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Topic: Oligonucleotide

Related Topics

Guanosine monophosphate

Guanosine triphosphate

Nucleotide

ATP

Adenosine

Adenosine triphosphate

Complementarity (molecular biology)

DNA replication

DNA

Western blot

HIV test

Protein structure

Glycoprotein

Hydrogen bond

HIV vaccine

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	Oligonucleotide Theraputic Society- Homepage
		OTS is an open, non-profit forum to foster academia and industry-based research and development of oligonucleotide therapeutics (RNAi, CpG, antisense, and others).
		OTS membership is open to all individuals from industry, academia and other institutions worldwide who are interested in research and development of oligonucleotide therapeutics (RNAi, CpG, antisense, ribozymes, and others).
		Membership includes a 1-year subscription to the society's journal "Oligonucleotides".
	www.myots.org (199 words)

	Oligonucleotide - Wikipedia, the free encyclopedia
		Oligonucleotides are often used as probes for detecting complementary DNA or RNA because they bind readily to their complements.
		In this instance, the oligonucleotide is often referred to as a primer, or a short piece of DNA that binds to its complementary target sequence.
		Antisense Oligonucleotides are strands of RNA that prevent translation of complementary RNA strands by binding to it.
	en.wikipedia.org /wiki/Oligonucleotide (321 words)

	United States Patent Application: 0030148980
		A hybrid oligonucleotide phosphorothioate or phosphorodithioate according to claim 1, having an oligonucleotide sequence that is complementary to a nucleic acid sequence from a virus, a pathogenic organism, or a cellular gene.
		A hybrid oligonucleotide phosphorothioate or phosphorodithioate according to claim 2, having an oligonucleotide sequence that is complementary to a nucleic acid sequence from a virus, a pathogenic organism, or a cellular gene.
		Oligonucleotides according to this aspect of the invention share the characteristics of the above-described oligonucleotides, except that the oligonucleotide sequence of oligonucleotides according to this aspect of the invention is complementary to a nucleic acid sequence that is from a virus, a pathogenic organism or a cellular gene.
	appft1.uspto.gov /netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1="20030045494".PGNR.&OS=DN/20030045494&RS=DN/20030045494 (5031 words)

	Genomics and Proteomics - Optimizing Oligonucleotide Microarray Printing Parameters (Site not responding. Last check: 2007-10-18)
		Proper design of oligonucleotide probes maximizes gene specificity by eliminating the potential for cross-hybridization between homologous exons that are present in many gene families, and by incorporating similar melting temperatures to optimize hybridization parameters for all genes on large microarrays (4).
		A 3'-Cy5-modified oligonucleotide that was complementary to one of the Cy3-labeled oligonucleotides was synthesized and hybridized at a concentration of 10nM.
		A Cy5-labeled antisense oligonucleotide was synthesized (complementary to one of the spotted Cy-labeled probe) to determine the ability of bound Cy3-labeled sense-strand oligonucleotide to hybridize.
	www.genpromag.com /PRArchivebyIssue~RELTYPE~RD~YEAR~2004~MONTH~11.html (2824 words)

	[No title] (Site not responding. Last check: 2007-10-18)
		The second oligonucleotide includes a complementarity region that is perfectly complementary in sequence to a second strand of the target across at least a portion of the target query region.
		The second oligonucleotide comprises base modifications, does not substantially bind recombinase, and includes a complementarity region that is perfectly complementary in sequence to a second strand of the target across at least a portion of the target query region.
		The second oligonucleotide complementarity region is perfectly complementary in sequence to a second strand of the target across at least a portion of the target query region.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=03/27640.030403&ELEMENT_SET=DECL (6962 words)

	oligo probes oligonucleotide probes
		oligonucleotide gene probes are supplied lyophilized with 2500 pmoles (~35ug) of unlabeled probe per vial.
		oligonucleotide gene probes (labeled or unlabeled) in sufficient quantities that allow for many hybridization experiments to be performed.
		oligonucleotide gene probe it may be difficult to see the lyophilized oligonucleotide at the bottom of the tube.
	www.genedetect.com /oligonucleotide.htm (1166 words)

	Oligonucleotide Purification by PAGE/DEAE (Site not responding. Last check: 2007-10-18)
		Use PAGE to purify 20-30 micrograms of oligonucleotide on a small 10% denaturing acrylamide urea gel (1 mm thick small gel).
		To do this, mix equal volumes of oligonucleotide and formamide gel loading buffer (max volume for our gels is 40 microliters, but 20 microliters total is a preferred volume).
		If a number of oligonucleotides are being purified at the same time, it is very easy to cross contaminate the oligos at the ETOH precipitation step as the pellets are very small and unstable.
	www.fhcrc.org /labs/hahn/methods/mol_bio_meth/oligo_purification.html (479 words)

	Oligonucleotide Arrays for High-Throughput SNPs Detection in the MHC Class I Genes: HLA-B as a Model System -- Guo et ...
		The K5 oligonucleotide probe (Table 1) was labeled with an amino group at its 5'-end and a Rhodamine dye at its 3'-end, and mixed with an oligonucleotide of the same sequence having an amino group labeled at its 5'-end (ratio of 1:10).
		Mixtures of oligonucleotides ranging from 15.65 to 2000 pmol/mL were spotted on activated glass slides, incubated at 37°C for 2 h and then washed with 1% NH OH and water.
		Oligonucleotide probes, labeled with a 5' amino group, were dissolved at a concentration of 500 pmol/µL in water.
	www.genome.org /cgi/content/full/12/3/447 (4725 words)

	Oligonucleotide therapeutic agent and methods of making same (US5919619)
		For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substantially complementary to a portion of messenger ribonucleic acid coding for a bological component, such as a protein, of the organism.
		The oligonucleotide sequence can be derived from the organism's ribonucleic or deoxyribonucleic acid that codes for a vital protein, and can be synthesized in bulk either chemically or by insertion into a plasmid.
		(iii) hybridizing the oligonucleotide to the subsequence of the messenger ribonucleic acid to inhibit the expression of the target protein.
	www.delphion.com /details?&pn=US05919619__ (1277 words)

	Oligonucleotide Properties Calculator
		The change in entropy (order or a measure of the randomness of the oligonucleotide) and enthalpy (heat released or absorbed by the oligonucleotide) are directly calculated by summing the values for nucleotide pairs obtained by Breslauer et al.
		The melting temperature (Tm) calculations assume the sequences are not symmetric and contain at least one G or C. The oligonucleotide sequence should be at least 8 bases long to give reasonable Tms.
		The addition of 79.0 gm/mole to the oligonucleotide molecular weight takes into account the 5' monophosphate left by most restriction enzymes.
	www.basic.northwestern.edu /biotools/OligoCalc.html (930 words)

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