The German biochemistOttoFritzMeyerhof (1884-1951) shared the Nobel Prize in Physiology or Medicine for his discovery of the fixed relationship between oxygen consumption and the metabolism of lactic acid in muscle and for establishing the cyclic character of energy transformations in the living cell.
In 1912 Meyerhof became an assistant in the department of physiology in the University of Kiel and in 1918 assistant professor.
Using a new rapid method devised by himself, Meyerhof showed in 1920 that, in anaerobic conditions, the lactic acid was derived from glycogen in the muscle and that the amount of lactic acid formed was proportional to the tension produced in the muscle.
Meyerhof's was the first attempt at explaining the function of a cell in terms of physics and chemistry; his research into the chemical processes of the muscle cell paved the way for the full understanding of the breakdown of glucose to provide body energy.
OttoMeyerhof helped lay the foundations for modern bioenergetics, the application of the principles of thermodynamics (the science of physics in relation to heat and mechanical action) to the analysis of chemical processes going on within the living cell.
Meyerhof's research attempted to explain the function of a cell in terms of physics and chemistry; his research into the chemical processes of the muscle cell paved the way for the full understanding of the breakdown of glucose to provide body energy.
OttoFritzMeyerhof was awared the Noble Pize in Physiology or Medicine in 1922 "for his discovery of the fixed relationship between the consumption of oxygen and the metabolism of lactic acid in the muscle."
Meyerhof was born in 1884 and graduated with an M.D. in 1909.
Meyerhof is best known for his work on glycolysis where he was one of the first to discover the role of phosphorylated intermediates.
OttoFritzMeyerhof was born on April 12, 1884, in Hannover.
Meyerhof's own account of his earlier work states that he was occupied chicfly with oxidation mechanisms in cells and with extending methods of gas analysis through the calorimetric measurement of heat production.
The discovery of OttoMeyerhof and his students that some phosphorylated compounds are rich in energy led to a revolution, not only of our concepts of muscular contraction, but of the entire significance of cellular metabolism.
Meyerhof worked at Krehl's laboratory for little over two years, but the establishment of ties with Krehl and the development of his close friendship with Warburg were to be factors which would continue to shape Meyerhof's career.
Meyerhof at the the time of the award of his Nobel Prize Between 1918 and 1922, Meyerhof worked out an extraordinary amount of this biochemical detail, including proofs that it is glycogen that is converted into lactic acid in the absence of oxygen.
Thus, Meyerhof tied the release of energy during this particular oxidation to the reconversion of the remaining four fifths of the lactic acid back to glycogen.
Meyerhof, Otto Fritz(Site not responding. Last check: 2007-10-15)
Meyerhof was born in Hanover and studied at a number of German universities.
In 1920 Meyerhof showed that, in anaerobic conditions, the amounts of glycogen metabolized and of lactic acid produced in a contracting muscle are proportional to the tension in the muscle.
He also demonstrated that 20-25% of the lactic acid is oxidized during the muscle's recovery period and that energy produced by this oxidation is used to convert the remainder of the lactic acid back to glycogen.
Otto Fritz Meyerhof - Cleverpedia, the ultimate encyclopedia(Site not responding. Last check: 2007-10-15)
OttoFritzMeyerhof (* 12 April1884 in Hanover; † 6 October1951 in Philadelphia, Pennsylvania) was a German biochemist, who received 1922 together with Archibald Vivian Hill for its research over the metabolism in the muscle the Nobelpreis for medicine.
Meyerhof was born as a son of wealthy Jewish parents.
1938 emigrierte OttoMeyerhof because of the Nazi rule in Germany first to Paris, had to flee from there however after the case of France 1940 into the USA, where it the Rockefeller Foundation financed a Forschungsprofessur for physiological chemistry at the University OF Pennsylvania in Philadelphia.
OttoFritzMeyerhof and the Elucidation of the Glycolytic Pathway Kresge et al 280 4 e3 Journal o...
OttoFritzMeyerhof and the Elucidation of the Glycolytic Pathway -- Kresge et al.
OttoFritzMeyerhof and the Elucidation of the Glycolytic Pathway.
www.healthline.com /search?q1=warburg (587 words)
Photo Archives(Site not responding. Last check: 2007-10-15)
Walter Ernst Meyerhof is the son of Professor OttoFritzMeyerhof, a noted biochemist and physiologist, and Hedwig (Schallenberg) Meyerhof.
Though OttoMeyerhof was not on the ECR list, Fry was more than willing to help the Nobel laureate, and in September 1940, Otto and Hedwig arrived in America.
Otto became a research professor at the University of Pennsylvania's medical school.
Under the influence of Otto Warburg, however, who was then at Heidelberg, he became more and more interested in cell physiology.
Hopkins had isolated from cells the SH bodies concerned, Meyerhof showed that the unsaturated fatty acids in the cell are oxidized with the help of the sulphydryl group.
For his discovery of the fixed relationship between the consumption of oxygen and the metabolism of lactic acid in the muscle, Meyerhof was awarded, together with the English physiologist
Meyerhof, Otto Fritz(Site not responding. Last check: 2007-10-15)
For this work he shared the 1922 Nobel Prize for Physiology or Medicine.
Meyerhof introduced the term glycolysis to describe the anaerobic degradation of glycogen to lactic acid, and showed the cyclic nature of energy transformations in living cells.
The complete metabolic pathway of glycolysis is known as the Embden-Meyerhof pathway after Meyerhof and Gustav George Embden (1874-1933).
April 12 - Today in Science History(Site not responding. Last check: 2007-10-15)
OttoFritzMeyerhof was a German biochemist and corecipient, with Archibald V. Hill, of the 1922 Nobel Prize for Physiology or Medicine for research on the chemical reactions of metabolism in muscle.
Meyerhof demonstrated that the production of lactic acid in muscle tissue, formed as a result of glycogen breakdown, was effected without the consumption of oxygen (i.e., anaerobically).
The lactic acid was reconverted to glycogen through oxidation by molecular oxygen, during muscle rest.
www.todayinsci.com /4/4_12.htm (3214 words)
Nobel Peace Prize(Site not responding. Last check: 2007-10-15)
1927 - Heinrich Otto Wieland for his investigations of the constitution of the bile acids and related substances.
1928 - Adolf Otto Reinhold Windaus for the services rendered through his research into the constitution of the sterols and their connection with the vitamins.
- OttoFritzMeyerhof for his discovery of the fixed relationship between the consumption of oxygen and the metabolism of lactid acid in the muscle.
El ascenso del partido nazi obligó a Meyerhof, de origen judío, a emigrar a París, y posteriormente a Estados Unidos.
Meyerhof comprobó que si la contracción muscular se produce en presencia de oxígeno, la glucosa se trasforma en ácido láctico y este, por la presencia del oxígeno, en anhídrido carbónico y agua
Obtuvo el Premio Nobel de Fisiología o Medicina en 1922, compartido con Archibald Vivian Hill