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Topic: Oxymetazoline

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Nasal decongestant

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	Oxymetazoline (Nasal) - MayoClinic.com (Site not responding. Last check: 2007-10-12)
		Oxymetazoline (ox-i-met-AZ-oh-leen) is used for the temporary relief of nasal (of the nose) congestion or stuffiness caused by hay fever or other allergies, colds, or sinus trouble.
		Oxymetazoline has not been studied in pregnant women.
		Children may be especially sensitive to the effects of oxymetazoline.
	www.mayoclinic.com /health/drug-information/DR202432 (1153 words)

	cold meds (Site not responding. Last check: 2007-10-12)
		Oxymetazoline (Afrin) is an alpha adrenergic agonist used in non-prescription nasal decongestants.
		There is one case report of excessive use of oxymetazoline nasal spray by a women late in the third trimester of her pregnancy.
		Caution is warranted with the use of oxymetazoline nasal spray in excessive amounts, as it has been associated with bradycardia (irregular heart beat) and hypotension (decreased blood pressure).
	www.genetics.missouri.edu /motis/coldmeds.html (1384 words)

	oxymetazoline nasal - Drug Finder - MSN Health & Fitness (Site not responding. Last check: 2007-10-12)
		Oxymetazoline nasal is used to treat congestion associated with allergies, hay fever, sinus irritation, and the common cold.
		Oxymetazoline nasal should not be used more often than twice a day (every 12 hours).
		Oxymetazoline nasal is available over the counter under may different brand and generic names in nasal spray and nasal drop formulations.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100106555 (1276 words)

	Oxymetazoline (Afrin®)
		Oxymetazoline is used as a temporary nasal decongestant and should only be administered for no more than three days.
		Oxymetazoline should be avoided in animals with heart disease, diabetes, thyroid disorders or high blood pressure.
		Oxymetazoline is available in a 0.05 percent nasal spray or nasal pump.
	www.petplace.com /drug-library/oxymetazoline-afrin/page1.aspx (566 words)

	Fruity flavored nasal decongestant composition - Patent 4970240
		Aqueous, topical, nasal decongestant compositions containing oxymetazoline hydrochloride, the longest acting nasal decongestant currently available, are applied to the nasal passages of mammals especially human beings to affect temporary relief of nasal congestion associated with colds, hay fever and sinusitis.
		Accordingly, the present invention provides an aqueous, flavored, topical nasal, decongestant composition comprising an amount of oxymetazoline or a pharmaceutically acceptable salt thereof sufficient to effect nasal decongestion and an aqueous carrier and an amount of a fruity flavor sufficient to mask the medicinal after-taste of the topical nasal decongestant composition.
		The amount of oxymetazoline or pharmaceutically acceptable salt thereof found sufficient to effect nasal decongestion is in the range of about 0.01% to about 0.1% by weight of the topical nasal decongestant composition.
	www.freepatentsonline.com /4970240.html (1564 words)

	Oxymetazoline (Ophthalmic) - MayoClinic.com (Site not responding. Last check: 2007-10-12)
		Oxymetazoline is available without a prescription; however, your doctor may have special instructions on the proper use of this medicine for your medical condition.
		Ophthalmic oxymetazoline may be absorbed into the body.
		There is no specific information comparing use of oxymetazoline in the elderly with use in other age groups.
	www.mayoclinic.com /health/drug-information/DR202433 (913 words)

	Allergy & Immunology - Researchers have shown how oxymetazoline in nasal spr...
		Oxymetazoline interferes with this process in different ways: on the one hand it inhibits the enzyme 5-lipoxygenase, which is involved in the production of proinflammatory substances - so-called leukotrienes.
		On the other hand oxymetazoline reduces the oxidative stress due to inflammatory reactions accompanying a cold, which damages the cells.
		This was shown by the scientists using stress marker substances in the alveolar macrophages.
	www.newsrx.com /health-articles/428985.html (339 words)

	Ocuclear side effects (Site not responding. Last check: 2007-10-12)
		Oxymetazoline ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.
		Oxymetazoline ophthalmic is used to relieve redness, burning, irritation, and dryness of the eye caused by wind, sun, and other minor irritants.
		Oxymetazoline ophthalmic is in the FDA pregnancy category C. This means that it is not known whether oxymetazoline ophthalmic will be harmful to an unborn baby.
	www.medicationadvisor.com /side_effects/Ocuclear.htm (1684 words)

	Nasal spray compositions exhibiting increased retention in the nasal cavity - Patent 5897858 (Site not responding. Last check: 2007-10-12)
		The aqueous nasal spray composition of claim 1 wherein the moisturizing agent is propylene glycol; the antimicrobial preservative is benzalkonium chloride; the aromatic alcohol is benzyl alcohol; and the buffer is a phosphate buffer.
		Oxymetazoline hydrochloride also reduces blood flow to the muco-secreting cells and as a result reduces nasal secretions.
		The amount of oxymetazoline hydrochloride found sufficient to effect nasal decongestion is from about 0.001 to about 0.2% by wt/vol of the total composition.
	www.freepatentsonline.com /5897858.html (3127 words)

	Oxymetazoline (Afrin)
		Elderly individuals (older than age 60) are more likely to experience side effects and have overdose symptoms, such as hallucinations, convulsions, and central nervous system depression, especially with long-acting products; short-acting products are generally safer for elderly individuals.
		Oxymetazoline may cause heart disturbances, such as abnormal heart rhythm, palpitations, increased heart rate, and increased blood pressure.
		Oxymetazoline may cause headache, lightheadedness, dizziness, tremor, insomnia, nervousness, and other central nervous system (CNS) disturbances.
	www.emedicinehealth.com /oxymetazoline_afrin/page6_em.htm (234 words)

	MedlinePlus Drug Information: Oxymetazoline (Ophthalmic) (Site not responding. Last check: 2007-10-12)
		Oxymetazoline (ox-i-met-AZ-oh-leen) is used to relieve redness due to minor eye irritations, such as those caused by colds, dust, wind, smog, pollen, swimming, or wearing contact lenses.
		However, oxymetazoline has not been shown to cause problems in nursing babies.
		Children—Check with your doctor before using oxymetazoline eye drops in children up to 6 years of age.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202433.html (896 words)

	The Journal of Family Practice
		Nasal congestion is the most common symptom of the common cold, and hundreds of millions of dollars are spent annually on decongestants.
		One placebo-controlled, randomized controlled trial evaluated the effect on mucociliary clearance from adding nasal saline, nasal steroids, or oxymetazoline to antibiotics in acute bacterial sinusitis.
		However, at 3 weeks, the improvement in mucociliary clearance in the oxymetazoline group was not significantly different than in the other groups.
	www.jfponline.com /Pages.asp?AID=1531 (580 words)

	Claritin Eye Allergy Relief on Sympatico / MSN Powered by MediResource
		It is used in eye drops to relieve symptoms of watery and irritated eyes caused by allergic conditions such as hayfever, and other irritations of the eye not caused by infection.
		For adults and children six years of age and older, the recommended dose of oxymetazoline eye drops is 1 or 2 drops into the eye 3 to 4 times daily.
		Medical conditions: Decongestants such as oxymetazoline eye drops should be used with caution by people with difficulty in urination due to enlarged prostate, heart disease, high blood pressure, glaucoma, thyroid disease, or diabetes.
	mediresource.sympatico.ca /drug_detail.asp?brand_name_id=1885&channel_id=139&dowhat=accept_disclaimer (963 words)

	Claritin Allergic Congestion Relief on Sympatico / MSN Powered by MediResource
		It is used in a nasal spray for the relief of symptoms of nasal congestion caused by allergic disorders such as hayfever, sinusitis (inflammation of the sinuses), and year-round allergies.
		The recommended dose of oxymetazoline nasal spray is two or three sprays into each nostril twice a day (every 12 hours).
		Medical conditions: Decongestants such as oxymetazoline nasal spray should be used with caution in people with, enlarged prostate, urinary tract blockage, heart disease, high blood pressure, glaucoma, overactive thyroid, or diabetes.
	mediresource.sympatico.ca /drug_detail.asp?brand_name_id=1886&dowhat=accept_disclaimer (854 words)

	Reversal of Endothelin-1 Release by Stimulation of Endothelial {alpha}2-Adrenoceptor Contributes to Cerebral ...
		Partial recording of three experiments performed on an isolated segment of the rabbit MCA preconstricted with serotonin (5HT, 1 µmol/L) and histamine (HIS, 1 µmol/L) showing the concentration-dependent relaxant effect of oxymetazoline (0.1 to 30 µmol/L) (top), which was abolished by removal of the endothelium using air flow (middle trace).
		Concentration-dependent relaxation induced by oxymetazoline in the absence (control) or in the presence of either ET-1 (0.1 nmol/L) or angiotensin II (A II, 10 nmol/L).
		Oxymetazoline (10 µmol/L) decreased the appearance of ir-ET-1 to 5.2±0.8 pmol/µg
	hyper.ahajournals.org /cgi/content/full/30/4/830 (3457 words)

	Carilion - OXYMETAZOLINE (Nasal) (Spray, Drop) - [Medication]
		You should not use this medicine if you have ever had an allergic reaction to oxymetazoline or to other nasal decongestants.
		You should not use oxymetazoline if you have narrow-angle glaucoma.
		Check with your doctor before using oxymetazoline if you have heart disease, high blood pressure, diabetes, overactive thyroid, or an enlarged prostate.
	www.carilion.com /kbase/htm/mdx-/qudr/279/mdx-qudr279.htm (485 words)

	Effects of Intrathecal alpha 1- and alpha 2-Noradrenergic Agonists and Norepinephrine on Locomotion in Chronic Spinal ...
		agonists clonidine and oxymetazoline markedly reduced or abolished the response to tap in 100 and 67%, respectively,
		agonists, FPS was abolished with clonidine (12 injections), oxymetazoline (5), and tizanidine (3) (Table 3).
		-Noradrenergic agonists (clonidine, tizanidine, and oxymetazoline) and the
	jn.physiology.org /cgi/content/full/79/6/2941 (7633 words)

	Control of Vascular Tone by Endogenous Endothelin-1 in Human Pial Arteries • Editorial Comment -- Thorin et al. 29 ...
		Relaxation mediated by oxymetazoline (0.01 to 30 µmol/L) of human pial arterial segments preconstricted with serotonin (10 µmol/L) in control conditions (n=3), after endothelial removal (-Endo; n=3), or inhibition of NO production with L-NA (100 µmol/L; n=5).
		Relaxation mediated by oxymetazoline (0.01 to 30 µmol/L) of human pial artery segments preconstricted with serotonin (10 µmol/L) after inhibition of NO production with L-NA (100 µmol/L; n=5) alone or combined with the addition of exogenous ET-1 (ET, 1 nmol/L; n=3).
		Effect of TEA (1 mmol/L) and glibenclamide (GLI, 1 µmol/L) on the relaxation induced by oxymetazoline of human pial arteries preconstricted with serotonin (10 µmol/L; n=4 to 6 per group) in the presence of L-NA (l-NA, 100 µmol/L).
	stroke.ahajournals.org /cgi/content/full/29/1/175 (4086 words)

	Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal ...
		Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal spray -- Loewen et al.
		Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal spray
		oxymetazoline associated with thunderclap headache due to reversible
	www.cmaj.ca /cgi/content/full/171/6/593 (853 words)

	Oxymetazoline as an anti-inflammatory drug in nose sprays: Mode of action now clear
		Oxymetazoline as an anti-inflammatory drug in nose sprays: Mode of action now clear
		The active ingredient in nose sprays has so far mainly been known as a substance reducing the swelling of the mucous membrane.
		Oxymetazoline interferes with this process in different ways: on the one hand it inhibits the enzyme 5-lipoxygenase, which is involved in the production of proinflammatory substances — so-called leukotrienes.
	www.innovations-report.com /html/reports/life_sciences/report-76323.html (385 words)

	MedlinePlus Drug Information: Oxymetazoline (Nasal) (Site not responding. Last check: 2007-10-12)
		Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to oxymetazoline or any other nasal decongestant.
		Children—Children may be especially sensitive to the effects of oxymetazoline.
		Other medical problems—The presence of other medical problems may affect the use of oxymetazoline.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202432.html (1136 words)

	Bayer Consumer Care - - Neo-Synephrine FAQs (Site not responding. Last check: 2007-10-12)
		The 4-hour decongestants contain phenylephrine hydrochloride and the 12-hour decongestants contain oxymetazoline hydrochloride.
		When applied directly to the nasal passages, it causes the constriction of blood vessels in the mucous membranes, resulting in their shrinkage; this promotes drainage, thus improving ventilation and relieving congestion.
		Oxymetazoline hydrochloride is a rapidly-acting topical nasal decongestant with a long duration of action which is recognized as safe and effective by the FDA.
	www.bayercare.com /htm/bayerprint2037.htm (531 words)

	Healthopedia.com Drugs Information - Oxymetazoline : Proper Use (Afrin Cherry 12 Hour Nasal Spray, Afrin Extra ...
		Tilt the head back while standing or sitting up, or lie down on a bed and hang the head over the side.
		Dosing—The dose of oxymetazoline will be different for different patients.
		Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
	www.healthopedia.com /drugs/detailed/oxymetazoline-nasal/proper-use.html (578 words)

	Nezeril (oxymetazoline) - treats rhinitis, sinusitis and nasal congestion
		Nezeril (oxymetazoline) - treats rhinitis, sinusitis and nasal congestion
		Nezeril is used to treat rhinitis (inflammation of the mucous membrane of the nose), sinusitis (inflammation of a sinus) and nasal congestion causing nutritional difficulties in infants.
		Any medical information on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.
	www.patienthealthinternational.com /product/2377.aspx (134 words)

	Do nasal decongestants relieve symptoms? - Clinical inquiries: from the Family Practice Inquries Network Journal of ...
		(3) Oxymetazoline was not significantly different from placebo.
		(2.) Inanli S, Ozturk O, Korkmaz M, Tutkun A, Batman C. The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in Me therapy of acute bacterial rhinosinusitis in vivo.
		(3.) Wilklund L, Stierna P, Berglund R, Westrin KM, Tonnesson M. The efficacy of oxymetazoline administered with a nasal bellows container and combined with oral phenoxymethyl-penicillin in the treatment of acute maxillary sinusitis.
	www.findarticles.com /p/articles/mi_m0689/is_9_52/ai_107996917 (742 words)

	Medical Dictionary: Oxymetazoline - WrongDiagnosis.com
		Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion.
		Because many drug names share similar spellings or sound almost identical when spoken, it is possible to mistake the name of a particular medication.
		Other drugs that are sometimes confused with Oxymetazoline include:
	www.wrongdiagnosis.com /medical/oxymetazoline.htm (221 words)

	Arch Otolaryngol Head Neck Surg -- Abstract: Ten Days' Use of Oxymetazoline Nasal Spray With or Without Benzalkonium ...
		Arch Otolaryngol Head Neck Surg -- Abstract: Ten Days' Use of Oxymetazoline Nasal Spray With or Without Benzalkonium Chloride in Patients With Vasomotor Rhinitis, October 1999, Graf et al.
		Ten Days' Use of Oxymetazoline Nasal Spray With or Without Benzalkonium Chloride in Patients With Vasomotor Rhinitis
		Conclusions It is safe to use topical nasal oxymetazoline
	archotol.ama-assn.org /cgi/content/abstract/125/10/1128 (200 words)

	Dissociation of the alpha-adrenergic inhibitory effects on glucagon- and secretin-stimulated bile volume and on cyclic ...
		phenylephrine but not by oxymetazoline, whereas the glucagon-induced cAMP
		increase in the effluent was suppressed by oxymetazoline in a
		oxymetazoline of the effects of glucagon on cAMP production from its effect
	endo.endojournals.org /cgi/content/abstract/116/5/1694 (280 words)

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