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Topic: Oxymorphone

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Morphinone

Oxycodone

Sufentanil

Naloxone

Methadone

Hydromorphone

Opioid

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Hydrocodone

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	Oxymorphone - Wikipedia, the free encyclopedia
		Oxymorphone HCL occurs as odorless white crystals or white to off-white powder.
		One gram of oxymorphone is soluble in 4ml of water and it is slightly soluble in alcohol and ether.
		Oxymorphone overdosage is characterized by respiratory depression, extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension.
	en.wikipedia.org /wiki/Oxymorphone (252 words)

	Oxymorphone HCl
		One gram of oxymorphone HCl is soluble in 4 ml of water and it is sparingly soluble in alcohol and ether.
		Uses/Indications - Oxymorphone is used in dogs and cats as a sedative/restraining agent, analgesic and preanesthetic and occassionally in horses as an analgesic and anesthesia induction agent.
		Oxymorphone should be used with extreme caution in patients with head injuries, increased intracranial pressure and acute abdominal conditions (e.g., colic) as it may obscure the diagnosis or clinical course of these conditions.
	www.elephantcare.org /Drugs/oxymorph.htm (1172 words)

	Oxymorphone
		Oxymorphone is a semi-synthetic agonist with a chemical structure similar to hydromorphone that is a narcotic substitute for morphine.
		It is a potent narcotic analgesic typically used for the relief of moderate to severe pain and also as a preoperative medication to alleviate apprehension, maintain anesthesia, and as an obstetric analgesic.
		Oxymorphone is metabolized to 6-oxymorphol by reduction of the 6-keto group.
	www.sdrl.com /druglist/oxymorphone.html (232 words)

	Numorphan Online, Description, Chemistry, Ingredients - Oxymorphone - RxList Monographs
		NUMORPHAN (oxymorphone hydrochloride, USP), a semi-synthetic opioid substitute for morphine, is a potent analgesic.
		Oxymorphone hydrochloride is a white or slightly off-white, odorless powder, which is sparingly soluble in alcohol and ether, but freely soluble in water.
		The NUMORPHAN Rectal Suppository is available in a concentration of 5 mg of oxymorphone hydrochloride in a base consisting of polyethylene glycol 1000 and polyethylene glycol 3350.
	www.rxlist.com /cgi/generic2/oxymorphone.htm (194 words)

	oxymorphone - Connecticut
		Oxymorphone is habit forming and should only be used under close supervision if you have an alcohol or drug addiction.
		Oxymorphone may cause addiction and withdrawal symptoms as well as other harmful effects in an unborn baby.
		Oxymorphone may also cause addiction and withdrawal symptoms in a nursing infant.
	www.saintfranciscare.com /110825.cfm (1092 words)

	UNODC - Bulletin on Narcotics - 1961 Issue 3 - 001
		Oxymorphone is the generic and proposed international non-proprietary name for 14-hydroxydihydromorphinone.
		Increasing their dose by a third did increase the percentage of satisfactory reports, but this difference might be questioned because with oxymorphone at least it was not greater than the difference in the satisfactory results with morphine in series II and III.
		The differences in systolic pressure were slightly greater for oxymorphone than for morphine or anileridine, but for each of the narcotics the changes were not greatly different from those after placebo, except for the less frequent occurrence with the latter of decreases in pressure of 20 mm Hg or more.
	www.unodc.org /unodc/es/bulletin/bulletin_1961-01-01_3_page002.html (3366 words)

	Boron Tribromide Demethylation of Oxycodone to Oxymorphone - [www.rhodium.ws]
		To maximize yield of oxymorphone, the quenched reaction mixture is advantageously hydrolyzed for a period of time and under hydrolysis conditions sufficient to increase the amount of recoverable oxymorphone present in the reaction medium.
		The aqueous layer was assayed to indicate an 85% yield of oxymorphone and a 15% yield of oxycodone.
		Altogether, 27.2g of oxymorphone and 7.1g of oxycodone are recovered.
	www.erowid.org /archive/rhodium/chemistry/oxymorphone.bbr3.html (1908 words)

	Current Science News - Endo Announces Positive Results From Its Extended-Release Oxymorphone Study (Site not responding. Last check: 2007-10-09)
		Of the patients in the intent-to-treat analysis population, the incidence of adverse events for oxymorphone ER versus placebo was as follows: nausea (11.4% vs. 9%), vomiting (7.6% vs. 1%), constipation (6.7% vs. 1%) and opioid-related CNS effects (11.4% vs. 6%).
		Oxymorphone is a semi-synthetic u-opioid agonist that has been formulated as a 12-hour extended-release (ER) tablet using Penwest Pharmaceuticals' proprietary time-release technology TIMERx(R) delivery system.
		Oxymorphone ER has been studied in a wide range of chronic pain conditions, including low back pain, osteoarthritis pain, post-surgical pain and cancer pain.
	www.lifesciencesworld.com /news/news-6023.htm (847 words)

	vgn-ext-hidden_Abstract (Site not responding. Last check: 2007-10-09)
		Oxymorphone ER is an extended-release formulation of oxymorphone that provides a true 12-hour dosing frequency.
		The mean daily dose of oxymorphone ER was 45.9 mg vs. 91.9 mg for oxycodone CR, confirming an equianalgesic dose ratio of 1:2.
		Establishing the dosage equivalency of oxymorphone extended release and oxycodone controlled release in patients with cancer pain: a randomized controlled study.
	www.asco.org /ac/1,1003,_12-002636-00_18-0023-00_19-00102809,00.asp (588 words)

	Clinical Trial of New Opioid Product Shows Pain Reduction in Chronic Low Back Pain
		Both oxymorphone ER and oxycodone CR were superior to placebo in change from baseline in pain intensity.
		Among the other oxymorphone clinical trial results announced at the APS meeting was a study illustrating the potential clinical utility of treating patients with moderate-to-severe osteoarthritis (OA) pain with oxymorphone ER.
		In this randomized, double-blind, placebo-controlled trial, oxymorphone ER 40 mg and 50 mg both provided statistically significant relief from pain compared to placebo (p=0.012 for 40 mg; p=0.006 for 50 mg).
	www.penw.com /032003.php (1042 words)

	Internet Wire: 20-03-2003 -- Clinical Trial of New Opioid Product Shows Pain Reduction in Chronic Low Back Pain
		Patients in the oxymorphone ER and oxycodone CR groups experienced significantly lower pain intensity scores compared to placebo (p= 0.0001 for oxymorphone ER, p=0.0001 for oxycodone CR).
		Among the other oxymorphone clinical trial results announced at the APS meeting was a study illustrating the potential clinical utility of treating osteoarthritis (OA) patients with oxymorphone ER.
		Data from two oxymorphone ER long-term safety studies, one in 152 osteoarthritis pain patients and another in 44 cancer pain patients, were also presented at APS.
	www.ecureme.com /enews/DB/052163.asp (1182 words)

	FDA Accepts New Drug Application for Oxymorphone Extend Release Formulations
		Oxymorphone ER is an oral extended-release opioid analgesic that was jointly developed with Endo for the treatment of moderate to severe pain in patients requiring continuous, around-the-clock opioid therapy for an extended period of time.
		As previously disclosed, Endo submitted the NDA for oxymorphone ER on December 19, 2002.
		We believe oxymorphone ER will offer physicians and their patients an important new option for managing chronic pain, and will contribute significantly to the approximately $2 billion market for long-acting oral opioids.
	www.penw.com /021903.php (383 words)

	ACS: Low-Dose Oxymorphone Effective for Pain Relief (Site not responding. Last check: 2007-10-09)
		Patients were randomized to either placebo or oxymorphone IR 5 mg and could administer treatment as needed once per hour for up to 8 hours (8 dose maximum).
		In contrast to placebo patients, most patients receiving oxymorphone IR did not require rescue pain medication (P =.0001), and 47% rated oxymorphone IR "very good," or "excellent" for pain relief compared with 25% of placebo patients.
		Low dose oxymorphone IR provided safe and effective treatment for mild to moderate acute pain in ambulatory patients.
	www.pslgroup.com /dg/24744e.htm (495 words)

	Investor's Business Daily: Breaking News
		(PPCO) today announced that Endo Pharmaceuticals Inc., Penwest's partner in the development and commercialization of oxymorphone extended-release tablets (oxymorphone ER), has reported the results from the Phase III clinical trial of this drug, which was conducted under the special protocol assessment (SPA) process of the U.S. Food and Drug Administration (FDA).
		In reporting the results of the study, Endo said that oxymorphone ER was generally well tolerated and that, as expected, the incidence of opioid-related adverse events in the oxymorphone ER group was higher compared to the placebo treatment group.
		Oxymorphone is a semi-synthetic u-opioid agonist that has been formulated as a 12-hour extended-release (ER) tablet using Penwest's proprietary time-release technology TIMERx(R) delivery system.
	www.investors.com /breakingnews.asp?journalid=31106698 (1051 words)

	AAPM: Oxymorphone Extended Release Effective Alternative for Treatment of Osteoarthritis Pain (Site not responding. Last check: 2007-10-09)
		Patients had participated in a previous randomised, double blind trial of oxymorphone ER and were enrolled in a 2-year, open-label multicentre trial of oxymorphone ER every 12 hours.
		The effectiveness of oxymorphone was determined through pain intensity scores (5-point categorical scale and Visual Analog Scale [VAS]) and patients' global assessment at each office visit.
		They concluded that oxymorphone ER is safe and effective and might be a new alternative for osteoarthritis patients with moderate to severe chronic pain who need long-term opioid therapy.
	www.docguide.com /dg.nsf/PrintPrint/9BD36157BA6FC3BF85256E4E006D32CA (421 words)

	PENWEST PHARMACEUTICALS CO - PPCO Quarterly Report (10-Q) Item 2. Management's Discussion and Analysis of Financial ...
		We are developing oxymorphone ER under a collaboration agreement with Endo Pharmaceuticals, Inc. In February 2003, the FDA accepted for filing a New Drug Application, or NDA, for oxymorphone ER.
		We did not incur any expenses relating to oxymorphone ER in the nine months ended September 30, 2004, and we do not expect to incur any significant expenses relating to oxymorphone ER in the fourth quarter of 2004, unless we resume our participation in the funding of the development and marketing of oxymorphone ER.
		If the NDA for oxymorphone ER is not approved on a timely basis or at all, it would have a material adverse effect on our business, financial condition and results of operations.
	sec.edgar-online.com /2004/11/09/0000950135-04-005235/section8.asp (10699 words)

	oxymorphone (Site not responding. Last check: 2007-10-09)
		Is oxymorphone she ask, whos dr. Doctor, i ask if you dont know adam branson wont.
		Clothes on a oxymorphone out on the whole recycling process should be.
		Lives of oxymorphone cult ashes to pass as a oxymorphone affiliate outside.
	fastfox.org /p/oxymorphone (920 words)

	Oxymorphone Extended Release Does Not Affect CYP2C9 or CYP3A4 Metabolic Pathways -- Adams et al. 45 (3): 337 -- The ...
		for oxymorphone and 6-OH-oxymorphone was 0.1 to 20 ng/mL plasma.
		The analgesic equivalence to morphine and relative side action liability of oxymorphone (4-hydroxydihydro-morphinone).
		Adams MP, Ahdieh H. Pharmacokinetics and dose-proportionality of oxymorphone extended release and its metabolites: results of a randomized crossover study.
	jcp.sagepub.com /cgi/content/full/45/3/337 (3289 words)

	Oxymorphone (Site not responding. Last check: 2007-10-09)
		Oxymorphone is a powerful synthetic narcotic analgesic drug that is similar to morphine.
		About Oxymorphone ER Oxymorphone ER is a semi-synthetic u-opioid agonist that has been formulated as a 12-hour extended-release tablet using Penwest Pharmaceuticals' proprietary time-release...
		Intranasal absorption of oxymorphone by Hussain MA, Aungst BJ The DuPont Merck Pharmaceutical...
	fithomepage.freewebpage.org /oxymorphone.htm (625 words)

	The Efficacy and Safety of Oral Immediate-Release Oxymorphone for Postsurgical Pain -- Gimbel and Ahdieh 99 (5): 1472 ...
		The Efficacy and Safety of Oral Immediate-Release Oxymorphone for Postsurgical Pain -- Gimbel and Ahdieh 99 (5): 1472 -- Anesthesia & Analgesia
		All oxymorphone IR doses were superior for providing
		The median dosing interval was >9.5 h for oxymorphone
	www.anesthesia-analgesia.org /cgi/content/abstract/99/5/1472 (295 words)

	QUANTITATIVE CONTRIBUTION OF CYP2D6 AND CYP3A TO OXYCODONE METABOLISM IN HUMAN LIVER AND INTESTINAL MICROSOMES -- ...
		of mediating the oxidation of oxycodone to oxymorphone and noroxycodone
		oxymorphone and noroxycodone in the commercial supply of oxycodone.
		and oxymorphone at 15, 150, and 500 µM oxycodone.
	dmd.aspetjournals.org /cgi/content/full/32/4/447 (5040 words)

	oxymorphone Drug Information
		Or click the first letter of a drug name: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
		Drugs other than those listed here may also interact with oxymorphone.
		Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
	www.drugs.com /MTM/oxymorphone.html (1179 words)

	Oxycodone and Oxymorphone from Codeine
		Now, from the _Pharmaceutical Manufacturing Encyclopedia_ (further info on this volume by request), a procedure is given for converting thebaine to oxymorphone with oxycodone as an intermediate.
		Also from the Merck, oxymorphone is obtained from oxycodone by "boiling with concd.
		Next time I'll go over the conversion of oxycodone to oxymorphone which is super potent and this is even more simple of a reaction.
	www.erowid.org /archive/rhodium/chemistry/oxycodone2.html (2034 words)

	News - Low-Dose Oxymorphone Effective for Pain Relief: Presented at ACS
		Low-Dose Oxymorphone Effective for Pain Relief: Presented at ACS
		The sum of pain intensity difference (VAS) over 0 to 8 hours was -4.2 (plus/minus 180.8) for placebo and 74.8 (plus/minus 127.4) for oxymorphone IR (
		=.0001), and 47% rated oxymorphone IR "very good," or "excellent" for pain relief compared with 25% of placebo patients.
	docguide.com /news/content.nsf/news/8525697700573E1885256F320049AFDA (607 words)

	MedlinePlus Drug Information: Narcotic Analgesics For Pain Relief (Systemic) (Site not responding. Last check: 2007-10-09)
		Keep liquid (including injections) and suppository forms of the medicine from freezing.
		Anesthesia adjunct, opioid analgesic --Butorphanol; Hydromorphone; Levorphanol; Meperidine; Morphine ; Nalbuphine; Oxymorphone; Pentazocine
		USP DI® and Advice for the Patient® are registered trademarks of USP used under license to Micromedex, a business of Thomson Healthcare Inc. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202390.html (4515 words)

	Opioids
		(b) Hydromorphone and oxymorphone have moderate sedative effect
		i) Oxymorphone or hydromorphone alternated with diazepam or midazolam
		(1) Vomiting is less frequent with oxymorphone but may still occur
	www.vasg.org /opioids.htm (601 words)

	The latest news on... OXYMORPHONE
		Click here for the latest news on this API.
		OXYMORPHONE HYDROCHLORIDE Injection 1.5MG/ML NUMORPHAN ENDO 011707 OXYMORPHONE HYDROCHLORIDE Injection 1MG/ML NUMORPHAN ENDO 011738 OXYMORPHONE HYDROCHLORIDE Suppository; Rectal 5MG NUMORPHAN ENDO
		For the most up-to-date approval information, please locate this API using the drug index.
	www.betterchem.com /news/OXYMORPHONE (53 words)

	Chemistry References for opioid analgesics
		Oxycodone -> Oxymorphone using Phosphoric or Sulfuric acid ***
		Oxycodone -> Oxymorphone using KOH and ethylene glycol ***
		N-allyl = opiate antagonists (used to revive overdose victims)
	hive.dopers.org (255 words)

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