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Topic: Olanzapine

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Atypical antipsychotic

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Clozapine

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Antipsychotic

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	sociology - Olanzapine
		Olanzapine (Zyprexa® or in a combination with fluoxetine as Symbyax®) was the second atypical antipsychotic to gain FDA approval and has become one of the most commonly used atypical antipsychotics.
		Olanzapine has been FDA approved for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder.
		Olanzapine is reported to cause extrapyramidal symptoms, tardive dyskinesia and neurological malignant syndrome, although at a much reduced rate when compared to the classical antipsychotics.
	www.aboutsociology.com /sociology/Olanzapine (451 words)

	Anxiety Zone - Olanzapine
		Olanzapine (Zyprexa® or in a combination with fluoxetine as Symbyax®) was the second atypical antipsychotic to gain FDA approval and has become one of the most commonly used atypical antipsychotics.
		Olanzapine has been FDA approved for the treatment of schizophrenia, acute mania in bipolar disorder, agitation associated with schizophrenia and bipolar disorder, and as maintenance treatment in bipolar disorder.
		Olanzapine is reported to cause extrapyramidal symptoms, tardive dyskinesia and neurological malignant syndrome, although at a much reduced rate when compared to the classical antipsychotics.
	www.anxietyzone.com /drugs/olanzapine.html (503 words)

	Olanzapine - Wikipedia, the free encyclopedia
		Olanzapine (oh-LAN-za-peen, sold as Zyprexa®, Zydis®, or in combination with fluoxetine, as Symbyax®) was the third atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics.
		Olanzapine is structurally similar to clozapine, and is classified as a thienobenzodiazepine.
		Olanzapine undergoes extensive first pass metabolism and bioavailability is not affected by food.
	en.wikipedia.org /wiki/Olanzapine (842 words)

	Olanzapine/Fluoxetine (Symbyax)
		Olanzapine is highly metabolized by glucuronidation and CYP1A2 and CYP2D6 and is eliminated in the urine and feces primarily as inactive metabolites.
		Olanzapine is not approved for use in patients with dementia-related psychosis, due to higher risk of death from cerebrovascular events in some patients.
		Olanzapine and fluoxetine are known to be excreted in rat and human breast milk, respectively.
	uuhsc.utah.edu /pharmacy/bulletins/symbyax.html (1103 words)

	Influence of Fluoxetine on Olanzapine Pharmacokinetics (Site not responding. Last check: 2007-10-30)
		Because CYP2D6 is one of the pathways of olanzapine metabolism, and various metabolic pathways for fluoxetine may compete with those for olanzapine, fluoxetine might influence the pharmacokinetic profile of olanzapine.
		Olanzapine was measured in plasma using high-performance liquid chromatography with electrochemical detection.
		To put the 15% olanzapine clearance decrease in perspective, for example, it is worth noting that olanzapine clearance is 30% lower in women than in men, but this gender-based difference_although twice as large as the effect of fluoxetine on olanzapine clearance_made no difference in olanzapine's effectiveness or in its recommended dosing regimen.
	www.aapspharmsci.org /view.asp?art=ps040211 (2402 words)

	[No title]
		Clinically effective doses of olanzapine (10–15 mg/day; 18.4–30.6 ng/ml plasma concentration [22-24]) or risperidone (3–6 mg/day; 15–30.8 ng/ml combined plasma concentration of risperidone and 9-hydroxy-risperidone [25]) correspond well with the dose of 1.0 mg/kg (equivalent to 12.5 ng/ml) in the present study.
		Patients who were newly initiated on olanzapine or risperidone and continued treatment with the index antipsychotic drug for one year post initiation were compared on three parameters of psychiatric hospitalization – percent of patients hospitalized, total hospitalized duration, and time to first psychiatric hospitalization.
		Patients treated with olanzapine received a significantly higher dose of concomitant lithium than those treated with risperidone (mean daily lithium doses: 863 ± 256 mg in risperidone patients and 1,210 ± 186 mg in olanzapine patients; p=0.03).
	www.lycos.com /info/risperidone--olanzapine.html (591 words)

	olanzapine - Drug Finder - MSN Health & Fitness (Site not responding. Last check: 2007-10-30)
		Olanzapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder.
		Olanzapine is in the FDA pregnancy category C. This means that it is not known whether olanzapine will be harmful to an unborn baby.
		Olanzapine is also available in an injectable dose form that is usually administered intramuscularly by a health care provider.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100060628 (1561 words)

	Olanzapine
		Fluvoxamine: Increases olanzapine levels; consider using a lower dose of olanzapine in patients receiving concomitant treatment with fluvoxamine.
		Olanzapine is a thienobenzodiazepine antipsychotic which is thought to work by antagonizing dopamine and serotonin activities.
		Olanzapine binds weakly to GABA-A, BZD, and beta-adrenergic receptors.
	www.umm.edu /altmed/ConsDrugs/Olanzapinecd.html (2036 words)

	Olanzapine Information on Healthline
		Olanzapine is not for use in psychotic conditions that are related to dementia.
		Olanzapine has caused fatal heart attack and stroke in older adults with dementia-related conditions.
		Olanzapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression).
	www.healthline.com /multumcontent/olanzapine (863 words)

	Olanzapine Information on Healthline
		Olanzapine is used to treat schizophrenia, to control manic episodes of bipolar disorder (manic-depressive disorder), or to treat dementia related to Alzheimer's disease.
		Olanzapine is eliminated from the body more quickly in young people than in older (over age 60) individuals, in men than in women, and in smokers faster than in non-smokers.
		Olanzapine should be used carefully in people with known seizure disorders since olanzapine may alter properties of the brain making seizures occur more easily.
	www.healthline.com /galecontent/olanzapine (690 words)

	APA: Olanzapine Reduces Behavioral and Psychotic Symptoms in Alzheimer's Patients (Site not responding. Last check: 2007-10-30)
		The efficacy of olanzapine was evaluated with the Neuropsychiatric Inventory/Nursing Home Version (NPI/NH) scale, which assesses psychopathology in dementia by measuring a patient's level of agitation, delusions, and hallucinations (Core Total).
		In particular, olanzapine was shown to reduce the incidence of hallucinations and aggression/agitation, two particularly disturbing events for sufferers and caregivers.
		Olanzapine is indicated in the United States for the management of the manifestations of psychotic disorders as demonstrated in short-term clinical trials with schizophrenia patients.
	www.pslgroup.com /dg/1d1ede.htm (878 words)

	Howstuffworks "Olanzapine: A Profile of an Antipsychotic Drug"
		Olanzapine is prescribed to treat symptoms of mental illness, such as the emotional symptoms of psychosis and schizophrenia.
		Olanzapine can increase the blood-pressure-lowering effects of antihypertensive medications and possibly increase their side effects.
		Olanzapine may increase your sensitivity to sunlight, so limit your exposure to sunlight and wear protective clothing and an effective sunscreen when you are outdoors during daylight hours.
	health.howstuffworks.com /define-olanzapine.htm (1149 words)

	RemedyFind: patient ratings of Zyprexa (Olanzapine) for Schizophrenia (Site not responding. Last check: 2007-10-30)
		Zyprexa (Olanzapine) will continue to be available and is approved for treating schizophrenia and bipolar mania, and is also prescribed for "off-label" uses including the treatment for depression, anxiety and dementia.
		The olanzapine treatment group had significantly greater mean improvement of mania ratings and a significantly greater proportion of patients achieving remission, compared with the divalproex treatment group.
		This Spanish study finds that Olanzapine may be a useful medication for the long-term adjunctive treatment of patients with bipolar disorder who exhibit a poor response to mood stabilizers, such as lithium, valproate, or carbamazepine.
	www.remedyfind.com /treatments/100/846 (1149 words)

	RedOrbit - Health - Persistent Choreoathetosis in a Fatal Olanzapine Overdose: Drug Kinetics, Neuroimaging, and ... (Site not responding. Last check: 2007-10-30)
		Olanzapine belongs to the thienobenzodiazepine drug class and is known to have a high affinity for dopamine D^sub 2^, D^sub 3^, and D^sub 4^ receptors, all five serotonin HT^sub 2^ receptor subtypes, the 5-HT^sub 6^ receptor, acetylcholine muscarinic receptors, and α^sub 1^-adrenergic and histamine H^sub 1^ receptors (2).
		Olanzapine and olanzapine metabolites were measured since there is limited information on the human pharmacokinetics of olanzapine overdose.
		Olanzapine and N-desmethyl olanzapine levels in human plasma have been shown to be stable at -20C for at least 90 days.
	www.redorbit.com /news/display?id=121073 (3997 words)

	Olanzapine - RxList Monographs
		Hepatic Impairment: Although the presence of hepatic impairment may be expected to reduce the clearance of olanzapine, a study of the effect of impaired liver function in subjects (n=6) with clinically significant (Childs Pugh Classification A and B) cirrhosis revealed little effect on the pharmacokinetics of olanzapine.
		Olanzapine should be used with particular caution in patients with known cardiovascular disease (history of myocardial infarction or ischemia, heart failure, or conduction abnormalities), cerebrovascular disease, and conditions which would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications).
		Olanzapine administration was also associated with increases in serum prolactin (see PRECAUTIONS), with an asymptomatic elevation of the eosinophil in 0.3% of patients, and with an increase in CPK.
	www.scsr.nevada.edu /brain/olanzapine.htm (6397 words)

	Complete Olanzapine information from Drugs.com
		Olanzapine may increase the risk of death in elderly patients with dementia-related mental problems.
		Olanzapine is usually administered as an injection at your doctor's office, hospital, or clinic.
		Olanzapine is to be used only by the patient for whom it is prescribed.
	www.drugs.com /cdi/Olanzapine.html (1331 words)

	BioMed Central \| Full text \| Weight loss dynamics during combined fluoxetine and olanzapine treatment
		For instance, whereas fluoxetine and olanzapine alone activate several signaling pathways involved in cell survival and plasticity [8-10], drug augmentation therapy reduces the levels of certain transcription factors (e.g., cAMP response element binding protein and FOS-like proteins) implicated in the chemical circuitry (e.g., prefrontal cortex and hippocampus) underlying emotional behaviors [5].
		In sharp contrast, treatment with olanzapine is associated with significant weight gain in schizophrenic patients, a serious side effect that may increase the risk for type II diabetes and may also lead to treatment non-compliance [13,14].
		As the pharmacokinetic and pharmacodynamic profile of olanzapine in rats is relatively obscure [27], it is possible that changes in glucuronidation metabolism in rodents may have impacted the ability of the parent drug to influence heterogeneous population of cells associated with body weight dynamics.
	www.biomedcentral.com /1471-2210/4/27 (5350 words)

	OLANZAPINE
		Olanzapine treatment improved the general and positive symptoms of acute schizophrenia compared with placebo and showed comparable efficacy to haloperidol.
		Olanzapine treatment for 52 weeks (in 93 patients) was associated with a reduced relapse rate compared to placebo and an ineffective dose of olanzapine (1mg/day)
		One year’s treatment with olanzapine at an average dose of 10mg daily is currently costs £1375 compared to one year treatment costs of £63 for fluphenazine decanoate depot injection 100mg every 4 weeks, £96 for oral haloperidol 10mg daily or £22 for oral chlorpromazine 300mg daily.
	www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/verdicts/O/OLANZAPINEv.html (382 words)

	Influence of Fluoxetine on Olanzapine Pharmacokinetics (Site not responding. Last check: 2007-10-30)
		Because CYP2D6 is one of the pathways of olanzapine metabolism, and various metabolic pathways for fluoxetine may compete with those for olanzapine, fluoxetine might influence the pharmacokinetic profile of olanzapine.
		Olanzapine was measured in plasma using high-performance liquid chromatography with electrochemical detection.
		To put the 15% olanzapine clearance decrease in perspective, for example, it is worth noting that olanzapine clearance is 30% lower in women than in men, but this gender-based difference_although twice as large as the effect of fluoxetine on olanzapine clearance_made no difference in olanzapine's effectiveness or in its recommended dosing regimen.
	www.aapsj.org /view.asp?art=ps040211 (2402 words)

	Olanzapine (Site not responding. Last check: 2007-10-30)
		Olanzapine is used to treat the symptoms associated with psychotic disorders, especially
		In a small double-blind study, people with schizophrenia being treated with olanzapine experienced an improvement in their symptoms when glycine was added to their treatment regimen.
		In addition, people who take antipsychotic agents such as olanzapine should avoid alcohol because it may intensify the effects of the drug on the nervous system and may cause low blood pressure.
	www.kroger.com /hn/Drug/Olanzapine.htm (480 words)

	Antipsychotic Medications Anti-psychotic Drugs olanzapine, Zyprexa
		Olanzapine is indicated for the acute and maintenance treatment of bipolar disorder, schizophrenia and related psychotic disorders.
		Olanzapine has been shown to be effective in maintaining clinical improvement during one year of continuation therapy in patients who had shown an initial treatment response.
		Olanzapine is contraindicated in those patients with a known hypersensitivity to the drug or the excipients of the product.
	www.support4hope.com /medications/antipsychotic/olanzapine_zyprexa.htm (575 words)

	Olanzapine IntraMuscular
		Olanzapine is an antipsychotic agent that belongs to the thienobenzodiazepine class.
		Maximal dosing of intramuscular olanzapine (ie, three 10 mg doses administered 2 to 4 hours apart) may be associated with an increased risk of orthostatic hypotension.
		Four fixed intramuscular olanzapine doses (2.5 milligrams (mg), 5 mg, 7.5 mg and 10 mg) were evaluated and all doses were significantly better as compared with placebo on the PANSS Excited Component at 2 hours post-injection.
	www.micromedex.com /products/updates/drugdex_updates/de/olanzapine.html (1111 words)

	ASHP News: Olanzapine-Fluoxetine Combination OK'd by FDA
		Olanzapine, an antipsychotic agent, is already in use for the short-term treatment of the acute manic episodes associated with bipolar disorder.
		This dosage is especially recommended for patients with hepatic impairment, a predisposition to hypotensive reactions, or a combination of factors that may slow the metabolism of olanzapine or fluoxetine.
		Symbyax will be available in four strengths: olanzapine 6 mg and fluoxetine 25 or 50 mg; and olanzapine 12 mg and fluoxetine 25 or 50 mg.
	www.ashp.org /news/ShowArticle.cfm?id=3719 (456 words)

	Antipsychotic Olanzapine Doesn’t Increase Prolactin Levels (Site not responding. Last check: 2007-10-30)
		Olanzapine, however, was not," said Bruce Kinon, M.D., an olanzapine medical advisor and lead author of both studies.
		The second study is an analysis from a randomised, double-blind trial comparing olanzapine and haloperidol in 1,996 patients with a diagnosis of schizophrenia, schizophreniform disorder or schizoaffective disorder.
		Olanzapine is currently indicated for use in the United States in the management of the manifestations of psychotic disorders as demonstrated in clinical trials with schizophrenia patients.
	www.pslgroup.com /dg/823F6.htm (1062 words)

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