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Topic: Orip

	The Minimal Replicator of Epstein-Barr Virus oriP -- Yates et al. 74 (10): 4512 -- The Journal of Virology
		oriP, the RSV LTR, and a nonfunctional EBNA-1 gene, was somewhat
		Cells were also cotransfected with either p367, a derivative of pHEBo that produces EBNA-1 (lanes 10 to 17), or with p396, a similar plasmid that produces mutant EBNA-1 that cannot bind to DNA (lanes 2 to 9).
		The results of this study reaffirm that the DS component of oriP is dependent on EBNA-1 for replicator activity.
	jvi.asm.org /cgi/content/full/74/10/4512 (10053 words)

	Ogiek Rural Integral Projects - Programmes (Site not responding. Last check: 2007-10-09)
		ORIP has initiated this programme because of illiteracy and lack of educational support from the government within the Ogiek residential.
		ORIP currently runs and funds a number of pre schools that are managed by the stake holders.
		ORIP convenes workshop to educate the Ogiek on leadership and co-operation.
	www.orip.or.ke /programmes.htm (600 words)

	Regional Attorneys' Manual
		ORIP is available to assist in framing initial requests for work force information stored on computer systems, and interpreting those responses.
		ORIP relies on existing Commission guidance in adopting a two-step approach that first requests a description of the respondent’s computer system and then requests specific computerized data.
		ORIP will provide assistance in converting the data from its raw form or widely used software to databases that can be readily analyzed.
	www.eeoc.gov /litigation/manual/4-1-c_services_orip.html (585 words)

	-- Roswell Park Cancer Institute
		OriP is somewhat misnamed, because it is really two distinct genetic components that are almost 1 kb apart, called FR and DS, only one of which supports replication directly.
		Circumstantial evidence indicates that replication at oriP is governed by "licensing" and "delicensing", the cellular mechanisms that limit chromosomal replication to one round per S phase, suggesting that initiation at oriP involves some or all of the factors and mechanisms that are expected to govern initiation of replication on human chromosomes (Yates and Guan, 1991).
		Studies in the laboratory of Carl Schildkraut have shown that replication initiates well away from oriP on most copies of the EBV chromosome most of the time, in at least one large zone that resembles the delocalized initiation that is typical of certain mammalian chromsomal loci.
	www.roswellpark.org /document_3519_631.html (1126 words)

	The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a ... (Site not responding. Last check: 2007-10-09)
		The amplified fragments from the oriP plasmid and the prokaryotic backbone plasmid are indicated by 'oriP' and 'backbone'.
		The profiles of total cellular DNA, oriP DNA and control DNA recovered from cells labeled with BrdU for 60 h in the presence or absence of EBNA-1 and separated by equilibrium density centrifugation in CsCl are shown in Figure 3.
		Furthermore, oriP plasmids and genomic DNA were distributed similarly in both gradients, demonstrating that semi-conservative replication of oriP plasmids (Yates and Guan, 1991) does not require EBNA-1.
	www.nature.com /emboj/journal/v17/n21/full/7591330a.html (7152 words)

	Analysis of a YAC with human telomeres and oriP from epstein-barr virus in yeast and 293 cells -- Tolmachova et al. 27 ...
		The oriP probe is the 0.9 kb SmaI fragment from the plasmid pTF5oriP.
		A strong hybridisation signal with the oriP probe was detected in 30 of the 32 clones analysed.
		Replication of the circular form of EBV is initiated bidirectionally in the dyad symmetry region of oriP but one fork is blocked at the family of repeats region or oriP leaving the other to replicate most of the genome unidirectionally (25).
	nar.oxfordjournals.org /cgi/content/full/27/18/3736 (6891 words)

	GSF: Department of Gene Vectors (Site not responding. Last check: 2007-10-09)
		OriP is a 1.7kbp fragment with two functions: It allows plasmids to be replicated once per cell cycle and to be stably maintained in human cells.
		OriP mediated replication is not only dependent on the cellular replication machinery, but relies also entirely on those proteins that are essential for chromosomal replication initiation.
		The ORC itself is a dynamic complex in that the largest subunit Orc1p is released from oriP during S phase whereas Orc2p-Orc6p and EBNA1 are present throughout the cell cycle.
	www.gsf.de /GENV/DNA_repl/objectives.html (822 words)

	Establishment of an oriP Replicon Is Dependent upon an Infrequent, Epigenetic Event -- Leight and Sugden 21 (13): 4149 ...
		The loss of oriP plasmids from a population of cells during 2 weeks posttransfection varies dramatically from an established oriP-positive cell clone.
		For each independent experiment, the level of replicated oriP test plasmid detected at the first time point posttransfection was set to 100% and the replication efficiency of this plasmid at later time points was set relative to this initial time point.
		Replicated, newly introduced oriP plasmids are lost precipitously from an established, oriP-positive cell clone, while resident oriP plasmids are stable.
	mcb.asm.org /cgi/content/full/21/13/4149 (8401 words)

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