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Topic: Orlistat

In the News (Thu 23 May 13)

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	ORLISTAT
		Treatment with orlistat should be discontinued after 3 months if patients have been unable to lose at least 5% of their body weight as measured at the start of drug therapy.
		Continued treatment with orlistat for a second year in combination with a eucaloric diet did not prevent weight regain in the majority of patients, although the magnitude of this was smaller than with placebo.
		Orlistat treatment is associated with gastrointestinal adverse events including oily spotting from the rectum (27%), flatus with discharge (24%), faecal urgency (22%) and faecal incontinence (8%).
	www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/summaries/O/ORLISTATs.html (1476 words)

	Evaluating the Effect of Orlistat in Obesity Treatment - November 15, 1999 - American Academy of Family Physicians
		Orlistat inhibits the activity of pancreatic and gastric lipases, thus preventing the absorption of about 30 percent of dietary fat.
		Two large placebo-controlled trials evaluated the effect of orlistat in a dosage of 120 mg three times daily or placebo in addition to a low-calorie diet for one year, followed by a second year of active drug or placebo and a weight-maintenance diet.
		Orlistat is contraindicated in patients with chronic malabsorption syndrome or cholestasis.
	www.aafp.org /afp/991115ap/tips/5.html (815 words)

	Obesity Online Slides: Xenical, orlistat, phentermine, Ã-phenethylamine (Site not responding. Last check: 2007-10-13)
		Orlistat binds to gastric, pancreatic, and carboxylester lipases in the gut lumen and blocks the digestion of dietary fat by preventing lipase from interacting with its lipid target [1].
		Orlistat is more effective in blocking fat absorption from a solid than a liquid meal because preemulsified triglycerides present in a liquid meal are rapidly hydrolyzed by intestinal lipases before significant inhibition by orlistat can occur [3].
		Orlistat therapy also resulted in a 37% reduction in the cumulative incidence of new-onset type 2 diabetes, primarily by preventing the development of diabetes in patients who had impaired glucose tolerance.
	www.obesityonline.org /slides/slide01.cfm?tk=37 (1507 words)

	MedlinePlus Drug Information: Orlistat
		Orlistat is used with a low-calorie diet to help you lose weight and to maintain your weight after weight loss.
		Orlistat is used in patients with a certain weight who may also have high blood pressure, diabetes, high cholesterol, or heart disease.
		Orlistat is in a class of drugs called lipase inhibitors.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601244.html (920 words)

	Xenical Pharmacology, Pharmacokinetics, Studies, Metabolism - Orlistat - RxList Monographs
		The average absolute bioavailability of intact orlistat was assessed in studies with male rats at oral doses of 150 and 1000 mg/kg/day and in male dogs at oral doses of 100 and 1000 mg/kg/day and found to be 0.12%, 0.59% in rats and 0.7%, 1.9% in dogs, respectively.
		Following 4 years of treatment, 28% of the placebo patients and 45% of the orlistat patients lost ≥5% of their baseline body weight and 10% of the placebo patients and 21% of the orlistat patients lost ≥10% of their baseline body weight.
		Orlistat did not reduce the risk for the development of diabetes in patients with normal glucose tolerance at baseline.
	www.rxlist.com /cgi/generic/orlistat_cp.htm (3466 words)

	The Skinny on Orlistat
		Orlistat is the first member of a new group of weight loss pills called lipase inhibitors.
		Orlistat may in effect function to "train" patients to eat less fatty foods due to the unpleasant side effects they experience when they eat fatty foods.
		All the studies showed that Orlistat helps most when in conjunction with dieting and that the side effects were less pronounced when fat intake was lowered.
	www.estronaut.com /a/orlistat_weight_loss.htm (670 words)

	Orlistat : by Ray Sahelian, M.D.
		Orlistat : by Ray Sahelian, M.D. Orlistat by Ray Sahelian, M.D. Orlistat is used with a low-calorie diet to help you lose weight and to maintain your weight after weight loss.
		Orlistat is a weight loss medication that is taken with meals to inhibit the absorption of dietary fat.
		Study results found that approximately 38 percent of orlistat -treated subjects had a favorable shift in their LDL cholesterol level in comparison to 11 percent in the placebo group.
	www.raysahelian.com /orlistat.html (1041 words)

	Xenical Online, Description, Chemistry, Ingredients - Orlistat - RxList Monographs
		Orlistat is (S)-2-formylamino-4-methyl-pentanoic acid (S)-1-[[(2S, 3S)-3-hexyl-4-oxo-2-oxetanyl] methyl]-dodecyl ester.
		Orlistat is a white to off-white crystalline powder.
		Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol.
	www.rxlist.com /cgi/generic/orlistat.htm (180 words)

	Orlistat Information from Drugs.com
		Orlistat is used in the management of obesity including weight loss and weight maintenance when used with a reduced-calorie diet.
		Orlistat is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby.
		If orlistat is taken with any one meal that is very high in fat, there is an increased chance of digestive side effects.
	drugs.com /Orlistat.html (1367 words)

	Orlistat: The New Diet Drug
		Orlistat works by inhibiting the action of an enzyme we produce (lipase) that breaks down dietary fat.
		After one year, the orlistat group lost an average of 19 pounds and the placebo group 13 pounds.
		Some individuals continued taking 120 milligrams of orlistat, some decreased their orlistat dosage by half, some moved from the orlistat to a placebo, or some continued with the placebo.
	www.hhp.ufl.edu /faculty/pbird/keepingfit/ARTICLE/Orlistat.HTM (694 words)

	Orlistat
		Orlistat is a lipase-inhibitor drug designed to help obese individuals lose and maintain their body weight.
		Orlistat causes a learned aversion response to over indulging in fatty foods and thus decreases the amount of calories and fat consumed by the body (drdiet.com).
		Roche is of the opinion that there is no connection between orlistat and breast cancer, yet there were a limited number of cases in the clinical trials where a very few number of cases occurred more in the orlistat group than in the placebo group.
	www.vanderbilt.edu /AnS/psychology/health_psychology/xenical.htm (1490 words)

	orlistat - Healthy Living: Living a healthy lifestyle for disease prevention on MedicineNet.com
		Candidates for treatment with orlistat are patients who are obese with a body mass index (a measure of obesity) of more than 30 kg/m2.
		When orlistat is taken, these vitamins are not absorbed and are eliminated in the stool in increased amounts along with the fat.
		Patients receiving orlistat with a history of oxalate kidney stones may develop increased levels of oxalate in their urine, which may increase the risk of kidney stones.
	www.medicinenet.com /orlistat/article.htm (829 words)

	orlistat
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		Orlistat in money and again 923 thirst about time, membrane it called orlistat is required for crater too orlistat.
		Where orlistat is focused on luck, bake without orlistat is the same as dance about orlistat without passport that was hole, orlistat.
	orlistat.toplog.nl (305 words)

	Orlistat - Drugs & Vitamins - Drug Library - DrugDigest
		Orlistat (Xenical®) is used to help obese people lose weight and keep the weight off while eating a reduced-calorie diet.
		Orlistat decreases the amount of fat that is absorbed from your diet.
		Orlistat is taken by mouth and swallowed with a drink of liquid.
	www.drugdigest.org /DD/DVH/Uses/0,3915,717\|Orlistat,00.html (766 words)

	Orlistat (Site not responding. Last check: 2007-10-13)
		Orlistat is used for obesity management, including weight loss and weight maintenance, in association with a low-calorie diet.
		The effect of orlistat, an inhibitor of dietary fat absorption, on the pharmacokinetics of beta-carotene in healthy volunteers.
		Melia AT, Koss-Twardy SG, Zhi J. The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers.
	www.kroger.com /hn/Drug/Orlistat.htm (609 words)

	Howstuffworks "Orlistat: A Profile of a Weight-Loss Drug"
		Orlistat is used as part of an overall treatment plan for weight loss.
		Orlistat works by blocking the absorption of fat from the gastrointestinal tract.
		Orlistat may increase the absorption of pravastatin, increasing its effects.
	health.howstuffworks.com /define-orlistat.htm (523 words)

	Obesity - orlistat
		Orlistat should be only be prescribed for people who have lost at least 2.5 kg in weight by diet and exercise in the month before their first prescription and have either:
		Orlistat should only be prescribed for people between the ages of 18 and 75 years.
		When treatment with orlistat is offered, arrangements should be made for appropriate health professionals to offer specific advice, support and counselling on diet, physical activity and strategies to manage behaviour.
	www.nice.org.uk /page.aspx?o=15712 (296 words)

	orlistatz (Site not responding. Last check: 2007-10-13)
		The most common reasons for discontinuation of orlistat beyond two years of use in significantly obese patients, steady state plasma levels when orlistat is effective in clinical trials.
		As orlistat reduces a mild hypocaloric diet during a starvation period, which compensate for the treatment of obesity and its high prevalence, obesity and currently does not contain any fat or adipose tissue in relation to lean body mass.
		Orlistat inhibits the absorption of fat soluble and care should be monitored every two weeks for first three months and up to the lipase-inhibiting properties of orlistat can be disastrous, broad-spectrum antibiotics is attractive.
	orlistatz.blogspot.com (412 words)

	Orlistat for obesity
		Orlistat prevents your intestines from absorbing some of the fat from the food you eat.
		Orlistat is prescribed to help people who are obese (those with a body mass index [BMI] of 30 or higher) to lose weight.
		Orlistat is designed to be used along with a reduced-calorie diet, which is a diet that includes no more than 30% of its calories from fat.
	www.webmd.com /hw/weight_control/aa50732.asp?printing=true (782 words)

	Orlistat Drug Information
		However, orlistat may decrease the amount of certain vitamins that your body can absorb from the food you eat.
		Orlistat prevents the absorption of some of the fat you eat.
		Because orlistat may decrease the amount of some vitamins that your body can absorb from food, you will need to take a multivitamin supplement once a day.
	www.drugs.com /cons/Orlistat.html (1267 words)

	ORLISTAT
		Continued treatment with orlistat for a second year in combination with a eucaloric diet did not prevent weight regain in the majority of patients.
		Orlistat treatment is associated with gastro-intestinal adverse events.
		In clinical trials orlistat treatment was associated with small decreases in serum vitamin A, D, E and b carotene.
	www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/verdicts/O/ORLISTATv.html (553 words)

	Orlistat - Wikipedia, the free encyclopedia
		Orlistat (marketed as Xenical® by Roche), also known as tetrahydrolipstatin, is a drug designed to treat obesity.
		Because orlistat's main effect is to prevent dietary fat from being absorbed, the fat is excreted unchanged in the feces and so the stool may become oily or loose.
		Despite claims that orlistat increases the risk of breast cancer amongst clinicial trial participants, there is evidence to suggest that the introduction of specific varied preparations containing Orlistat can induce cell death in tumor cells and block their growth.
	en.wikipedia.org /wiki/Orlistat (714 words)

	Orlistat (Xenical) Linked to Precancerous Colon Condition
		Orlistat use may lead to the formation of abnormal or “aberrant crypt foci.” Crypts are folds found in the lining of the intestine that lead into the tissue of the gastrointestinal tract.
		The Public Citizen petition cites a Brazilian study that shows that orlistat caused aberrant crypt foci in rats (Cancer Letter, 2005 Dec 22) and an extensive review of medical literature that suggests that aberrant crypt foci are precursors to colon cancer in humans (Biochim Biophys Acta., 2005 Nov 25; 1756(2): 83–96).
		Orlistat is not that much more effective than other drugs used for weight reduction, the Public Citizen petition said.
	www.braytonlaw.com /news/mednews/063006_olistat-xenical.htm (622 words)

	Efficacy and Tolerability of Orlistat in Obese Patients -- August 1, 2000 - American Family Physician
		Orlistat, a selective and potent inhibitor of gastrointestinal lipases involved in triglyceride hydrolysis, restricts the absorption of triglycerides.
		The weight loss in patients who were treated with orlistat and completed the study was sufficient to produce changes in total cholesterol levels, low density lipoprotein (LDL) cholesterol levels and the LDL/high density lipoprotein cholesterol ratio.
		Orlistat in the long-term treatment of obesity in primary care settings.
	www.aafp.org /afp/20000801/tips/9.html (610 words)

	Orlistat - Talk Medical
		· Orlistat is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby.
		Orlistat can be taken during meals or up to one hour after a meal.
		Continue to take Orlistat and talk to your doctor if you experience ·oily spotting, ·gas with discharge, ·an urgent need to go to the bathroom, ·oily or fatty stools, ·an oily discharge, ·an increased number of bowel movements, ·an inability to control bowel movements, or ·orange or brown colored oil in your stool.
	www.talkmedical.com /medications/4526/Orlistat (1163 words)

	TA22 Obesity - orlistat: Guidance (html) (Site not responding. Last check: 2007-10-13)
		The effect of the use of orlistat in off setting this situation in the longer term is impossible to estimate accurately.
		Orlistat (Xenical) is a capsule that prevents the absorption of some fat in the intestine.
		As a result it can mean that a person taking orlistat may feel the urgent need to go to the toilet, an increase in the number of times they need to go to the toilet, and when they do go they produce 'fatty stools'.
	www.nice.org.uk /page.aspx?o=15724 (3349 words)

	Public Citizen \| Publications - Comments before the Food and Drug Administration's Endocrinologic and Metabolic Drugs ...
		Also shown are the doses of orlistat tested, the studies' results, and the percent difference in mean weight loss between the orlistat and placebo groups.
		We have no doubt that if approved, orlistat will be promoted as a "magic bullet" and a "breakthrough" treatment for the chronic management of obesity just as lipid lowering drugs and antihypertensive agents are advertised to treat high cholesterol and high blood pressure.
		Orlistat (RO 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study.
	www.citizen.org /publications/release.cfm?ID=6614 (1030 words)

	BARBARA'S OBESITY MEDS AND RESEARCH NEWS -- Xenical (orlistat) Information
		Xenical (orlistat) is a drug that works locally in the gastrointestinal tract to inhibit the absorption of fat.
		When orlistat is taken with fat-containing foods, the fat passes through the gastrointestinal tract unchanged, and the calories are not absorbed.
		Pancreatic lipase reacts with the orlistat to reduce the absorption of about 30 percent of dietary fat, resulting in a reduction of approximately 200 calories per day.
	www.weightloss-news.com /orlistat.htm (511 words)

	Drugs and Treatments - Orlistat Oral - Patient Handout from WebMD
		Orlistat works by blocking the enzyme that breaks down fats in your diet.
		Orlistat does not block the absorption of calories from sugar and other non-fat foods, so you still need to restrict your total intake of calories.
		Before taking orlistat, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
	webmd.com /drugs/drug-17220-Orlistat+Oral.aspx?drugid=17220&...+Oral (1104 words)

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