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Topic: Nuclear lamina

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	Searle Scholar Profile : Larry R. Gerace (1982)
		The nuclear envelope is a specialized domain of the endoplasmic reticulum that forms the boundary of the nucleus in eukaryotes.
		We are using a combination of biochemical, structural and functional approaches to investigate the mechanisms involved in the nuclear import of protein and the role of the lamina in the nuclear organization.
		These and other data indicate that the nuclear lamina engages in a complex set of cooperative, developmentally regulated interactions with chromatin that involves both lamins and integral membrane proteins, which could be important for stabilizing or modifying patterns of gene expression in cells.
	www.searlescholars.net /people/1982/gerace.html (767 words)

	nuclear lamina
		The nuclear lamina is a proteinaceous layer apposed to the inner nuclear membrane.
		During mitosis, the lamina meshwork is reversibly disassembled in parallel with phosphorylation of the lamins.
		The nuclear envelope is composed of the nuclear lamina, the nuclear pore complexes, and the nuclear membranes.
	www.humpath.com /article.php3?id_article=536 (219 words)

	Nuclear lamina - Wikipedia, the free encyclopedia
		The nuclear lamina is the dense, fibrillar network composed of intermediate filaments made of lamin that lines the inner surface of the nuclear envelope.
		This network of filaments is essential for the disarrangement of the nuclear envelope into vesicles during mitosis or meiosis, and its posterior reassembly.
		When, during the cell cycle, a certain cyclin-dependent kinase complex phosphorylates the lamins they undergo a conformational change that triggers the disassembly of the nuclear envelope.
	en.wikipedia.org /wiki/Nuclear_lamina (126 words)

	Nuclear lamina (Site not responding. Last check: 2007-11-03)
		A nuclear lamina is a dense, fibrillar meshwork composed of intermediate filament s that lines the inner surface of the nuclear envelope.
		American Nuclear Society Resources on nuclear science and technology: nuclear medicine, nuclear energy, food irradiation, and nuclear techniques used in manufacturing and processing industries.
		Nuclear weapon research on the Internet Nuclear news, as well as background information, searches on nuclear topics, software to model nuclear blast effects, commentary, links.
	www.serebella.com /encyclopedia/article-Nuclear_lamina.html (391 words)

	nuclear lamina (Site not responding. Last check: 2007-11-03)
		The nuclear lamina is a discontinuous structure that occupies only a fraction of the nuclear periphery, and at some points, the inner nuclear membrane may interact directly with the chromatin.
		The peripheral nuclear lamina is located near the nuclear inner membrane and consists of lamin filaments and integral membrane proteins, including the lamin B receptor and various isoforms of lamina-associated polypeptides (LAP) 1 and 2.
		The internal lamins, together with Tpr-based filaments that connect to nuclear pore complexes, are proposed to be major structural elements of the internal nuclear matrix.
	www.humpath.com /article-printable.php3?id_article=536 (202 words)

	Nuclear Envelope
		The inner membrane of the nuclear envelope lies next to a layer of thin filaments which surrounds the nucleus except at the nuclear pores.
		Nuclear pores are formed at sites where the inner and outer membranes of the nuclear envelope are joined.
		The figure to the left illustrates a preparation of nuclear pore complexes that were isolated from an oocyte and spread on plastic.
	www.cytochemistry.net /Cell-biology/nuclear_envelope.htm (1740 words)

	Nuclear envelope -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-11-03)
		The inner membrane is erected upon the nuclear lamina, a network of (Click link for more info and facts about intermediate filaments) intermediate filaments made of (Click link for more info and facts about lamin) lamin.
		After the (A threadlike body in the cell nucleus that carries the genes in a linear order) chromosomes have migrated to each pole, dephosphorylation of lamins causes the nucleus to reassemble.
		The nuclear envelope may also play a role in the disposition of (The readily stainable substance of a cell nucleus consisting of DNA and RNA and various proteins; during mitotic division the chromatin condenses into chromosomes) chromatin inside the nucleus.
	www.absoluteastronomy.com /encyclopedia/n/nu/nuclear_envelope.htm (209 words)

	How do mutations in lamins A and C cause disease? -- Worman and Courvalin 113 (3): 349 -- Journal of Clinical ...
		At the periphery of the nucleus, heterochromatin is preferentially associated with the inner nuclear membrane and the lamina.
		Worman, H.J., and Courvalin, J.-C. The nuclear lamina and inherited disease.
		Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene.
	www.jci.org /cgi/content/full/113/3/349 (1878 words)

	Gerace Laboratory - Research Interests
		The nuclear lamina in vertebrates contains a polymer of 2-4 related intermediate filament proteins called lamins, associated with a number of transmembrane proteins of the inner nuclear membrane.
		The lamina plays essential roles in nuclear structure and functions, as demonstrated by the recent findings that over 15 inherited human diseases, including a range of muscular dystrophies, are caused by mutations in lamins or lamina-associated transmembrane proteins.
		The involvement of the lamina in disease could stem from its importance for nuclear integrity or from a role in chromatin structure and gene expression.
	www.scripps.edu /cb/gerace/research.html (871 words)

	TSRI - News and Publications
		The nuclear envelope is a specialized domain of the endoplasmic reticulum that forms the boundary of the eukaryotic cell nucleus.
		Attachment of the lamina to the inner nuclear membrane during interphase and reassembly of the nuclear envelope at the end of mitosis appear to involve interactions between lamins and integral membrane proteins of the inner nuclear membrane, including LAP1 and LAP2.
		In related studies, we are analyzing the role of the lamina in the anchoring of chromosomes within the 3-dimensional space of the interphase nucleus and the importance of this interaction for chromosome functions.
	www.scripps.edu /news/sr/sr2001/cb10.html (929 words)

	Dr. Howard Worman
		The higher order structure of chromatin is influenced by its interactions with this organelle and nuclear envelope proteins and may play a role in the regulation of gene of chromatin is influenced by its interactions with this organelle and nuclear envelope proteins and may play a role in the regulation of gene expression.
		The nuclear envelope undergoes disassembly and reassembly during mitosis and cell cycle-dependent phosphorylation of protein components may regulate cell division.
		Research on the nuclear envelope is therefore of fundamental importance to our understanding of normal cell function as well as the pathobiology of cancer and other human diseases.
	cpmcnet.columbia.edu /dept/gsas/anatomy/Faculty/Worman (468 words)

	Nuclear lamins: building blocks of nuclear architecture -- Goldman et al. 16 (5): 533 -- Genes and Development
		Nuclear lamins were initially identified as the major components of the nuclear lamina, a proteinaceous layer found at the
		heterochromatin is not adjacent to the nuclear membrane in the
		Fawcett, D.W. On the occurrence of a fibrous lamina on the inner aspect of the nuclear envelope in certain cells of vertebrates.
	www.genesdev.org /cgi/content/full/16/5/533 (6926 words)

	BioMed Central \| Full text \| Altered protein dynamics of disease-associated lamin A mutants
		Each protein was processed into mature lamin A [29] and incorporated into the nuclear lamina, as evident by the bright nuclear ring of staining visualised either by immunofluorescence with anti-FLAG antibody or from the GFP signal (Figure 2).
		To further analyse the movement of lamin A within the nuclear lamina, and between the lamina and the nucleoplasm, FLIP experiments were performed on wt, and N195K and L530P mutant GFP-lamin A expressing cells.
		After successive rounds of photobleaching at a region of the nuclear periphery, the fluorescence at a region of the nuclear periphery distant from the bleach, and at a region within the nucleoplasm were measured (Figure 4) in 10 cells each.
	www.biomedcentral.com /1471-2121/5/46 (4817 words)

	Genome Biology \| Full text \| Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope
		In higher eukaryotes, the nuclear envelope is lined by a protein meshwork, the nuclear lamina, which is an attachment site for NPCs [3] and chromatin [4].
		They took advantage of previous findings that the nuclear lamina is insoluble in both nonionic detergent and salt, and that many integral proteins of the INM remain associated with the lamina after detergent or salt extraction.
		Thus, in comparing the proteins appearing in the three nuclear envelope fractions, Dreger and colleagues [11] found that all well characterized intranuclear proteins were absent from the chaotrope-resistant fraction, and most known INM proteins were in all three fractions.
	www.genomebiology.com /2002/3/4/reviews/1008 (2342 words)

	fs(1)Ya - Mitosis initiation protein fs(1)Ya
		We propose that the localization of YA to the nuclear lamina involves interaction with polymerized lamin Dm0 mediated by the lamin- targeting domain of YA.
		The ubiquitous major lamina protein, lamin Dm, interacts with both otefin, a peripheral protein of the inner nuclear membrane, and YA, an essential, developmentally regulated protein of the nuclear lamina.
		In order to identify factors that affect the recruitment of nuclear lamina proteins to the male pronucleus, we examined the subcellular localization of YA and lamin Dm in mutant embryos defective for the function of either the male pronucleus (mh, K81, and pal or both pronuclei (gnu, png, and plu).
	www.ihop-net.org /UniPub/iHOP/gg/57752.html (381 words)

	Re: Is there a connection between the nuclear lamina and signal transduction?
		The nuclear lamina is a meshwork of intermediate fillament proteins (called nuclear lamins) that adhere to the inner surface of the double- layered nuclear membrane.
		The DNA (chromatin) binds to the nuclear lamina and, in turn, the lamina is bound to the envelope.
		I could not find any evidence of the nuclear lamina providing any "active" role in signal transduction, however, the structural role of the lamina provides a close spatial connection between a signal "gate" (the nuclear pore complex) and the genes which are modified (the DNA).
	www.madsci.org /posts/archives/jan2000/947694738.Cb.r.html (357 words)

	The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. (Site not responding. Last check: 2007-11-03)
		Using isolated Xenopus oocyte nuclei, we have established swelling conditions that separate the intact nuclear envelope (membranes, pore complexes and underlying lamin filament network) from nucleoplasm and the majority of chromatin.
		Micropipette aspiration of swollen and unswollen nuclear envelopes is also reversible and yields a network elastic modulus, unaffected by nucleoplasm, that averages 25 mN/m.
		Our results suggest that the nuclear lamina forms a compressed network shell of interconnected rods that is extensible but limited in compressibility from the native state, thus acting as a 'molecular shock absorber'.
	www.arclab.org /medlineupdates/abstract_15331638.html (232 words)

	Nuclear lamina and nuclear matrix organization in sperm pronuclei assembled in Xenopus egg extract -- Zhang et al. 109 ...
		Nuclear lamina and nuclear matrix organization in sperm pronuclei assembled in Xenopus egg extract -- Zhang et al.
		Nuclear lamina and nuclear matrix organization in sperm pronuclei assembled in Xenopus egg extract
		Nuclear lamina and matrices were prepared from sperm pronuclei assembled in
	jcs.biologists.org /cgi/content/abstract/109/9/2275 (594 words)

	A New Model for Nuclear Envelope Breakdown -- Terasaki et al. 12 (2): 503 -- Molecular Biology of the Cell
		Nuclear envelope breakdown was investigated during meiotic maturation of starfish oocytes.
		The nuclear envelope is a double-membrane barrier that is continuous with the endoplasmic reticulum (ER).
		Nuclear lamina disassembly is required for normal mitosis and occurs at approximately the same time, but its role in the disruption of the nuclear envelope membrane barrier is uncertain.
	www.molbiolcell.org /cgi/content/full/12/2/503 (4947 words)

	Functional Dissection of YA, an Essential, Developmentally Regulated Nuclear Lamina Protein in Drosophila melanogaster ...
		The conserved carboxy-terminal cysteine of nuclear lamins is essential for lamin association with the nuclear envelope.
		In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase.
		Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state.
	mcb.asm.org /cgi/content/full/18/1/188 (7455 words)

	Nuclear Compartments: Nuclear Lamina
		Various functions have been suggested for the nuclear lamina including: maintenance of nuclear shape; spatial organisation of nuclear pores within the nuclear membrane; regulation of transcription; anchoring of interphase heterochromatin; as well as, a role in DNA replication.
		Foisner, R. (2001) Inner nuclear membrane proteins and the nuclear lamina.
		Morris, G.E. (2001) The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy.
	npd.hgu.mrc.ac.uk /compartments/lamina.html (972 words)

	Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading ... (Site not responding. Last check: 2007-11-03)
		Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein in interphase and mitosis.
		Nuclear envelope disassembly and nuclear lamina depolymerization during germinal vesicle breakdown in starfish.
		Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis.
	www.jcb.org /cgi/content/full/160/7/1055 (7422 words)

	What is the Nuclear Envelope? (Site not responding. Last check: 2007-11-03)
		The nuclear membranes are divided into three morphologically distinct but interconnected domains termed the inner nuclear membrane, outer nuclear membrane and pore membrane.
		The nuclear pore complexes, macromolecular structures through which transport between the nucleus and cytoplasm takes place, are associated with the pore membranes.
		The inner nuclear membrane is associated with the nuclear lamina, a meshwork of intermediate filament proteins termed lamins, and the heterochromatin on its nucleoplasmic face.
	www.columbia.edu /%7Ehjw14/NE.html (147 words)

	Lamins and Apoptosis: A Two-Way Street? -- Burke 153 (3): 5 -- The Journal of Cell Biology
		Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells.
		Peter, M., Nakagawa, J., Dorée, M., Labbé, J.C., and Nigg, E.A. In vitro disassembly of the nuclear lamina and M phase–specific phosphorylation of lamins by cdc2 kinase.
		Steen, R.L., Martins, S.B., Tasken, K., and Collas, P. Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly.
	www.jcb.org /cgi/content/full/153/3/F5 (1574 words)

	fig002jel: A schematic view of inner nuclear membrane proteins and their binding interactions with the nuclear lamina ... (Site not responding. Last check: 2007-11-03)
		The outer and inner nuclear membranes (ONM and INM, respectively) are shown in cross-section, with a nuclear pore complex spanning the two membranes.
		The exact interactions and organisation of the inner nuclear membrane, nuclear lamina and chromatin are unknown and are hypothetically depicted in this figure.
		Interactions occur between the inner nuclear membrane proteins and the A-type lamins (shown in blue) and B-type lamins (shown in orange), which are helical filamentous proteins of the nuclear lamina and nucleoplasm.
	www.expertreviews.org /02004866h.htm (305 words)

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