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Topic: Osteomalacia

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	Osteomalacia
		Osteomalacia is a disease in which insufficient mineralization leads to a softening of the bones.
		Osteomalacia can occur because of reduced exposure to sunlight (which, after touching the skin, causes the body to make vitamin D), insufficient intake of vitamin D–enriched foods (like vitamin D–fortified milk), or improper digestion and absorption of food with vitamin D (as in bowel disorders such as lactose intolerance or celiac disease).
		Osteomalacia should not be confused with osteoporosis, which is a disease of normal mineralization but decreased amounts of bone.
	www.faqs.org /nutrition/Ome-Pop/Osteomalacia.html (291 words)

	THE MERCK MANUAL OF GERIATRICS, Ch. 49, Metabolic Bone Disease
		Osteomalacia should be suspected in patients with typical ribbonlike cortical lucencies (pseudofractures) that are found with plain x-rays and in patients in whom the serum Ca level is low or low-normal, the serum phosphorus level is low, and the serum alkaline phosphatase and parathyroid hormone levels are high.
		Osteomalacia (analogous to rickets in children) is relatively rare in the elderly, although deficiency of vitamin D and Ca is common.
		Osteomalacia due to vitamin D deficiency should be suspected when the serum Ca level is low or low-normal, the serum phosphorus level is low, and the serum alkaline phosphatase and PTH levels are high.
	www.merck.com /mrkshared/mmg/sec7/ch49/ch49d.jsp (1175 words)

	Fluoridation, Dialysis, & Osteomalacia
		Osteomalacia is a serious disease that softens bones, often causing incapacitating pain and fracture.
		We conclude that the osteomalacia that occurs in dialysis patients is due to multiple factors that are removed by deionization.
		Thus, the progression of osteomalacia appears to be the main reason for the increasing incidence of bone pain and pseudofractures which we and others have observed in patients on chronic dialysis for periods longer than 6 months.
	www.fluoridealert.org /health/bone/fluorosis/dialysis.html (2161 words)

	WPXI.com - Health Centers - Osteomalacia
		Osteomalacia is softening of the bones, caused by not having enough vitamin D, or by problems with the metabolism (breakdown and use) of this vitamin.
		Use of very strong sunscreen, limited exposure of the body to sunlight, short days of sunlight, and smog are factors that reduce formation of vitamin D in the body.
		Call for an appointment with your health care provider if you have symptoms of osteomalacia, or if you think that you may be at risk for this disorder.
	www.wpxi.com /encyclopedia/6860051/detail.html (623 words)

	Phosphaturic Mesenchymal Tumor/Oncogenic Osteomalacia
		Oncogenic osteomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia, normocalcemia, and increased levels of alkaline phosphatase.
		Tumor-induced (oncogenic) osteomalacia is a rare clinicopathologic entity in which the clinical signs and symptoms of osteomalacia and the specific laboratory abnormalities of hypophosphatemia, hyperphosphaturia, and low serum levels of 1,25(OH)2 vitamin D are associated with the finding of a neoplastic process in the patient.
		Oncogenic osteomalacia is an uncommon syndrome characterized by bone pain, proximal muscle weakness, hypophosphatemia, hyperphosphaturia, and a low concentration of 1,25-dihydroxyvitamin D. This syndrome is induced by a tumor, usually benign, of mesenchymal origin and resolves after its excision.
	www.thedoctorsdoctor.com /diseases/phosphaturic_mesenchymal_tumor.htm (5327 words)

	Arthritis Research Campaign \| Osteomalacia (Soft Bones) (Site not responding. Last check: 2007-10-09)
		Osteomalacia, particularly osteomalacia caused by a lack of vitamin D, causes bone pain and muscle weakness.
		Osteomalacia can also be caused by tablets for epilepsy, and it can sometimes occur if you have had surgery on your stomach.
		Osteomalacia, or soft bones, often happens because of a lack of vitamin D. It causes severe symptoms of bone pain and muscle weakness.
	www.arc.org.uk /about_arth/booklets/6058/6058.htm (2111 words)

	What Is Osteomalacia? (Sidebar), THE MERCK MANUAL OF HEALTH & AGING
		In osteomalacia, the two activities are balanced, but the bone that is formed does not become dense and hard (mineralized).
		Osteomalacia is usually caused by vitamin D deficiency or by a digestive tract or kidney disorder.
		Osteomalacia is treated with vitamin D or phosphate supplements depending on the cause.
	www.merck.com /pubs/mmanual_ha/sidebars/sb22_1.html (165 words)

	OSTEOMALACIA - RICKETS
		Osteomalacia is a condition where the calcium salts are lost from the bone (osteomalacia of adults), or inadequately deposited (rickets in children): the protein network is usually not affected.
		Once the osteomalacia or rickets has been cured, vitamin D treatment is still required to keep the calcium content of the bones normal.
		If rickets or osteomalacia develops in Asians, it is often useful to give vitamin D to other members of the family who are likely to be at risk of developing this disorder later in life.
	www.surgerydoor.co.uk /medical_conditions/Indices/O/osteomalacia.htm (677 words)

	Glossary: Osteomalacia
		A disease of adults that is characterized by softening of the bones due to loss of bone mineral.
		Osteomalacia is characteristic of vitamin D deficiency in adults, while children with vitamin D deficiency suffer from rickets.
		Osteomalacia is "an abnormal condition of the lamellar bone, characterized by a loss of calcification of the matrix resulting in softening of the bone, accompanied by weakness, fracture, pain, anorexia, and weight loss.
	www.greenfacts.org /glossary/mno/osteomalacia.htm (180 words)

	INCIDENCE OF OSTEOMALACIA IN KOHISTANI WOMEN PRESENTING WITH BODYACHES
		Osteomalacia is a metabolic bone disease caused by deficiency of vitamin D or its active metabolites.
		Osteomalacia was diagnosed on the basis of a history of bone aches or pains, muscle weakness, low or low normal serum calcium and urinary calcium, decreased concentrations of serum inorganic phosphorus and 25-hydroxyvitamin D and increased serum intact PTH and alkaline phosphatase levels.
		It is possible that excessive clothing may be a risk factor for osteomalacia in young to middle-aged and otherwise healthy women as was reported by Gulu et al from Turkey.
	www.ayubmed.edu.pk /JAMC/PAST/16-3/Sahibzada.htm (1369 words)

	Fluoride & Osteomalacia
		Osteomalacia is a bone-softening disease caused by an excess amount of osteoid in bone.
		Bone resorption decreased and osteomalacia improved, coincident wtih the lowering of dialysate, serum and bone concentrations of fluoride
		We conclude that the presence of fluoride in the dialysate, perhaps in conjunction with other substances, is associated with an increased incidence of osteomalacia.
	www.fluoridealert.org /health/bone/fluorosis/osteomalacia.html (1875 words)

	AllRefer Health - Osteomalacia
		In children, the condition is called rickets and is usually caused by a deficiency of vitamin D.
		Conditions that may lead to osteomalacia include inadequate dietary intake of vitamin D, inadequate exposure to sunlight (ultraviolet radiation), which produces vitamin D in the body and malabsorption of vitamin D by the intestines.
		Other conditions that can cause osteomalacia include hereditary or acquired disorders of vitamin D metabolism; kidney failure and acidosis; phosphate depletion associated with low dietary intake of phosphates; kidney disease or cancer (rare), and side effects of medications used to treat seizures.
	health.allrefer.com /health/osteomalacia-info.html (391 words)

	Osteomalacia
		Many cases of osteomalacia are related to abnormalities in vitamin D.
		Osteomalacia may be suspected on a clinical basis, especially when there is a family history or lab abnormalities listed on the table above.
		This was from a dialysis patient with severe osteomalacia.
	courses.washington.edu /bonephys/hypercalU/opmal2.html (492 words)

	MedlinePlus Medical Encyclopedia: Osteomalacia
		Osteomalacia involves softening of the bones caused by a deficiency of vitamin D or problems with the metabolism of this vitamin.
		Use of very strong sunscreen, limited exposure of the body to sunlight, short days of sunlight, and smog are factors that decrease formation of vitamin D within the body.
		An adequate dietary intake of dairy products that are fortified with vitamin D and exposure of the body to sunlight can prevent osteomalacia caused by vitamin D deficiency in adults.
	www.nlm.nih.gov /medlineplus/ency/article/000376.htm (520 words)

	Osteomalacia
		Osteomalacia is a condition in which the bones lose calcium and become softer.
		In the United States, osteomalacia and rickets rarely occur because of a lack of vitamin D. Most milk is supplemented with vitamin D. Additionally, the skin makes vitamin D after getting even a little sunlight.
		Once osteomalacia is diagnosed, the next step is to learn what has caused it.
	www.csmc.edu /9910.html (382 words)

	OSTEOMALACIA
		Osteomalacia and rickets are essentially the same process.
		Osteomalacia and rickets are both characterized by an abnormally high ratio of osteoid (inadequately mineralized bone matrix) to mineralized bone, and over 30 causes or associated diseases have been identified.
		In some cases of osteomalacia (rare in my experience), collections of osteoid may build up to the point that these "seams" of osteoid may be seen on plain radiographs as linear lucencies oriented perpendicular to the cortical margin.
	www.mypacs.net /cases/OSTEOMALACIA--835045.html (775 words)

	Osteomalacia - Wikipedia, the free encyclopedia
		Immigrants and 'Osteomalacia' (pronounced /ˌɑstioməˈleɪʃiə/) is the adult equivilent of the disease rickets.
		Osteomalacia denotes those disorders where mineralisation of newly formed bone matrix is defective.
		Osteomalacia starts as aches and pains insidiously, in lumbar spine and thighs spreading later to arms and ribs.
	en.wikipedia.org /wiki/Osteomalacia (256 words)

	eMedicine - Osteomalacia and Renal Osteodystrophy : Article by Mitchell J Kline, MD (Site not responding. Last check: 2007-10-09)
		Osteomalacia may be part of the spectrum of osseous abnormalities that can be observed in patients with chronic renal insufficiency.
		Osteomalacia is a disorder of bone that results from hypomineralization following the cessation of bone growth.
		Age: Rickets and osteomalacia are different manifestations of the same underlying pathologic process, depending on whether the patient is a child or an adult, respectively.
	www.emedicine.com /radio/topic500.htm (3424 words)

	Osteomalacia - WrongDiagnosis.com
		Osteomalacia is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		Osteomalacia (pronounced /ˌɑstioməˈleɪʃiə/), known as rickets (taken from the Greek word ῥάχις - rhákis) in children, refers to a softening of the bone.
		With a diagnosis of Osteomalacia, it is also important to consider whether there is an underlying condition causing Osteomalacia.
	www.wrongdiagnosis.com /o/osteomalacia/intro.htm (685 words)

	Osteoporosis and Osteomalacia in Patients with Celiac Disease
		In osteomalacia, the amount of bone may be normal, but there is less mineral in the bone.
		The definitive diagnosis of osteomalacia is made by bone biopsy, where excess unmineralized bone can be seen, although tests of blood and urine may also be helpful.
		Osteomalacia is treated with a lot of vitamin D and calcium.
	www.enabling.org /ia/celiac/osteopo.html (2606 words)

	Osteomalacia - Wheeless' Textbook of Orthopaedics
		- osteomalacia and rickets are rare osteoendocrine or neuroendocrine manifestations
		- osseous changes in osteomalacia are similar to those in children but are much less evident
		- phosphorus level is low or very low depending on type of osteomalacia, except in renal osteodystrophy;
	www.wheelessonline.com /ortho/osteomalacia (419 words)

	MotherNature.com - Rickets/Osteomalacia
		Osteomalacia should be diagnosed, and its treatment monitored, by a doctor.
		Symptoms of osteomalacia include bowing of the legs and a decrease in height.
		Conventional treatment of rickets and osteomalacia includes oral vitamin D supplementation, sometimes accompanied by intravenous calcium.
	www.mothernature.com /Library/Ency/Index.cfm?id=1258006 (924 words)

	Osteomalacia
		Osteomalacia is a condition in which the bones become soft.
		The cause of osteomalacia is not getting enough vitamin D (vitamin D deficiency).
		A vitamin D deficiency leading to osteomalacia may be caused by a poor diet (malnutrition) or by a problem with the intestine (such as sprue) that prevents it from absorbing nutrients.
	www.webmd.com /hw/health_guide_atoz/sto167518.asp (144 words)

	Biochemical recovery time scales in elderly patients with osteomalacia -- Allen and Raut 97 (11): 527 -- Journal of the ...
		Osteomalacia is not rare in the UK and climatically similar
		Osteomalacia is a generalized disorder of bone in which impairment
		Low prevalence of osteomalacia in elderly patients with hip fracture.
	www.jrsm.org /cgi/content/full/97/11/527 (2004 words)

	Oncogenic Osteomalacia: Diagnostic Pitfalls and Long-Term Outcome
		The oncogenic cause of osteomalacia is often unrecognized because the tumors are frequently very small and may be osseous or in the soft tissues.
		The lesions were detected by skeletal survey in 5 cases, radionuclide scan in 8 cases, CT scan in 2 cases and MRI in 4 cases.
		Oncogenic osteomalacia is a rare clinicopathologic syndrome characterized by mesenchymal tumors that produce osteomalacia and biomechanical abnormalities consisting of hypophosphatemia, normocalcemic, and increased levels of alkaline phosphatase.
	www.datatrace.com /medical/jsoa/JSOA_alabama-10.htm (327 words)

	Oncogenic Osteomalacia
		Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia.
		Use of long-term intravenous phosphate infusion in the palliative treatment of tumor-induced osteomalacia.
		Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia.
	www.medical-journals.com /r032443.htm (1334 words)

	Diseases Info
		In children, the condition is called rickets and is usually caused by a deficiency of vitamin D. Conditions that may result in osteomalacia include inadequate dietary intake of vitamin D, inadequate exposure to sunlight (ultraviolet radiation), which forms vitamin D in the body, and malabsorption of vitamin D by the intestine.
		Comparison of the gothic architecture with the pelvis makes it easy to see where the lines of mechanical stress might go and this is where the Looser zones can be seen.
		This table shows a list of causes of osteomalacia and some of the biochemical abnormalites that can be seen.
	www.phoenity.com /diseases/osteomalacia.html (652 words)

	Osteomalacia and rickets (vitamin D deficiency)
		They are really the same condition; rickets is the name used when it occurs in children whereas osteomalacia is the term used for adults.
		Osteomalacia: widespread bone pains and sometimes muscle weakness.
		Most people with osteomalacia find their pain is reduced about two weeks after the injection.
	www.netdoctor.co.uk /diseases/facts/osteomalaciarickets.htm (449 words)

	Osteomalacia and rickets (vitamin D deficiency) (via CobWeb/3.1 planet03.csc.ncsu.edu) (Site not responding. Last check: 2007-10-09)
		Osteomalacia and rickets (vitamin D deficiency) (via CobWeb/3.1 planet03.csc.ncsu.edu)
		Blood tests are most helpful in identifying osteomalacia in adults but some patients also have a reduced bone density on bone density scanning.
		In children, X-rays, particularly of the wrists and knees, are useful but blood tests may also help.
	www.netdoctor.co.uk.cob-web.org:8888 /diseases/facts/osteomalaciarickets.htm (458 words)

	Symptoms of Osteomalacia - WrongDiagnosis.com
		When considering symptoms of Osteomalacia, it is also important to consider Osteomalacia as a possible cause of other medical conditions.
		This signs and symptoms information for Osteomalacia has been gathered from various sources, may not be fully accurate, and may not be the full list of Osteomalacia signs or Osteomalacia symptoms.
		Furthermore, signs and symptoms of Osteomalacia may vary on an individual basis for each patient.
	www.wrongdiagnosis.com /o/osteomalacia/symptoms.htm (404 words)

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