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Topic: Oxidative phosphorylation


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ATP

  
  Mitochondrial Oxidative Phosphorylation Disorders: Inherited Disorders of Metabolism: Merck Manual Professional
Cellular respiration (oxidative phosphorylation) occurs in the mitochondria, where a series of enzymes catalyze the transfer of electrons to molecular oxygen and the generation of energy-storing ATP.
The increase in the lactate:pyruvate ratio distinguishes oxidative phosphorylation defects from other genetic causes of lactic acidosis such as pyruvate carboxylase or pyruvate dehydrogenase deficiency, in which the lactate:pyruvate ratio remains normal.
A large number of oxidative phosphorylation defects have been described; only the most common ones are outlined here, along with their distinguishing features.
www.merck.com /mmpe/sec19/ch296/ch296g.html   (513 words)

  
 Strong increase in the tyrosine phosphorylation of actin upon inhibition of oxidative phosphorylation: correlation with ...
Strong increase in the tyrosine phosphorylation of actin upon inhibition of oxidative phosphorylation: correlation with reversible rearrangements in the actin skeleton of Dictyostelium cells -- Jungbluth et al.
Strong increase in the tyrosine phosphorylation of actin upon inhibition of oxidative phosphorylation: correlation with reversible rearrangements in the actin skeleton of Dictyostelium cells
Phosphorylation of actin Tyr-53 inhibits filament nucleation and elongation and destabilizes filaments
jcs.biologists.org /cgi/content/abstract/107/1/117   (725 words)

  
 blobs.org - resources - Oxidative Phosphorylation   (Site not responding. Last check: 2007-10-26)
Oxidative phosphorylation is a process that occurs inside a part of cells called mitochondria.
For the purposes of explaining oxidative phosphorylation, we are going to concentrate on just the double-membrane part of the structure, but it is important to remember that that's not the full story.
In terms of oxidative phosphorylation, CoQ doesn't have a particularly difficult job - it just moves the hydrogens on along the electron transport chain, but in doing so it effectively 'carries the oxidation along', which is inevitably a very important role.
www.blobs.org /science/metabolism/oxidative.shtml   (1618 words)

  
 MCA 99 Korzeniewski paper
Therefore, the theoretical studies with the dynamic computer model of oxidative phosphorylation suggest that something very important is lacking from our knowledge and that experimental studies should be directed towards discovering the postulated universal effector and regulatory mechanism.
For example, oxidative phosphorylation is regulated in response to changing energy demand in order to adjust the rate of ATP synthesis to current energy demand.
The effect of a decreasing fraction of active mitochondria on the function of oxidative phosphorylation was studied with use of the dynamic computer model of oxidative phosphorylation discussed.
bip.cnrs-mrs.fr /bip10/korzen.htm   (1897 words)

  
 Cellular respiration - Wikipedia, the free encyclopedia
Most of the ATP produced by cellular respiration is by oxidative phosphorylation, ATP molecules are made due to the chemiosmotic potential driving ATP synthase.
The initial phosphorylation of glucose is required to destabilize the molecule for cleavage into two triose sugars.
In eukaryotes, oxidative phosphorylation occurs in the mitochondrial cristae.
en.wikipedia.org /wiki/Cellular_respiration   (1284 words)

  
 Biological Oxidations, Oxidative Phosphorylation
Oxidation of NADH with phosphorylation of ADP to form ATP are processes supported by the mitochondrial electron transport assembly and ATP synthase, which are integral protein complexes of the inner mitochondrial membrane.
Oxidative phosphorylation traps this energy as the high-energy phosphate of ATP.
In order for oxidative phosphorylation to proceed, two principal conditions must be met.
www.indstate.edu /thcme/mwking/oxidative-phosphorylation.html   (3279 words)

  
 Conference 5: Oxidative phosphorylation gluconeogenesis, glycogen metabolism
This causes a diversion of metabolism from oxidative metabolism to glycolysis.
The uncouplers increase the permeability of the inner mitochondrial membrane to protons.
What specific enzyme is the target of protein kinase A? Protein kinase A phosphorylates PFK-2, which inactivates the kinase acitivity and instead causes the activation of its phosphatase activity; the enzyme is converted to fructose-2,6- bisphosphatase.
www.usd.edu /med/biochem/courses/bioc520/b520c5.htm   (1283 words)

  
 oxidative phosphorylation   (Site not responding. Last check: 2007-10-26)
PGC-lalpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Agents that uncouple mitochondrial oxidative phosphorylation are known to cause severe hyperthermia.
Maurer I: Evidence for a mitochondrial oxidative phosphorylation defect in brain from patients with schizophrenia.
www.mongabay.com /igapo/biotech/oxidative_phosphorylation.html   (185 words)

  
 Magnetic Resonance Bio-Oxidative Therapy for Rheumatoid and Other Degenerative Diseases
It is an oxidative therapy by virtue of the increase in oxygen that occurs under the influence of a negative magnetic field.
Oxidative phosphorylation is the process by which humans and other oxygen respiratory organisms produce ATP.
Oxidative phosphorylation is supported and activated by a negative magnetic field.
www.garynull.com /Documents/Arthritis/Magnetic_Resonance_Bio-Oxidative_Therapy.htm   (8190 words)

  
 Biological Oxidations, Oxidative Phosphorylation
Oxidation of NADH with phosphorylation of ADP to form ATP are processes supported by the mitochondrial electron transport assembly and ATP synthase, which are integral protein complexes of the inner mitochondrial membrane.
Oxidative phosphorylation traps this energy as the high-energy phosphate of ATP.
In order for oxidative phosphorylation to proceed, two principal conditions must be met.
web.indstate.edu /thcme/mwking/oxidative-phosphorylation.html   (3279 words)

  
 Glossary: Oxidative phosphorylation   (Site not responding. Last check: 2007-10-26)
Process occurring in the cell, which produces energy and synthesizes ATP (energy carrier of the body).
Oxidative phosphorylation is a biochemical process in cells.
26 of the total 30 ATP (energy carrier) molecules generated from a single glucose molecule during cellular respiration come from oxidative phosphorylation.
www.greenfacts.org /glossary/mno/oxidative-phosphorylation.htm   (242 words)

  
 Oxidative Phosphorylation
For example, oxidative phosphorylation generates 26 of the 30 molecules of ATP that are formed when glucose is completely oxidized to CO and H
Thus, the oxidation of fuels and the phosphorylation of ADP are coupled by a proton gradient across the inner mitochondrial membrane (Figure 18.2).
Oxidative phosphorylation is the culmination of a series of energy transformations that are called cellular respiration or simply respiration in their entirety.
www.ncbi.nlm.nih.gov /books/bv.fcgi?rid=stryer.chapter.2484   (475 words)

  
 The TCA Cycle
The enzymatic activities of the TCA cycle (and of oxidative phosphorylation) are located in the mitochondrion.
Phosphorylation of PDH is catalyzed by a specific PDH kinase.
Mitochondrial GTP is used in a trans-phosphorylation reaction catalyzed by the mitochondrial enzyme nucleoside diphospho kinase to phosphorylate ADP, producing ATP and regenerating GDP for the continued operation of succinyl CoA synthetase.
web.indstate.edu /thcme/mwking/tca-cycle.html   (2336 words)

  
 Measurement of the activation time of oxidative phosphorylation in isolated mouse hearts -- Gustafson and Van Beek 279 ...
of oxidative phosphorylation and the intracellular transport of
In summary, we have presented a technique for the study of myocardial oxidative phosphorylation in the mouse.
The dynamic regulation of myocardial oxidative phosphorylation: analysis of the response time of oxygen consumption.
ajpheart.physiology.org /cgi/content/full/279/6/H3118   (3794 words)

  
 Oxidative Phosphorylation--Overview
Oxidative phosphorylation is the process by which ATP is formed as electrons are transferred from NADH or FADH
Most of the NADH used in oxidative phosphorylation is formed by pathways leading to the formation of pyruvate.
This section is a review of the basic principles needed to understand biological oxidative phosphorylation.
www.db.uth.tmc.edu /faculty/alevine/1521_2000/oxphos1.htm   (712 words)

  
 Oxidative phosphorylation is the process by which ATP is formed as electrons are transferred from NADH or FADH2 to ...
Oxidative phosphorylation is the process by which ATP is formed as electrons are transferred from NADH or FADH2 to molecular oxygen
The structure of the mitochondria is a very important feature of the oxidative phosphorylation process.
See the diagrams in your textbook to review the important properties of the mitochondria with respect to oxidative phosphorylation.
fig.cox.miami.edu /~cmallery/255/255atp/oxphos.htm   (618 words)

  
 Oxidative Phosphorylation
The coupling in oxidative phosphorylation uses a more complicated (and amazing!) mechanism, but the end result is the same: the reactions are linked together, the net free energy for the linked reactions is negative, and, therefore, the linked reactions are spontaneous.
The mitochondrial membranes are crucial for this organelle's role in oxidative phosphorylation.
The ATP synthetase is essential for the phosphorylation to occur (Equation 8).
www.chemistry.wustl.edu /~edudev/LabTutorials/Cytochromes/cytochromes.html   (5202 words)

  
 Oxidative phosphorylation
All living organisms couple the oxidation of foods to the generation of ATP by phosphorylation of adenosine diphosphate (ADP), then utilise the energy contained within the terminal phosphate ester bond to drive other chemical reactions which are themselves energy-requiring, at the same time breaking the terminal phosphate bond to produce ADP again.
Oxidative phosphorylation can be understood qualitatively, which might satisfy most without previous Biochemistry.
Oxidative phosphorylation occurs on the inner mitochondrial membrane.
florey.biosci.uq.edu.au /GMC/oxphos.html   (3049 words)

  
 A model of oxidative phosphorylation in mammaliam skeletal muscle — Portal
Oxidative phosphorylation in mitochondria is the main process responsible for the synthesis of ATP in most animal tissues under most conditions.
The energy required for ATP synthesis in the mitochondria is released by substrate dehydrogenation in the TCA cycle and in the beta-oxidation of fatty acids.
This model was further modified in 1992, in 1996 it was adapted to be specific to intact hepatocytes and in 2001 a model was developed for oxidative phosphorylation in mammalian skeletal muscle.
www.cellml.org /models/korzeniewski_zoladz_2001_version01   (434 words)

  
 Oxidative phosphorylation - Wikipedia, the free encyclopedia
Oxidative phosphorylation is the terminal process of cellular respiration in eukaryotes.
During oxidative phosphorylation electrons are transferred from NADH or FADH
The process occurs across the thylakoid membrane when chlorophyll is energized by light and donates an excited electron to an electron transport chain.
en.wikipedia.org /wiki/Oxidative_phosphorylation   (585 words)

  
 Dynamic adaptation of cardiac oxidative phosphorylation is not mediated by simple feedback control -- van Beek et al. ...
Dynamic adaptation of cardiac oxidative phosphorylation is not mediated by simple feedback control -- van Beek et al.
The aim of the present study was to test the hypothesis that cardiac oxidative phosphorylation is regulated by a simple feedback
Control of oxidative metabolism and oxygen delivery in human skeletal muscle: a steady-state analysis of the work/energy cost transfer function.
ajpheart.physiology.org /cgi/content/full/277/4/H1375   (5915 words)

  
 Chapter 21 - Electron Transport and Oxidative Phosphorylation   (Site not responding. Last check: 2007-10-26)
This potential energy is used to drive the phosphorylation of ATP from ADP.
In eukaryotic cells, electron transport and oxidative phosphorylation are carried out in mitochondria (Fig.
The complexes of electron transport and oxidative phosphorylation are in the folded inner membrane, whose area is enlarged by the cristae, or folds, that extend inward.
nsm1.utdallas.edu /bio/DGray/Syllabi/Fall_03/3361GG21.htm   (1191 words)

  
 SparkNotes: Oxidative Phosphorylation and Electron Transport: Terms
Responsible for establishing an electrochemical gradient across the inner mitochondrial membrane that powers the synthesis of ATP in oxidative phosphorylation.
Most of the ATP needed for daily functioning is produced within its bounds during the citric acid cycle, the electron transport chain, and oxidative phosphorylation.
Oxidative phosphorylation - A process occurring in the intermembrane space of the mitochondria that results in the formation of ATP from the flow of electrons to oxygen.
www.sparknotes.com /biology/cellrespiration/oxidativephosphorylation/terms.html   (277 words)

  
 Oxidative Phosphorylation--Synthesis of ATP
This coupled flow is essential for oxidative phosphorylation to continue.
Oxidative phosphorylation is regulated by the level of ADP.
The [ADP] will increase as ATP is used by the cell so oxidative phosphorylation is coupled to the use of ATP.
www.dentistry.leeds.ac.uk /biochem/uttb/OXPHOS3.HTM   (1366 words)

  
 SparkNotes: Oxidative Phosphorylation and Electron Transport: Mitochondria
Thus, before we begin our discussion of the specific reactions that occur in the electron transport chain and oxidative phosphorylation, it will be helpful to have an understanding of the physical structures of the mitochondria that allow these processes to take place.
A relatively large structure that can occupy a significant amount of the volume of a cell, the mitochondria is a double membrane-bound organelle found in nearly all eukaryotic cells.
It plays a critical role in the conversion of energy through metabolism, and is composed of an outer and inner membrane that divide the structure into two distinct regions--the inner membrane space and the matrix.
www.sparknotes.com /biology/cellrespiration/oxidativephosphorylation/section1.html   (311 words)

  
 Oxidative Phosphorylation--Overview
Oxidative phosphorylation is the process by which ATP is formed as electrons are transferred from NADH or FADH
The respiratory assemblies required for the reactions of oxidative phosphorylation are found on the outer mitochondrial membrane.
This section is a review of the basic principles needed to understand biological oxidative phosphorylation.
www.dentistry.leeds.ac.uk /biochem/uttb/OXPHOS1.HTM   (701 words)

  
 Effect of hypoenergetic feeding on muscle oxidative phosphorylation and mitochondrial complex I-IV activities in rats ...
Effect of hypoenergetic feeding on muscle oxidative phosphorylation and mitochondrial complex I-IV activities in rats -- Madapallimattam et al.
The state 3 oxidative phosphorylation was reduced in proportion
that the reduction in in vitro mitochondrial oxidative phosphorylation
www.ajcn.org /cgi/content/full/76/5/1031   (4972 words)

  
 Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats -- Selak et al. 285 (1): ...
Impaired oxidative phosphorylation in skeletal muscle of intrauterine growth-retarded rats -- Selak et al.
Livnat TM, Chen-Zion M, and Beitner R. Uncoupling of mitochondrial oxidative phosphorylation abolishes the stimulatory action of insulin on the binding of glycolytic enzymes to muscle cytoskeleton.
Application of inhibitors and uncouplers for a study of oxidative phosphorylation.
ajpendo.physiology.org /cgi/content/full/285/1/E130   (5065 words)

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