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Topic: Opsoclonus myoclonus syndrome

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	PNSEUROENT: Paraneoplastic Neurological syndromes: Professional area
		Opsoclonus is defined by the presence of spontaneous, arrhythmic, large amplitude conjugate saccades occurring in all directions of gaze without a saccadic interval.
		The pathogenesis of the opsoclonus-myoclonus syndrome is unclear.
		Opsoclonus is usually associated with myoclonus of the limbs and trunk, and sometimes encephalopathy; these symptoms cannot be clinically differentiated from those caused by non-paraneoplastic etiologies.
	www.pnseuronet.org /professionals/opso.htm (420 words)

	Dr. Pranzatelli - Opsoclonus-Myoclonus syndrome (Site not responding. Last check: 2007-10-25)
		Madalin was diagnosed later with opsoclonus-myoclonus syndrome (OMS) at a Chicago hospital.
		In the peak of the syndrome, the child is extremely irritable and wants to be held constantly.
		In children with this syndrome, the B cell population is many times higher than normal," explains Pranzatelli.
	www.siumed.edu /news/releasesFY04/Pranzatelli-OMS.htm (1239 words)

	Palatal myoclonus in postinfectious opsoclonus myoclonus syndrome : a case report. Srivastava T, Thussu A Neurol India
		Opsoclonus is often associated with diffuse or focal myoclonus and truncal titubation with or without other cerebellar signs.
		Lesion in dentatorubral pathway may be responsible for opsoclonus and myoclonus of limbs and palate.
		In cases of post infectious opsoclonus myoclonus syndrome patient should be thoroughly investigated for detection of cause and to exclude paraneoplastic process.
	www.neurologyindia.com /article.asp?issn=0028-3886;year=1999;volume=47;issue=2;spage=133;epage=5;aulast=Srivastava (1080 words)

	Opsoclonus - myoclonus syndrome in an adult: A case report and response to clonazepam Garg RK, Kar AM, Dixit V - Indian ...
		Opsoclonus is a striking disorder of eye movement reflecting the presence of unwanted saccades.
		His opsoclonus and myoclonus were reduced, and he was able to sit and stand with support.
		Syndrome of opsoclonus-myoclonus caused by Coxsackie B3 infection.
	www.ijo.in /article.asp?issn=0301-4738;year=1996;volume=44;issue=2;spage=101;epage=102;aulast=Garg (958 words)

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	CIGNA - Opsoclonus-Myoclonus Syndrome (Site not responding. Last check: 2007-10-25)
		Opsoclonus-myoclonus syndrome is characterized by repeated, rapid eye movements in both horizontal and vertical directions (opsoclonus); unsteady, gait (ataxia); brief, repeated, shock-like spasms of several muscles within the arms, legs (myoclonus) and interrupted, rhythmic and involuntary motion during a voluntary movement of an arm or leg.
		Myoclonus is a group of movement disorders characterized by sudden, involuntary contractions of a skeletal muscle or group of muscles.
		The diagnosis of opsoclonus myoclonus is confirmed by a thorough clinical evaluation and a variety of specialized tests, detailed patient history, and special-ized laboratory tests.
	www.cigna.com /healthinfo/nord679.html (1569 words)

	Indian Pediatrics - Editorial
		Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder characterized by progressive opsoclonus (irregular, rapid, horizontal and vertical eye movements), myoclonus, cerebellar dysfunction and severe hypotonia.
		A provisional diagnosis of idiopathic opsoclonus myoclonus syndrome was made, and he was investigated to rule out an occult neuroblastoma.
		Serum autoantibodies in childhood opsoclonus- myoclonus syndrome: an analysis of antigenic targets in neural tissues.
	www.indianpediatrics.net /may2004/may-499-502.htm (1612 words)

	Opsoclonus Myoclonus
		Opsoclonus myoclonus is a rare neurological disorder characterized by an unsteady, trembling gait, myoclonus (brief, shock-like muscle spasms), and opsoclonus (irregular, rapid eye movements).
		Opsoclonus myoclonus may occur in association with tumors or viral infections.
		The prognosis for opsoclonus myoclonus varies depending on the symptoms and the presence and treatment of tumors.
	www.clevelandclinic.org /health/health-info/docs/1300/1313.asp?index=6110 (297 words)

	Opsoclonus-Myoclonus Syndrome as a Paraneoplastic Manifestation of Renal Cell Carcinoma
		Opsoclonus is a rare but distinctive disorder of ocular motility, characterized by irregular, continual and conjugated chaotic saccades of the eyes.
		Opsoclonus appears more commonly in children and in half of such cases in association with neuroblastoma.
		Opsoclonus when accompanied by other symptoms of central nervous system involvement (head, appendicular myoclonus and truncal ataxia) constitutes a clinical picture, known as opsoclonus-myoclonus syndrome.
	content.karger.com /ProdukteDB/produkte.asp?Doi=48454 (230 words)

	Abstracts
		To study the purported role of central monoamine disturbances in the pathophysiology of the opsoclonus-myoclonus syndrome, the serotonin metabolite 5-hydroxyindoleacetic acid and the dopamine metabolite homovanillic acid were measured in cerebrospinal fluid samples from 27 affected children and 47 age- and gender-matched control subjects by high-pressure liquid chromatography with electrochemical detection.
		Clinical variables that could be excluded were paraneoplastic etiology, anesthetic for lumbar puncture, syndrome duration, age at onset, gender, response to steroids, length of time until initiation of corticotropin or steroids, presence of seizures, opsoclonus, and functional impairment.
		The opsoclonus-myoclonus syndrome (OMS) is a neurological syndrome with involuntary myoclonic jerks of the head, trunk, and limbs; ataxia; opsoclonus; developmental delay; and behavioral problems.
	www.omsusa.org /pranzatelli-abstracts.htm (5591 words)

	Opsoclonus Myoclonus Neuroblastoma Gabrielle's Garden
		I was also diagnosed with an extremely rare disease called opsoclonus myoclonus syndrome that was caused by the cancer.
		The reason for this is children that have Neuroblastoma with Opsoclonus Myoclonus have a very small chance of the tumor being aggressive or reoccurring.
		The theory is the body's immune system is trying to destroy the tumor however the tumor and the brain must have similar properties, as the immune system cannot tell them apart and the brain is an innocent bystander caught in the "cross-fire" between the immune system and the tumor, which it is trying to destroy.
	www.gabriellemoss.com (2296 words)

	The Opsoclonus Myoclonus Home Page
		The Opsoclonus Myoclonus Support Network recognizes the immediate need of Opsoclonus Myoclonus patients and their families to network with others affected by the syndrome, to have access to comprehensive information relating to the syndrome, and to be informed of the latest research.
		The Opsoclonus Myoclonus Support Network believes the syndrome's causes are discernible, and therefore advocates and supports research investigating the syndrome's neuro-biological and biochemical basis.
		The Opsoclonus Myoclonus Support Network Home Page is therefore designed to assist opsoclonus myoclonus patients and their families network with others also affected by the opsoclonus myoclonus syndrome and to serve as a resource center.
	www.geocities.com /HotSprings/Spa/2190 (339 words)

	Opsoclonus-Myoclonus Syndrome - OMSUSA.ORG
		You have probably arrived at this website because your child was recently diagnosed with opsoclonus-myoclonus syndrome (OMS).
		The National Pediatric Myoclonus Center disclaims all liability in connection with the use of medical information contained in this website.
		The National Pediatric Myoclonus Center is available for referrals and consultations.
	www.omsusa.org (88 words)

	Immunologic and Clinical Responses to Rituximab in a Child With Opsoclonus-Myoclonus Syndrome -- Pranzatelli et al. 115 ...
		Immunologic and Clinical Responses to Rituximab in a Child With Opsoclonus-Myoclonus Syndrome -- Pranzatelli et al.
		CSF B-cell expansion in opsoclonus-myoclonus syndrome: a biomarker of disease activity.
		Serum autoantibodies in childhood opsoclonus-myoclonus syndrome: an analysis of antigenic targets in neural tissues.
	pediatrics.aappublications.org /cgi/content/full/115/1/e115 (2841 words)

	vgn-ext-hidden_PubMed (Site not responding. Last check: 2007-10-25)
		Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma.
		Opsoclonus-myoclonus syndrome (OMS) is a rare paraneoplastic syndrome that occurs in 2%-3% of patients with neuroblastoma.
		The cause of this syndrome is believed to be immune mediated, but the exact mechanism still remains unclear.
	www.plwc.org /portal/site/ASCO/menuitem.a3fb42726842a82627c4c291ee37a01d/?vgnextoid=d70b3608f9958010VgnVCM100000f2730ad1RCRD&index=n&pmid=16900484 (165 words)

	Treatment of idiopathic opsoclonus-myoclonus syndrome with intravenous immunoglobulin Unal Aysun, Murat Sumer M, Tugrul ...
		Unal A, Murat Sumer M, Tugrul Atasoy H, Atasoy N. Treatment of idiopathic opsoclonus-myoclonus syndrome with intravenous immunoglobulin.
		Opsoclonus-myoclonus syndrome (OMS) is a rare but distinctive disorder, characterized by irregular, continual, and conjugated chaotic saccades of the eyes accompanied by appendicular myoclonus and truncal ataxia.
		Neurological examination revealed coarse eye movements with severe truncal ataxia and limb myoclonus.
	www.neurologyindia.com /article.asp?issn=0028-3886;year=2004;volume=52;issue=4;spage=520;epage=521;aulast=Unal (602 words)

	B- and T-cell markers in opsoclonus-myoclonus syndrome: Immunophenotyping of CSF lymphocytes -- Pranzatelli et al. 62 ...
		B- and T-cell markers in opsoclonus-myoclonus syndrome: Immunophenotyping of CSF lymphocytes -- Pranzatelli et al.
		Address correspondence and reprint requests to Dr. M.R. Pranzatelli, National Pediatric Myoclonus Center, SIU School of Medicine, PO Box 19658, Springfield, IL 62794-9658; e-mail: mpranzatelli{at}siumed.edu
		Immunologic and Clinical Responses to Rituximab in a Child With Opsoclonus-Myoclonus Syndrome
	www.neurology.org /cgi/content/abstract/62/9/1526 (394 words)

	Opsoclonus-myoclonus syndrome - Descipher Health
		Kinsbourne syndrome, myoclonic encephalopathy of infants, dancing eyes-dancing feet syndrome
		This work is licensed under a Creative Commons License.
		Please email webmaster@descipher.com with any comments you may have.
	www.descipher.com /health/info/Opsoclonus-myoclonus_syndrome (28 words)

	The Arc of Virginia Resources- Specific Diagnosis Card Catalog- Opsoclonus-Myoclonus Syndrome (Site not responding. Last check: 2007-10-25)
		This mailing list is dedicated to those that are affected by Opsoclonus-Myoclonus Syndrome.
		Through our experience we can help each other on the OMS rollercoaster.
		Learn More About It Opsoclonus Myoclonus Information Page
	www.arcfip.org /lib_oms.htm (72 words)

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