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Topic: Osteopontin

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	Osteopontin - Wikipedia, the free encyclopedia
		Osteopontin is synthesized by a variety of tissue types including preosteoblasts, osteoblasts, osteocytes, extraosseous cells in the inner ear, brain, kidney, deciduum, placenta, odontoblasts, some bone marrow cells, hypertrophic chondrocytes, macrophages, smooth muscle, and endothelial cells.
		Synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin D3).
		Osteopontin is overexpressed in a variety of cancers, including lung cancer, breast cancer, colorectal cancer, stomach cancer, ovarian cancer, melanoma and mesothelioma.
	en.wikipedia.org /wiki/Osteopontin (322 words)

	Osteopontin: Marker for Mesothelioma
		Osteopontin is a type of protein that is involved in communication between cells, including signaling involved in the development of cancer.
		In order to evaluate osteopontin as a potential marker for mesothelioma, researchers from several institutions conducted a clinical study to compare osteopontin levels in patients diagnosed with mesothelioma and patients with benign (non-cancerous) lung conditions.
		The researchers concluded that osteopontin may be a promising marker for the detection of mesothelioma.
	patient.cancerconsultants.com /news.aspx?id=35165 (588 words)

	The Cytokine Osteopontin Modulates the Severity of Rotavirus Diarrhea -- Rollo et al. 79 (6): 3509 -- The Journal of ...
		Osteopontin is a ligand for the alpha4beta1 integrin.
		Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival.
		Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages.
	jvi.asm.org /cgi/content/full/79/6/3509 (5359 words)

	Mesothelioma-line - Asbestos Exposure, Pleural Mesothelioma, and Serum Osteopontin Levels (Site not responding. Last check: 2007-11-03)
		We investigated the presence of osteopontin in pleural mesothelioma and determined serum osteopontin levels in three populations: subjects without cancer who were exposed to asbestos, subjects without cancer who were not exposed to asbestos, and patients with pleural mesothelioma who were exposed to asbestos.
		Serum osteopontin levels were significantly higher in the group with pleural mesothelioma than in the group with exposure to asbestos (133±10 ng per milliliter vs. 30±3 ng per milliliter, P<0.001).
		An analysis of serum osteopontin levels comparing the receiver-operating-characteristic curve in the group exposed to asbestos with that of the group with mesothelioma had a sensitivity of 77.6 percent and a specificity of 85.5 percent at a cutoff value of 48.3 ng of osteopontin per milliliter.
	www.mesothelioma-line.com /mambo/content/view/117 (448 words)

	Angiotensin II Induction of Osteopontin Expression and DNA Replication in Rat Arteries -- deBlois et al. 28 (6): 1055 ...
		Immunohistochemical analysis of osteopontin protein levels in normal and injured carotid arteries of rats infused continuously with angiotensin II (250 ng/kg per minute) or Ringer's lactate 5 and 6 weeks after balloon injury to the left carotid artery.
		Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.
		Osteopontin is synthesized by macrophage, smooth muscle and endothelial cells in primary and restenotic human coronary atherosclerotic plaques.
	hyper.ahajournals.org /cgi/content/full/28/6/1055 (5759 words)

	Osteopontin Facilitates Prostate Cancer Progression In Laboratory Study
		Osteopontin is a phosphoprotein that comprises 2% of bone.
		Osteopontin expression was increasingly present in models of low-grade PIN, high-grade PIN, adenocarcinoma and metastatic adenocarcinoma.
		The effect of osteopontin overexpression was more pronounced in the LNCaP cells, perhaps due to the fact that their basal expression of osteopontin was less.
	www.medicalnewstoday.com /medicalnews.php?newsid=38140&nfid=rssfeeds (333 words)

	Angiotensinogen and AT1 antisense inhibition of osteopontin translation in rat proximal tubular cells -- Ricardo et al. ...
		increased synthesis of osteopontin in the obstructed kidney (8).
		Osteopontin was statistically decreased in proximal tubular cells following cell stretch and transfection with either angiotensinogen (0.042 ± 0.02 vs. 0.10 ± 0.00, P < 0.004) or AT (0.10 ± 0.00 vs. 0.16 ± 0.00, P < 0.001) antisense oligonucleotide, compared with stretched cells or cells transfected with the corresponding scrambled control oligonucleotide.
		IL-1 upregulates osteopontin expression in experimental crescentic glomerulonephritis in the rat.
	ajprenal.physiology.org /cgi/content/full/278/5/F708 (5644 words)

	Phosphate is a specific signal for induction of osteopontin gene expression -- Beck et al. 97 (15): 8352 -- Proceedings ... (Site not responding. Last check: 2007-11-03)
		Osteopontin is believed to be regulated primarily at the transcriptional level (15).
		777 to +79 of the mouse osteopontin gene was transiently
		inhibits the induction of osteopontin in response to the phosphate
	www.pnas.org /cgi/content/full/97/15/8352 (5058 words)

	Osteopontin Levels May Identify Patients with Early Stage Mesothelioma
		The current study evaluated measurement of osteopontin, which is a glycoprotein over-expressed in lung, breast, colorectal, gastric, ovarian cancer and melanoma.
		They reported that serum levels of osteopontin were elevated in patients with pulmonary plaques and fibrosis but not in those with normal X-rays.
		They found very high levels of osteopontin in paitents with pleural mesothelioma compared to patients without mesothelioma who were exposed to asbestos.
	professional.cancerconsultants.com /oncology_main_news.aspx?id=35167 (601 words)

	Osteopontin: A Component of Matrix in Capsular Opacification and Subcapsular Cataract -- Saika et al. 44 (4): 1622 -- ...
		Osteopontin: A Component of Matrix in Capsular Opacification and Subcapsular Cataract -- Saika et al.
		Recombinant osteopontin protein containing a carboxyl-terminal His-Tag (0.5 µg) was subjected to SDS-polyacrylamide gel electrophoresis (5%–20%) and electrotransferred to a PVDF membrane.
		Osteopontin protein expression in an injured mouse lens.
	www.iovs.org /cgi/content/full/44/4/1622 (3140 words)

	Role of Osteopontin in Idiopathic Pulmonary Fibrosis
		They found that osteopontin was the most upregulated gene in the lungs of patients with idiopathic pulmonary fibrosis, and that it was mainly expressed by alveolar epithelial cells.
		Osteopontin is a multifunctional cytokine that has been implicated in several physiological and pathological processes including bone resorption, malignant transformation, and metastasis.
		For example in kidney fibrosis, osteopontin enhances macrophage recruitment and stimulates the development of renal scarring after an acute ischemic insult; most importantly, mice that do not express the gene for osteopontin are protected from lung fibrosis induced by the drug bleomycin.
	www.rxpgnews.com /research/respiratorymedicine/article_2317.shtml (751 words)

	News - Biomarker, Osteopontin, Associated With Ovarian Cancer (Site not responding. Last check: 2007-11-03)
		The investigators explain their immunohistochemistry results indicate that different histologic subtypes of ovarian cancer have different osteopontin expression patterns: "In serous ovarian cancer, high levels of osteopontin were localised to the psamomma bodies, which are laminated calcified concretions commonly found in serious cancers.
		The discrepancy could be explained by the fact the osteopontin protein may be actively secreted by serous epithelial cancer cells and subsequently translocated to the psamomma bodies.
		Osteopontin levels in plasma were significantly higher in 51 patients with epithelial ovarian cancer, compared with levels from 107 controls, 46 patients with benign ovarian disease and 47 patients with other gynaecological cancers.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256B90004E3E0A (457 words)

	Osteopontin (Site not responding. Last check: 2007-11-03)
		Osteopontin is a single-chain polypeptide with a molecular weight of approximately 32,600
		Osteopontin binds to osteoclasts in vitro via the avb3 integrin [Flores et al., 1992].
		Addition of RGD-integrin binding peptides is able to interfere with bone turnover [Horton et al., 1991, Sato et al., 1990], suggesting a key role for osteopontin.
	www.cmb.lu.se /ctb/html/OPN.htm (463 words)

	Detection of Osteopontin in Calcified Human Aortic Valves -- Mohler et al. 17 (3): 547 -- Arteriosclerosis, Thrombosis, ... (Site not responding. Last check: 2007-11-03)
		The arrow indicates the 66-kD protein thought to be osteopontin; control, human milk; calcified, calcified aortic valve; regurgitant, noncalcified purely regurgitant aortic valve; transplant, noncalcified aortic valve explant removed from a patient who underwent cardiac transplantation; and autopsy, normal aortic valve collected at autopsy.
		Osteopontin was prominent in the 250 to 300 mmol/L NaCl fractions
		Osteopontin is expressed in human aortic valvular lesions.
	atvb.ahajournals.org /cgi/content/full/17/3/547 (3834 words)

	Altered bleomycin-induced lung fibrosis in osteopontin-deficient mice -- Berman et al. 286 (6): L1311 -- AJP - Lung ...
		Bleomycin-induced lung fibrosis in osteopontin –/– and osteopontin +/+ mice.
		Obstructive uropathy in the mouse: role of osteopontin in interstitial fibrosis and apoptosis.
		Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro.
	ajplung.physiology.org /cgi/content/full/286/6/L1311 (4968 words)

	NEJM -- Asbestos Exposure, Pleural Mesothelioma, and Serum Osteopontin Levels
		Tumor tissue was examined for osteopontin by immunohistochemical
		osteopontin levels were associated with pulmonary plaques and
		Using serum osteopontin to help identify pleural mesothelioma.
	content.nejm.org /cgi/content/abstract/353/15/1564 (580 words)

	Osteopontin N-terminal Domain Contains a Cryptic Adhesive Sequence Recognized by alpha 9beta 1 Integrin -- Smith et al. ...
		Osteopontin is an adhesive glycoprotein implicated in numerous diseases associated with inflammation and remodeling.
		We compared these osteopontin fragments with native osteopontin in their ability to support adhesion of several different cell lines and identified the receptors mediating these interactions.
		Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
	www.jbc.org /cgi/content/abstract/271/45/28485 (1442 words)

	Osteopontin Expression by Osteoclast and Osteoblast Progenitors in the Murine Bone Marrow: Demonstration of Its ...
		Osteopontin Expression by Osteoclast and Osteoblast Progenitors in the Murine Bone Marrow: Demonstration of Its Requirement for Osteoclastogenesis and Its Increase After Ovariectomy -- Yamate et al.
		P-labeled osteopontin cDNA or GAPDH cDNA probe, a housekeeping gene (A).
		Osteopontin mRNA in bone marrow cell cultures from sham and OVX mice.
	endo.endojournals.org /cgi/content/full/138/7/3047 (5561 words)

	Osteoprotegerin and osteopontin serum values in postmenopausal advanced breast cancer patients treated with anastrozole ...
		Oates AJ, Barraclough R and Rudland PS 1997 The role of osteopontin in tumorigenesis and metastasis.
		Seregni E, Martinetti A, Ferrari L and Bombardieri E 2001 Clinical utility of biochemical marker of bone remodelling in patients with bone metastases of solid tumors.
		Tuck AB and Chambers AF 2001 The role of osteopontin in breast cancer: clinical and experimental studies.
	erc.endocrinology-journals.org /cgi/content/full/11/4/771 (3667 words)

	Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection -- Nau et al. 157 (1): ...
		Osteopontin Expression Correlates with Clinical Outcome in Patients with Mycobacterial Infection -- Nau et al.
		Carlson I, Tognazzi K, Manseau EJ, Dvorak HF, Brown LF: Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology.
		Giachelli CM, Bae N, Almeida M, Denhardt DT, Alpers CE, Schwartz SM: Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.
	ajp.amjpathol.org /cgi/content/full/157/1/37 (3425 words)

	Prenatal Detection of Embryo Resorption in Osteopontin-Deficient Mice Using Serial Noninvasive Magnetic Resonance ... (Site not responding. Last check: 2007-11-03)
		Liaw L, Lindner V, Schwartz SM, Chambers AF, Giachelli CM 1995 Osteopontin and beta 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro.
		Weintraub AS, Schnapp LM, Lin X, Taubman MB 2000 Osteopontin deficiency in rat vascular smooth muscle cells is associated with an inability to adhere to collagen and increased apoptosis.
		O’Regan A, Berman JS 2000 Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation.
	www.pedresearch.org /cgi/content/full/55/3/419 (4179 words)

	Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy ... (Site not responding. Last check: 2007-11-03)
		infiltration and the expression of the chemokine osteopontin
		Osteopontin expression in progressive renal injury in remnant kidney: role of angiotensin II.
		Regulation of proximal tubular osteopontin in experimental hydronephrosis in the rat.
	ndt.oxfordjournals.org /cgi/content/full/17/6/985 (3136 words)

	Cross-linking of Osteopontin by Tissue Transglutaminase Increases Its Collagen Binding Properties -- Kaartinen et al. ...
		Osteopontin, a major noncollagenous bone protein, is an in vitro and in vivo substrate of tissue transglutaminase, which catalyzes
		Osteopontin Is Synthesized by Uterine Glands and a 45-kDa Cleavage Fragment Is Localized at the Uterine-Placental Interface Throughout Ovine Pregnancy
		Osteopontin Is Involved in the Initiation of Cutaneous Contact Hypersensitivity by Inducing Langerhans and Dendritic Cell Migration to Lymph Nodes
	www.jbc.org /cgi/content/abstract/274/3/1729 (623 words)

	Osteopontin: a bridge between bone and the immune system -- Gravallese 112 (2): 147 -- Journal of Clinical Investigation
		Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
		Expression of osteopontin at sites of bone erosion in a murine experimental arthritis model of collagen-induced arthritis: possible involvement of osteopontin in bone destruction in arthritis.
		Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.
	www.jci.org /cgi/content/full/112/2/147 (1602 words)

	Osteopontin as an Adjunct to CA125 in Detecting Recurrent Ovarian Cancer -- Schorge et al. 10 (10): 3474 -- Clinical ...
		Osteopontin as an Adjunct to CA125 in Detecting Recurrent Ovarian Cancer -- Schorge et al.
		Osteopontin (OPN) levels (median and interquartile range) of complete clinical responders and partial/nonresponders at every 3 months of follow-up since diagnosis as predicted by the longitudinal mixed effects models.
		Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma.
	clincancerres.aacrjournals.org /cgi/content/full/10/10/3474 (2961 words)

	Osteopontin and Its Receptor {alpha}v{beta}3 Integrin Are Coexpressed in the Human Endometrium during the Menstrual ...
		Osteopontin and Its Receptor {alpha}v{beta}3 Integrin Are Coexpressed in the Human Endometrium during the Menstrual Cycle But Regulated Differentially -- Apparao et al.
		of osteopontin was primarily induced in response to progesterone,
		Osteopontin Is Colocalized with the Adhesion Molecule CEACAM1 in the Extravillous Trophoblast of the Human Placenta and Enhances Invasion of CEACAM1-Expressing Placental Cells
	jcem.endojournals.org /cgi/content/abstract/86/10/4991 (927 words)

	Hyaluronic Acid Induces Osteopontin via the Phosphatidylinositol 3-Kinase/Akt Pathway to Enhance the Motility of Human ... (Site not responding. Last check: 2007-11-03)
		the involvement of PTEN in HA-induced osteopontin expression.
		A biochemical characterization of the binding of osteopontin to integrins
		Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter.
	cancerres.aacrjournals.org /cgi/content/full/65/3/686 (3016 words)

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