
	Where results make sense

Topic: Noscapine

In the News (Thu 16 Feb 12)

EXECUTIVE POWER

Iran

ANALYSIS

Pakistan

Family compact

	Noscapine derivatives as adjuvant compositions and methods of use thereof - Patent 7090853
		The response of the gut to Noscapine is one of mild irritation.
		Noscapine is an alkaloid occurring in abundance in the opium plant, Papaver somniferum L. papaveraceae.
		The concentration of noscapine was raised in increments of 0.5.mu.M, until the decrease in the fluorescence intensity was saturated.
	www.freepatentsonline.com /7090853.html (8208 words)

	Noscapina (Noscapine) - Últimos artículos en medline (Site not responding. Last check: 2007-11-05)
		Synthesis and in vitro cytotoxicity of haloderivatives of noscapine.
		Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.
		Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro.
	www.galenicom.com /medline/term/Noscapine (189 words)

	MEDLINE Search on Medscape.com
		Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation.
		Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth.
		HPLC determination of aminophylline, methoxyphenamine hydrochloride, noscapine and chlorphenamine maleate in compound dosage forms with an aqueous-organic mobile phase.
	search.medscape.com /uslclient/searchMedline.do?queryText=Noscapine (382 words)

	Drug News and Perspectives
		Noscapine, an antitussive drug, has been previously shown to inhibit the growth of cultured tumor cells and tumors implanted in nude mice.
		As a result, noscapine causes the aberrant assembly of the cellular machinery necessary for cell division, the mitotic spindle.
		Thus, noscapine and its analogues are potential cost-effective chemotherapeutic agents for the treatment of human cancers.
	www.prous.com /journals/dnp/20001309/summary/dn0543.cfm (162 words)

	Process of making cough syrup with masked noscapine - Patent 4029797
		A process of utilizing the drug noscapine in a palatable cough syrup which masks the characteristic unpalatable taste of the drug comprising the steps of preparing an alkaline carrier and adding noscapine in a form which is a non-acidic solution, but rather in suspension which is finely dispersed.
		The present invention has as a several object the provision of a method of formulation of noscapine to obtain a liquid suspension in which the noscapine is maintained in the alkaloid form, which is relatively tasteless, therefore resulting in a more palatable preparation for use in treating coughs.
		The noscapine alkaloid which is in powdered from is mixed in the quantity of 1,200 Gm.
	www.freepatentsonline.com /4029797.html (916 words)

	Noscapine
		Noscapine (also known as Narcotine) is an opioid analgesic agonist.
		It is grouped as part of the Benzylisoquinolines, of which papaverine, a smooth muscle relaxant isolated from opium, is also included.
		Noscapine is used for its antitussive effects or cough suppression.
	www.mrsci.com /Pharmacologic-Agents/Noscapine.php (41 words)

	BioPortfolio News : Cougar Biotechnology Announces Presentation of Positive Preclinical Data for CB3304 (Noscapine) in ...
		The preclinical studies demonstrate that noscapine exhibits potent antitumor activity against non-Hodgkin's lymphoma and myeloma in vitro as well as in vivo in xenograft models.
		As noscapine may represent a new, well-tolerated, oral therapy for the treatment of lymphoma and myeloma, further clinical studies with the drug are warranted."
		This is the first data to demonstrate the effectiveness of CB3304 (noscapine) in the various subtypes of non-Hodgkin's lymphoma as well as multiple myeloma.
	www.bioportfolio.com /dec_05/14_12_2005/Cougar_Biotechnology.html (530 words)

	[Brainlife] LANDEN JW et al (2004) - Noscapine crosses the blood-brain barrier and inhibits glioblastoma growth (Site not responding. Last check: 2007-11-05)
		In this study, we show that noscapine inhibits the proliferation of rat C6 glioma cells in vitro (IC(50) = 100 microm) and effectively crosses the blood-brain barrier at rates similar to the ones found for agents such as morphine and [Met]enkephalin that have potent central nervous system activity (P < or = 0.05).
		Furthermore, noscapine treatment resulted in little evidence of toxicity to dorsal root ganglia cultures as measured by inhibition of neurite outgrowth and yielded no evidence of peripheral neuropathy in animals.
		These unique properties of noscapine, including its ability to cross the blood-brain barrier, interfere with microtubule dynamics, arrest tumor cell division, reduce tumor growth, and minimally affect other dividing tissues and peripheral nerves, warrant additional investigation of its therapeutic potential.
	www.brainlife.org /abstract/landen_20040801.htm (360 words)

	SEQT - Noticias Destacadas
		Noscapine (CB-3304) is an oral opiate alkaloid currently being tested in phase I studies by Cougar Biotechnology in non-Hodgkin's lymphoma.
		Intraperitoneal and oral doses of noscapine were evaluated in vivo in SCID-beige murine xenograft models over 14-day dosing periods.
		Noscapine was well tolerated, with no grade 3 or grade 4 hematological toxicities.
	www.seqt.org /seqt/contenidos/noticia.asp?NoticiasId=55288 (243 words)

	Result Content View (Site not responding. Last check: 2007-11-05)
		Noscapine is an oral opiate alkaloid with structural similarity to colchicine that induces cell cycle arrest and apoptosis.
		In a trypan blue exclusion assay, noscapine exhibits increasing potency with increasing duration of exposure in B- and T-cell lymphomas, and myelomas (MM).
		Noscapine may represent a new well tolerated oral therapy for the control of lymphoma and myeloma.
	www.abstracts2view.com /hem_ash05atlanta/view.php?nu=HEM05L1_3208 (375 words)

	Brominated Derivatives of Noscapine Are Potent Microtubule-interfering Agents That Perturb Mitosis and Inhibit Cell ...
		The tubulin fluorescence emission spectrum is quenched by noscapine (B), 5-Br-nosc (E), and Rd 5-Br-nosc (H) in a concentration-dependent manner.
		C, immunofluorescence micrographs of microtubule arrays (green) and DNA (red) in control interphase, prometaphase, and metaphase HeLa cells and in cells arrested by noscapine, 5-Br-nosc, and Rd 5-Br-nosc at the concentrations needed to arrest 50% of the cells at mitosis (18.4, 7.7, and 3.6 µM, respectively).
		Noscapine, 5-Br-nosc, and Rd 5-Br-nosc affect kinetochore-microtubule attachment as revealed by the presence of Mad2 (green) at the kinetochores on the chromosomes (red).
	molpharm.aspetjournals.org /cgi/content/full/63/4/799 (5822 words)

	Noscapine - Wikipedia, the free encyclopedia
		Noscapine (also known as Narcotine) is an opioid agonist without significant analgesic properties [1].
		Pretreatment with rimcazole,a sigma specific antagonist, causes a dose-dependent reduction in antitussive activity of noscapine [2].
		Noscapine(Nospen)has a history of OTC abuse in a several countries being readily available from local pharmacies as a prescription drug.
	en.wikipedia.org /wiki/Noscapine (287 words)

	[No title] (Site not responding. Last check: 2007-11-05)
		Noscapine drastically decreased tumor sizes without any obvious weight loss in the mouse or any other tissue toxicities detected after noscapine treatment.
		To see if noscapine can inhibit human breast and bladder cancer cells, these cells were implanted in nude mice and it caused an 80% reduction in number of tumors in a 3-week treatment.
		Ye, K. Ke, Y. Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells.
	sulcus.berkeley.edu /mcb/165_001/papers/manuscripts/_18.html (2669 words)

	UNODC - Bulletin on Narcotics - 1981 Issue 1 - 007
		It is used as an antitussive drug, particularly in wet cough, and is included in the British pharmacopoeia (BP), British Pharmaceutical Codex (B.P.C.) and Japanese Pharmacopoeia (J.P.) under the name of noscapine [ 6] [ 7] [ 8] [ 9] [ 10] [ 11] [ 12].
		Noscapine B.P. and noscapine hydrochloride, United States National Formulary (U.S.N.F. XII) and J.P. are administered in the form of lozenges, linctus, syrup, tablets and resin-bound products.
		Noscapine B.P. An amount of 40 kg of papaverine-free narcotine was dissolved in 200 l of hot toluene.
	www.unodc.org /unodc/bulletin/bulletin_1981-01-01_1_page008.html (3678 words)

	Result Content View (Site not responding. Last check: 2007-11-05)
		Noscapine is an alkaloid derived from opium, which lacks sedative, euphoric, analgesic or respiratory depressant properties.
		Noscapine induces conformational changes in tubulin, which results in altered microtubule assembly.
		We conclude that a larger study of Noscapine is warranted to evaluate the efficacy of the compound in patients with lymphoma.
	www.abstracts2view.com /hem_ash05atlanta/view.php?nu=HEM05L1_4927 (354 words)

	AllergyNet - Allergy Advisor Find (Site not responding. Last check: 2007-11-05)
		Incisions are made in the walls of the green seed pods, and the milky exudation is collected and dried.
		Opium and the isoquinoline alkaloids morphine, codeine, noscapine, papaverine, and thebaine are isolated from the dried material.
		In addition to codeine and morphine, narcotine (noscapine), papaverine, and thebaine were found in Indian and Netherlands poppy seeds (Papaver somniferum L).
	allallergy.net /fapaidfind.cfm?cdeoc=1218 (1048 words)

	NOSCAPINE
		The UK Committee on Safety of Medicine has recommended that products containing noscapine be contra-indicated in women of child bearing potential.
		Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
		Noscapine: Oral rat LD50: 1520 mg/kg; oral mouse LD50: 853 mg/kg.
	bulkpharm.mallinckrodt.com /_attachments/msds/NOSIE.htm (861 words)

	Yeni Sayfa 1
		Biological Activity : Noscapine is an antitussive agent, acting on a Central Nervous System site.
		However, unlike Codeine and other narcotics, Noscapine lacks addictive, analgesic, respiratory depressant, and sedative properties.
		Although Noscapine (up to 1 mM) does not affect directly basal Phosphoinositide turnover or cAMP levels, it inhibits Carbachol-stimulated Phosphoinositide turnover (EC50 = 10 µM), and augments the stimulation by forskolin of cAMP levels (EC50 = 50 µM) (3).
	www.geocities.com /worldofnutraceuticals/sayfalar/page05.htm (378 words)

	Cougar Biotechnology, Inc.
		Los Angeles, CA, December 13, 2005 - Cougar Biotechnology, Inc, a privately held biotechnology company, today announced the presentation of results from preclinical experiments that demonstrate the effectiveness of the Company's drug CB3304 (noscapine) for the treatment of non-Hodgkin's lymphoma and multiple myeloma.
		About Cougar Biotechnology Cougar Biotechnology, Inc. is a Los Angeles-based private biotechnology company established to in-license and develop clinical stage drugs, with a specific focus on the field of oncology.
		Cougar assumes no obligation to update these forward-looking statements, except as required by law.
	www.cougarbiotechnology.com /pr121305.html (508 words)

	Advance Scientific and chemical - , chemical company, chemical compound, spectrum chemical, chemical distributor, ...
		For Bulk quotations on "Noscapine Hydrochloride", be sure to contact our Bulk Chemical Department at 1-800-524-2436.
		MSDS for Noscapine Hydrochloride, is available upon request.
		Advance carries the largest catalog of ACS, Reagent, USP/NF, FCC and technical/commercial chemicals nationwide.
	www.advance-scientific.com /Properties.asp?CODE=N3859 (110 words)

	Clinical Trial: Study of Noscapine for Patients With Low Grade Non Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia ...
		This study is for patients with non-hodgkin's lymphoma or chronic lymphocytic leukemia, which has failed to shrink or has returned after previous treatment with chemotherapy.
		The purpose of this study is to find out whether patients with these types of cancer will have their tumor shrunk after treatment with a drug called Noscapine.
		The second purpose is to see what are the side effects of this drug.
	clinicaltrials.gov /ct/show/NCT00183950 (319 words)

	Noscapine hydrochloride-induced numerical aberrations in cultured human lymphocytes: a comparison of FISH detection ...
		Noscapine hydrochloride-induced numerical aberrations in cultured human lymphocytes: a comparison of FISH detection methods and multiple end-points -- Schuler et al.
		Noscapine hydrochloride-induced numerical aberrations in cultured human lymphocytes: a comparison of FISH detection methods and multiple end-points
		various concentrations of the cough medicine noscapine hydrochloride
	mutage.oxfordjournals.org /cgi/content/abstract/18/3/235 (378 words)

	Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in mice -- Aneja et ...
		a tubulin-binding, natural compound, noscapine, that was nontoxic
		show that a synthetic analogue of noscapine, 9-bromonoscapine,
		10-fold to 15-fold more potent than noscapine in inhibiting
	mct.aacrjournals.org /cgi/content/abstract/5/9/2366 (287 words)

	NOSCAPINE HYDROCHLORIDE
		Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Noscapine hydrochloride 912-60-7 100% Yes
		--------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Noscapine hydrochloride (912-60-7) Exempt Yes NE* Yes --------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil.
		----------------------------------------------- ----- --- ---- ----- Noscapine hydrochloride (912-60-7) No No No No --------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg.
	bulkpharm.mallinckrodt.com /_attachments/msds/NOSEI.htm (800 words)

	NITEPAX SUSPENSION (Suspension) (Site not responding. Last check: 2007-11-05)
		Each 5 mL contains: Noscapine Resin Complex equivalent to 25 mg
		Very large doses of noscapine can depress smooth and cardiac muscle but this effect is not seen with doses used for cough.
		If side-effects occur, the dosage should be reduced or medication stopped, according to severity.
	home.intekom.com /pharm/lagamed/nitepax.html (184 words)

Try your search on: Qwika (all wikis)