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Topic: Osteoblast

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	Osteoblast definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms
		It does so by producing a matrix that then becomes mineralized.
		Bone mass is maintained by a balance between the activity of osteoblasts that form bone and other cells called osteoclasts that break it down.
		MedicineNet does not provide medical advice, diagnosis or treatment.
	www.medterms.com /script/main/art.asp?articlekey=24502 (110 words)

	CiteULike: Hypergravity stimulates osteoblast phenotype expression: a therapeutic hint for disuse bone atrophy. (Site not responding. Last check: )
		We investigated the possibility that the appropriate level of hypergravity could improve osteoblast functions that are susceptible to mechanical unloading.
		Cell culture plates were centrifuged for 24 h at 3, 6, 12, 24, and 48 g in a 37 degrees C incubator.
		Alternatively, Runx2, a master gene of osteoblast differentiation, might be responsible for the osteocalcin induction, since the Runx2 mRNA levels were also increased to 247% of control at 12 g.
	www.citeulike.org /user/joshfly/article/900225 (505 words)

	Local and systemic control of the osteoblast -- Strewler 107 (3): 271 -- Journal of Clinical Investigation
		activation of the PTH receptor in the osteoblast lineage is
		osteoblast function is also impaired in this condition (5).
		Activated parathyroid hormone/parathyroid hormone–related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone.
	www.jci.org /cgi/content/full/107/3/271 (1403 words)

	osteoblast \| English \| Dictionary & Translation by Babylon
		An osteoblast (from the Greek words for "bone" and "germ" or embryonic) is a mononucleate cell that is responsible for bone formation.
		Osteoblasts produce osteoid, which is composed mainly of Type I collagen.
		Osteoblasts are also responsible for mineralization of the osteoid matrix.
	www.babylon.com /definition/osteoblast (81 words)

	Osteoblast - Wikipedia, the free encyclopedia
		Osteoblasts and osteoclasts on trabecula of lower jaw of calf embryo.
		An osteoblast (from the Greek words for "bone" and "germ" or embryonic) is a mononucleate cell that produces osteoid, which is composed mainly of collagen.
		Osteoblasts arise when osteoprogenitor cells (mesenchymal cells), which are located near all bony surfaces and within the bone marrow, differentiate under the influence of growth factors, such as fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β) and other bone morphogenetic proteins (BMPs).
	en.wikipedia.org /wiki/Osteoblast (231 words)

	Bioactivity of Osteoblasts to Microparticles Generated From Materials Used in Orthopedic Device Applications
		In order to truly characterize the osteoblastic reactivity to these wear particles a series of experiments were performed to realistically model the interactions of osteoblasts when introduced to the wear debris.
		The osteoblasts that were exposed to the 1:10 dilution of particles increased 30%.
		The number of osteoblasts that were seeded directly in the wells was approximately twice that of osteoblasts which were seeded in inserts though both populations significantly increased.
	biomed.brown.edu /Courses/BI108/BI108_1999_Groups/THRdebris_Team/gordon.html (2323 words)

	Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment -- ...
		Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment -- Spector et al.
		VEGF mRNA half-life in osteoblasts is unchanged by an acidic pH.
		Osteoblast metabolic activity and gene expression are modulated by the pH of cellular environment (36).
	ajpcell.physiology.org /cgi/content/full/280/1/C72 (5393 words)

	Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of ... (Site not responding. Last check: )
		progenitors to the osteoblastic lineage is prerequisite for
		Apoptotic osteoblasts (shown in brown) are adjacent to an intact osteoblast (shown in blue), on the surface of a trabecula occupying the right lower portion of the picture in which two intact (blue stained) osteocytes are also seen.
		Moreover, as in mice, an increase in osteoblast and osteocyte
	edrv.endojournals.org /cgi/content/full/21/2/115 (8843 words)

	Research (Site not responding. Last check: )
		It is unclear if these alterations are solely a consequence of decreased osteoblast responsiveness to extracellular signals, but the diminished recruitment of osteogenic precursors to replace senescent osteoblasts may potentially explain many aspects of age-related bone loss.
		Adipocytes can be induced to differentiate into osteoblasts and vice versa, suggesting that elevated bone marrow adipocytes may be a result of pluripotent mesenchymal cells being diverted from an osteogenic program to an adipogenic program.
		Identification of signals that mediate osteoblast differentiation may implicate molecules that limit or suppress adipogenesis or induce bone marrow adipocytes to transdifferentiate into osteoblasts.
	www.uphs.upenn.edu /orl/research/fop/osteoblast.htm (342 words)

	Regulation of Osteoblast Differentiation Mediated by Bone Morphogenetic Proteins, Hedgehogs, and Cbfa1 -- Yamaguchi et ...
		A), AML3 (acute myelocytic leukemia 3) and OSF2 (osteoblast
		In the differentiation of osteoblasts, it is notable
		Osteoblasts, chondrocytes, myotubes, and adipocytes arise from a common pluripotent mesenchymal cell.
	edrv.endojournals.org /cgi/content/full/21/4/393 (7981 words)

	The University of Chicago Medical Center
		The bone-forming osteoblasts are derived from pluripotent bone marrow fibroblasts (a.k.a., MSCs).
		Our findings suggest that Ids and CTGF may play an important role in promoting the proliferation of early osteoblast progenitor cells and that their expression must be down-regulated during the terminal differentiation of committed osteoblasts, suggesting that a balanced regulation of their expression may be critical to BMP-induced osteoblast lineage-specific differentiation of MSCs.
		Because both adipocytes and osteoblasts are derived from mesenchymal progenitor cells, we found that PPARgamma agonists, along with their co-ligands retinoic acids, induce terminal differentiation and apoptosis in human OS cells, suggesting these agents could be used as effective differentiation therapy agents for the treatment of primary osteosarcoma and/or prevention of recurrent osteosarcoma.
	www.boneandcancer.org /research.htm (2159 words)

	Nanostructures and Osteoblast Behavior of Thermal Sprayed Calcium Phosphate Splats
		This is an AZo Open Access Rewards System (AZo-OARS) article distributed under the terms of the AZo—OARS http://www.azom.com/oars.asp which permits unrestricted use provided the original work is properly cited but is limited to non-commercial distribution and reproduction.
		Obvious attachment and proliferation of the osteoblast cells on the HA splats, (a) SEM picture before the incubation and (b) after the incubation.
		T.J. Webster, R.W. Siegel and R. Bizios, ”Osteoblast adhesion on nanophase ceramics”, Biomaterials, 20 (1999) 1221-1227.
	www.azom.com /Details.asp?ArticleID=3453 (1780 words)

	osteoblast - OneLook Dictionary Search
		osteoblast : The American Heritage® Dictionary of the English Language [home, info]
		Osteoblast : Drug Discovery and Development [home, info]
		Words similar to osteoblast: osteoblastic, bone-forming cell, more...
	www.onelook.com /?w=osteoblast (204 words)

	Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma -- Thomas et al. 167 ...
		Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma -- Thomas et al.
		Osteoblasts are target cells for transformation in c-fos transgenic mice.
		Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development.
	www.jcb.org /cgi/content/full/167/5/925 (5853 words)

	Increased Osteoblast Adhesion on Nano-rough Anodized Titanium and CoCrMo
		Increased Osteoblast Adhesion on Nano-rough Anodized Titanium and CoCrMo
		The objective of the present study was to anodize titanium and CoCrMo and then determine osteoblast adhesion on such materials.
		Osteoblast adhesion was determined by cell counting under a fluorescence microscope.
	www.nsti.org /Nanotech2006/showabstract.html?absno=844 (276 words)

	Dlx3 Transcriptional Regulation of Osteoblast Differentiation: Temporal Recruitment of Msx2, Dlx3, and Dlx5 Homeodomain ...
		Temporal expression of Dlx3 during osteoblast growth and differentiation in relation to that of the Msx2 and Dlx5 HD proteins.
		The proximal promoter regulatory elements during osteoblast growth and differentiation of the rat OC gene are represented with bound transcription factors at each stage of osteoblast differentiation.
		of chick and mouse osteoblasts, as reflected in increased OC expression (19, 50, 78).
	mcb.asm.org /cgi/content/full/24/20/9248 (9664 words)

	Osteoblast Precursor Cells are Found in CD34+ Cells from Human Bone Marrow -- Chen et al. 15 (5): 368 -- Stem Cells
		Osteoblast Precursor Cells are Found in CD34+ Cells from Human Bone Marrow -- Chen et al.
		osteoblast progenitor frequency increased to an average of 1/5,000.
		populations were determined by using a hemacytometer and the osteoblast precursor cell frequencies of each population were determined by limiting dilution assay.
	stemcells.alphamedpress.org /cgi/content/full/15/5/368 (3841 words)

	Osteoblast Recruitment and Bone Formation Enhanced by Cell Matrix-associated Heparin-binding Growth-associated Molecule ...
		by the osteoblast lineage cells that are migrating toward the
		with the inhibition of osteoblast migration by PP1.
		osteoblast induction are probably induced in the environment of
	www.jcb.org /cgi/content/full/143/4/1113 (8033 words)

	Osteoblast fibronectin mRNA, protein synthesis, and matrix are unchanged after exposure to microgravity -- ...
		Immunofluorescence localization of FN in MC3T3-E1 osteoblast cultures grown on earth (GR), in microgravity (0 G), or in an on-board 1-g centrifuge (1 G).
		Total protein extracts were obtained from osteoblast grown at GR (lane 1), 0-G (lane 2), and 1 G (lane 3).
		RNA was extracted from osteoblast sera activated on ground (GR) or in microgravity (0 G) or in an on-board 1-G centrifuge (1 G).
	www.fasebj.org /cgi/content/full/13/9001/S121 (3793 words)

	Implant Surface Roughness Affects Osteoblast Gene Expression -- Schneider et al. 82 (5): 372 -- Journal of Dental ...
		osteoblasts were grown on either rough or grooved implant surfaces.
		Restricted and coordinated expression of beta3-integrin and bone sialoprotein during cultured osteoblast differentiation.
		Histological and biochemical evaluation of osteoblast cultured on bioactive glass, hydroxyapatite, titanium alloy, and stainless steel.
	jdr.iadrjournals.org /cgi/content/full/82/5/372 (2861 words)

	RedOrbit - Science - Lactoferrin and Bone: an Overview of Recent Progress (Site not responding. Last check: )
		The proliferative actions of lactoferrin in primary rat osteoblastic cells are abrogated by pre-treatment of the cultures with RAP (Grey et al.
		These data demonstrate that lactoferrin-induced osteoblast mitogenesis requires a functional LRP receptor, but do not allow discrimination between the individual contributions of LRP1 and LRP2, since both receptors are expressed in primary rat osteoblasts and RAP inhibits binding of ligands to each receptor (Gliemann 1998).
		Lactoferrin's effects on both the proliferation and survival of osteoblasts are profound, being far greater than those observed in response to several established osteoblast growth factors that we have studied in the same in vitro assays.
	www.redorbit.com /news/display/?id=148718&source=r_science (4283 words)

	Arthritis Research & Therapy \| Full text \| Effects on osteoclast and osteoblast activities in cultured mouse ...
		Aseptic loosening of a joint prosthesis is associated with remodelling of bone tissue in the vicinity of the prosthesis.
		The finding that serum levels of osteocalcin are increased in patients with a loosened hip prosthesis [4] is compatible with the morphological observation that suggests an increase in bone turnover [1,3] similar to bone remodelling in postmenopausal osteoporosis.
		By means of quantitative real-time PCR, osteoblastic differentiation was assessed by analysing the mRNA expressions of the enzyme alkaline phosphatase and the bone-specific extracellular matrix protein osteocalcin, both suggested to be associated with mineralisation of bone osteoid and used as clinical parameters of anabolic events in bone.
	arthritis-research.com /content/9/1/R18 (7689 words)

	Inflammatory Microcrystals Alter the Functional Phenotype of Human Osteoblast-Like Cells In Vitro: Synergism with IL-1 ...
		Osteoblasts are essential cellular components of the bone remodeling unit
		Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.
		An ultrastructural study of phagocytosis in bone by osteoblastic cells from fetal mouse calvaria in vitro.
	www.jimmunol.org /cgi/content/full/168/10/5310 (5583 words)

	Osteoblast Medium & Growth Supplement
		Osteoblast Medium (ObM) is a complete medium designed for optimal growth of normal human osteoblasts in vitro.
		The medium is formulated (quantitatively and qualitatively) to provide a defined and optimally balanced nutritional environment that selectively promotes proliferation and growth of normal human osteoblasts in vitro.
		Osteoblast growth supplement is also available for puchasing seperately
	www.sciencellonline.com /products/4601.htm (244 words)

	Osteoblasts - Wheeless' Textbook of Orthopaedics
		- osteoblasts have cytoplasmic processes that extend to adjacent osteoblasts and into bone substance by way of canaliculi to join processes of osteocytes;
		- both cytoplasm and nucleus of osteoblasts contain enzyme alkaline phosphatase, which can be used as a marker for osteoblast activity;
		The effect of corticosterone on osteoblast expression of beta 1 integrins.
	www.wheelessonline.com /ortho/osteoblasts (201 words)

	Smurf1 Inhibits Osteoblast Differentiation and Bone Formation in Vitro and in Vivo -- Zhao et al. 279 (13): 12854 -- ...
		Smurf1 Inhibits Osteoblast Differentiation and Bone Formation in Vitro and in Vivo -- Zhao et al.
		role in osteoblast differentiation and bone formation in vivo.
		The zinc finger transcription factor gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.
	www.jbc.org /cgi/content/abstract/279/13/12854 (913 words)

	Roles of Bone Morphogenetic Protein Type I Receptors and Smad Proteins in Osteoblast and Chondroblast Differentiation ...
		Osteoblast differentiation by Smads was then examined by induction of alkaline phosphatase activity by staining the cells
		Asahina, I., Sampath, T.K., Nishimura, I., and Hauschka, P.V. Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria.
		Zou, H., Wieser, R., Massague, J., and Niswander, L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage.
	www.molbiolcell.org /cgi/content/full/10/11/3801 (6086 words)

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