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Topic: Norepinephrine reuptake inhibitor

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	Antidepressant effect of norepinephrine uptake 2 inhibitors and combined medications including them - Patent 6403645
		Norepinephrine uptake 2 inhibitors (or their precursors) are administered to enhance the effect of norepinephrine reuptake inhibitors and other antidepressants.
		One therapy for clinical depression is administration of drugs known as norepinephrine reuptake inhibitors, such as imipramine, desipramine, or reboxetine, which inhibit the reuptake of norepinephrine into the presynaptic neuron ("uptake 1"), the main mechanism of inactivating norepinephrine at the synapse.
		The uptake 2 inhibitor or precursor may be normetanephrine or a normetanephrine precursor that crosses the blood-brain barrier where it is converted to normetanephrine, the latter being a norepinephrine uptake 2 inhibitor that increases the level of extraneuronal norepinephrine in the brain.
	www.freepatentsonline.com /6403645.html (3065 words)

	Bupropion - Encyclopedia, History, Geography and Biography
		Bupropion is both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor.
		Bupropion is a selective catecholamine (norepinephrine and dopamine) reuptake inhibitor.
		Dopamine reuptake inhibitors: {Bupropion} {Amineptine} {Methylphenidate} {Phenmetrazine} {Vanoxerine}
	www.arikah.net /encyclopedia/Bupropion (1875 words)

	norepinephrine reuptake inhibitor - Search Results - MSN Encarta
		- norepinephrine removal blocker: a drug, often an antidepressant, that blocks the removal of the neurotransmitter norepinephrine from the synaptic gap, thus increasing its local concentration.
		One well-known example is the drug fluoxetine (Prozac), which blocks the reuptake of serotonin.
		Another group of antidepressants, known as selective serotonin reuptake inhibitors (SSRI), became available in 1987.
	encarta.msn.com /norepinephrine+reuptake+inhibitor.html (89 words)

	Serotonin-norepinephrine reuptake inhibitor - Voyager, the free encyclopedia (Site not responding. Last check: 2007-10-31)
		Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders.
		Activity on norephinephine reuptake is thought necessary for an antidepressant to be effective on neuropathic pain, a property shared with the older tricyclic antidepressants but not with the SSRIs.
		Modern antidepressants usually achieve this effect by blocking the transporter proteins that reabsorb certain neurotranmitters, hence the name "reuptake inhibitors".
	voyager.in /Serotonin-norepinephrine_reuptake_inhibitor (570 words)

	Cymbalta, Duloxetine Hydrochloride Pharmacology - HealthyPlace.com
		Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake.
		Inhibitors of CYP1A2 — When duloxetine was co-administered with fluvoxamine, a potent CYP1A2 inhibitor, to male subjects (n=14) the AUC was increased approximately 6-fold, the Cmax was increased about 2.5-fold, and duloxetine t1/2 was increased approximately 3-fold.
		Inhibitors of CYP2D6 — Because CYP2D6 is involved in duloxetine metabolism, concomitant use of duloxetine with potent inhibitors of CYP2D6 would be expected to, and does, result in higher concentrations of duloxetine (see PRECAUTIONS, Drug Interactions).
	concernedcounseling.com /Medications/cymbalta.asp (9127 words)

	Sexual Dysfunction and Antidepressants
		Twenty-four subjects treated with serotonin reuptake inhibitors for a depressive disorder who had new-onset sexual side effects coincident with antidepressant treatment were treated with escalating doses of bupropion SR up to 300 mg daily for 7 weeks.
		Selective serotonin reuptake inhibitors have become the drugs of choice in the treatment of depression, and they are also effective in the treatment of obsessive-compulsive disorder, panic disorder, and social phobia.
		Mirtazapine, which is unrelated to the selective serotonin reuptake inhibitors, is unique in its action--stimulating the release of norepinephrine and serotonin.
	www.rxbyfax.com /sexualantidep.htm (4887 words)

	Effects of the Selective Norepinephrine Reuptake Inhibitor Reboxetine on Norepinephrine and Serotonin Transmission in ...
		In addition, reboxetine and duloxetine (a dual NE/5-HT reuptake inhibitor) possess nearly identical ED values on LC firing suppression, but reboxetine is five times more potent in prolonging the RT value to applications of NE on CA pyramidal neurons as compared to duloxetine (Figure 2; Kasamo et al.
		Dong J, de Montigny C, Blier P (1999): Assessment of the serotonergic reuptake blocking property of YM992: electrophysiological studies in the rat hippocampus and dorsal raphe.
		Szabo ST, Blier P (2001): Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons.
	www.nature.com /npp/journal/v25/n6/full/1395727a.html (7393 words)

	Cymbalta.com - Cymbalta and Depression Glossary (Site not responding. Last check: 2007-10-31)
		Neurotransmitters are found in the brain and throughout the body along pathways to the brain, such as the spinal cord.
		SNRI (serotonin and norepinephrine reuptake inhibitor) - A class of antidepressants that are thought to relieve the symptoms of depression by affecting the balance of serotonin and norepinephrine in the brain and body.
		SSRI (selective serotonin reuptake inhibitor) - A class of antidepressants that are thought to relieve the symptoms of depression by affecting the balance of serotonin.
	www.cymbalta.com /depression/patient/glossary.jsp (519 words)

	Effexor-venlafaxine.
		Effexor is a novel antidepressant whichis an inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake.
		Antidepressants that block reuptake of both serotonin and norepinephrine, such as the tricyclic antidepressants (e.g., amitriptyline), have been used to treat pain syndromes in patients with or without comorbid MDD or GAD.
		The purpose of this study is to further examine the utility of bupropion sustained release (SR) augmentation in patients with inadequate response to selective serotonin reuptake inhibitors.
	www.rxbyfax.com /effexor.htm (5812 words)

	Norepinephrine (Site not responding. Last check: 2007-10-31)
		Norepinephrine news vertical portal can now be syndicated quickly and easily using our new Really Simple Syndication feeds.
		sibutramine) increases the activity of the mood chemicals norepinephrine and serotonin......
		For any further understanding that could lead to the prevention, treatment, and/or cure of the disorders, we recommend that affected individuals seek the advice or counsel of his or her own personal physician(s).
	norepinephrine.diseasemap.com (316 words)

	DULOXETINE (MDXexchange)
		Neonates exposed to serotonin and norepinephrine reuptake inhibitors (SNRIs) late in the third trimester have required prolonged hospitalization, respiratory support, and tube feeding.
		Duloxetine is a dual-selective serotonin (5HT) and norepinephrine reuptake inhibitor (Wong et al, 1993).
		All three agents have been demonstrated to inhibit norepinephrine and 5HT uptake in preclinical studies; both duloxetine and venlafaxine were more potent inhibitors of 5HT than norepinephrine reuptake, whereas milnacipran was a more potent inhibitor of norepinephrine uptake (Goodnick, 1999; Artigas, 1995).
	www.micromedex.com /products/updates/drugdex_updates/de/duloxetine.html (3750 words)

	Depression Hurts - Patient Resources: Glossary for Depression
		Neurotransmitters are found in the brain and along pathways to the brain, such as the spinal cord.
		SSNRI (selective serotonin and norepinephrine reuptake inhibitor) A class of antidepressants that are thought to relieve the symptoms of depression by helping to correct an imbalance of serotonin and norepinephrine in the brain and body.
		SSRI (selective serotonin reuptake inhibitor) A class of antidepressants that are thought to relieve the symptoms of depression by helping to correct an imbalance in the brain's level of serotonin.
	www.depressionhurts.com /resources/glossary.jsp?reqNavId=3.7 (475 words)

	Cypress Bioscience Inc. Press Release Friendly Print
		Agents that interfere with the reuptake of norepinephrine, particularly tricyclic antidepressants (TCAs), have demonstrated superior analgesic efficacy compared to agents that selectively block the reuptake of serotonin.
		Milnacipran is a norepinephrine serotonin reuptake inhibitor (NSRI) being developed for the treatment of fibromyalgia syndrome and other chronic pain disorders.
		Pharmacologically, this agent is differentiated from serotonin norepinephrine reuptake inhibitors (SNRIs), such as duloxetine (Eli Lilly), by its preferential blockage of norepinephrine reuptake over serotonin.
	www.fmaware.org /sponsors/cypress_articleFP.htm (623 words)

	Nicotine and serotonin
		Foods High in Serotonin Serotonin Deficiency%2BZelnorm chocolate serotonin what raises serotonin levels selektive serotonin reuptake inhibitoren serotonin type 1A receptors Serotonin sex effects of Prevacid on serotonin serotonin limbic pituitary axis tramadol and serotonin syndrome research of serotonin and norepinephrine reuptake inhibitors natural sources of serotonin serotonin level emotion Food High In Serotonin.
		selective serotonin reuptake inhibitors and NSAIDs
		Selective Serotonin Reuptake Inhibitor serotonin blood pressure serotonin disorders serotonin syndrome symptoms Lexapro serotonin syndrome management treatment increase serotonin naturally serotonin reuptake weight gain marijuana and serotonin foods that boost serotonin insulinoma serotonin depression serotonin physiology serotonin fda approval serotonin reuptake inhibitors

www.bambazina.com /board/messages/64075.html (1281 words)

	Reboxetine efficacy and tolerability
		Reboxetine is a unique selective norepinephrine reuptake inhibitor (NRI) with proven antidepressant efficacy in pharmacologic and biochemical tests predictive of antidepressant properties.
		Comprehensive clinical trials, including 8 placebo-controlled and/or active treatment-controlled studies, plus 4 open studies, have assessed the short-term and long-term efficacy and tolerability of reboxetine in patients with major depressive disorders and dysthymia.
		The first in its class, reboxetine, a selective NRI, will provide a valuable addition to the existing armamentarium of agents used in the treatment of depression.
	reboxetine.org /reboxetine/reboxetine-review.htm (244 words)

	Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in ...
		Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats -- Iyengar et al., 10.1124/jpet.104.070656 -- Journal of Pharmacology And Experimental Therapeutics
		Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats
		Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor
	jpet.aspetjournals.org /cgi/content/abstract/jpet.104.070656v1 (383 words)

	Selective Norepinephrine Reuptake Inhibitors
		Selective Norepinephrine Reuptake Inhibitors (SNRIs) are prescribed primarily for Attention-Deficit/Hyperactivity Disorder (ADHD).
		Although the mechanism of action would seem also to relate to depression, the SNRI Atomoxetine (Strattera) is prescribed primarily for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD).
		The action of the SNRI Atomoxetine (Strattera) is thought to be related to selective inhibition of the pre-synaptic norepinephrine transporter, but its full mechanism of action is not understood.
	counsellingresource.com /medications/medication-types/snri.html (185 words)

	RemedyFind: patient ratings of Cymbalta etc. (Duloxetine) for Depression
		Unlike âselective serotonin reuptake inhibitorsâ (SSRIâs) such as Prozac etc. (Fluoxetine), Paxil (Paroxetine) etc., which only balance levels of the nerve transmitter serotonin, SSNRIâs have the ability to affect two neurotransmitters - serotonin and norepinephrine.
		Clinical studies have shown that the SSNRIâs are generally quicker acting and more effective in treating severe major depressive disorder, treatment-resistant depression, and depressive symptom remission than SSRI antidepressants, and tricyclic antidepressants.
		Neurotransmitters like serotonin and norepinephrine (also known as noradrenaline), are involved in the regulation of pain, pleasure, anxiety, panic, arousal, and sleep behavior (the sleep-wake cycle).
	www.remedyfind.com /treatments/9/1847 (1813 words)

	Treatment with Serotonin-Norepinephrine Reuptake Inhibitor Reduces Rate of Relapse in Panic Disorder: Presented at CPA (Site not responding. Last check: 2007-10-31)
		Panic disorder is a chronic illness often associated with comorbid psychiatric conditions, including depression and social anxiety disorder.
		Short-term treatment with the serotonin norepinephrine reuptake inhibitor (SNRI) venlafaxine XR has been shown to be effective, said investigator James Ferguson MD, Clinical Professor of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, United States.
		Ferguson and colleagues conducted a prospective, randomised, double-blind, placebo-controlled study to investigate the ability of venlafaxine XR to prevent relapse in patients who had experienced improvements in PD symptoms with short-term therapy with venlafaxine XR.
	www.pslgroup.com /dg/254CEE.htm (466 words)

	Drugs and Treatments - WebMD with AOL Health - Patient Handout
		Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.
		This medication is an antidepressant (serotonin-norepinephrine reuptake inhibitor type) used in the treatment of depression.
		Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before or 7 days after treatment with this medication.
	aolsvc.health.webmd.aol.com /drugs/mono-5047-VENLAFAXINE+-+ORAL.aspx?d... (1364 words)

	Treating binge eating disorder with sibutramine - Eating Disorders - serotonin and norepinephrine reuptake inhibitor - ... (Site not responding. Last check: 2007-10-31)
		Treating binge eating disorder with sibutramine - Eating Disorders - serotonin and norepinephrine reuptake inhibitor - Author Abstract
		Sibutramine, a serotonin and norepinephrine reuptake inhibitor, commonly used for the treatment of obesity, has been shown to be consistently effective in weight loss across a variety of studies.
		Binge-eating disorder (BED) is a common diagnosis among those who are overweight or obese and who are candidates for sibutramine therapy.
	www.findarticles.com /p/articles/mi_m0887/is_6_22/ai_104439017 (705 words)

	Managing AD/HD with Medication — An Overview - SchwabLearning.org
		Of these, only the stimulants and the selective norepinephrine reuptake inhibitor have been approved by the U.S. Food and Drug Administration (FDA) for treating AD/HD in children.
		Scientists believe it works by blocking or slowing the reuptake of norepinephrine, a neurotransmitter that regulates attention, impulsivity, and activity levels in the brain.
		Important Note: In September of 2004, an expert panel advising the U.S. Food and Drug Administration recommended that the SSRI (Selective Seratonin Reuptake Inhibitor) category of anti-depressants carry a warning on their labels saying that these medications can sometimes lead children and teenagers to become suicidal.
	www.schwablearning.org /articles.asp?r=340&g=2 (1326 words)

	SSRI DISCUSSION FORUM
		Radafaxine, GW353162 Norepinephrine reuptake inhibitor and weak dopamine reuptake inhibitor (metabolite of bupropion) GSK Depression, obesity Phase III - to begin in 2006
		The drug causes the release of norepinephrine more potently than it causes the release of dopamine; it is much less effective as a serotonin releasing agent (1) The drug also directly inhibits norepinephrine and dopamine reuptake at higher concentrations (1).
		The clinical development program for major depressive disorder supporting the NDA investigated desvenlafaxine extended release, a serotonin/norepinephrine reuptake inhibitor (SNRI), in patients with a broad range of symptoms associated with depression, including both emotional and somatic symptoms.
	network54.com /Forum/281849/thread/1135352543/Future+Treatments+for+... (3145 words)

	Desvenlafaxine Succinate (DVS-233) Phase 3 Data Show Significant Improvement In Symptoms Of Depression In Adult ...
		Because many drugs are known to be associated with a potential to prolong QT interval, the FDA developed guidance recommending that all manufacturers conduct a QT interval study to help determine whether any new agent may potentially prolong the QT/QTc interval, one of many important measures of cardiovascular safety.
		Abstract: Desvenlafaxine: Preclinical Evidence for Serotonin and Norepinephrine Reuptake Inhibition, Antidepressant, and Antinociceptive Activity
		According to research also presented during the APA, desvenlafaxine succinate exhibited activity in preclinical models of depression and anxiety.
	www.pharma-lexicon.com /medicalnews.php?newsid=44128 (1295 words)

	All The Support You Can Handle - Desipramine as a Replacement for Effexor? (Site not responding. Last check: 2007-10-31)
		inhibits norepinephrine reuptake as the dosage is increased.
		Desipramine is a norepinephrine selective reuptake inhibitor at all
		dosages and has minimal direct effect on serotonin reuptake.
	www.supportalk.com /detail-295533.html (458 words)

	BehaveNet® Clinical Capsule: selective serotonin norepinephrine reuptake inhibitor (SNRI) (Site not responding. Last check: 2007-10-31)
		BehaveNet® Clinical Capsule: selective serotonin norepinephrine reuptake inhibitor (SNRI)
		This class of drugs probably acts by limiting the reabsorption of serotonin and norepinephrine by neurons (nerve cells) in the brain where they meet (the synapse).
		Also: dual reuptake inhibitor, norepinephrine serotonin reuptake inhibitor (NSRI)
	www.behavenet.com /capsules/treatments/drugs/snri.htm (44 words)

	Duloxetine: A Dual Reuptake Inhibitor -- Dugan and Fuller 38 (12): 2078 -- The Annals of Pharmacotherapy
		Duloxetine: A Dual Reuptake Inhibitor -- Dugan and Fuller 38 (12): 2078 -- The Annals of Pharmacotherapy
		Articles by Dugan, S. Articles by Fuller, M. Duloxetine: A Dual Reuptake Inhibitor
		inhibitor being considered for treatment of MDD and stress urinary incontinence.
	www.theannals.com /cgi/content/abstract/38/12/2078 (295 words)

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