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Topic: Osteolysis

In the News (Fri 1 Jan 10)

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Hugh Jackman

	The Hip Society - 2001 Open Meeting
		Sixty-eight well-fixed cups with osteolysis in the pelvis and polyethylene wear were identified from a series of 124 consecutive re-operations for failed cementless sockets.
		Radiographic measurements were fixation of the socket and stem; osteolysis of pelvis and femur; and penetration (creep) of the plastic liner in the metal shell.
		There was no mechanical failure rate of fixation, no osteolysis, and less than 0.04 mm of creep of the polyethylene liner which means that the center of rotation of the femoral head remains in the center of the cup.
	www.hipsoc.org /openmeet03032001.html (9635 words)

	The Physician and Sportsmedicine: Osteolysis of the Distal Clavicle
		In Brief: Osteolysis of the distal clavicle is a pathologic process involving resorption of the distal clavicle and is usually posttraumatic or caused by the repetitive microtrauma of weight lifting.
		Osteolysis of the distal clavicle is typically associated with AC pain and, on radiographs, a loss of subchondral bone detail, AC separation, and cystic changes (1).
		The mechanical cause of atraumatic osteolysis appears to be repetitive microtrauma to the shoulder (eg, caused by weight-training exercises), whereas traumatic osteolysis is induced by a single blunt trauma to the shoulder.
	www.physsportsmed.com /issues/2000/12_00/stephens.htm (1706 words)

	Shoulder Pain Info .com - Acromioclavicular (AC) Osteolysis
		The word "osteolysis" refers to a softening, absorption, and dissolution of bone or the removal or loss of calcium in bone.
		Osteolysis of the distal clavicle usually comes on slowly and results in shoulder pain, stiffness and/or swelling.
		The goal of treatment of osteolysis of the distal clavicle is to reduce pain while the clavicle "remineralizes".
	www.shoulderpaininfo.com /shoulderACOsteolysis.html (713 words)

	RedOrbit NEWS \| Polyethylene and Titanium Particles Induce Osteolysis By Similar, Lymphocyte-Independent, Mechanisms (Site not responding. Last check: 2007-10-24)
		Osteolysis is induced by implant-derived wear particles, primarily from the polyethylene bearing surfaces.
		Osteolysis is a major clinical problem that leads to aseptic loosening and thereby limits the long-term survival of total joint arthroplasties [44].
		Osteolysis was measured in female C57BL/6 mice 7days after implantation of sodium hyaluronate as a negative control (first bar), virtually "endotoxin-free" Ceridust 130 polyethylene particles (second bar), virtually "endotoxin-free" titanium particles (third bar), or titanium particles with adherent endotoxin (fourth bar).
	www.redorbit.com /modules/news/tools.php?tool=print&id=137066 (3897 words)

	eMedicine - Distal Clavicle Osteolysis : Article by Brett D Owens, MD (Site not responding. Last check: 2007-10-24)
		As distal clavicle osteolysis is usually unilateral, inflammatory disease should be considered in bilateral cases.
		Cahill BR: Osteolysis of the distal part of the clavicle in male athletes.
		Tao HM, Chen J, Ji YY: Post-traumatic osteolysis of the distal clavicle, pubis and ischium in 7 patients.
	www.emedicine.com /orthoped/topic483.htm (1538 words)

	About Revision Total Joint Arthroplasty
		Osteolysis is the loss of bone in the area surrounding the prosthesis.
		Over the past decade, the scientific community has become aware that the development of osteolysis is associated with the accumulation of wear particles from the prosthesis.
		It is important to understand that not all prostheses with worn plastic have osteolysis and not all cases of osteolysis have worn plastic.
	www.aboutjoints.com /patientinfo/topics/revisionarthroplasty/revtja.htm (1017 words)

	Gorham-Stout syndrome (Gorham's massive osteolysis): A report of six cases with histopathological findings, The Journal ...
		We report six cases of the condition and present evidence that osteolysis is due to an increased number of stimulated osteoclasts.
		Osteolysis, a localised resorption of bone, is a common radiological observation.
		Idiopathic osteolysis was first described in 1838 and again in 1872 by Jackson1,2 who reported a case of a `boneless arm'.
	www.findarticles.com /p/articles/mi_qa3767/is_199905/ai_n8836702 (374 words)

	[No title]
		Osteolysis Numerous studies show that acetabular osteolysis is very often asymptomatic, meaning that the patient presents no visible symptoms.
		Of course, it is understood that these researchers are among the first to address osteolysis in stable, cementless components, thus their choice for such a retrospective analysis may be appropriate for preliminary purposes.
		Unfortunately, because osteolysis is often asymptomatic, the patient may not feel that a revision is necessary, or may in fact be weakened by another invasive surgery.
	www.cs.jhu.edu /~cis/cista/446_2002/class/nicholas/review.doc (1941 words)

	Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with ...
		Osteolysis, which is considered to be a major source of morbidity following total hip joint replacement, has been notoriously difficult to measure accurately, particularly in the acetabular area.
		Several groups have postulated that wear-debris-induced osteolysis is the major cause of prosthetic implant failure [4,5,6,7].
		First, we have demonstrated that precise quantification of osteolysis and wear rate allows analysis of their relationship, despite a relatively small sample size (20 patients) compared to previous series with hundreds of patients [12,13].
	bmc.ub.uni-potsdam.de /ar384/text.htm (2683 words)

	Radiology Rounds, periprosthetic osteolysis total hip arthroplasty, taken from Johns Hopkins Rheumatology.
		Periprosthetic osteolysis, also known as “cement” or “particle” disease, is one of the feared long-term complications of total hip arthroplasty.
		Because the disease is caused by particulate matter, the osteolysis can occur anywhere along the bone:component interface, including areas such as empty screw holes in the acetabular component.
		As the osteolysis becomes increasingly severe, aseptic loosening may occur, with failure of the femoral and/or acetabular components.
	www.hopkins-arthritis.som.jhmi.edu /radrds/radiology_17/17_radrds_diagnosis.html (338 words)

	Bioline International Official Site (site up-dated regularly)
		Radiologically, there was diffuse osteolysis of the tibia and fibula suggestive of vanishing bone disease.
		Vanishing bone disease is characterized by progressive osteolysis of the involved bones.
		X-rays of the left leg, AP and lateral views, showed diffuse osteolysis of the tibia and fibula with widening of the medullary cavity and thinning of the cortex, surrounded by a soft tissue swelling [Figure - 2], suggestive of vanishing bone disease.
	www.bioline.org.br /request?dv04057 (1033 words)

	HJD \| Department of Rheumatology
		To assess the effect of daily oral alendronate 35mg and 10 mg on the progression of femoral osteolysis (increase in total osteolytic lesion area) when administered for up to 6 months in patients with progressive femoral osteolysis.
		To assess the effect of daily oral alendronate 35 mg and 10 mg on the progression of femoral osteolysis (maximum lesion depth of the primary osteolytic lesion and total osteolytic lesion interface length) when administered for up to 6 months in patients with progressive femoral osteolysis.
		The patient has documented progressive femoral osteolysis defined as an increase in the total osteolytic lesion area (sum of all lesions) of at least 20 mm based upon a comparison of two AP radiographs taken on separate occasions within 3 years of entry into this study.
	hjd-www.med.nyu.edu /Rheumatology/trial_osteolysis.html (665 words)

	Review article: Polyethylene wear and osteolysis in total hip arthroplasty Journal of Orthopaedic Surgery - Find ...
		Polyethylene wear and osteolysis can be prevented by reducing the wear such as using a small femoral head, adaptive polyethylene thickness, suitable surgical techniques, non-polyethylene articulation, etc. The presence of cement or circumferential coatings may also retard the distal migration of particles.
		As far as treatment, revision surgery is able to reconstruct the joint by replacing partial or total prosthesis and repair the defect by bone grafting according to intraoperative assessment.
		Periprosthetic osteolysis after total hip arthroplasty now constitutes one of the most common complications and the leading reason for revision after primary replacement 15,9 and also makes joint reconstruction much more difficult.
	www.findarticles.com /p/articles/mi_qa3794/is_200106/ai_n8988057 (397 words)

	Orthopaedic Journal at Harvard Medical School - annual publication Harvard Combined Orthopaedic Residency Program ...
		that periprosthetic osteolysis is the cause of radiolucent zones at the interface between cement and the acetabular bone.
		Femoral osteolysis developed in 29% of the hips with an HG femoral component compared with none that had the Precoat cemented femoral component, a highly statistically significance difference.
		While the issue of patched porous surfaces on the HG femoral component was a major contributor to periprosthetic osteolysis in that study, this is but one major manifestation of a general observation, namely that the specific features of individual designs play very important roles in the incidence of periprosthetic osteolysis.
	www.orthojournalhms.org /volume5/manuscripts/ms09.htm (1634 words)

	RELATIONSHIP BETWEEN PROGRESSION OF OSTEOLYSIS AND POLYETHYLENE WEAR AND PATIENT-RELATED FACTORS
		Knowledge of the extend and progression of osteolysis is important in deciding the timing of surgical intervention, the type of surgery and also for monitoring the potential effects of medical treatments.
		The aim of this study was to use quantitative computed tomography (CT), with wear and migration analyses, to determine the rate of progression of osteolysis and to examine the relationship between osteolysis and polyethylene wear and patient-related variables.
		There was a statistically significant association between progression of osteolysis and total polyethylene wear, total polyethylene wear rate and volumetric polyethylene wear rate and volumetric polyethylene wear in the 12 month period between CT scans (p=0.026, p=0.025 and p=0.035 respectively).
	www.anzors.org.au /abstracts2005/abstract31.html (284 words)

	News - Age and Gender are Significant Risk Factors for Osteolysis after Total Hip Arthroplasty
		Osteolysis can progress asymptomatically or painfully, and there is increasing controversy as to whether intervention is necessary for asymptomatic osteolysis.
		An understanding of the factors that increase the risk of osteolysis is necessary in order for appropriate and early intervention to be implemented.
		Radiographic evaluation of osteolysis was conducted by three independent reviewers at 3 months, 6 months, 1 year and annually thereafter.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256D8C00326FF1 (541 words)

	VirtualScopics - Osteolysis Case Study (Site not responding. Last check: 2007-10-24)
		A compound targeted at the disease would be a blessing for patients, as it would replace painful and expensive revision surgery.
		At first, the client was unaware that a fast and reliable measurement protocol existed for evaluating osteolysis.
		Based on previous studies that had been attempted using plain film x-ray, there was an expectation that any trial would require three to five years.
	www.virtualscopics.com /technology/osteolysis.aspx (356 words)

	[No title]
		Sources of osteolysis around total knee arthroplasty: wear of the bearing surface.
		The development of osteolysis is often related to wear of the polyethylene bearing surface with production of biologically active particulate debris.
		There are many structural and design factors related to the polyethylene bearing surface that have been shown to affect the extent of wear that occurs over time.
	www.chez.com /orthopedix/text/osteolyse_prothese_genou.html (318 words)

	Prevent Disease.com - Osteolysis of Clavicle - Weighlifters at Risk for Collarbone Damage
		One type of injury found in weightlifters is osteolysis of the distal clavicle (ODC), a condition in which the collarbone slowly breaks down and dissolves, causing pain, instability, and reduced mobility and strength.
		Night pain is not often a complaint but the patient typically will have difficulty sleeping on the afffected side if pressure on the shoulder is increased.
		The prevalence of osteolysis of the distal clavicle in recreational weight trainers.
	preventdisease.com /news/articles/weightlifters_risk_collarbone_damage.shtml (496 words)

	Arthritis Research & Therapy \| Full text \| Volumetric computerized tomography as a measurement of periprosthetic ...
		CT images were acquired using GE CTi with 1 mm collimation, a pitch of 1.5, and a 14–22 cm field of view.
		The WOMAC and SF-36 values tended to correlate well with each other and with the Harris Hip score, but their correlations with osteolysis were no better than that shown by the Harris Hip score.
		Howie DW, Vernon-Roberts B, Oakeshott R, Manthey B: A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles.
	arthritis-research.com /content/4/1/59 (2610 words)

	Post-traumatic Osteolysis (Site not responding. Last check: 2007-10-24)
		There is an uncommon entity which is often missed initially or misdiagnosed as a Type I strain/sprain of the acromioclavicular joint: term post-traumatic osteolysis of the distal clavicle.
		If post-traumatic osteolysis of the clavicle is suspected, additional views of the A-C joint can be performed to better demonstrate the distal clavicle.
		There are four phases of post-traumatic osteolysis: latent, early, resorption, late resorption, and repair.
	www.chiroweb.com /hg/11/22/13.html (464 words)

	DEXA-scanning in description of bone remodeling and osteolyses around cemnetless acetabular cups
		Hip-revision surgery is frequently complicated by unexpected periacetabular osteolysis.
		Preoperative x-rays normally do not reveal sufficient information about the amount of osteolysis, but in the course of the operation, huge localized osteolytic lesions in the pelvic bone may appear.
		The aim of the present studies was to utilize DEXA-scanning to determine periacetabular osteolysis and to quantify the extent of osteolysis, including estimation of precision and accuracy of such a measure.
	www.danmedbul.dk /Dmb_2006/0106/0106-phd/DMB3786.htm (519 words)

	Reversal of Osteolysis by PEMFs.
		Osteolytic changes developed around the distal end of a femoral prosthesis implanted 36 mo earlier in a 44-yr old male to correct a congenital hip defect.
		The patient was still doing well clinically at 40 mo, however X-rays showed that the osteolysis had progressed.
		PEMF stimulation in combination with appropriate medication appeared to reverse osteolytic changes associated with a femoral prosthesis used during hip arthroplasty.
	infoventures.com /emf/currlit/bu13315.html (224 words)

	Merry Jo Oursler (Site not responding. Last check: 2007-10-24)
		Osteolysis result in a great deal of pain and suffering in patients and there are no current therapies to block tumor-driven osteolysis.
		Using both metastatic tumors and an animal model for in vivo metastasis, we are currently identifying the paracrine factors being secreted by metastatic cancer lesions and determining which of these factors are responsible for metastatic cancer-induced osteolysis.
		Further in vitro studies have focused on defining the signaling pathways by which these identified factors influence osteolysis by examining the pathways regulating osteoclast differentiation, programmed cell death, and activity.
	www.d.umn.edu /~lshannon/Biology_2002/faculty/Oursler_page.htm (442 words)

	Arthritis Research & Therapy \| Full text \| Osteoclasts; culprits in inflammatory osteolysis
		The osteoclast, which is a member of the monocyte/macrophage family, is the exclusive bone resorptive cell, and its differentiation and activation are under the aegis of a variety of cytokines.
		It is abundant in affected joints of patients with rheumatoid [2] or psoriatic [3] arthritis as well as in implant particle-induced inflammation prompting prosthetic loosening [4].
		Periarticular osteolysis, which may be particularly draconian, reflects accelerated osteoclast differentiation and function under the aegis of cytokines produced within the inflammatory environment.
	arthritis-research.com /content/8/1/201 (5872 words)

	THR: Osteolysis - Wheeless' Textbook of Orthopaedics
		Patterns of osteolysis around total hip components inserted with and without cement.
		Aseptic loosening in total hip arthroplasty secondary to osteolysis induced by wear debris from titanium alloy modular femoral heads.
		Treatment of Pelvic Osteolysis Associated with a Stable Acetabular Component Inserted with Cement as Part of a Total Hip Replacement.
	www.wheelessonline.com /ortho/thr_osteolysis (1303 words)

	Familial expansile osteolysis in a large Spanish kindred resulting from an insertion mutation in the TNFRSF11A gene -- ...
		Familial expansile osteolysis in a large Spanish kindred resulting from an insertion mutation in the TNFRSF11A gene -- Palenzuela et al.
		osteolysis, and the lamina dura was conserved, unlike in PDB.
		Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis.
	jmg.bmjjournals.com /cgi/content/full/39/10/e67 (2338 words)

	Osteolysis of the mandible associated with progressive systemic sclerosis -- Ruprecht et al. 19 (1): 31 -- ...
		Osteolysis of the mandible associated with progressive systemic sclerosis -- Ruprecht et al.
		Osteolysis of the mandible associated with progressive systemic sclerosis
		osteolysis of both coronoid processes of the mandible together with the
	dmfr.birjournals.org /cgi/content/abstract/19/1/31 (102 words)

	Osteolysis (Site not responding. Last check: 2007-10-24)
		Large amounts of particulate may dissolve in joint fluid, staining the fluid and synovium a flish color.
		Osteolysis and metallosis in a patient with a total knee replacement.
		A focal area of osteolysis is seen in the posterior medial femur.
	www.gentili.net /thr/osteolys.htm (213 words)

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