| | Patent 5936739: Gated frequency-resolved optical imaging with an optical parametric amplifier |
 | | A short-pulse optical parametric amplifier is capable of ultrafast temporal gating, direct two-dimensional image acquisition, and spectral conversion over a broad wavelength range defined by the signal/idler tuning curve, quantum sensitivity approaching one photon per spatial resolution element, and a high degree of coherent discrimination against diffuse light obscuration of image quality. |
 | | Noninvasive optical imaging diagnostics to quantitatively measure absorption and scattering characteristics of biological tissues are a fundamental prerequisite for a growing number of physiological monitoring procedures and preventative protocols, such as cerebrovascular oxygenation status, photodynamic dosimetry, transillumination shadowgraphy of malignant lesions, and dermatological and ocular photopathology. |
 | | The near-infrared is the spectral region of greatest optical transparency, but multiple scattering is pervasive in fatty tissue at these wavelengths and hinders image formation and the determination of absorption coefficients. |
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