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Topic: Ornithine decarboxylase

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	Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.
		Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention.
		BACKGROUND: Previous research suggests that the G315A single-nucleotide polymorphism in the ornithine decarboxylase (ODC) gene may be a genetic marker for risk of colorectal neoplasia and may also modify the association of aspirin use with risk.
		METHODS: We tested these hypotheses among participants in the Aspirin/Folate Polyp Prevention Study who were randomly assigned to placebo or to aspirin treatment (81 or 325 mg daily) and followed for 3 years for the occurrence of new adenomas.
	aspirin.researchtoday.net /archive/3/10/281.htm (331 words)

	Ornithine - Wikipedia, the free encyclopedia
		Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen.
		Ornithine is not an amino acid coded for by DNA, and in that sense, is not involved in protein synthesis.
		Ornithine, via the action of ornithine decarboxylase (E.C. 4.1.1.17), is the starting point for the synthesis of polyamines such as putrescine.
	en.wikipedia.org /wiki/Ornithine (183 words)

	Ornithine decarboxylase as an underexploited anticancer target
		Increased cellular activity of ornithine decarboxylase, the first and rate-limiting enzyme in polyamine synthesis, is an independent adverse prognostic factor for overall survival in human breast cancer, thus suggesting an important role for polyamines in tumor progression.
		Irreversible inhibition of ornithine decarboxylase, significantly reduced, in a dose-dependent manner, the invasiveness in matrigel of highly invasive breast cancer cells by approximately 70 and likewise blocked 'stellate' colony formation (an indicator of aggressive phenotype).
		These results suggest that ornithine decarboxylase inhibitors should not only prevent tumor growth but that such molecules should also be able to prevent metastatic progression even in the event that cells escape the environment of the primary tumor.
	www.bioportfolio.com /leaddiscovery/PubMed-050224.htm (702 words)

	Ornithine by Ray Sahelian, MD. Ornithine alpha-ketoglutarate (OKG)
		Ornithine by Ray Sahelian, M.D. Ornithine or L ornithine is an amino Acid used by the body to make arginine, proline, and polyamines.
		Ornithine alpha-ketoglutarate is a salt formed of 2 molecules of ornithine and 1 alpha-ketoglutarate.
		Ornithine may have to be ingested in massive amounts, such as 30 grams orally, to have any effect on growth hormone release, and even then, the release may be temporary.
	www.raysahelian.com /ornithine.html (1788 words)

	Hair Removal Methods: Vaniqa
		Regulation of this enzyme, called ornithine decarboxylase (ODC), was later shown to reduce hair growth in mice [4] and sheep [5].
		Probst E, Krebs A. Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles.
		Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions.
	www.quackwatch.com /01QuackeryRelatedTopics/Hair/vaniqa.html (685 words)

	Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
		Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
		Ornithine decarboxylase is a key enzyme in the regulation of polyamine metabolism.
		The aim of this study is to analyze MTAP and ornithine decarboxylase (ODC) expression in primary pancreatic tumor specimens.
	pancreaticcancer.researchtoday.net /archive/1/3/647.htm (394 words)

	Distribution Patterns of Ornithine Decarboxylase in Cells and Tissues: Facts, Problems, and Postulates -- Schipper and ...
		Armstrong DG (1987) Ornithine decarboxylase activity in small ovarian follicles from the laying hen (Gallus domesticus): a comparison of follicles from several regions of the ovary.
		Bartholeyns J (1983) Subcellular distribution of ornithine decarboxylase in rat liver and accessibility of the enzyme to alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
		Haddox MK, Schmidt KL, Johnson LR (1992) Cell-specific expression of ornithine decarboxylase in the gastrointestinal tract.
	www.jhc.org /cgi/content/full/50/9/1143 (6248 words)

	Ornithine decarboxylase activity during neonatal development of the rat ventral prostate. (Site not responding. Last check: 2007-11-05)
		Ornithine decarboxylase activity during neonatal development of the rat ventral prostate.
		The relationship between ornithine decarboxylase activity and growth has been examined in ventral prostates from rats aged 2--60 weeks.
		After 10 weeks post-partum the incorporation of [1252]iododeoxyuridine/prostate and ornithine decarboxylase activity/prostate levelled off, whereas the DNA and protein content of the prostate continued to increase at a slow rate.
	www.arclab.org /medlineupdates/abstract_889880.html (138 words)

	Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation -- Heiskala ... (Site not responding. Last check: 2007-11-05)
		Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation -- Heiskala et al.
		Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation
		Ornithine decarboxylase (ODC) is highly up-regulated in proliferating and transforming cells.
	embojournal.npgjournals.com /cgi/content/abstract/18/5/1214 (406 words)

	A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis -- Ahmad et al. 159 (3): 885 -- American Journal of ...
		Choudhary SK, Sharma D, Dixit A: D,L-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, induces differentiation in MEL cells.
		Flamigni F, Facchini A, Capanni C, Stefanelli C, Tantini B, Caldarera CM: p44/42 mitogen-activated protein kinase is involved in the expression of ornithine decarboxylase in leukaemia L1210 cells.
		O’Brien TG: The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis.
	ajp.amjpathol.org /cgi/content/full/159/3/885 (4076 words)

	Synergistic induction of ornithine decarboxylase by asparagine and gut peptides in intestinal crypt cells -- Wang et ...
		conversion of ornithine to putrescine, the diamine precursor of
		Molecular mechainsms of the synergistic induction of ornithine decarboxylase by asparagine and glucagon in primary culture hepatocytes.
		Ornithine decarboxylase and mucosal growth in response to feeding.
	ajpcell.physiology.org /cgi/content/full/274/6/C1476 (5521 words)

	Control of Filament Formation in Candida albicans by Polyamine Levels -- Herrero et al. 67 (9): 4870 -- Infection and ...
		Cloning and disruption of the ornithine decarboxylase gene of Ustilago maydis: evidence for a role of polyamines in its dimorphic transition.
		Inhibition of the dimorphic transition of Candida albicans by the ornithine decarboxylase inhibitor 1,4-diaminobutanone: alterations in the glycoprotein composition of the cell wall.
		Ornithine decarboxylase gene of Neurospora crassa: isolation, sequence, and polyamine-mediated regulation of its mRNA.
	iai.asm.org /cgi/content/full/67/9/4870 (3965 words)

	NEJM -- Ornithine decarboxylase as a biologic marker in familial colonic polyposis
		We investigated whether the activity of ornithine decarboxylase might serve as a diagnostic test for detecting the presence of the genotype for familial polyposis.
		In colonic mucosa from clinically unaffected, first-degree relatives of patients with familial polyposis, there was a bimodal distribution of ornithine decarboxylase activity, with one peak at the mean for normal controls and the other near the mean for normal-appearing mucosa from affected patients.
		Our study suggests that ornithine decarboxylase activity in colonic mucosa may reflect the abnormal proliferative state in familial polyposis and identify clinically normal family members who carry the genotype.
	content.nejm.org /cgi/content/abstract/311/2/80 (500 words)

	Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate -- Zhang et al. 22 ... (Site not responding. Last check: 2007-11-05)
		Ghoda,L., Phillips,M.A., Bass,K.E., Wang,C.C. and Coffino,P. (1990) Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the C terminus of the mouse enzyme which target the latter for intracellular degradation.
		Murakami,Y. and Hayashi,S. (1985) Role of antizyme in degradation of ornithine decarboxylase in HTC cells.
		Murakami,Y., Matsufuji,S., Tanaka,K., Ichihara,A. and Hayashi,S. (1993) Involvement of the proteasome and antizyme in ornithine decarboxylase degradation by a reticulocyte lysate.
	embojournal.npgjournals.com /cgi/content/full/22/7/1488 (6028 words)

	Ornithine Decarboxylase (Site not responding. Last check: 2007-11-05)
		A comparison of the structure of ornithine decarboxylase as resolved by X-ray crystallography and HRTEM.
		(A) Computer model of ornithine decarboxylase from the X-ray projection structure (courtesy, M.L. Hackert).
		(B) HRTEM structure of ornithine decarboxylase The hexagonal symmetry of the dodecamer is represented, as well as substructural information within each dimer.
	www.botany.utexas.edu /facstaff/facpages/mbrown/odc.htm (145 words)

	Orbigen Inc. - Orbigen Inc.
		The full length mouse ornithine decarboxylase gene including a polyhistidine (His6) tag has been inserted into baculovirus to be expressed under the strong AcNPV polyhedrin promoter control.
		Zhu C, Lang DW, Coffino P: Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport.
		Ornithine decarboxylase (OrnDCase; L-ornithine carboxy-lyase, EC 4.1.1.17) is the first and rate-limiting enzyme in the biosynthesis of polyamines in mammalian cells.
	www.orbigen.com /commerce/catalog/product.jsp?product_id=1023 (177 words)

	Interaction of asparagine and EGF in the regulation of ornithine decarboxylase in IEC-6 cells -- Ray et al. 276 (3): ...
		Molecular mechanism of the synergistic induction of ornithine decarboxylase by asparagine and glucagon in primary cultured hepatocytes.
		Asparagine transport and the induction of ornithine decarboxylase in H-35 rat hepatoma cells.
		Induction of ornithine decarboxylase activity by insulin and growth factors is mediated by amino acids.
	ajpgi.physiology.org /cgi/content/full/276/3/G773 (5129 words)

	Translocation of ornithine decarboxylase to the surface membrane during cell activation and transformation
		Ornithine decarboxylase (ODC) regulates the rate of polyamine synthesis by catalyzing the generation of putrescine and CO from ornithine.
		Auvinen M, Paasinen A, Andersson LC and Hölttä E (1992) Ornithine decarboxylase activity is critical for cell transformation.
		Djurhuus R (1981) Ornithine decarboxylase (EC 4.1.1.17) assay based upon the retention of putrescine by a strong cation-exchange paper.
	www.nature.com /emboj/journal/v18/n5/full/7591554a.html (5472 words)

	Ornithine decarboxylase along the mouse and rat nephron -- Levillain and Hus-Citharel 274 (6): 1020 -- AJP - Renal ...
		Stimulation of ornithine decarboxylase activity by arginine vasopressin in the rat medullary thick ascending limb of Henle's loop.
		Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney.
		Ornithine decarboxylase antizyme in kidneys of male and female mice.
	ajprenal.physiology.org /cgi/content/full/274/6/F1020 (4984 words)

	Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells -- Yuan et al. 280 (1): ...
		Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells -- Yuan et al.
		Synergistic induction of ornithine decarboxylase by asparagine and gut peptides in intestinal crypt cells.
		Expression of the ornithine decarboxylase gene in response to asparagine in intestinal epithelial cells.
	ajpgi.physiology.org /cgi/content/full/280/1/G130 (5183 words)

	L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis -- Fozard et al. 208 (4443): 505 -- Science
		The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage.
		An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.
		Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
	www.sciencemag.org /cgi/content/abstract/208/4443/505 (428 words)

	Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells -- ...
		Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells -- Luk et al.
		The ornithine decarboxylase inhibitor DL-alpha-difluoromethyl ornithine inhibited a proliferation-associated increase in ornithine decarboxylase activity in cultured human promyelocytic leukemia cells, resulting in a marked suppression of cell proliferation and subsequent cell loss.
		It also inhibited increases in ornithine decarboxylase activity associated with the phorbol ester-induced conversion of promyelocytic HL-60 cells to monocyte-like cells and the retinoic acid-induced conversion to granulocyte-like cells.
	www.sciencemag.org /cgi/content/abstract/216/4541/75 (423 words)

	Developmental pattern of ornithine decarboxylase activity, S-adenosylmethionine decarboxylase, and polyamines of rat ...
		Developmental pattern of ornithine decarboxylase activity, S-adenosylmethionine decarboxylase, and polyamines of rat adrenal glands.
		The concentrations of polyamines and the activities of ornithine decarboxylase (ODC) and of S-adenosylmethionine decarboxylase (SAM-DC) were measured in the adrenal glands of rats during development.
		The activity of adrenal ornithine decarboxylase increases after birth and attains a peak at 17 days of age.
	www.arclab.org /medlineupdates/abstract_3593807.html (162 words)

	W0167: The Crystal Structure of Human Ornithine Decarboxylase (Site not responding. Last check: 2007-11-05)
		Polyamines such as spermidine and spermine are ubiquitous to eukaryotic and prokaryotic cells and are required for cell growth and differentiation.
		Eukaryotic Ornithine Decarboxylase (ODC) catalyzes the first step in polyamine biosynthesis by decarboxylating ornithine to putrescine.
		Here we report the crystal structure of expressed full-length ornithine decarboxylase from human pituitary (hODC) determined by molecular replacement to 2.1Å using truncated mouse ODC as a search model.
	www.hwi.buffalo.edu /ACA/ACA99/abstracts/text/W0167.html (290 words)

	Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine.
		Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine.
		We believe that treatment outcome (survival) is inversely related to tumor ornithine decarboxylase (ODC) levels.
		To prove this, we needed to develop an assay to quantify ODC levels in formalin-fixed tumor tissues, which would enable a retrospective study of tumor biopsy specimens from the landmark clinical trial.
	braintumors.researchtoday.net /archive/1/3/1289.htm (359 words)

	Acute glomerular upregulation of ornithine decarboxylase is not essential for mesangial cell proliferation and matrix ... (Site not responding. Last check: 2007-11-05)
		Acute glomerular upregulation of ornithine decarboxylase is not essential for mesangial cell proliferation and matrix expansion in anti-Thy-1-nephritis -- Ketteler et al.
		Tobias KE, Kahana C. Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells.
		Renal ornithine decarboxylase activity, polyamines, and compensatory renal hypertrophy in the rat.
	ndt.oxfordjournals.org /cgi/content/full/15/1/16 (3148 words)

	Hexachlorobenzene-Induced Early Changes in Ornithine Decarboxylase and Protein Tyrosine Kinase Activities, Polyamines ...
		Desiderio, M. A., Pogliaghi, G., and Dansi, P. Hepatocyte growth factor-Induced expression of ornithine decarboxylase, c-met, and c-myc is differently affected by protein kinase inhibitors in human hepatoma cells HepG2.
		Raunio, H., and Pelkonen, O. Effect of polycyclic aromatic compounds and phorbol esters on ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in mouse liver.
		Shanz, L. M., and Pegg, A. Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.
	toxsci.oxfordjournals.org /cgi/content/full/76/2/291 (4610 words)

	References - ornithine decarboxylase - HORT640 - Metabolic Plant Physiology - Department of Horticulture and Landscape ...
		Alabadi D, Carbonell J 1998 Expression of ornithine decarboxylase is transiently increased by pollination, 2,4-dichlorophenoxyacetic acid, and gibberellic acid in tomato ovaries.
		Cohen E, Heimer YM, Mizrahi Y 1982 Ornithine decarboxylase and arginine decarboxylase activities in meristematic tissue of tomato and potato plants.
		Guevara-Olvera L, Xoconostle-Cazares B, Ruiz-Herrera J 1997 Cloning and disruption of the ornithine decarboxylase gene of Ustilago maydis: evidence for a role of polyamines in its dimorphic transition.
	www.hort.purdue.edu /rhodcv/hort640c/referen/odc.htm (2992 words)

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