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Topic: Oseltamivir

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	Oseltamivir - Wikipedia, the free encyclopedia
		Oseltamivir is indicated for the treatment of infections due to influenza A and B virus in people at least one year of age, and prevention of influenza in people at least 1 year or older.
		Oseltamivir was widely used during the H5N1 avian influenza epidemic in Southeast Asia in 2005.
		Oseltamivir appears to be active against canine parvovirus, feline panleukopenia, the canine respiratory complex known as "kennel cough," and the emerging disease dubbed "canine flu", an equine virus that began affecting dogs in 2005.
	en.wikipedia.org /wiki/Oseltamivir (3104 words)

	Tamiflu Online, Description, Chemistry, Ingredients - Oseltamivir Phosphate - RxList Monographs
		Oseltamivir is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate.
		The proposed mechanism of action of oseltamivir is inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.
		The antiviral activity of oseltamivir carboxylate against laboratory strains and clinical isolates of influenza virus was determined in cell culture assays.
	www.rxlist.com /cgi/generic3/oseltamiv.htm (669 words)

	MedlinePlus Drug Information: Oseltamivir (Systemic) (Site not responding. Last check: 2007-11-03)
		Oseltamivir (Oh–sel–TAM–i–veer) belongs to the family of medicines called antivirals, which are used to treat infections caused by viruses.
		Oseltamivir is used in the treatment of the infection caused by the flu virus (influenza A and influenza B).
		Oseltamivir is not a substitute for your yearly flu shot.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500062.html (1359 words)

	Experience with Oseltamivir in the Control of a Nursing Home Influenza B Outbreak - CCDR Volume 27-05
		Oseltamivir prophylaxis was very effective in protecting nursing home residents from ILI and in halting this outbreak of influenza B. A portion of the total ILI cases may have been due to influenza A, as this strain was isolated in one resident.
		Oseltamivir prophylaxis was not used to manage this second outbreak of laboratory-confirmed influenza B. Of the 236 residents, 45 developed ILI for an overall attack rate of 19%, nearly double the rate in the oseltamivir-controlled setting (10%).
		Isolation of residents with ILI and prophylaxis of non-ill residents on the initial outbreak wards was insufficient to prevent the spread of the outbreak, although it was subsequently halted once prophylaxis was extended to all residents.
	www.phac-aspc.gc.ca /publicat/ccdr-rmtc/01vol27/dr2705ea.html (1671 words)

	oseltamivir Information on Healthline
		Oseltamivir is used to treat illness due to influenza virus in patients who have had symptoms for less than 2 days.
		Oseltamivir is also used to prevent infection with the influenza virus.
		Oseltamivir is in the FDA pregnancy category C. This means that it is not known whether oseltamivir will harm an unborn baby.
	www.healthline.com /drugs/tamiflu/d04462A1.htm (787 words)

	New Data Proves Oseltamivir Effective Against Human H5N1 and Avian H5N1 Influenza Virus
		Oseltamivir has previously been proven effective in the management of an outbreak of the H7N7 avian strain in the Netherlands in 2003, which infected around one thousand people.
		Oseltamivir was found to protect infected poultry workers from contracting the virus, where mouth and nose masks did not.
		Since oseltamivir can take up to a year to produce, I urge governments to follow WHO guidance and ensure that stockpiles of antivirals are assembled in good time to ensure they can protect their citizens until a vaccine is developed," concludes Professor John Oxford.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/10-31-2004/0002345346&EDATE= (608 words)

	Mouse Studies of Oseltamivir Show Promise Against H5N1 Influenza Virus (Site not responding. Last check: 2007-11-03)
		Although the recommended human dose of oseltamivir is taken for five days, the researchers also tested an extended eight-day course in half of the mice.
		Oseltamivir decreases the ability of influenza virus to spread from infected cells to uninfected cells by inhibiting neuraminidase, which is an influenza protein required for the virus to exit infected cells.
		Although oseltamivir suppressed the virus in the mice, the virus continued to grow if the drug was stopped after five days.
	www3.niaid.nih.gov /news/newsreleases/2005/oseltamivir.htm (787 words)

	Oseltamivir or zanamivir for influenza (flu) - [Medication] - Quest Diagnostics Patient Health Library (Site not responding. Last check: 2007-11-03)
		Zanamivir and oseltamivir may be used to treat flu caused by both the influenza A and B viruses.
		Both zanamivir and oseltamivir have been shown to effectively treat and prevent the flu, although zanamivir is not currently labeled for preventive use.
		A well-controlled study found that oseltamivir, taken within 36 hours of the first flu symptoms, reduced the length of illness by 30%, the severity by 40%, and the time to resume normal activities by 2 or 3 days.
	www.questdiagnostics.com /kbase/topic/detail/drug/aa85986/detail.htm (563 words)

	Children aged 1—12 years: Oseltamivir indications expanded (Site not responding. Last check: 2007-11-03)
		Oseltamivir was previously approved by FDA for both the prevention and treatment of influenza in adolescents 13 years and older and in adults.
		Oseltamivir also is approved for treatment of influenza in pediatric patients older than 1 year of age.
		Oseltamivir is not a substitute for the influenza vaccine, FDA noted in a news release.
	www.pharmacist.com /articles/h_ts_1007.cfm (394 words)

	Oseltamivir
		Oseltamivir, also know as Tamiflu, is a neuraminidase inhibitor.
		According to further studies, the prophylactic oral administration was 74% effective in reducing the incidence of influenza illness.
		The most common side effects of oseltamivir consist of nausea and vomiting.
	www.stanford.edu /group/virus/pox/2000/oseltamivir.html (375 words)

	Tamiflu - Drugs & Vitamins - Drug Library - DrugDigest
		OSELTAMIVIR (Tamiflu™) is a drug used to treat infections caused by two of the most common flu viruses.
		Oseltamivir may decrease the length of time you experience symptoms of the flu by 1—2 days.
		Oseltamivir is not a substitute for the flu shot.
	www.drugdigest.org /DD/DVH/Uses/0,3915,769\|Tamiflu,00.html (579 words)

	Oseltamivir (Tamiflu) (Site not responding. Last check: 2007-11-03)
		Oseltamivir should not be considered a substitute for influenza vaccination.
		Oseltamivir treatment should begin as soon as possible after the onset of influenza symptoms or after known exposure to influenza.
		There are no data concerning the safety and efficacy of oseltamivir when initiated more than 40 hours after the onset of symptoms.
	www.multum.com /oseltamivir.htm (136 words)

	Taxus Pharma Traitement Influenza A (H5N1)
		—Oseltamivir is indicated for the prophylaxis of influenza in adults and adolescents 13 years of age and older.
		Oseltamivir is an inhibitor of influenza virus neuraminidase, possibly altering particle aggregation and release
		Oseltamivir and oseltamivir carboxylate are distributed into the milk of lactating rats.
	us.geocities.com /gdh5n1/h5n1_tamiflu_3.html?200513 (2396 words)

	MedForumsLive.com - oseltamivir, Tamiflu (Site not responding. Last check: 2007-11-03)
		Oseltamivir blocks the action of neuraminidase (it is a neuraminidase inhibitor) thereby reducing the spread of influenza.
		By preventing the spread of virus from cell to cell, the symptoms and duration of influenza infection are reduced.
		On average, oseltamivir reduces the duration of symptoms by one and a half days if treatment is started within forty-eight hours after symptoms begin.
	www.medforumslive.com /drugs/o/oseltamivir.html (240 words)

	Order Tamiflu : Buy Tamiflu :: Pharmacy :: Prescription Medications
		Tamiflu (Oseltamivir Phosphate) is a medicine to treat flu (infection caused by influenza virus).
		Although viruses resistant to Tamiflu (Oseltamivir) emerge less frequently than those resistant to amantadine or rimantadine, information on Tamiflu (Oseltamivir)-resistant viruses arising during clinical use of the drug in children is limited.
		Patients with chronic respiratory disease, such as chronic bronchitis, obstructive emphysema, bronchial asthma, bronchiectasis or chronic cardiac disease, and with symptoms of influenza were enrolled in a study.
	www.chemiststore.biz /tamiflu.html (1109 words)

	Oseltamivir Reduces Flu Severity and Duration In Adults (Site not responding. Last check: 2007-11-03)
		Among those infected with influenza, severity of illness was reduced by 38 percent with oseltamivir, 75 mg twice daily, and by 35 percent with oseltamivir, 150 mg twice daily, both compared with placebo.
		Oseltamivir treatment reduced the duration of fever and oseltamivir recipients returned to usual activities two to three days earlier than placebo recipients.
		Severity of illness was reduced by 28 percent and 29 percent among all recipients of oseltamivir for the 75 mg and 150 mg doses respectively.
	www.pslgroup.com /dg/16D33A.htm (485 words)

	Lack of Pharmacokinetic Interaction between the Oral Anti-Influenza Prodrug Oseltamivir and Aspirin -- Oo et al. 46 ... (Site not responding. Last check: 2007-11-03)
		75 mg of oseltamivir in the absence and presence of 900 mg of
		Steady-state pharmacokinetic parameters of oseltamivir carboxylate and oseltamivir in the absence and presence of aspirin
		Mean (± standard deviation) steady-state plasma concentration-versus-time profiles of oseltamivir carboxylate in the absence and presence of aspirin.
	aac.asm.org /cgi/content/full/46/6/1993 (1079 words)

	oseltamivir - [Medication]
		You may not be able to take oseltamivir, or you may require a dosage adjustment or special monitoring during treatment.
		The safety and effectiveness of oseltamivir have not been established for children younger than 18 years of age in the treatment of the influenza virus and in children younger than 13 years of age for the prevention of infection with the influenza virus.
		Oseltamivir is available with a prescription under the brand name Tamiflu in a capsule formulation.
	www.peacehealth.org /kbase/multum/d04462a1.htm (966 words)

	OSELTAMIVIR SUSPENSION - ORAL (Tamiflu) side effects, medical uses, and drug interactions.
		USES: Oseltamivir is used to treat symptoms caused by the flu virus (influenza).
		It is not a substitute for the flu vaccine.
		Oseltamivir works best if you start taking it within 2 days of either of these events.
	www.medicinenet.com /oseltamivir_suspension-oral/article.htm (493 words)

	Effect Measure: How oseltamivir (Tamiflu) works (and does it?) (Site not responding. Last check: 2007-11-03)
		It appears that the mutations in the N spike needed to make the virus resistant to oseltamivir also compromise the function of the neuraminidase enzyme so it is much less effective in releasing the virus.
		Experience in animal models and human outbreaks shows that oseltamivir is quite effective if given prophylactically or within the first 48 hours of onset of illness, where it can shorten the duration and decrease the severity of illness.
		So while oseltamivir works, it is unlikely to help much if a pandemic comes within the next year or two, as many expect.
	effectmeasure.blogspot.com /2005/03/how-oseltamivir-tamiflu-works-and-does.html (1719 words)

	CIDRAP >> Oseltamivir-resistant H5N1 virus isolated from Vietnamese girl
		This mutation is considered indicative of oseltamivir resistance, according to the researchers.
		The authors then tested the sensitivity of the virus to oseltamivir and found that the dose required for 50% inhibition of neuraminidase activity (IC) was higher than for oseltamivir-sensitive viruses (90 nM versus 0.1-10 nM).
		The researchers cloned the sample from the girl through plaque purification; randomly picked a number of clones, classifying them according to oseltamivir sensitivity; and then compared genes from the various clones with genes from the virus isolated from her brother during his illness.
	www.cidrap.umn.edu /cidrap/content/influenza/avianflu/news/oct1405resistance.html (794 words)

	TAMIFLU / OSELTAMIVIR - Getpharma - The Real Pharmacy!
		Oseltamivir works by binding to the neuraminidase on the surface of the virus particles, and stopping it from working.
		Oseltamivir therefore confines the infection to a smaller area.
		Oseltamivir can be taken at the same time as paracetamol, ibuprofen or aspirin.
	www.getpharma.com /productdetail.asp?productid=33939&affid=3187 (1241 words)

	MedlinePlus Drug Information: Oseltamivir
		Oseltamivir is used to treat some types of influenza (flu) in patients who have had symptoms of the flu for 2 days or less.
		Oseltamivir is in a class of drugs called neuraminidase inhibitors.
		Oseltamivir helps shorten the time you have flu symptoms such as nasal congestion, sore throat, cough, muscle aches, tiredness, headache, fever, and chills.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a699040.html (569 words)

	WHO \| Donation of three million treatments of oseltamivir to WHO will help early response to an emerging influenza ...
		As part of its work to prepare for, detect and mitigate the impact of an influenza pandemic, WHO is creating an international stockpile of antiviral drugs for rapid response at the start of a pandemic.
		Oseltamivir could help to reduce illness and death, and when combined with other measures, could potentially contain an emerging pandemic virus or slow its national and international spread.
		Planning must include international cooperation between wealthy and poor countries to reduce the opportunity for national and international spread, and to reduce the death, illness and social disruption which have been a feature of all previous influenza pandemics.
	www.who.int /mediacentre/news/releases/2005/pr36/en (564 words)

	Consumer Reports Medical Guide - Oseltamivir
		Oseltamivir is used to treat some types of influenza infection ('flu') in adults and children (older than 1 year of age) who have had symptoms of the flu for 2 days or less.
		Oseltamivir is in a class of medications called neuraminidase inhibitors.
		Oseltamivir helps shorten the time you have flu symptoms such as a stuffy or runny nose, sore throat, cough, muscle or joint aches, tiredness, headache, fever, and chills.
	www.consumerreports.org /mg/drug-reports/oseltamivir.htm (298 words)

	Metabolism of the Influenza Neuraminidase Inhibitor Prodrug Oseltamivir in the Rat -- Sweeny et al. 28 (7): 737 -- Drug ... (Site not responding. Last check: 2007-11-03)
		C radioactivity from rats orally dosed oseltamivir was 93.2%, with 61.1 and 24.27% of the radioactive
		-carboxylic acid metabolite of oseltamivir was not detected in vitro in hepatic microsomal studies.
		Incubation of oseltamivir with rat hepatic microsomes and an NADPH
	dmd.aspetjournals.org /cgi/content/full/28/7/737 (2997 words)

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