a medicine that opens blood vessels to improve blood flow.
To improve blood flow to the heart, nitroglycerin opens up (dilates) the arteries in the heart (coronary arteries), which improves symptoms and reduces how hard the heart has to work.
Taking nitroglycerin can lower your blood pressure, which sometimes may cause you to pass out, especially if you are standing up.
www.webmd.com /heart-disease/tc/Using-Nitroglycerin-for-Sudden-Chest-Pain-Topic-Overview   (766 words)

 Nitroglycerin Not Foolproof In Diagnosing Heart Disease
If a patient presents with chest pain, and a nitroglycerin pill or spray under the tongue relieves the pain within a few minutes, the likely diagnosis is coronary artery disease (CAD).
Overall, nitroglycerin was only 28 percent accurate in predicting CAD as the source of pain.
Nitroglycerin works by relaxing the veins (reducing the amount of blood that returns to the heart and easing the heart's workload) and arteries (increasing the heart's blood supply).
www.hopkinshospital.org /health_info/Heart/Reading/nitroglycerin.html   (447 words)

Nitroglycerin - is derived from the glycerol molecule (highlighted in red) which is a common biological molecule from which triglycerides fats and oils are constructed, where all the -OH groups have been replaced by -NO It is the speed of the decomposition reaction which makes nitroglycerin such a violent explosive.
This allows nitroglycerin to be used to make 'smokeless powders', which is of great advantage to artillery or naval gunners whose field of vision does not then become obscured during battle by clouds of billowing smoke.
Clearly, nitroglycerin is far too dangerous for this, and many people lost their lives in the last century trying to use nitroglycerin for peaceful purposes (like quarrying).
www.ch.ic.ac.uk /rzepa/mim/environmental/html/nitroglyc_text.htm   (707 words)

 MedlinePlus Drug Information: Nitroglycerin Tablets, Capsules, and Sprays
Nitroglycerin comes as a sublingual tablet, buccal tablet, extended-release (long-acting) capsule, or spray to be used orally.
Nitroglycerin controls chest pain but does not cure it.
Nitroglycerin tablets also are used with other drugs to treat congestive heart failure and heart attacks.
www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601086.html   (1197 words)

 The Straight Dope: How does nitroglycerin stop heart attacks?
The nitroglycerin in the pills, patches, and sprays that heart patients use for angina (chest pain) is in fact the same stuff you find in dynamite--the residue the drug leaves on patients' skin and clothing is often enough to set off airport bomb-sniffing machines.
Turned out the nitroglycerin vapor in the factory air was acting as a vasodilator, increasing blood flow both to the heart (which needed it, at least in the case of the angina sufferers) and to the head (which didn't).
Nitroglycerin pills have been a standard treatment for angina and heart attack symptoms since 1879--doctors prescribed them for Nobel himself not long before his death in 1896 (he refused to take them--couldn't brook the headaches).
www.straightdope.com /columns/040430.html   (864 words)

 Chronic use of nitroglycerin for chest pain could lead to mitochondrial damage
Nitroglycerin relaxes blood vessels to boost blood flow, yet the mechanism by which the drug works has remained a matter of scientific controversy.
Nitroglycerin loses its effects on blood flow in animals lacking a particular mitochondrial enzyme called aldehyde dehydrogenase (mtALDH), the Duke team reported in the August 23, 2005, Proceedings of the National Academy of Sciences.
In normal mice, treatment with nitroglycerin led to a drop in blood pressure, which increased with drug dose, the researchers showed.
www.news-medical.net /?id=12506   (871 words)

 Megalomania's Method of Making Nitroglycerin
Nitroglycerin was first prepared by a scientist named A. Sobrero around 1847 where it was used as a medicine.
The devastation nitroglycerin caused on both the battlefield and the factory earned Nobel the title "Merchant of Death." Nobel was haunted by the lives nitroglycerin claimed so he created the Nobel Peace Prize to honor champions of peace, and later, supreme accomplishments in science.
Nitroglycerin can be destroyed by boiling in a solution of potassium or sodium hydroxide and ethyl alcohol.
www.roguesci.org /megalomania/explo/nitroglycerin.html   (1007 words)

 Aqueous nitroglycerin injection and manufacturing process - Patent 4879308
Nitroglycerin injection that is free of the customary organic solvents and has an extended shelf life of at least 1 year, consisting essentially of water, lactose, and nitroglycerin.
A sterile and nonpyrogenic aqueous solution of nitroglycerin that is stable for at least 1 year and consists essentially of nitroglycerin, said nitroglycerin being present at a concentration of at least about 0.5 mg/ml, water, and a component selected from the group consisting of lactose, lactose and sodium chloride, and lactose and dextrose.
Although nitroglycerin is not used medically in explosive concentrations, it was the primary explosive ingredient of dynamite, and nitroglycerin's explosive properties control the commercial manufacture of drugs in which "blasting oil" is the active ingredient.
www.freepatentsonline.com /4879308.html   (5748 words)

 nitroglycerin Consumer Drug Information
Nitroglycerin is used to prevent angina attacks (oral tablets, buccal tablets) and to treat attacks once they have started (sublingual tablets, chewable tablets, spray).
Nitroglycerin is in the FDA pregnancy category C. This means that it is not known whether nitroglycerin will be harmful to an unborn baby.
Symptoms of a nitroglycerin overdose include a severe throbbing headache, difficult or slow breathing, muscle cramps, nausea, vomiting, diarrhea, fever, dizziness, fainting, an irregular or slow heartbeat, changes in vision, confusion, flushing, and seizures.
www.drugs.com /MTM/nitroglycerin.html   (1831 words)

Nitroglycerin tablets, spray, or patches should not be left in or near hot or humid environments (i.e., in your car during the summer).
Nitroglycerin tablets may be carried in a special metal cylinder that can be carried on a key chain or as a necklace, but the nitroglycerin MUST be replaced with new tablets at the end of each month.
Nitroglycerin tablets should be replaced with a fresh bottle within 6 months after it was first opened or after you have accumulated six check marks on the bottle.
www.hmc.psu.edu /heartandvascular/patient/articles/pe104.htm   (724 words)

 nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat, Transderm-Nitro, Minitran, Deponit, Nitrol) - drug class, medical uses, ...
It is believed that all nitrates, including nitroglycerin, correct the imbalance between the flow of blood and oxygen to the heart and the work that the heart must do by dilating the arteries and veins in the body.
Additionally, in patients with angina, nitroglycerin preferentially dilates blood vessels that supply the areas of the heart where there is not enough oxygen, thereby delivering oxygen to the heart tissue that needs it most.
Nitroglycerin can be used during pregnancy if in the judgment of the physician the potential benefits justify the potential (though unknown) risks to the fetus.
www.medicinenet.com /nitroglycerin/article.htm   (1005 words)

 nitroglycerin. The Columbia Encyclopedia, Sixth Edition. 2001-05
It is mixed with an absorbent material to form dynamite (which is not so sensitive to slight shocks) and is also used as a component of smokeless powder.
Nitroglycerin was discovered (c.1847) by the Italian chemist Ascanio Sobrero and was first produced commercially by Alfred Nobel.
It is used medicinally to provide temporary relief from the symptoms of angina pectoris; the body converts it to nitric oxide, which causes narrowed blood vessels to relax.
www.bartleby.com /65/ni/nitrogly.html   (168 words)

 [No title]
Nitroglycerin slowed gastric emptying (P<0.02), and this was associated with greater retention of the drink in the proximal stomach (P<0.05).
The hemodynamic responses to nitroglycerin were substantially different from those observed in the AVP infusion studies in normal subjects, three of whom...
These responses to nitroglycerin infusions are consistent with a predominant vasodilatory effect on venous capacitance vessels, leading to a reduction in right atrial filling and to decreased CI and SI.
www.lycos.com /info/nitroglycerin.html   (697 words)

 nitroglycerin topical (patches and ointment) - [Medication]
Nitroglycerin topical is in the FDA pregnancy category C. This means that it is not known whether nitroglycerin topical will harm an unborn baby.
Symptoms of a nitroglycerin overdose include a severe throbbing headache, difficult or slow breathing, muscle cramps, nausea, vomiting, diarrhea, fever, dizziness, fainting, an irregular heartbeat, changes in vision, flushing, and seizures.
Nitroglycerin topical is available with a prescription generically and under several brand names.
www.peacehealth.org /kbase/multum/d00321t1.htm   (1315 words)

 Nitroglycerin is most frequent medication for chronic heart pain
Prior to the invention of nitroglycerin in the latter part of the last century, the handful of truly effective drugs, like aspirin, digitalis, morphine and quinine, were all derived from plant sources.
Nitroglycerin -- glyceryl trinitrate -- doesn't exist in nature, which is hardly surprising, given its tendency to explode at the least provocation.
Patients taking nitroglycerin have to interrupt their use of the drug for at least eight hours a day if it is to remain effective.
www.medhelp.org /general/nitrogly.htm   (564 words)

 Nitroglycerin Ointment
Nitroglycerin ointment is absorbed through the skin into the bloodstream.
Nitroglycerin ointment is not used to relieve chest pain during an attack because it takes 30 minutes to take effect.
Nitroglycerin ointment comes with paper with a ruled line for measuring the dose (in inches).
www.clevelandclinic.org /health/health-info/docs/0700/0717.asp?index=4897   (893 words)

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