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Topic: Opsoclonus Myoclonus Ataxia

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OMA

Ataxia

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	Movement Disorders (Site not responding. Last check: 2007-10-21)
		Reflex epilepsies are in the differential diagnosis of the paroxysmal choreoathetotic disorders and startle disease.
		Hypnic jerks, a type of myoclonus, are sleep jerks accompanied by the sensation of falling, usually at the time of falling to sleep, and physiologic fragmentary myoclonus consists of twitches, particularly about the face, that occur during sleep in normal individuals.
		Myoclonus: Myoclonus is the fastest movement disorder, with a burst range between 50 and 200 ms.
	home.coqui.net /myrna/move.htm (2038 words)

	PNSEUROENT: Paraneoplastic Neurological syndromes: Professional area
		Opsoclonus is defined by the presence of spontaneous, arrhythmic, large amplitude conjugate saccades occurring in all directions of gaze without a saccadic interval.
		Opsoclonus is usually associated with myoclonus of the limbs and trunk, and sometimes encephalopathy; these symptoms cannot be clinically differentiated from those caused by non-paraneoplastic etiologies.
		Opsoclonus, myoclonus, ataxia and encephalopathy in adults with cancer: A distinct paraneoplastic syndrome.
	www.pnseuronet.org /professionals/opso.htm (420 words)

	Ataxia (Coordination)
		Ataxia is usually caused by damage to the cerebellum or to its inputs or outputs.
		Tumors of the cerebellum or brainstem, neuroblastoma in the chest or abdomen (associated with the myoclonus-opsoclonus-ataxia syndrome).
		If the child has myoclonus or myoclonic eye movements (opsoclonus) in addition to the ataxia, it is important to look for a neuroblastoma in the chest or abdomen, as these tumors may cause opsoclonus-myoclonus-ataxia syndrome.
	huntingtonsdiseasejm.tripod.com /hdsymptoms/id17.html (1505 words)

	Opsoclonus-myoclonus-ataxia syndrome in neuroblastoma: clinical outcome and antineuronal antibodies--a report from the ... (Site not responding. Last check: 2007-10-21)
		Opsoclonus-myoclonus-ataxia (OMA) is a paraneoplastic neurologic syndrome affecting 2-3% of children with neuroblastoma.
		Although children with OMA and neuroblastoma may have higher survival, many experience a significant amount of late neurologic impairment, which may be immunologically mediated.
		Sera from 16 of the OMA patients and 48 case-controls with neuroblastoma were assayed for anti-neuronal antibodies.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=MEDL/21243019 (352 words)

	MDVU - Pediatric Movement Disorders - Myoclonus: Examination
		In some cases, a myoclonic jerk may be caused by an unexpected, loud noise or a gentle tap on the tip of the nose or on the forehead.
		To test for negative myoclonus, also known as asterixis, children are asked to extend their arms with the wrists back or to perform some other movement that requires holding the limb against gravity.
		Since myoclonus may occur along with other movement disorders, it is important to look for evidence of dystonia, tremor, ataxia, or spasticity.
	www.mdvu.org /library/pediatric/myoclonus/myo_exa.html (218 words)

	oms
		Opsoclonus Myoclonus is a rare neurological disorder characterized by unsteady gait, tremor (rhythmic, involuntary motions of the limbs during voluntary movements), myoclonus(brief, shock-like muscle spasms), and opsoclonus(irregular, rapid, horizontal and vertical eye movements).
		Opsoclonus Myoclonus may occur in association with tumors or viral infections.
		The prognosis for Opsoclonus Myoclonus varies depending on the symptoms and the presence and treatment of tumors.
	www.brownemily.com /oms.html (198 words)

	MDVU - Pediatric Movement Disorders - Ataxia: Workup
		The first question is whether the child has ataxia or some other condition that looks like ataxia.
		In particular, a child with leg weakness, spasticity, or dystonia may have an unstable and wide-based gait and may thus appear to have ataxia when in fact symptoms are due to an entirely different movement disorder.
		The MRI and initial laboratory tests are important to perform early as these tests may find causes for the ataxia that may require rapid treatment.
	www.mdvu.org /library/pediatric/ataxia/ata_wor.html (302 words)

	Opsoclonus myoclonus syndrome (Site not responding. Last check: 2007-10-21)
		Opsoclonus myoclonus syndrome (OMS) is a rare neurological disorder of unknown causes which appears to be the result of an autoimmune process involving the nervous system.
		Kinsbourne in 1962 (The term 'Opsoclonus' was coined by Orezechowski in 1913, but it was classically described and associated with neuroblastoma by Kinsbourne).
		About half of all cases are associated with neuroblastoma and most of the others are suspected to be associated with an undetected neuroblastoma.
	www.mrsci.com /Neurology/Opsoclonus_myoclonus_syndrome.php (654 words)

	Opsoclonus myoclonus syndrome - Wikipedia, the free encyclopedia
		The three-year survival rate for children with non-metastatic neuroblastoma and OMA was 100% according to Children’s Cancer Group data (gathered from 675 patients diagnosed between 1980 to 1994); three-year survival in comparable patients with OMA was 77% (Rudnick et al., 2001).
		Although the symptoms of OMA are typically steroid-responsive and recovery from acute symptoms of OMA can be quite good, children often suffer lifelong neurologic sequelae that impair motor, cognitive, language, and behavioral development (Dale, 2003; Mezey and Harris, 2002).
		Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma.
	en.wikipedia.org /wiki/Opsoclonus_myoclonus_syndrome (1084 words)

	Pranzatelli-oms patient information
		Some infants, children, and adults suddenly develop a syndrome of opsoclonus, myoclonus, ataxia and encephalopathy.
		Myoclonus occurs most when movement is attempted, worsens with agitation or stimulation, but may be present at rest.
		When opsoclonus and myoclonus occur as separate disorders, they have many causes, but the combination is rather specific for tumors and infections.
	www.omsusa.org /pranzatelli-Brochure1.htm (1795 words)

	Myoclonus Ataxia
		MELAS, myoclonus, ataxia and deficiencies of complexes I and IV in...
		MELAS, myoclonus, ataxia and deficiencies of complexes I and IV in muscle mitochondria.
		An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver...
	www.medicality.org.uk /diseases/myoclonus-ataxia.php (219 words)

	Clinical Trial: Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma
		The purpose of this study is to evaluate the feasibility of giving four weekly doses of Rituximab (anti-CD20 antibody) in the treatment of children with refractory neuroblastoma associated opsoclonus-myoclonus.
		Patients must have continued symptoms of opsoclonus, myoclonus and or ataxia despite surgical resection and a minimum of one month of steroid therapy.
		Opsoclonus-myoclonus ataxia syndrome (OMS) is a rare immune mediated paraneoplastic syndrome that occurs in approximately 2 to 3% of children with neuroblastoma.
	clinicaltrials.gov /ct/show/NCT00202930 (544 words)

	Symptoms of Opsoclonus Myoclonus - WrongDiagnosis.com
		characterized by unsteady gait, intention tremor (rhythmic, involuntary motions of the limbs during voluntary movements), myoclonus (brief, shock-like muscle spasms), and opsoclonus (irregular, rapid, horizontal and vertical eye movements).
		When considering symptoms of Opsoclonus Myoclonus, it is also important to consider Opsoclonus Myoclonus as a possible cause of other medical conditions.
		This signs and symptoms information for Opsoclonus Myoclonus has been gathered from various sources, may not be fully accurate, and may not be the full list of Opsoclonus Myoclonus signs or Opsoclonus Myoclonus symptoms.
	www.wrongdiagnosis.com /o/opsoclonus_myoclonus/symptoms.htm (466 words)

	Research
		Abnormal Cortico-muscular Coherence is Associated with the Small Amplitude Cortical Myoclonus in Parkinson's disease.
		Clinical-Electrophysiological Correlation of Tremor and Myoclonus in a Kindred with the N279K tau Mutation.
		Focal cortical transient preceding myoclonus during lithium and tricyclic antidepressant therapy.
	www.mayoclinic.org /myoclonus/research.html (407 words)

	Arch Pediatr Adolesc Med -- Abstract: Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal ... (Site not responding. Last check: 2007-10-21)
		Arch Pediatr Adolesc Med -- Abstract: Cerebellar ataxia, opsoclonus, and occult neural crest tumor.
		Cerebellar ataxia, opsoclonus, and occult neural crest tumor.
		A 9-month-old female with opsoclonus and ataxia was examined.
	archpedi.ama-assn.org /cgi/content/abstract/134/11/1057 (85 words)

	Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus -- Bataller et al. 124 (2): 437 -- ...
		Aggarwal A, Williams D. Opsoclonus as a paraneoplastic manifestation of pancreatic carcinoma [letter].
		Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus and polyendocrine autoimmunity.
		Schwartz M, Sharf B, Zidan J. Opsoclonus as a presenting symptom in thymic carcinoma [letter].
	brain.oxfordjournals.org /cgi/content/full/124/2/437 (3087 words)

	Últimas novedades por revista
		The exact immunopathogenesis and neuroanatomical localization of opsoclonus-myoclonus ataxia syndrome remains unclear.
		We postulate on the etiological factors that may have played a role in the disease pathogenesis of the patient's opsoclonus-myoclonus ataxia.
		We report the case of a 3.5-year-old boy who presented with truncal ataxia, microcephaly and delayed global development in infancy.
	www.lasalud.com /busquedas/buscar_por_revista.htm?revi=992 (1808 words)

	The Opsoclonus Myoclonus Home Page (via CobWeb/3.1 planet03.csc.ncsu.edu) (Site not responding. Last check: 2007-10-21)
		An attempt is made to provide as comprehensive list of literature relating to the opsoclonus myoclonus syndrome as possible.
		A 29-month-old girl with worsening ataxia, nystagmus, and subsequent opsoclonus and myoclonus Íclinical conferenceÍ N Engl J Med, 333(9):579-86 1995 Aug 31
		Opsoclonus myoclonus syndrome secondary to Epstein-Barr virus infection.
	www.geocities.com.cob-web.org:8888 /HotSprings/Spa/2190/lit.html (2512 words)

	Paraneoplastic opsoclonus-myoclonus associated with renal cell carcinoma and responsive to tumour ablation -- VIGLIANI ...
		Opsoclonus is a rare but distinctive disorder of ocular motility, characterised by irregular, continual, and conjugated chaotic
		Koukoulis A, Cimas I, Gomara S. Paraneoplastic opsoclonus associated with papillary renal cell carcinoma.
		Omnipause neurons in two cases of opsoclonus associated with oat cell carcinoma of the lung.
	jnnp.bmjjournals.com /cgi/content/full/70/6/814 (859 words)

	Opsoclonus-Myoclonus Syndrome - OMSUSA.ORG
		The National Pediatric Myoclonus Center disclaims all liability in connection with the use of medical information contained in this website.
		Important decisions about treatment must be made by individuals with their health care providers.
		The National Pediatric Myoclonus Center is available for referrals and consultations.
	www.omsusa.org (88 words)

	The First Workshop on Dancing Eye Syndrome Clinical and Basic Science Abingdon
		Dancing Eye Syndrome, also known as opsoclonus - myoclonus, opsoclonus ataxia, or myoclonic encephalopathy of Kinsbourne is a rare disease that primarily afflicts children but it is likely that the number of cases will increase as awareness of the disease and correct clinical diagnosis improves.
		The onset of the disease is sub-acute, usually over a period of a few days, or weeks, and characterised by a jerky ataxia, shivering movements, and bursts of multi-directional conjugate eye movements along both horizontal and vertical axes.
		In some instances the target antigens for the antibodies have been identified in biochemical preparations of brain tissue and the distribution of brain cells that express the antigen has been mapped by examining the binding of the antibodies to brain tissue sections.
	website.lineone.net /~rjsdsr/workshop%20summary.htm (4013 words)

	Managing Paraneoplastic Neurological Disorders -- de Beukelaar and Smitt 11 (3): 292 -- The Oncologist
		acute or subacute nonfamilial ataxia are estimated to have an
		Opsoclonus is a disorder of ocular motility that consists of
		Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor.
	theoncologist.alphamedpress.org /cgi/content/full/11/3/292 (5647 words)

	The Opsoclonus Myoclonus Home Page (via CobWeb/3.1 planet03.csc.ncsu.edu) (Site not responding. Last check: 2007-10-21)
		He had diagnosed her with acute cerebellar ataxia, and said see you in six weeks.
		The doctor said that with acute cerebellar ataxia, she would have her good days and her bad days.
		They changed her diagnoses to opsoclonus myoclonus ataxia syndrome with no neuroblastoma.
	www.geocities.com.cob-web.org:8888 /HotSprings/Spa/2190/Estes.html (594 words)

	AccessMedicine - Harrison's Internal Medicine: Paraneoplastic Opsoclonus-Myoclonus Syndrome
		"Opsoclonus is a disorder of eye movement characterized by involuntary, chaotic saccades that occur in all directions of gaze; it is frequently associated with myoclonus and ataxia.
		A small subset of patients with ataxia, opsoclonus, and other eye movement disorders develop anti-Ri antibodies; in rare instances muscle rigidity, autonomic dysfunction, and dementia also occur.
		The tumor most frequently involved in anti-Ri-associated syndromes is breast cancer; however, only 50% of patients with anti-Ri antibodies develop opsoclonus...."
	www.accessmedicine.com /content.aspx?aID=63751 (228 words)

	Clinical Trials
		Determine whether immunosuppressive therapy with cyclophosphamide and prednisone is an effective backbone therapy for OMA upon which to build additional treatment for these patients.
		Determine whether these regimens improve OMA syndrome in these patients.
		Presence of opsoclonus, myoclonus, and/or ataxia associated with neuroblastoma considered eligible
	www.muschealth.com /clintrials/Default.aspx?DocID=NCT00033293.xml (479 words)

	HHMI News: Controlling the Synapse 49 Proteins at a Time
		Several years ago, Darnell and colleagues discovered that Nova is a key player in regulating alternative splicing of RNA molecules in the brain.
		The team initially identified Nova because it was the target of autoimmune attack in an uncommon neurological disorder known as paraneoplastic opsoclonus myoclonus ataxia, which causes progressive loss of motor control.
		Further investigation revealed that the protein, which is found only in the brain, bound to RNA molecules and regulated their splicing.
	www.hhmi.org /news/darnell2.html (1106 words)

	Opsoclonus-Myoclonus Syndrome
		It is characterized by the sudden onset of brief, repeated, shock-like spasms of muscles within the arms, legs, or entire body (myoclonus), an impaired ability to control voluntary movements (ataxia), and continual, involuntary, rapid eye movements in both horizontal and vertical directions (opsoclonus).
		In approximately 50 percent of affected individuals, a malignant tumor, usually a tumor of embryonic nerve cells (neuroblastoma), is responsible for the symptoms associated with opsoclonus myoclonus.
		In most other cases, the disorder may be due to a viral infection such as Coxsackievirus B3, poliovirus, or St. Louis encephalitis virus.
	www.webmd.com /hw/raising_a_family/nord679.asp (434 words)

	Wrong diagnosis of Underlying Causes of Opsoclonus Myoclonus - WrongDiagnosis.com
		With a diagnosis of Opsoclonus Myoclonus, it is important to consider whether there is an underlying condition causing Opsoclonus Myoclonus.
		These are other medical conditions that may possibly cause Opsoclonus Myoclonus.
		For general information on this form of misdiagnosis, see Underlying Condition Misdiagnosis or Overview of Misdiagnosis.
	www.wrongdiagnosis.com /o/opsoclonus_myoclonus/underly.htm (201 words)

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