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Topic: Nuclear pore complex

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	Nuclear Envelope
		The inner membrane of the nuclear envelope lies next to a layer of thin filaments which surrounds the nucleus except at the nuclear pores.
		Nuclear pores are formed at sites where the inner and outer membranes of the nuclear envelope are joined.
		The figure to the left illustrates a preparation of nuclear pore complexes that were isolated from an oocyte and spread on plastic.
	cellbio.utmb.edu /cellbio/nuclear_envelope.htm (1744 words)

	The Nuclear Pore Complex (Site not responding. Last check: 2007-10-15)
		Molecular trafficking between the nucleus and the cytoplasm of interphase cells occurs via the nuclear pore complexes (NPCs), large supramolecular assemblies that are embedded in the double-membraned nuclear envelope (NE).
		The central pore is often plugged with a distinct particle, called central plug or transporter, of highly variable appearance whose molecular architecture and functional significance remain to be established.
		A 3-D reconstruction of detergent extracted and negatively stained nuclear pore complexes (NPCs; Hinshaw et al., 1992) revealing the central framework which exhibits strong 822 symmetry and thus consists of two identical halves relative to the central plane of the nuclear envelope (NE).
	www.scripps.edu /~stoffler/proj/NPC/npc.html (559 words)

	Nuclear pore Summary
		Nuclear pores are large protein complexes that cross the nuclear envelope, which is the double membrane surrounding the eukaryotic cell nucleus.
		Although smaller molecules simply diffuse through the pores, larger molecules may be recognized by specific signal sequences and then be diffused with the help of nucleoporins into or out of the nucleus.
		The whole pore complex has a diameter of about 150 nm, and the diameter of the opening is about 50 nm wide.
	www.bookrags.com /Nuclear_pore (1404 words)

	Importin {beta} Negatively Regulates Nuclear Membrane Fusion and Nuclear Pore Complex Assembly -- Harel et al. 14 (11): ...
		pore complexes in nuclei was assessed with anti-FG antibody.
		nuclear membranes and the assembly of nuclear pore complexes
		Miller, B.R., and Forbes, D.J. Purification of the vertebrate nuclear pore by biochemical criteria.
	www.molbiolcell.org /cgi/content/full/14/11/4387 (5250 words)

	The Scientist : A Peek at the Pore
		The group was also able to organize image data to reveal "major rearrangements within the pore complex" as material passes through it – adding evidence to the conjecture that the pore must flex like an esophagus to allow large molecules to reach the nucleus but screen out smaller, harmful ones.
		Ellenberg's own recent work[2] indicates that the pore dynamically sheds some nucleoporins, although at a much lower rate than cargo travels through it – a finding that some,[3] although not Ellenberg himself, use to shore up the argument that the plug is cargo.
		The researchers are parsing the structures of the pore complex's individual proteins and recently charted the structure of nup133, a member of the pore subcomplex nup160-107 that has been shown to be key in forming the NPC's structural framework.
	www.the-scientist.com /2005/4/25/18/1 (1592 words)

	Regulation of Nuclear Pore Complex Conformation by IP3 Receptor Activation -- Moore-Nichols et al. 83 (3): 1421 -- ...
		Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein.
		Hinshaw, J. Architecture of the nuclear pore complex and its involvement in nucleocytoplasmic transport.
		Nuclear calcium and the regulation of the nuclear pore complex.
	www.biophysj.org /cgi/content/full/83/3/1421 (4702 words)

	The Nuclear Pore Complex
		The nuclear pore complex (NPC), perhaps the largest protein complex in the cell, is responsible for the protected exchange of components between the nucleus and cytoplasm and for preventing the transport of material not destined to cross the
		The body of the vertebrate NPC is approximately 145 nm in diameter and 80 nm length across the nuclear envelope.
		The yeast NPC is smaller at approximately 96 nm in diameter and 35 nm in length (
	www.ks.uiuc.edu /Research/npc (1199 words)

	Nuclear pore - Wikipedia, the free encyclopedia
		There are about on average 2000 nuclear pore complexes in the nuclear envelope of a vertebrate cell, but it varies depending on the number of transcriptions of the cell.
		The whole pore complex has a diameter of about 120 nm, the diameter of the opening is about 50 nm wide and its "depth" is about 200 nm
		The molecular mass of the NPC (Nuclear Pore Complex) is about 125 million dalton.
	en.wikipedia.org /wiki/Nuclear_pore (850 words)

	The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import -- Walther ...
		complexes from the NPC (Rexach and Blobel, 1995; Gorlich et al., 1996).
		A monoclonal antibody against the nuclear pore complex inhibits nucleocytoplasmic transport of protein and RNA in vivo.
		Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex.
	www.jcb.org /cgi/content/full/158/1/63 (8448 words)

	Steps of nuclear pore complex disassembly and reassembly during mitosis in early Drosophila embryos -- Kiseleva et al. ...
		breakdown of the nuclear membranes and disassembly of the NPCs
		9 is a montage of the NPC assembly intermediates that we
		Stafstrom, J. and Staehelin, L. Dynamics of the nuclear envelope and of nuclear pore complexes during mitosis in the Drosophila embryo.
	jcs.biologists.org /cgi/content/full/114/20/3607 (6689 words)

	Nuclear Compartments: Nuclear Pore
		The NPC is inturn anchored in the NE by the nuclear lamina, a meshwork of lamins and lamin-associated proteins that forms a 15 nm thick fibrous structure between the inner nuclear membrane and peripheral chromatin.
		Nuclear pore complex components are implicated in both autoimmune disease and cancer.
		Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells.
	npd.hgu.mrc.ac.uk /compartments/nuc_pore.html (1133 words)

	Molecular Architecture of the Yeast Nuclear Pore Complex: Localization of Nsp1p Subcomplexes -- Fahrenkrog et al. 143 ...
		The Nsp1p-Nup49p-Nup57p- Nic96p complex (i.e., the Nsp1p complex) is localized at both the cytoplasmic and nuclear periphery of the central gated channel, and the Nsp1p-Nup82p complex resides only at the cytoplasmic periphery of the central gated channel.
		Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking.
		Nuclear pore proteins are involved in the biogenesis of functional tRNA.
	www.jcb.org /cgi/content/full/143/3/577 (6620 words)

	Gating mechanism of the nuclear pore complex channel in isolated neonatal and adult mouse liver nuclei -- TONINI et al. ...
		Gating mechanism of the nuclear pore complex channel in isolated neonatal and adult mouse liver nuclei -- TONINI et al.
		Gating mechanism of the nuclear pore complex channel in isolated neonatal and adult mouse liver nuclei
		are distinct from nucleocytoplasmic pathways, the nuclear pores
	www.fasebj.org /cgi/content/full/13/11/1395 (4688 words)

	RanGTP mediates nuclear pore complex assembly : Nature
		In metazoa, the nuclear envelope breaks down and reforms during each cell cycle.
		Nuclear pore complexes (NPCs), which serve as channels for transport between the nucleus and cytoplasm
		The data demonstrate that RanGTP triggers distinct steps of NPC assembly, and suggest a mechanism for the spatial restriction of NPC assembly to the surface of chromatin.
	www.nature.com /doifinder/10.1038/nature01898 (247 words)

	UniProtKB/Swiss-Prot entry Q8N1F7 [NUP93_HUMAN] Nuclear pore complex protein Nup93
		Grandi P. Dang T. Pane N. Shevchenko A. Mann M. Forbes D. Hurt E. "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly.";
		: Component of the p62 complex, a complex composed of NUP62, NUP54.
		Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.
	www.expasy.org /uniprot/Q8N1F7 (346 words)

	UniProtKB/Swiss-Prot entry P49790 [NU153_HUMAN] Nuclear pore complex protein Nup153
		McMorrow I. Bastos R. Horton H. Burke B. "Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153.";
		The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
		Cellular component: nuclear pore (traceable author statement from ProtInc).
	www.expasy.org /uniprot/P49790 (345 words)

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