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Topic: Oxidoreductase


In the News (Tue 29 Dec 09)

  
 [No title]
The pyridine nucleotide-disulphide reductases (PNDR) use the isoalloxazine ring of FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue that is usually a part of a redox-active disulphide bridge.
IPR004099 Pyridine nucleotide-disulphide oxidoreductase dimerisation region 481 - 611
IPR004099 Pyridine nucleotide-disulphide oxidoreductase dimerisation region 380 - 498
www.ebi.ac.uk /interpro/IEntry?ac=IPR001100   (1084 words)

  
  Oxidoreductase - Wikipedia, the free encyclopedia
In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the oxidant, also called the hydrogen donor or electron acceptor) to another (the reductant, also called the hydrogen acceptor or electron donor).
Oxidoreductases are classified as EC 1 in the EC number classification of enzymes.
EC 1.2 includes oxidoreductases that act on the aldehyde or oxo group of donors
en.wikipedia.org /wiki/Oxidoreductase   (467 words)

  
 Method of water purification - Patent 5403450
In order to immobilize oxidoreductases and electron carriers the (activated or non-activated) carrier matrix can be reacted directly with the oxidoreductase or the electron carrier or firstly reacted with a bifunctional spacer molecule to which the oxidoreductase or the electron carrier is coupled in a second step.
Oxidoreductases and the electron carriers which may be present in the cell according to the present invention are for example immobilized directly on the carrier material by cross-linking or via a spacer by means of an epoxy, cyanogen bromide, diisocyanate, carbodiimide glutardialdehyde, EDC or FMP compound.
When the oxidoreductase and, if desired, the electron carriers are immobilized directly on the electrode, reduction or oxidation equivalents can be transferred directly from the electrode body onto the oxidoreductases or, if desired, onto the electron carriers without the necessity for an electrolysis of the water (i.e.
www.freepatentsonline.com /5403450.html   (5336 words)

  
 Hydroxylamine oxidoreductase
Hydroxylamine oxidoreductase (HAO; EC 1.7.3.4) catalyses the four­electron oxidation of hydroxylamine to nitrite (1).
HAO is one of several abundant periplasmic cytochromes c (cyt c) in a nitrifying chemoautotrophic bacterium Nitrosomonas europaea and is a key enzyme in the respiratory chain [1].
Arciero, D.M., Golombek, A., Hendrich, M.P. and Hooper, A.B. Correlation of optical and EPR signals with the P460 heme of hydroxylamine oxidoreductase from Nitrosomonas europaea.
metallo.scripps.edu /PROMISE/HAO.html   (542 words)

  
 NAD(P)H:menadione oxidoreductase of the amitochondriate eukaryote Giardia lamblia: a simpler homologue of the ...
NAD(P)H:menadione oxidoreductase of the amitochondriate eukaryote Giardia lamblia: a simpler homologue of the vertebrate enzyme -- Sánchez et al.
NAD(P)H:menadione oxidoreductase of the amitochondriate eukaryote Giardia lamblia: a simpler homologue of the vertebrate enzyme
oxidoreductase (EC 1.6.99.2) (glQR) that catalyses the two-electron
mic.sgmjournals.org /cgi/content/full/147/3/561   (4390 words)

  
 2-Oxoglutarate:NADP+ Oxidoreductase in Azoarcus evansii: Properties and Function in Electron Transfer Reactions in ...
oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Azoarcus evansii.
Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.
2-Oxoacid:ferredoxin oxidoreductase from the thermoacidophilic archaeon, Sulfolobus sp.
jb.asm.org /cgi/content/full/185/20/6119   (6373 words)

  
 Differential-display polymerase chain reaction identifies nicotinamide adenine dinucleotide-ubiquinone oxidoreductase ...   (Site not responding. Last check: 2007-10-10)
Conclusions: The NADH:ubiquinone oxidoreductase gene is up-regulated during global cardiac ischemia/reperfusion injury during CPB in canines.
The NADH:ubiquinone oxidoreductase gene may have a role in the regulation of molecular changes during the global cardiac ischemia/reperfusion injury during CPB, such as the up-regulation of Bcl-2, which might block release of cytochrome e from the mitochondria and prevent cardiomyocytic apoptosis.
One of the genes isolated by ddPCR was the mitochondrial nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase gene, a mitochondrial respiratory chain gene located in the inner membrane of mitochondria.
findarticles.com /p/articles/mi_m0984/is_1_125/ai_112903403   (906 words)

  
 Recombinant Disulfide Oxidoreductase - ENZ-276   (Site not responding. Last check: 2007-10-10)
This thio/disulfide oxidoreductase is required for efficient disulfide bond formation in the periplasm of E. coli.
Mechanistic implications of the structure of the mixed-disulfide intermediate of the disulfide oxidoreductase, 2-ketopropyl-coenzyme M oxidoreductase/carboxylase.
Insights on a new PDI-like family: structural and functional analysis of a protein disulfide oxidoreductase from the bacterium Aquifex aeolicus.
www.prospec.co.il /~prospec/cart/catalog/rDsbA.html   (477 words)

  
 Pyruvate:Quinone Oxidoreductase from Corynebacterium glutamicum: Purification and Biochemical Characterization -- ...
Pyruvate:Quinone Oxidoreductase from Corynebacterium glutamicum: Purification and Biochemical Characterization -- Schreiner and Eikmanns 187 (3): 862 -- The Journal of Bacteriology
oxidoreductase, the cg2891 gene was amplified from the genome
of pyruvate:quinone oxidoreductase to the detergent was reversible
jb.asm.org /cgi/content/full/187/3/862   (5603 words)

  
 Deficiency, fatty alcohol: NAD+ oxidoreductase definition - Medical Dictionary definitions of popular medical terms
Deficiency, fatty alcohol: NAD+ oxidoreductase: Also known as the Sjogren-Larsson syndrome, this is a genetic (inherited) disease usually characterized by a triad of clinical findings consisting of ichthyosis (thickened fish-like skin), spastic paraplegia (spasticity of the legs) and mental retardation.
The Sjogren of the Sjorgren-Larsson syndrome was Torsten Sjogren (1896-1974), professor of psychiatry at the celebrated Karolinska Hospital in Stockholm and a pioneer in modern psychiatry and medical genetics.
The Sjogren-Larsson syndrome is known variously as SLS; the ichthyosis, spastic neurologic disorder, and oligophrenia (an old word for mental retardation) syndrome; fatty alcohol: NAD+ oxidoreductase deficiency (FAO deficiency); fatty aldehyde dehydrogenase deficiency (FALDH deficiency); and fatty aldehyde dehydrogenase 10 deficiency (FALDH10 deficiency).
www.medterms.com /script/main/art.asp?articlekey=8027   (573 words)

  
 Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease -- Brass et al. ...
Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease -- Brass et al.
Thus NADH-cytochrome c oxidoreductase is a measure of complex I and III function, succinate-cytochrome c oxidoreductase is a measure of the function of complexes II and III, ubiquinol-cytochrome c oxidoreductase is specific for complex III, and cytochrome c-oxygen oxidoreductase (or cytochrome c oxidase) is a measure of complex IV function.
Values for NADH-cytochrome c oxidoreductase, succinate-cytochrome c oxidoreductase, and succinate dehydrogenase were multiplied by 10 to allow plotting of all activities on a single scale.
ajpheart.physiology.org /cgi/content/full/280/2/H603   (3657 words)

  
 Title page for ETD etd-10302005-151207
Both the oxidoreductase and transcriptional regulator genes were transformed into three cercosporin non–degrading bacteria to determine if they are sufficient for cercosporin degradation.
In an effort to determine if the oxidoreductase gene has a role in pathogenesis, quantitative RT–PCR was used to assay for oxidoreductase regulation in XCZ–3 grown in the presence of zinnia and tobacco extracts.
The oxidoreductase gene was upregulated in the presence of both plant extracts, but the response was greater with the tobacco extract.
www.lib.ncsu.edu /theses/available/etd-10302005-151207   (334 words)

  
 Differential Gene Expression of NAD(P)H:Quinone Oxidoreductase and NRH:Quinone Oxidoreductase in Human Hepatocellular ...
the predominant quinone oxidoreductase in liver is NQO2.
Oxidoreductases in carcinoma of the colon and the breast.
Moran JL, Siegel D and Ross D (1999) A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.
molpharm.aspetjournals.org /cgi/content/full/61/2/320   (4308 words)

  
 Aldehyde ferredoxin oxidoreductase family
Enzymes of the aldehyde ferredoxin oxidoreductase (AOR) family [1, 2] contain, as a rule, a tungsten cofactor and an [Fe cluster and catalyse the interconversion of aldehydes to carboxylates (1).
This family includes AOR, formaldehyde ferredoxin oxidoreductase (FOR), glyceraldehyde­3­phosphate ferredoxin oxidoreductase (GAPOR), all isolated from hyperthermophilic archea [2]; carboxylic acid reductase found in clostridia [3]; and hydroxycarboxylate viologen oxidoreductase from Proteus vulgaris, the sole member of the AOR family containing molybdenum [4].
AOR has been proposed to be the primary enzyme responsible for oxidising the aldehydes that are produced by the 2­keto acid oxidoreductases [6].
metallo.scripps.edu /PROMISE/AOR.html   (464 words)

  
 Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications -- Berry ...
Expression of xanthine oxidoreductase in mouse mammary epithelium during pregnancy and lactation: regulation of gene expression by glucocorticoids and prolactin.
Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions.
Xanthine oxidoreductase is asymmetrically localised on the outer surface of human endothelial and epithelial cells in culture.
jp.physoc.org /cgi/content/full/555/3/589   (7504 words)

  
 E0054: Predicting Function In The Short Chain Oxidoreductase Proteome   (Site not responding. Last check: 2007-10-10)
The short chain oxidoreductase (SCOR) family of enzymes includes over 1500 members identified thus far in sequenced genomes.
Over 200 of these enzymes have been functionally characterized and the crystal structures of twenty have been reported.
Variation in the pattern of these quasi-conserved residues controls the details of dimer association and generates subfamilies of aggregated forms.
www.hwi.buffalo.edu /ACA/ACA01/abstracts/text/E0054.html   (376 words)

  
 The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking ...   (Site not responding. Last check: 2007-10-10)
We conducted a hospital-based case-control study of 814 lung cancer patients and 1123 controls to examine the association of the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene polymorphism with lung cancer susceptibility.
Using PCR-RFLP genotyping assay techniques, we analyzed DNA samples to detect the variant forms of the NQO1 gene in exon 6 on chromosome 16q.
The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior.
www.rti.org /abstract.cfm?pubid=2759   (320 words)

  
 Physicochemical and Kinetic Properties of Purified Sheep's Milk Xanthine Oxidoreductase -- Benboubetra et al. 87 (6): ...
Kinetic parameters for xanthine oxidation and NADH oxidation of xanthine oxidoreductase (XOR) purified from sheep’s, human, goats’, and cows’ milks.
Goats’ milk xanthine oxidoreductase is grossly deficient in molybdenum.
Reduction of nitrite to nitric oxide catalysed by xanthine oxidoreductase.
www.dairy-science.org /cgi/content/full/87/6/1580   (2383 words)

  
 The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing ...
The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland -- Vorbach et al.
Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism occurring in most cell types.
Decreased xanthine oxidoreductase is a predictor of poor prognosis in early-stage gastric cancer.
www.genesdev.org /cgi/content/abstract/16/24/3223   (911 words)

  
 TSRI - News and Publications
In most aerobic organisms, the terminal oxidation of foodstuffs, the capture of the energy derived from this oxidation, and the use of the energy for ATP synthesis are accomplished by 5 enzyme complexes, which are associated with the inner membrane of mitochondria in eukaryotes and the plasma membrane in prokaryotes.
We showed that treatment of bovine mitochondrial complex I (NADH:ubiquinone oxidoreductase) with NADH or NADPH, but not with NAD or NADP, increases the susceptibility of a number of subunits to tryptic degradation.
Matsuno-Yagi, A., Hatefi, Y. Ubiquinol:cytochrome c oxidoreductase: The redox reactions of the bis-heme cytochrome b in unenergized and energized submitochondrial particles.
www.scripps.edu /news/sr/sr98/memgen04.htm   (1181 words)

  
 ExactAntigen human genes annotated with oxidoreductase activity
"oxidoreductase activity" is defined by Gene Ontology Consortium as "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.
NDUFB4 also called: adh ubiquinone oxidoreductase b15 subunit, nadh dehydrogenase ubiquinone 1 beta subcomplex 4 15kd b15, nadh dehydrogenase ubiquinone 1 beta subcomplex 4 15kda, ndufb4, mgc5105, b15, cib15
NDUFB6 also called: mgc13675, nadh ubiquinone oxidoreductase b17 subunit, ndufb6, nadh dehydrogenase ubiquinone 1 beta subcomplex 6 17kda, complex i mitochondrial respiratory chain b17 subunit, nadh ubiquinone oxidoreductase beta subunit 6, nadh dehydrogenase ubiquinone 1 beta subcomplex 6 17kd b17, b17
gene-ontology.exactantigen.com /function/oxidoreductase-activity.html   (6798 words)

  
 Differential-Display Polymerase Chain Reaction Identifies Nicotinamide Adenine Dinucleotide-Ubiquinone Oxidoreductase ...
Differential-Display Polymerase Chain Reaction Identifies Nicotinamide Adenine Dinucleotide-Ubiquinone Oxidoreductase as an Ischemia/Reperfusion-Regulated Gene in Cardiomyocytes -- Yeh et al.
NADH:ubiquinone oxidoreductase gene mRNA in cardiac tissue from
Sequenced NADH:ubiquinone oxidoreductase gene ß complex, 8 kd (NDUFB2), are bands at 200 bp.
www.chestjournal.org /cgi/content/full/125/1/228   (3008 words)

  
 NAD(P)H:Quinone Oxidoreductase 1 Expression in Kidney Podocytes -- Zappa et al. 51 (3): 297 -- Journal of ...
Begleiter A, Leith MK (1993) Role of NAD(P)H(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions.
Begleiter A, Robotham E, Leith MK (1992) Role of NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.
Wiencke JK, Spitz MR, McMillan A, Kelsey KT (1997) Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H:quinone oxidoreductase polymorphism.
www.jhc.org /cgi/content/full/51/3/297   (2990 words)

  
 Association of the NAD(P)H:Quinone Oxidoreductase (NQO1) 609C->T Polymorphism with Lung Cancer Risk among Male Smokers ...
Characterization of a polymorphism in NAD(P)H:quinone oxidoreductase (DT-diaphorase).
Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H:quinone oxidoreductase polymorphism.
Polymorphisms in the NAD(P)H:quinone oxidoreductase gene and small cell lung cancer risk in a UK population.
cebp.aacrjournals.org /cgi/content/full/14/9/2275   (1563 words)

  
 Oxidative-stress-inducible qorA encodes an NADPH-dependent quinone oxidoreductase catalysing a one-electron reduction ...
Oxidative-stress-inducible qorA encodes an NADPH-dependent quinone oxidoreductase catalysing a one-electron reduction in Staphylococcus aureus -- Maruyama et al.
Oxidative-stress-inducible qorA encodes an NADPH-dependent quinone oxidoreductase catalysing a one-electron reduction in Staphylococcus aureus
oxidoreductase and demonstrated that the activity was similar
mic.sgmjournals.org /cgi/content/full/149/2/389   (4164 words)

  
 Pyruvate : NADP Oxidoreductase from the Mitochondrion of Euglena gracilis and from the Apicomplexan Cryptosporidium ...
Primary structure and eubacterial relationship of the pyruvate : ferredoxin oxidoreductase of the amitochondriate eukaryote Trichomonas vaginalis.
Mechanism of the Clostridium thermoaceticum pyruvate : ferredoxin oxidoreductase: evidence for the common catalytic intermediacy of the hydroxyethylthiamine pyropyrosphate radical.
Isolation and characterization of the pyruvate : ferredoxin oxidoreductase from the sulfate-reducing bacterium Desulvovibrio africanus.
mbe.oxfordjournals.org /cgi/content/full/18/5/710   (5436 words)

  
 [No title]
GFO is a glucose--fructose oxidoreductase, which converts D-glucose and D-fructose into D-gluconolactone and D-glucitol in the sorbitol-gluconate pathway.
The oxidoreductase, N-terminal domain is almost always associated with the oxidoreductase, C-terminal domain (see IPR004104).
Nurizzo D. Halbig D. Sprenger G.A. Baker E.N. Crystal structures of the precursor form of glucose-fructose oxidoreductase from Zymomonas mobilis and its complexes with bound ligands.
www.ebi.ac.uk /interpro/IEntry?ac=IPR000683   (274 words)

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