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Topic: Oligodendroglioma

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	Oligodendroglioma : Cancerbackup
		Oligodendroglioma is a type of glioma and develops from cells called oligodendrocytes.
		Grade 1 and 2 oligodendrogliomas may be referred to as low-grade tumours, and grade 3 and 4 as high-grade.
		Oligodendrogliomas can grow in different parts of the brain, and symptoms may relate to the area of the brain which is affected.
	www.cancerbackup.org.uk /Cancertype/Brain/Typesofbraintumour/Oligodendroglioma (1508 words)

	Oligodendroglioma - WrongDiagnosis.com
		Oligodendroglioma is a well-differentiated (WHO grade II), diffusely infiltrating tumor of adults, typically located in the cerebral hemispheres and composed predominantly of cells which morphologically resemble oligodendroglia.
		Oligodendrogliomas generally recur locally, with median post-operative survival times ranging from 3 to 5 years for patients with all histological grades.
		Oligodendrogliomas are a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell.
	www.wrongdiagnosis.com /o/oligodendroglioma/intro.htm (631 words)

	Oligodendroglioma Information on Healthline
		Oligodendrogliomas can grow in different parts of the brain, but they are most commonly found in the frontal or temporal lobes of the cerebrum.
		Oligodendrogliomas and mixed gliomas account for approximately 4 to 5% of all primary brain tumors and 10% of all gliomas.
		Oligodendrogliomas may also be accompanied by a weakness or paralysis on the side of the body opposite to the side of the brain where the tumor is located.
	www.healthline.com /galecontent/oligodendroglioma (931 words)

	New Page 1
		Oligodendrogliomas comprise a class of glial tumours in which the oligodendroglial cell is the predominant cell type (see appendix 1 for brain tumour classification).
		Oligodendroglioma may be benign, where the cells do not spread from the site of origin, or malignant (cancerous), where the cells invade and destroy surrounding tissue and may spread to other parts of the brain and occasionally outside the brain.
		Oligodendrogliomas is normally found in the cerebral white matter, particularly in the frontal and temporal lobes of the brain (CancerBACUP, 2001; Hariharan, 2002).
	members.tripod.com /mri_sota/brainfiles/brain3.htm (1565 words)

	The Brain Tumor Foundation
		Oligodendrogliomas comprise a class of glial tumors in which the oligodendroglial cell is the predominant cell type.
		Oligodendrogliomas probably evolve from a mixed glioma, which has in turn evolved from primitive precursor or stem cells.
		Oligodendrogliomas should not be termed benign or malignant as no glial tumor is so prognostically fl or white.
	www.braintumorfoundation.org /Oligodendrogliomas.asp (1058 words)

	eMedicine - Oligodendroglioma : Article by ABM Salah Uddin, MD (Site not responding. Last check: 2007-10-26)
		Pathophysiology: Oligodendrogliomas arise in the cerebral hemispheres and are distributed among the frontal, parietal, temporal, and occipital lobe, in approximately a 3:2:2:1 ratio.
		Although differences of opinion exist regarding the efficacy of radiotherapy for oligodendrogliomas, radiation is used routinely at diagnosis in patients who have undergone incomplete removal of nonanaplastic oligodendrogliomas and generally is recommended for patients with anaplastic oligodendrogliomas regardless of the extent of resection.
		As oligodendrogliomas commonly present with a long history of seizure, every patient with a history of intractable seizure and middle-aged patients with new onset of seizure should be evaluated aggressively by MRI scans.
	www.emedicine.com /NEURO/topic281.htm (3320 words)

	Oligodendroglioma
		In the 3 anaplastic oligodendrogliomas, 1 was not informative for 1p and none of the informative tumors exhibited LOH at 1p or 17p; 1 case (33%) exhibited LOH at 19q.
		By histopathologic grade, 67% of grade II oligodendrogliomas (14/21), 46% of grade III anaplastic oligodendrogliomas (6/13), and 50% of mixed oligoastrocytomas (3/6) were positive for amplification of at least 1 gene.
		Whereas the expression of betaIII in neuronal/neuroblastic tumors is differentiation-dependent, the aberrant expression of this cytoskeletal protein in astrocytomas is associated with an ascending gradient of malignancy.
	www.thedoctorsdoctor.com /diseases/oligodendroglioma.htm (4712 words)

	AANS.org \| Education and Meetings \| AANS Scientific Journals \| Neurosurgical Focus
		Oligodendrogliomas commonly demonstrate a uniform population of small cells with round nuclei and conspicuous perinuclear halos, an artifact due to delayed fixation.
		The tumor cells are arranged in a diffuse pattern or in a pseudolobulated pattern due to the separation of the tumor cells by delicate arcuate blood vessels.
		Smear preparations of oligodendrogliomas demonstrate cells with uniform round nuclei and relatively unclear cytoplasm within a granular matrix.
	www.aans.org /education/journal/neurosurgical/feb02/figuresC-E.html (529 words)

	Oligodendroglioma - Wikipedia, the free encyclopedia
		In anywhere from fifty to eighty percent of cases, the first symptom of an oligodendroglioma is the onset of seizure activity.
		Oligodendrogliomas recapitulate the appearance of the normal resident oligodendroglia of the brain.
		Oligodendrogliomas may invade preferentially around vessels or under the pial surface of the brain.
	en.wikipedia.org /wiki/Oligodendroglioma (1089 words)

	eMedicine - Oligodendroglioma : Article by Paule Peretti, MD (Site not responding. Last check: 2007-10-26)
		Background: Oligodendroglioma is a well-differentiated, diffusely infiltrating tumor of adults typically located in the cerebral hemispheres and composed predominantly of cells morphologically resembling oligodendroglia.
		Oligodendrogliomas exhibit a structure type II or III but never adopt a structure type I. According to Daumas-Duport, the "diffuse fibrillary astrocytomas" are composed of isolated tumoral oligodendrocytes, which induce chronic fibrillary astrogliosis in the infiltrated white matter.
		A large proportion of oligodendrogliomas is peripherally situated, and the tumor usually involves the whole thickness of the cortex.
	www.emedicine.com /radio/topic481.htm (3365 words)

	Brain Tumors
		Oligodendrogliomas are glial tumors in which the oligodendroglial cell is the predominant cell type.
		In the oligodendroglioma the mitotic rate of the oligodendroglial cells has exceeded the mitotic rate of the other cells and eventually the oligodendroglial cells become the most numerous - the predominant cell type and, therefore, an oligodendroglioma.
		Tumor tissue in an anaplastic or malignant oligodendroglioma requires a rich blood supply and for this reason prominent contrast enhancement on CT and MRI is noted.
	www.med.nyu.edu /neurosurgery/subspecialty/braintumors_5.html (1706 words)

	Oligodendroglioma - My Child Has - Children's Hospital Boston
		An oligodendroglioma is low-grade tumor arising from a type of cell of the central nervous system known as a glial cell.
		Symptoms at the time of diagnosis related to increased pressure within the brain, such as headache, vomiting and lethargy, and/or from compression of the nerves that control movement of the extremities, are often relieved by surgical debulking of the tumor.
		Oligodendrogliomas are associated with a high rate of cure.
	www.childrenshospital.org /az/Site1383/mainpageS1383P0.html (863 words)

	Oligodendroglioma Brain Tumors
		An oligodendroglioma tumor is a slow-growing brain tumor that usually occurs in young adults.
		These tumors are frequently located within the frontal, temporal or parietal lobes and cause seizures in a relatively high percentage of patients.
		To diagnose an oligodendroglioma brain tumor, a neurologist (a doctor with special additional training in the diagnosis and treatment of disorders of the brain, spinal cord and nerves) performs a complete examination, which may include a magnetic resonance imaging (MRI) scan or a computed tomography (CT or CAT) scan.
	www.csmc.edu /5300.html (254 words)

	eSynopsis of Oligodendroglioma of the Brain
		•The etiology of the oligodendroglioma is unknown but most tumors show abnormalties of chromosome 19 and 1.
		•Oligodendrogliomas are grey gelatinous masses in the brain that act as mass lesions.
		•Oligodendrogliomas act as mass lesions, infiltrating areas of brain.
	pathweb.uchc.edu /esynopsis/S479.htm (180 words)

	UCLA NEUROSURGERY \| Brain Tumor Diseases & Disorders (Site not responding. Last check: 2007-10-26)
		Oligodendroglioma comprise approximately 4% of primary brain tumors.
		The remainder of the presenting symptoms are nonspecific for oligodendroglioma, and are more often related to local mass effect and less commonly generalized increase in intracranial pressure.
		Most oligodendrogliomas respond to some form of chemotherapy, usually in less than 3 months.
	www.neurosurgery.ucla.edu /Diagnoses/BrainTumor/BrainTumorDis_4.html (222 words)

	Bauleke.com - Angel Island Adventure - Oligodendroglioma (Site not responding. Last check: 2007-10-26)
		Oligodendrogliomas develop from glial cells called oligodendroglia and represent about 5% of all gliomas.
		Oligodendroglioma, a relatively rare brain tumor, grows slowly as a rule and is moderately sensitive to radiation therapy.
		There is a malignant form of oligodendroglioma and a mixed malignant astrocytoma-oligodendroglioma, both of which are treated much like the glioblastoma multiforme.
	www.bauleke.com /angelisland/oligodendroglioma.html (157 words)

	Bioline International Official Site (site up-dated regularly)
		Oligodendrogliomas are rare glial tumors with a long natural history.
		It is difficult to evaluate the role of various treatment modalities in oligodendrogliomas due to their relative rarity and long natural history.
		Lindergaard KF, Mork SJ, Halvorsen TB et al : Oligodendroglioma: Incidence and biological behaviour in a defined population.
	www.bioline.org.br /request?ni02123 (2436 words)

	Oligodendroglioma : Epilepsy.com/Professionals
		Oligodendroglial tumors are closely related to fibrillary astrocytic tumors and are generally graded as oligodendroglioma, or anaplastic oligodendrogliomas if they have a high cell density, mitotic rate, and necrosis.
		Oligodendrogliomas present with seizures in 70—90% of cases.
		Presentation at a young age, seizures, and a Karnofsky Performance Status over 70 (able to live at home and care for self) are significant positive prognostic indicators for survival in low-grade tumors.
	professionals.epilepsy.com /page/brain_oligodendrog.html (440 words)

	Genetic Determinants of Malignancy in a Mouse Model for Oligodendroglioma -- Weiss et al. 63 (7): 1589 -- Cancer ...
		Lack of contrast enhancement is typical of low-grade oligodendroglioma in humans and indicates an intact blood–brain barrier.
		To assess the penetrance of oligodendroglioma, 38 transgenic
		oligodendroglioma (12, 30) and is associated with a poor prognosis
	cancerres.aacrjournals.org /cgi/content/full/63/7/1589 (4623 words)

	St. Jude Children's Research Hospital - Copyright 2003 (Site not responding. Last check: 2007-10-26)
		Oligodendrogliomas often contain a large amount of mineral deposits, called calcification.
		The cells of the well-differentiated oligodendroglioma look only slightly abnormal when viewed under a microscope.
		An anaplastic (malignant) oligodendroglioma has very abnormal looking cells, and is faster growing.
	www.stjude.org /print/0,2510,404_2160_7271,00.html (296 words)

	Oligodendroglioma
		More common that pure oligodendrogliomas are low grade and anaplastic tumors that are a mixture of astrocytoma and oligodendroglioma ("oligoastrocytomas").
		The role of radiation therapy has been disputed, but younger people with minimal residual disease after surgery may have radiation therapy deferred as long as there is adequate monitoring of the tumor by MRI or CT scanning.
		Additionally, low grade oligodendrogliomas are also sensitive to chemotherapy, and PCV can be used when low grade tumors begin to grow despite prior radiation therapy.
	www.bt-treatment.com /oligo.htm (192 words)

	Salvage chemotherapy for oligodendroglioma
		We reviewed the records of 23 patients with oligodendroglioma who received salvage chemotherapy: 15 patients were treated at the London Regional Cancer Centre, London, Ontario, Canada; five at Evanston Hospital, Evanston, Illinois; two at the University of Minnesota Medical Center, Minneapolis, Minnesota; and one at the Tom Baker Cancer Centre, Calgary, Alberta, Canada.
		Third, patients with oligodendrogliomas that respond to single-agent treatment with nitrosoureas may have durable responses to salvage therapy with PCV (two patients), but responders to an initial course of PCV may have PCV-resistant disease at recurrence (two patients).
		Duffan H, Albuquerque L, Ameri A, et al: Chemotherapy for newly diagnosed and recurrent anaplastic oligodendrogliomas and mixed gliomas: an analysis of 42 cases.
	www.c3.hu /~mavideg/jns/1.2.p1.html (2333 words)

	Molecular Diagnosis of Metastasizing Oligodendroglioma: A Case Report -- Wang et al. 6 (1): 52 -- Journal of Molecular ...
		A: Intracranial oligodendroglioma from second resection, hematoxylin and eosin (HandE) revealing a highly cellular tumor composed of sheets of cells with rounded nuclei and prominent perinuclear halos.
		A: Hematoxylin and eosin (HandE) staining of the resected metastasis revealing sheets of oligodendroglioma tumor cells with cleared cytoplasm and central nucleus ("fried-egg" pattern) to the left and normal lymphocytes to the right with some central overlap of lymphocytes and tumor cells centrally.
		the accuracy of the diagnosis of extracranial oligodendroglioma
	jmd.amjpathol.org /cgi/content/full/6/1/52 (3076 words)

	Imaging Molecular Signatures in Oligodendroglioma: Commentary on Walker et al., pages 7182-7191 -- Cairncross 10 (21): ... (Site not responding. Last check: 2007-10-26)
		Photomicrograph of a highly cellular low-grade oligodendroglioma with round regular nuclei, perinuclear halos, low mitiotic activity, and a fine branching vascular pattern.
		Giammarile F, Cinotti LE, Jouvet A, et al High and low grade oligodendrogliomas (ODG): correlation of amino-acid and glucose uptakes using PET and histological classifications.
		Smith JS, Perry A, Borell TJ, et al Alterations of chromosome arms 1p and 19q as predictors of survival in oligodendrogliomas, astrocytomas, and mixed oligoastrocytomas.
	clincancerres.aacrjournals.org /cgi/content/full/10/21/7109 (1885 words)

	9402 Oligodendroglioma
		Oligodendrogliomas are uncommon tumors thought to arise from the oligodendrocyte or its precursors.
		Accepting that diagnostic criteria vary, oligoastrocytomas appear to be at least as common as "pure" oligodendrogliomas and either the oligodendroglial or astroglial element may be anaplastic.
		Critical evaluation of treatment toxicity must be a component of any study evaluating the treatment of pure and mixed anaplastic oligodendrogliomas, particularly in light of their better natural history.
	www.rtog.org /members/protocols/94-02/main.html (11609 words)

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