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Topic: Nuclear gene

    Note: these results are not from the primary (high quality) database.

FUNCTIONAL DOMAINS OF THE C-ABL PROTEIN TYROSINE KINASE Unlike p160gag-abl, which has cytoplasmic and plasma membrane localization, much of the c-abl (IV) protein is nuclear, the remainder in the cytoplasm and plasma membrane, largely associated with actin stress filaments. Thus, these nuclear localization signals play a passive role, allowing the abl protein to be recognized for nuclear transport. Mapping of amino acid sequences responsible for nuclear localization in p150c-abl((IV)) reveals a C-terminal signal similar to that of SV40 large T antigen and a second nuclear localization signal further C-terminal. www.aegis.com /aidsline/1990/dec/M90C3720.html

Krawetz group chromatin structure and the nuclear matrix... In response to a maturation signal, the previously tethered regions between the LCR/5'HS and the b-globin gene are released from the nuclear matrix and the chromatin domain is remodeled. Two additional regions are tethered to the nuclear matrix between the LCR and b-globin gene to spatially separate and silence the locus. TEMicrograph of mouse fibroblast nuclear matrix[left] and surrounding cytoplasm. compbio.med.wayne.edu /matrix.html   (668 words)

PPE - Working Class Encyclopedia - Dump List 2 N3 gen - Florence Nightingale, Nike, 1913 Christmas Party Massacre Michigan, 1913 General Strike NZ, 1913 Waterfront Strike, 1951 Waterfront Lockout, 1951 Waterfront Strike, 1984, Nineteen Eighty-Four, Niue, Richard Nixon, Nobel Prize, Noncooperation, Nonviolence, Norfolk Island, Normans, Nuclear Issues, Nuclear Weapons, Nuclear Umbrella, Nuclear Arms, Nucleic Acid, Nuffield. NB: Working Class biography (bio) entries placed after general (gen) entries. M6 gen - Monthly Review, Monument, Moon, Moonies - see Unification Church, Mike Moore (NZ pm), Moral Majority, Moral ReArmament, Morality, Jean Paul Morat, Moravian Church, Hannah More, Sir Thomas More, Sir Henry Morgan, J.P. Morgan, Mormons, Desmond Morris, William Morris, Herbert Morrison, Sir Howard Morrison. www.embassy.org.nz /encycl/index2.htm   (668 words)

Myb - Myb protein Myb is a homologue of MYB (Myb proto-oncogene protein) from Homo sapiens. Stonewall is a germ cell nuclear protein; Stonewall has a DNA binding domain that shows similarities to the Myb and Adf-1 transcription factors and has other features that suggest that it is a transcription activating factor. Several obvious goals for future research will be to define the function of myb proteins within the nucleus, to understand the regulation of myb expression during the cell cycle, to establish which molecular alterations are essential for converting c-myb into a transforming gene, and the determine the role of myb in human malignancies. www.pdg.cnb.uam.es /UniPub/iHOP/gg/58849.html   (668 words)

NOVA Transcripts The Doomsday Asteroid PBS GENE SHOEMAKER: One was to study the structure, the deformation on the walls of the crater, and how rocks had been pushed out and then peeled up and overturned, and I could compare that deformation directly with experimental craters, smaller craters formed by nuclear explosions. GENE SHOEMAKER: If we get to a really big event, say, a ten-kilometer crater, which is still small compared to the biggest, that's equal to the energy of all of the nuclear weapons in the world, if you heaped them up in a pile and set them off. GENE SHOEMAKER: Maybe it looks obvious now that the craters on the moon were formed by impact, but in fact, the vast majority of scientists who study the moon, astronomers in particular, at the time that I began this work, thought that these craters on the moon were probably formed by volcanoes. www.pbs.org /wgbh/nova/transcripts/2212doom.html   (6315 words)

Dr. Howard Worman The higher order structure of chromatin is influenced by its interactions with this organelle and nuclear envelope proteins and may play a role in the regulation of gene of chromatin is influenced by its interactions with this organelle and nuclear envelope proteins and may play a role in the regulation of gene expression. The nuclear envelope is composed of the nuclear membranes, the nuclear pore complexes and the nuclear lamina. The nuclear envelope undergoes disassembly and reassembly during mitosis and cell cycle-dependent phosphorylation of protein components may regulate cell division. cpmcnet.columbia.edu /dept/gsas/anatomy/Faculty/Worman   (468 words)

PMag v19n3p16 -- Gene Sharp 101 GENE SHARP:Well, from high school age, I was aware of the world's problems.The Second World War was just finishing, nuclear weapons were new, Stalin was in control of the Soviet Union, colonialism was strong, and war was a problem because we knew a little about nuclear weapons. Sharp is senior scholar at the Albert Einstein Institution. SHARP: I have a few pages on that point in the booklet From Dictatorship to Democracy, which was written for the Burmese democrats and published in Bangkok in 1993. www.peacemagazine.org /archive/v19n3p16.htm   (4233 words)

Jumping genes and containment - Nature Biotechnology Intact gene transfer from the chloroplast to nuclear genome and expression requires the acquisition of regulatory elements for transcription, translation, and protein transport, the rate of which must be minimal, as documented above (two cases detected so far in ca. For proper expression in the nucleus, chloroplast genes transposed to the nucleus would have to acquire appropriate nuclear regulatory sequences for transcription and translation. Both genes, along with regulatory sequences, were inserted into the spacer region between chloroplast trnV and rps 12/17 genes to facilitate homologous recombination and site-specific integration of transgenes. www.nature.com /cgi-taf/DynaPage.taf?file=/nbt/journal/v21/n4/full/nbt0403-374.html   (1713 words)

Big Blue's Baby Blue Gene Supercomputer It is expected to operate at about 360 teraflops LLNL researchers hope to use Blue Gene/L to investigate areas such as cosmology and the behavior of stellar binary pairs, laser-plasma interactions, and the behavior of nuclear explosives. To wit, Blue Gene/L is part of the National Nuclear Security Administration (NNSA)'s Advanced Simulation and Computing (ASC) Program. Blue Gene/L has been clocked at a peak speed of 2 teraflops, or 2 trillion mathematical operations per second, and currently sits at number 73 in the current Top 500 list, which will be formally issued at the event next week. www.internetnews.com /infra/article.php/3108931   (925 words)

A new family of yeast nuclear pore complex proteins. A new family of yeast nuclear pore complex proteins.Only NUP49 is essential for cell viability. Employing immunoelectron and immunofluorescence microscopy on yeast cells, we found that the binding of a polyspecific monoclonal antibody recognizing this family was predominantly at the nuclear pore complexes. Furthermore, the tagging of NUP49 with a unique epitope enabled the immunolocalization of this protein to the nuclear pore complex by both fluorescence and electron microscopy. www.pdg.cnb.uam.es /UniPub/iHOP/gp/74142.html   (925 words)

Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins -- Lutzmann et al. 21 (3): 387 -- The EMBO Journal Heath,C.V., Copeland,C.S., Amberg,D.C., Del Priore,V., Snyder,M. and Cole,C.N. (1995) Nuclear pore complex clustering and nuclear accumulation of poly(A) RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene. Li,O., Heath,C.V., Amberg,D.C., Dockendorff,T.C., Copeland,C.S., Snyder,M. and Cole,C.N. (1995) Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A) RNA and constitutive clustering of nuclear pore complexes. Vasu,S.K. and Forbes,D.J. (2001) Nuclear pores and nuclear assembly. embojournal.npgjournals.com /cgi/content/full/21/3/387   (925 words)

Laurie Fitzgerald - MLML Invertebrate Zoology To reconstruct phylogenetic relationships and determine the direction of life history change, nuclear introns of a G-protein coupled receptor (GPCR) gene (~250 bp) and an arginine kinase (AK) gene (~570 bp) were sequenced. Unusually slow rates of mitochondrial DNA evolution in anthozoans necessitate the use of quickly evolving nuclear genes for evolutionary studies of closely related species. The gene genealogies, however, do not show reciprocal monophyly of species. invert.mlml.calstate.edu /fitzgerald.htm   (925 words)

Meagher Laboratory E.C. McKinney CV McKinney, E., and Meagher, R. Members of the Arabidopsis actin gene family are widely dispersed in the genome. The Arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli. Silencing the nuclear actin-related protein AtARP4 in Arabidopsis has multiple effects on plant development, including early flowering and delayed floral senescence. www.genetics.uga.edu /rbmlab/cvs/McKinney.html   (877 words)

CMGS-RNA BINDING DOMAINS/7.11.97 The human SNRPN (small nuclear ribonucleoprotein polypeptide N) gene is one of a gene family that encode proteins involved in pre-mRNA splicing and maps to the smallest deletion region involved in the Prader-Willi syndrome (PWS) within chromosome 15q11-q13. In eukaryotic cells, messenger RNAs are formed by extensive post-transcriptional processing of primary transcripts, assembled with a large number of proteins and processing factors in ribonucleoprotein complexes. Intronic sequence is removed from RNA pol II transcripts in a well defined multistep pathway ( Kramer A 1996). www.ich.ucl.ac.uk /cmgs/rnabind.htm   (877 words)

Characterization of a Nuclear Protein Conferring Brefeldin A Resistance in Schizosaccharomyces pombe -- Turi et al. 271 (15): 9166 -- Journal of Biological Chemistry This gene encodes an essential protein that shares homology with the mammalian protein RanBP1 and the protein encoded by the Saccharomyces cerevisiae gene YRB1 and contains a peptide motif present in several proteins found within the nuclear pore complex. Characterization of a Nuclear Protein Conferring Brefeldin A Resistance in Schizosaccharomyces pombe -- Turi et al. Random Mutagenesis and Functional Analysis of the Ran-binding Protein, RanBP1 www.jbc.org /cgi/content/abstract/271/15/9166   (877 words)

American Society for Photobiology Luciferase from the North American firefly (Photinus pyralis) naturally emits yellow-green (557 nm) light and is commonly used as a reporter gene to monitor gene expression. The American Cancer Society estimates that in 2005, about 60,000 American adults will be diagnosed with melanoma and about 7,700 will die from it. The American Academy of Dermatology considers "excessive exposure to the ultraviolet radiation of the sun [to be] the most important preventable cause of melanoma" www.pol-us.net /ASP_Home/newsarchives.html   (13689 words)

"Planetary Survival and Consciousness Evolution: Psychological Roots of Human Violence and Greed" by Stanislav Grof We have been able to learn the secrets of nuclear energy, send spaceships to the moon and all the planets of the solar system, transmit sound and color pictures all over the globe and across cosmic space, and crack the DNA code and start genetic engineering. Among these are industrial pollution of soil, water, and air; the threat of nuclear waste and accidents; destruction of the ozone layer; the greenhouse effect; possible loss of planetary oxygen through reckless deforestation and poisoning of the ocean plankton; and the dangers of toxic additives in our food and drinks. At the same time, these superior technologies are being used in the service of primitive emotions and instinctual impulses that are not very different from those that motivated people of the Stone Age. www.primalspirit.com /Grof_PlanetarySurvival_art.htm   (10143 words)

BUAD884 Dan Bristow's Resume      As a Field Engineer at Limerick and Eddystone, provided technical direction, field leadership, and shift management for irradiated fuel receipt at Eddystone Generating Station, cask off-load and rail shipment to Limerick, fuel unload, and cask transfer back to Shoreham. As the GENE technical leader, worked laterally with MPR Engineering Co. design engineers and Welding Services Inc. fabrication shops to lead the GENE team in developing custom tooling and installation procedures for the first MPR-designed BWR reactor core shroud repair. Responsible for preparing design engineering projects in primarily mechanical and instrumentation and controls engineering disciplines. www.udel.edu /alex/mecomm/resumedb.html   (10143 words)

Nuclear matrix - Wikipedia, the free encyclopedia There is evidence that the nuclear matrix is involved in regulation of gene expression in Arabidopsis thaliana. In biology, the nuclear matrix is the network of fibers found throughout the inside of a cell nucleus. The exact function of this matrix is still disputed. en.wikipedia.org /wiki/Nuclear_matrix   (80 words)

Gene Scott Scott performed a feasibility study, analyzing operating history, evaluating options and potential expansion of a cogeneration facility and served as an expert witness, prepared testimony and supported litigation of construction claims on several projects including oil processing and cogeneration facilities, prisons, hospitals, commercial buildings, airports and post offices. Scott has worked on a wide range of projects worldwide including mineral recovery plants, industrial facilities, hydro, geothermal,, waste-to-energy, nuclear and fossil power plants, petro-chemical plants, commercial buildings, institutional facilities, hospitals and infrastructure projects. Scott’s Risk Management experience includes the analysis of contract and project execution risks, claims management and prevention, the development of action plans to avoid or mitigate risk, and monthly audits to track fluctuations in risk over time. www.nielsen-wurster.com /gene_scott.htm   (407 words)

Gene kelly Gene Kelly, a one-man choreographic and thespianical dynamo who danced his way into the heart of a postwar nation starved for art and eager to envision its young men as clean, ambitious and, especially, straight, died Feb. Kelly was killed performing what he described as "one last mission," a perilous airborne assault on a heretofore secret Finnish center for offensive intercontinental nuclear dental research. Kelly epitomized an attitude towards dance and the musical which brought them smack into the middle of the nation's bourgeois cultural ambitions and then smartly fulfilled them—he got the girl with breasts like melons, made a living, and had a laugh-riot. www.goodbyemag.com /feb/kelly.htm   (881 words)

Cell nucleus - Wikipedia, the free encyclopedia Gene expression at the nuclear level involves complex processes of transcription, pre mRNA processing and the export of the mature mRNA to the cytoplasm. The nuclear face of the nuclear envelope is surrounded by a scaffold of filaments called the nuclear lamina. The nuclear envelope regulates and facilitates transport between the nucleus and the cytoplasm, while separating the chemical reactions taking place in cytoplasm from reactions happening within the nucleus. en.wikipedia.org /wiki/Cell_nucleus   (516 words)

Cell nucleus - Wikipedia, the free encyclopedia In cell biology, the nucleus (from Latin nucleus or nuculeus, kernel) is found in all eukaryotic cells and contains the nuclear genes which form most of the cell's genetic material. Gene expression at the nuclear level involves complex processes of transcription, pre mRNA processing and the export of the mature mRNA to the cytoplasm. The nuclear face of the nuclear envelope is surrounded by a scaffold of filaments called the nuclear lamina. en.wikipedia.org /wiki/Cell_nucleus   (487 words)

British Journal of Biomedical Science: Hypothesis for the influence of fixatives on the chromatin patterns of interphase nuclei, based on shrinkage and retraction of nuclear and perinuclear structures The nuclear matrix/scaffold model is based on the discovery of relatively insoluble proteins in nuclei, which it suggests forms a 'matrix' and modulates gene expression by affecting transcription of The nuclear membrane-bound, chromosomal-- domain model is based on the discoveries of chromatin-nuclear membrane attachments and of the localisation of the chromatin of each chromosome within discrete, exclusive parts of the nucleus (the 'domain of each partly unfolded chromosome). Nuclear chromatin patterns are used to distinguish normal and abnormal cells in histopathology and cytopathology. www.findarticles.com /p/articles/mi_qa3874/is_200201/ai_n9059920   (1096 words)

Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos When lysates from rabbit fibroblasts were fractionated using the same procedure, the hypophosphorylated IIa form distributed equally between the cytosolic and nuclear fractions, whereas the hyperphosphorylated IIo form remained almost totally in the nuclear fraction (Figure 6, lanes 2 and 3). Again, the nuclear staining was faint at the 1-cell stage (Figure 7B, panel 1), weak but clearly visible at the 2-cell stage (panel 2), stronger at the 4-cell stage (panel 3) and more intense at the 8/16-cell stage (panel 4). Indeed, the IIe form lacks the CC-3 phosphoepitope which was shown to be generated in vitro by phosphorylation with the TFIIH-associated kinase (Dubois et al., 1997). www.nature.com /emboj/journal/v16/n20/full/7590599a.html   (8825 words)

Definition of Horizontal gene transfer Analysis of DNA sequences suggests that horizontal gene transfer has also occurred within eukaryotes, from their chloroplast and mitochondrial genome to their nuclear genome. Horizontal gene transfer is a potentially confounding factor in inferring phylogenetic trees based on the sequence of one gene. For example, the most common gene to be used for constructing phylogenetic relationships in prokaryotes is the 16s rRNA gene, since its sequences tend to be conserved among members with close phylogenetic distances, but variable enough that differences can be measured. www.wordiq.com /definition/Horizontal_gene_transfer   (8825 words)

UB Reporter: Gene tied to tooth-root formation identified Researchers made this discovery by creating a mouse lacking the gene responsible for encoding a protein known as nuclear factor I-C (Nfic). When mice lacking the gene were fed soft food, they lived as long as mice in the wild and appeared normal in all other ways, the scientists observed. Mice lacking the Nfia gene were born with massive brain deficits, including hydroencephaly, and died shortly after birth. www.buffalo.edu /reporter/vol34/vol34n19/articles/Gronostajski.html   (746 words)

Reisman Lab p53 Home Page The ability of many mutant and oncogenic tumor-derived p53 alleles to modulate gene expression may be of prime importance in their transforming and oncogenic activities since missense mutations are very rarely observed in either the amino terminal transactivation domain of the protein or in the nuclear localization signals. The wild type p53 gene is a tumor suppressor gene which encodes a protein that regulates a cell cycle checkpoint and the induction of programmed cell death (apoptosis) in response to DNA damage, cell stress or the aberrant expression of some oncogenes. In a number of cases elevated transcription of the p53 gene contributes the overall high levels of the mutant protein in tumor cells. www.biol.sc.edu /~reisman   (519 words)

Molecular Basis for Effects of Carcinogenic Heavy Metals on Inducible Gene Expression We have postulated that inducible genes are strongly affected by chemically-induced DNA damage as a result of both targeting of DNA damage and the intrinsic structural and biochemical properties of those genes, and have proposed a model in which these effects occur as a consequence of chromatin structure and/or nuclear architecture (10,13). Inducible genes such as PEPCK may be preferentially susceptible to these effects because of their large DNase-hypersensitive regions which represent areas of nonnucleosomal decondensed chromatin and regions of complex DNA-transcription factor interactions. Effects on inducible gene expression have been observed in both the rat and chick embryo in vivo (10,13,34,55,59) and in primary chick embryo, adult rat, and rat embryo hepatocytes and rat hepatoma cell lines in culture (56-58). ehp.niehs.nih.gov /members/1998/Suppl-4/1005-1015hamilton/hamilton-full.html   (519 words)

Electrical Dimension of the Nuclear Envelope -- Mazzanti et al. 81 (1): 1 -- Physiological Reviews nuclear swelling and gene activation (52, 54, 117, 137, Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores. The outer nuclear membrane is continuous with the endoplasmic reticulum so that the perinuclear space (cisterna) of the NE is contiguous with the lumen of the endoplasmic reticulum. physrev.physiology.org /cgi/content/full/81/1/1   (8229 words)

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