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	Ondansetron - Wikipedia, the free encyclopedia
		Ondansetron (INN) (IPA: [ɒnˈdænsɛˌtrɒn]) is a serotonin 5-HT receptor antagonist used mainly to treat nausea and vomiting following chemotherapy.
		Ondansetron was developed around 1984 by scientists working at Glaxo's laboratories in London.
		Ondansetron was granted Food and Drug Administration (FDA) approval as Zofran in January 1991.
	en.wikipedia.org /wiki/Ondansetron (630 words)

	Ondansetron for Anxiety & Novel Applications
		Ondansetron, an antiemetic with anxiolytic properties, has been shown to be effective for treatment of social phobia in a double-blind, placebo-controlled study.
		Ondansetron is a selective 5-hydroxytryptamine(3) (5-HT(3)) receptor antagonist that has been introduced to clinical practice as an antiemetic for cancer treatment-induced and anesthesia-related nausea and vomiting.
		Ondansetron in all the doses tested (0.01, 0.1 and 1 mg/kg i.p.) showed significant anxiolytic action as compared to naive mice, but it was less potent as compared to a well-known anxiolytic, diazepam (1 mg/kg).
	www.angelfire.com /journal2/sadhelp/zoanx.htm (2268 words)

	MedlinePlus Drug Information: Ondansetron
		Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, anesthesia, and surgery.
		The first dose of ondansetron usually is taken in a hospital or clinic 30 minutes before chemotherapy is begun.
		Ondansetron injections are given by qualified health care professionals.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601209.html (531 words)

	Ondansetron - Drugs & Vitamins - Drug Library - DrugDigest
		Ondansetron may also be used to prevent or treat nausea and vomiting that occurs after surgery, and occasionally is used to treat severe vomiting during pregnancy.
		Ondansetron tablets are taken by mouth, refer to the directions below that match the type of tablets you were prescribed.
		If you are taking ondansetron to prevent nausea due to chemotherapy, the first dose of ondansetron is usually given 30 minutes before chemotherapy, followed by a dose at regular intervals for one or two days after chemotherapy.
	www.drugdigest.org /DD/DVH/Uses/0,3915,507\|Ondansetron,00.html (539 words)

	Ondansetron for Alcoholism
		Ondansetron reduced their drinking to one-sixth of its previous level, and they were abstinent on 70% of days as compared with 50% of comparable patients taking a placebo.
		Unlike disulfiram (Antabuse), ondansetron does not alter the breakdown of alcohol in the body, so it is safer to take while drinking.
		OBJECTIVE: To determine whether the combination of naltrexone and ondansetron is superior to a placebo at reducing craving among EOA, and the relationship between craving and drinking behavior in both treatment groups.
	www.angelfire.com /journal2/sadhelp/zoalc.htm (1701 words)

	HGSA Medical Policy: I-36 - Ondansetron Hydrochloride (Zofran) Injection (Site not responding. Last check: 2007-11-01)
		Ondansetron (Zofran) is an antiemetic, which prevents nausea and vomiting by blocking serotonin peripherally, centrally, and in the small intestines.
		Ondansetron injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of moderately or highly emetogenic cancer chemotherapy.
		Ondansetron tablets are indicated for the prevention of nausea and vomiting associated with radiotherapy.
	www.hgsa.com /professionals/policy/i36.html (1109 words)

	Ondansetron Combined With IV Fluids Decreases Emesis and Need for Admission in Certain Pediatric Patients With Acute ...
		Ondansetron had a clinically significant effect on cessation of vomiting, but did not reduce the overall number of hospitalizations.
		A placebo controlled, double blind, randomized trial compared the effect of 0.15mg/kg IV ondansetron as a single dose with standard IV fluid treatment compared with IV fluid treatment alone in patients aged 1 month to 22 years (mean age 5.3) with acute gastroenteritis.
		Ondansetron had a clinically significant effect on cessation of vomiting.
	www.med.umich.edu /pediatrics/ebm/cats/ondans.htm (429 words)

	Howstuffworks "Ondansetron: A Profile of an Antiemetic Drug"
		Ondansetron is used to prevent the nausea, vomiting, and retching associated with cancer chemotherapy or radiation therapy.
		Ondansetron can be taken with meals or with a full glass of water if you are bothered by stomach upset (unless your doctor directs you otherwise).
		The effectiveness of this treatment is thought to be related to keeping a steady level of ondansetron in the bloodstream.
	health.howstuffworks.com /define-ondansetron.htm (520 words)

	Ondansetron (Zofran®) - PetPlace.com (Site not responding. Last check: 2007-11-01)
		Ondansetron has does not stimulate gastric or intestinal peristalsis, and has little effect on blood pressure, heart rate or rhythm.
		Ondansetron should not be used in animals with known hypersensitivity or
		Injectable ondansetron should only be mixed with solutions with which it has been shown to be compatible.
	www.petplace.com /drug-library/ondansetron-zofran/page1.aspx (538 words)

	Ondansetron Decreases Gastroenteritis-Associated Emesis in Children
		If otherwise healthy children are diagnosed with acute gastroenteritis and require IV fluids, one dose of intravenous ondansetron shortens the duration of emesis.
		A randomized, double-blind, placebo-controlled trial of a single dose of IV ondansetron was conducted in a pediatric emergency department.
		Ondansetron decreases vomiting associated with acute gastroenteritis: a randomized, controlled trial.
	www.med.umich.edu /pediatrics/ebm/cats/gastro.htm (635 words)

	ondansetron Consumer Drug Information
		Before receiving ondansetron injection, tell your doctor if you have liver disease, a personal or family history of Long QT syndrome, or if you have had an allergic reaction to any medicine similar to ondansetron, including dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).
		Ondansetron injection is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy).
		Ondansetron injection is not for preventing nausea or vomiting that are caused by factors other than chemotherapy or surgery.
	www.drugs.com /MTM/ondansetron.html (1198 words)

	Ondansetron Reduced IFN-Fatigue/depression
		Patients were randomised to receive ondansetron tablets 4 mg twice daily or placebo for one month followed by an additional four weeks of observation.
		Laxatives were used by three patients in the ondansetron group and by one patient in the placebo group.
		Although fatigue scores evaluated on day 30 were not statistically different between the ondansetron and placebo groups, a statistical trend in favour of ondansetron was observed and the difference was significant by day 15 and also one month after treatment was stopped.
	www.natap.org /2005/HCV/090505_03.htm (2232 words)

	Nausea drug may aid alcoholism treatment - ondansetron - Brief Article Science News - Find Articles
		Ondansetron, a medication currently prescribed to quell nausea and vomiting in chemotherapy patients, helps to reduce drinking and foster abstinence among adults who developed alcoholism before age 25, report psychiatrist Bankole A. Johnson of the University of Texas Health Science Center in San Antonio and his colleagues.
		For example, volunteers taking the middle dose of ondansetron spent 70 percent of study days abstinent and imbibed an average of 1 1/2 drinks daily; those in the placebo group were abstinent 50 cent of the days and averaged nearly 3 1/2 drinks daily.
		Ondansetron blocks the activity of serotonin directly, which leads to reductions in other neurotransmitters, including dopamine.
	www.findarticles.com /p/articles/mi_m1200/is_9_158/ai_65368551 (526 words)

	Baxter Healthcare Corporation :: Baxter Receives Tentative FDA Approvals For Ondansetron Injection In Vials And Premix ... (Site not responding. Last check: 2007-11-01)
		Ondansetron will be the newest addition to Baxter's existing portfolio of anesthesia, critical care and oncology products, which include enhanced packaging, proprietary drugs and other generics.
		Ondansetron is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin.
		Ondansetron Injection is contraindicated for patients known to have hypersensitivity to the drug and other selective 5-HT3 receptor antagonists.
	sev.prnewswire.com /health-care-hospitals/20060615/CGTH05015062006-1.html (442 words)

	Ondansetron for Nausea (Pt. Info.) : BC Cancer Agency (Site not responding. Last check: 2007-11-01)
		Ondansetron is a drug that is used to prevent or reduce nausea or vomiting caused by cancer chemotherapy.
		Ondansetron may be taken with food or on an empty stomach with a glass of water.
		ondansetron tablets out of the reach of children, at room temperature, away from heat, light and moisture.
	www.bccancer.bc.ca /HPI/DrugDatabase/Appendices/Appendix3/ManagingNauseaPtInfo/OndansetronforNauseaPtInfo.htm (346 words)

	ACS :: Cancer Drug Guide: ondansetron hydrochloride
		Ondansetron hydrochloride belongs to a general class of drugs called serotonin antagonists.
		Ondansetron hydrochloride blocks the serotonin pathway to the vomiting center in the brain so the brain no longer receives a vomiting message.
		Ondansetron hydrochloride is taken by mouth as a pill, on the tongue as a tablet that dissolves, as a liquid, or as an injection in a vein over 30 minutes.
	www.cancer.org /docroot/CDG/content/CDG_ondansetron_hydrochloride.asp (410 words)

	Antinausea Drugs: Encyclopedia of Surgery
		Some antihistamines such as dimenhydrinate (Dramamine) and meclizine (Antivert, Bonine) are useful for treatment of the nausea and vomiting associated with motion sickness.
		A group of drugs called the 5HT3 inhibitors, ondansetron (Zofran) and granisetron (Kytril), are used to control the nausea and vomiting associated with anticancer drugs.
		Ondansetron and granisetron are also valuable for controlling nausea and vomiting following surgery.
	health.enotes.com /surgery-encyclopedia/antinausea-drugs (786 words)

	RedOrbit - Health - Hana Biosciences Presents Zensana(TM) (Ondansetron HCl) Oral Spray Pivotal Trials at ASCO (Site not responding. Last check: 2007-11-01)
		This survey was conducted to determine current trends and market potential for the introduction of Zensana(TM) (ondansetron HCl) Oral Spray, currently being developed by Hana Biosciences (HNAB) for the prevention of chemotherapy-induced nausea and vomiting (CINV) for a targeted US launch in 2007.
		Ondansetron is an FDA approved drug that is commonly used to prevent chemotherapy and radiation-induced, and post-operative, nausea and vomiting.
		Annual US sales for ondansetron were approximately $1.0 billion, representing a 66% market share among the four approved 5-HT3 products in 2004.
	www.redorbit.com /news/health/521125/hana_biosciences_presents_zensanatm_ondansetron_hcl_oral_spray_pivotal_trials/index.html?source=r_health (1163 words)

	News - Ondansetron Helps Control Vomiting In Children With Gastroenteritis (Site not responding. Last check: 2007-11-01)
		Intravenous (IV) ondansetron therapy decreases vomiting in children with acute gastroenteritis, reducing the rate of hospital admission in children first treated in emergency and who have serum carbon dioxide equal to or greater than 15 milliequivalent per litre.
		Children given the selective 5-hydroxytryptamine (5-HT)-3 receptor antagonist ondansetron and IV fluids were more likely to stop vomiting completely than children on IV fluids and placebo, United States researchers found.
		A total of 26 percent of the ondansetron patients (14) were admitted to hospital, compared to 30 percent of the placebo patients (16).
	www.docguide.com /news/content.nsf/news/8525697700573E1885256B8F00718B7F?OpenDocument&c=&count=10&id=48dde4a73e09a969852568880078c249 (484 words)

	Ondansetron (Site not responding. Last check: 2007-11-01)
		Ondansetron (Zofran) is used extensively to treat nausea and vomiting; particularly for chemotherapy patients using cisplatin.
		Ondansetron in tablet form is often referred to as oral ondansetron.
		However the drug is often administered to cancer patients after chemotherapy in the form of an intravenous drip, or it may be injected.
	www.chem.ox.ac.uk /course/ityearone/week6-8/Ondansetron3.htm (235 words)

	Cocaine Treatment: Ondansetron
		These findings are the first to show the value of ondansetron in battling cocaine and its addictive qualities.
		Individuals treated with the highest dose of ondansetron (4 mg) had the lowest dropout rates and a greater rate of improvement in percentage of participants with a cocaine-free week as compared with the placebo group.
		The results of this study suggest that ondansetron may be beneficial in reducing cocaine’s reinforcing effects, which in turn may help cocaine users to quit.
	www.healthsystem.virginia.edu /internet/news/archives06/cocaine_treatment_ondansetron.cfm (442 words)

	Australian Adverse Drug Reactions Bulletin, Volume 17, Number 4, November 1998
		In another case, a 62 year old female was given intravenous ondansetron for nausea due to migraine and she experienced angina-like chest pain associated with ECG changes.
		In a third case, two weeks after maintenance chemotherapy, a 20 year old female was administered intravenous ondansetron and within a minute of starting the infusion, she developed central chest pain, shortness of breath and a dry cough.
		In two other cases in which ondansetron was the only suspected drug, chest pain was associated with the use of two oral doses given to control nausea and vomiting in one report, and in the other, chest tightness occurred after intravenous ondansetron.
	www.tga.gov.au /docs/html/aadrbltn/aadr9811.htm (1219 words)

	Prophylactic ondansetron does not reduce the incidence of itching induced by intrathecal sufentanil: [L'administration ...
		Prophylactic ondansetron does not reduce the incidence of itching induced by intrathecal sufentanil: [L'administration prophylactique d'ondansetron ne reduit pas l'incidence de prurit induit par le sufentanil intrathecal] -- Waxler et al.
		Ondansetron is effective to treat spinal or epidural morphine-induced pruritus.
		Prophylactic ondansetron is effective in the treatment of nausea and vomiting but not on pruritus after cesarean delivery with intrathecal sufentanil-morphine.
	www.cja-jca.org /cgi/content/full/51/7/685 (2037 words)

	Atrial fibrillation after ondansetron for the prevention and treatment of postoperative nausea and vomiting: a case ...
		Atrial fibrillation after ondansetron for the prevention and treatment of postoperative nausea and vomiting: a case report: [Fibrillation auriculaire causee par l'ondansetron administre pour prevenir et traiter les nausees et les vomissements postoperatoires : une etude de cas] -- Kasinath et al.
		ONDANSETRON is a 5-hydroxytryptamine 3 (5-HT) receptor antagonist
		Cardiac dysrrhythmias associated with the intravenous administration of ondansetron and metoclopramide.
	www.cja-jca.org /cgi/content/full/50/3/229 (1353 words)

	A Comparison of Oral Ondansetron and Intravenous Granisetron for the Prevention of Nausea and Emesis Associated with ...
		Efficacy of ondansetron (GR38032F) and the role of serotonin in cisplatin-induced nausea and vomiting.
		Comparison of single-dose oral granisetron and intravenous ondansetron in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy: a multicenter, double-blind, randomized parallel study.
		Ondansetron plus dexamethasone is superior to ondansetron alone in the prevention of emesis in chemotherapy-naïve and previously treated patients.
	theoncologist.alphamedpress.org /cgi/content/full/3/6/432 (2970 words)

	MedlinePlus Drug Information: Ondansetron (Systemic) (Site not responding. Last check: 2007-11-01)
		Ondansetron (on-DAN-se-tron) is used to prevent the nausea and vomiting that may occur after therapy with anticancer medicines (chemotherapy) or radiation, or after surgery.
		Allergy to selective 5-HT receptor antagonists (alosetron [e.g., Lotronex], dolasetron [e.g., Anzemet], granisetron [e.g., Kytril], palonosetron [e.g., Aloxi])— If you are allergic to one of these, you may be allergic to ondansetron because they are in the same group of medicines.
		The dose of ondansetron will be different for different patients.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202424.html (1483 words)

	Ondansetron (Site not responding. Last check: 2007-11-01)
		Ondansetron is a selective 5-hydroxytryptamine-3 receptor antagonist used to prevent nausea and vomiting associated with the initial and repeated courses of emetogenic cancer chemotherapy.
		It is taken in the form of ondansetron hydrochloride.
		Efficacy was demonstrated in two double-blind, placebo-controlled clinical trials conducted with female patients in the United States and Europe.
	www.chem.ox.ac.uk /course/ityearone/week6-8/Ondansetron2.htm (214 words)

	A Comparison of Ondansetron and Dolasetron
		The few studies comparing ondansetron and dolasetron to one another have demonstrated insignificant difference between the two.
		The current thesis study was performed for the purpose of comparing ondansetron and dolasetron to one another in the prevention and treatment of PONV in an outpatient surgical population.
		A Double-Blind Assessment of Ondansetron, Droperidol, and Placebo in Pediatric Patients Undergoing Ambulatory Surgery.
	fred.ccsu.edu:8000 /archive/00000058/02/etd-2003-14.html (10113 words)

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