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Topic: Octreotide

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	Octreotide - Wikipedia, the free encyclopedia
		Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octopeptide that mimics natural somatostatin pharmacologically, though is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone.
		The Food and Drug Administration (FDA) has approved the usage of a salt form of this peptide, octreotide acetate, as an injectable depot formulation for the treatment of acromegaly, the treatment of diarrhea and flushing episodes associated with carcinoid syndrome, and treatment of diarrhea in patients with vasoactive intestinal peptide-secreting tumors (VIPomas).
		Octreotide has also been used off-label for the treatment of severe, refractory diarrhea from other causes.
	en.wikipedia.org /wiki/Octreotide (229 words)

	Octreotide (somatostatin analogue)
		Octreotide was FDA-approved in October 1988 for the treatment of carcinoid tumors and VIPomas.
		Octreotide's effects were seen in patients with progressive autonomic failure, multiple-organ-system atrophy, and diabetic autonomic neuropathy but not in patients with sympathotonic orthostatic hypotension.
		Further investigation is needed to determine octreotide's role as an alternative for patients with thyrotropinomas that are refractory to surgery and radiation.
	www.rockford.uic.edu /jc/octreotide.htm (933 words)

	Sandostatin LAR Online, Description, Chemistry, Ingredients - Octreotide - RxList Monographs
		Octreotide is the acetate salt of a cyclic octapeptide.
		Depot (octreotide acetate for injectable suspension) is available in a vial containing the sterile drug product, which when mixed with diluent, becomes a suspension that is given as a monthly intragluteal injection.
		The octreotide is uniformly distributed within the microspheres which are made of a biodegradable glucose star polymer, D,L-lactic and glycolic acids copolymer.
	www.rxlist.com /cgi/generic2/octreotide.htm (182 words)

	Acromegaly & Octreotide - Neuroendocrine Clinical Center & Pituitary Tumor Center at MGH/Harvard
		Octreotide, a somatostatin analogue administered subcutaneously, is chemically modified to result in a prolonged half life, less insulin suppression and no post-infusion rebound.
		Octreotide may be administered continuously by a subcutaneous pump to patients with refractory acromegaly to prevent escape of GH between injections.
		A PET scan is used to localize binding of the radiolabeled octreotide to the pituitary adenoma, and binding of the radiolabeled octreotide suggests the presence of octreotide receptors.
	pituitary.mgh.harvard.edu /e-f-943.htm (1241 words)

	MedlinePlus Drug Information: Octreotide (Systemic) (Site not responding. Last check: 2007-10-22)
		Octreotide (ok-TREE-oh-tide) is used to treat the severe diarrhea and other symptoms that occur with certain intestinal tumors.
		Octreotide may also be used for other medical conditions as determined by your doctor.
		Octreotide is packaged in a kit containing an ampul opener, alcohol swabs, ampuls of the medicine, and, in some kits, a vial of diluent to mix with the medicine.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202421.html (1706 words)

	Indium
		While researchers are now using the In-111 Octreotide as a new treatment for TED and apparently finding some success, I am still thinking that it may be the Indium, the biotin, or the combination of the two nutrients that are really the reason for the success of the treatment.
		The role of octreotide in the treatment of carcinoid tumour and the usefulness of In-111-pentetreotide (octreoscan) in the localization and prediction of the response to treatment with octreotide is discussed.
		The aims of the present study were to confirm the beneficial effect of octreotide in patients with TED, to investigate the presence of somatostatin receptors in the orbital area and also, if possible, to ascertain whether this technique could select those patients with TED who might benefit from treatment with octreotide.
	www.ithyroid.com /indium.htm (10230 words)

	Octreotide
		Octreotide relieves certain symptoms of your cancer, including diarrhea, abdominal pain, and blotchy redness of your face and chest.
		Octreotide is usually injected beneath the skin or into the veins several times a day.
		Octreotide may change your blood sugar levels and you may need to adjust your insulin, or food intake.
	www.hci.utah.edu /patientdocs/hci/drugs/octreotide.htm (555 words)

	Octreotide - Talk Medical
		Octreotide decreases the production of many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion.
		Octreotide is also used to reduce flushing and watery diarrhea caused by metastatic cancerous tumors (carcinoid syndrome) or tumors called vasoactive intestinal peptide tumors (VIPomas).
		A depot formulation of Octreotide called Sandostatin LAR is injected into the muscle and is intended for use every four weeks.
	www.talkmedical.com /medications/4444/Octreotide (853 words)

	Effects of octreotide on responses to colorectal distension in the rat -- Su et al. 48 (5): 676 -- Gut
		Intrathecal octreotide dose dependently attenuated the visceromotor (A) and pressor (B) responses to CRD in saline treated rats.
		Octreotide was injected intra-arterially in a cumulative dose as indicated by the arrows.
		Octreotide: a potent new non-opiate analgesic for intrathecal infusion.
	gut.bmjjournals.com /cgi/content/full/48/5/676 (4058 words)

	Sandostatin Injection Drug Information Sandostatin Injection
		In healthy volunteers the distribution of octreotide from plasma was rapid (t(alpha) ½ = 0.2 h), the volume of distribution (Vdss) was estimated to be 13.6 L, and the total body clearance ranged from 7 L/hr to 10 L/hr.
		(octreotide acetate) is indicated to reduce blood levels of growth hormone and IGF-I (somatomedin C) in acromegaly patients who have had inadequate response to or cannot be treated with surgical resection, pituitary irradiation, and bromocriptine mesylate at maximally tolerated doses.
		(octreotide acetate) is indicated for the symptomatic treatment of patients with metastatic carcinoid tumors where it suppresses or inhibits the severe diarrhea and flushing episodes associated with the disease.
	www.drugs.com /pdr/Sandostatin_Injection.html (3875 words)

	Octreotide : BC Cancer Agency (Site not responding. Last check: 2007-10-22)
		Octreotide acetate, SMS 201-995, synthetic octapeptide analogue of somatostatin, SMS-LAR
		Octreotide is used to control hormone-mediated symptoms in GEP endocrine tumours such as insulinoma, gastrinoma, VIPoma, glucagonoma, somatostatinoma, GRFoma/acromegaly, and carcinoid tumours.
		Octreotide LAR pharmacokinetics is similar once the drug is released from microspheres.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/Octreotide1of2 (1807 words)

	Octreotide (Systemic)
		Octreotide for the FDA approved indication of acromegaly is considered medically necessary if the medical appropriateness criteria are met.
		Octreotide, for the FDA approved indication of carcinoid tumors, for the long term treatment of the associated severe diarrhea and facial flushing episodes, when initial treatment with octreotide injection has been shown to be effective and tolerated, is considered medically necessary.
		Octreotide, for the FDA approved indication of vasoactive intestinal polypeptide tumors (VIPomas), for the long term treatment of the associated profuse watery diarrhea, when initial treatment with octreotide injection has been shown to be effective and tolerated, is considered medically necessary.
	www.bcbst.com /MPManual/Octreotide_Systemic.htm (1072 words)

	Octreotide Injection - Drugs & Vitamins - Drug Library - DrugDigest
		OCTREOTIDE (Sandostatin®, Sandostatin LAR® Depot) decreases the production of many chemical substances in the body including glucagon, a substance that increases blood sugar, growth hormone, and chemicals that influence digestion.
		Octreotide is a synthetic (man-made) hormone that is similar to the naturally occurring hormone called somatostatin.
		Octreotide is for injection under the skin or into a vein (in emergency situations).
	www.drugdigest.org /DD/DVH/Uses/0,3915,500\|Octreotide+Injection,00.html (639 words)

	The effect of octreotide on gastric emptying at a dosage used to prevent complications after pancreatic surgery: a ...
		The effect of octreotide on gastric emptying at a dosage used to prevent complications after pancreatic surgery: a randomised, placebo controlled study in volunteers -- van Berge Henegouwen et al.
		Octreotide is used in many centres to prevent complications after pancreatic surgery.
		The effect of octreotide on gastric motility and emptying rate in patients after pancreatic surgery is unknown.
	gut.bmjjournals.com /cgi/content/full/41/6/758 (3212 words)

	octreotide side effects (Site not responding. Last check: 2007-10-22)
		Octreotide solution may be allowed to come to room temperature prior to administration by removal from the refrigerator.
		Octreotide is a synthetic (man-made) protein that is similar to the naturally-occurring hormone called somatostatin.
		Octreotide is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
	www.medicationadvisor.com /side_effects/octreotide.htm (1366 words)

	MedlinePlus Drug Information: Octreotide Injection
		Your doctor has ordered octreotide to help control diarrhea and other symptoms of abdominal illness and other medical conditions such as intestinal tumors.
		Octreotide will be either injected subcutaneously (beneath the skin) or added to an intravenous fluid that will drip through a needle or catheter placed in your vein for 15-30 minutes, one to four times a day.
		If you are receiving octreotide in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a693049.html (687 words)

	BestBETs: Use of octreotide acetate to prevent rebound hypog...
		You wonder about the use of the somatostatin analogue octreotide, which causes marked suppression of serum immunoreactive insulin and C-peptide concentration, and whether it is safe and effective under such circumstances.
		Octreotide appears to be safe and effective in preventing rebound hypoglycaemia in sulfonlyurea overdose.
		Octreotide in combination with dextrose should be considered for first-line therapy in treatment of sulfonlyurea-induced hypoglycemia.
	www.bestbets.org /cgi-bin/bets.pl?record=00535 (441 words)

	Recall of Octreotide Acetate Omega 500 µg/mL
		Consumers who have used Octreotide Acetate Omega from this lot and have experienced any of the symptoms listed below or are concerned about their health should seek medical attention immediately.
		Octreotide Acetate Omega is packaged in boxes of five vials.
		Octreotide Acetate can be administered under the skin by patients at home to treat symptoms created by hormone-secreting tumours.
	www.hc-sc.gc.ca /ahc-asc/media/advisories-avis/2006/2006_03_e.html (370 words)

	Differential Regulation of Somatostatin Receptor Type 2 (sst 2) Expression in AR4-2J Tumor Cells Implanted into Mice ...
		Octreotide binds to sst 2, sst 5, and, to a lesser extent, sst
		A, concentration dependence of sst 2 regulation; the duration of octreotide stimulation was of 16 h.
		After washing off octreotide, the cells were incubated in the absence or presence of cycloheximide or actinomycin D for various periods of time.
	cancerres.aacrjournals.org /cgi/content/full/59/15/3652 (5343 words)

	Influence of Short-Term Octreotide Administration on Chronic Tissue Injury, Transforming Growth Factor {beta} ...
		The somatostatin analog octreotide was recently found to ameliorate radiation-induced tissue injury in rat intestine.
		Octreotide ameliorated all three parameters of tissue injury at both observation times in a dose-dependent manner.
		Weckbecker G, Liu R, Tolcsvai L and Bruns C (1992) Antiproliferative effects of the somatostatin analogue octreotide (SMS 201-995) on ZR-75-1 human breast cancer cells in vivo and in vitro.
	jpet.aspetjournals.org /cgi/content/full/297/1/35 (4691 words)

	Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and ...
		Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies -- Vezzosi et al.
		somatostatin analogs, octreotide and lanreotide, that are by
		Preoperative octreotide treatment of growth hormone-secreting and clinically nonfunctioning pituitary macroadenomas: effect on tumor volume and lack of correlation with immunohistochemistry and somatostatin receptor scintigraphy.
	www.eje-online.org /cgi/content/full/152/5/757 (5921 words)

	Octreotide Therapy for Thyroid-Stimulating Hormone-Secreting Pituitary Adenomas: A Follow-up of 52 Patients -- Chanson ...
		Octreotide Therapy for Thyroid-Stimulating Hormone-Secreting Pituitary Adenomas: A Follow-up of 52 Patients -- Chanson et al.
		Octreotide Therapy for Thyroid-Stimulating Hormone-Secreting Pituitary Adenomas: A Follow-up of 52 Patients
		Octreotide acetate-induced size reduction of a large thyrotropin (TSH)-secreting pituitary tumor with correction of hyperthyroidism and hypopituitarism (Abstract).
	www.annals.org /cgi/content/full/119/3/236 (3960 words)

	Phase III Evaluation of Octreotide versus Chemotherapy with 5-Fluorouracil or 5-Fluorouracil Plus Leucovorin in ...
		The somatostatin analogue octreotide is a synthetic octapeptide
		Octreotide, RC-160, and somatuline are the primary somatostatin analogues
		with the use of octreotide at this dose (30).
	clincancerres.aacrjournals.org /cgi/content/full/6/9/3486 (4001 words)

	Sandostatin (Octreotide Acetate) and Sandostatin Dosing
		In patients with renal failure requiring dialysis, the half-life of octreotide may be increased, necessitating adjustment of the maintenance dosage.
		Although responsiveness of GH to octreotide acetate can be ascertained quickly, patients should be maintained on immediate release Sandostatin® Injection for at least 2 weeks to determine tolerance to octreotide (1).
		In patients with renal failure requiring dialysis, the half-life of octreotide may be increased, necessitating adjustment of the maintenance dosage (1).
	www.us.sandostatin.com /hcp/about/dosing.jsp (1706 words)

	Octreotide :: O
		Octreotide acetate: Has similar effects to a natural hormone called somatostatin and is given by injection.
		Octreotide IM injection (Sandostatin LAR): International site for this medication used for Acromegaly.
		Sandostatin LAR (Octreotide Acetate Injection) By Norvartis: Both patient and professional information about Acromegaly and GEP tumors and treatment with Sandostatin LAR Depot.
	www.gourt.com /Health/Pharmacy/Drugs-and-Medications/O/Octreotide.html (361 words)

	Octreotide Therapy of Pediatric Hypothalamic Obesity: A Double-Blind, Placebo-Controlled Trial -- Lustig et al. 88 (6): ...
		The somatostatin analog octreotide binds to the somatostatin
		Octreotide, by binding to the somatostatin receptor-5 on the
		Giustina A, Bussi AR, Pizzocolo G, Cimino A, Giustina G 1994 Acute effects of octreotide, a long-acting somatostatin analog, on the insulinemic and glycemic responses to a mixed meal in patients with essential obesity: a dose-response study.
	jcem.endojournals.org /cgi/content/full/88/6/2586 (4267 words)

	The Somatostatin Analog Octreotide Inhibits GH-Stimulated, But Not IGF-I-Stimulated, Bone Growth in Hypophysectomized ...
		The reduction by octreotide of GH-stimulated liver IGF-I mRNA
		In the context of octreotide’s inhibition of GH-stimulated
		Serri O, Brazeau P Kachra Z, Posner B 1992 Octreotide inhibits insulin-like growth factor-I hepatic gene expression in the hypophysectomized rat: evidence for a direct and indirect mechanism of action.
	endo.endojournals.org /cgi/content/full/143/8/2944 (4630 words)

	Octreotide Acetate Long-Acting Formulation Versus Open-Label Subcutaneous Octreotide Acetate in Malignant Carcinoid ...
		Mean serum octreotide concentration (pg/mL) (efficacy-assessable population) after intramuscular administration of octreotide LAR at 10 mg (n = 16), 20 mg (n = 13), or 30 mg (n = 19) every 4 weeks.
		Median number of supplemental SC octreotide doses taken by patients (efficacy-assessable population) requiring rescue during the preceding 4-week interval by treatment group.
		The efficacy of octreotide LAR 10 mg, 20 mg, or 30 mg administered
	www.jco.org /cgi/content/full/17/2/600 (3798 words)

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