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Topic: Oxyntomodulin

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	Teaching Brief - MedPage Today
		Oxyntomodulin is a peptide product of the proglucagon gene released by the L-cells of the small intestine in response to food ingestion, the researchers wrote.
		Oxyntomodulin's name derives from oxyntic cell modifying, as in acid in stomach is slightly lower.
		Oxyntomodulin did not significantly affect insulin, glucose, cholesterol, high-density lipoprotein, ghrelin, or peptide YY levels, the investigators reported.
	www.medpagetoday.com /tbprint.cfm?tbid=1622 (966 words)

	Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled ... (Site not responding. Last check: 2007-10-10)
		Oxyntomodulin was synthesized by Bachem U.K., sterile for culture and negative for pyrogen, as previously described (10).
		In total, 6.9% of all oxyntomodulin injections and 6.6% of all saline injections were reported to cause minor discomfort; thus discomfort did not appear related to the substance injected.
		The use of oxyntomodulin for the treatment of obesity is the subject of two pending patent applications (WO 2003/ 022304 and WO 2004/06285) in the name of Imperial College Innovations, which have been exclusively licensed to Thiakis Limited.
	www.highbeam.com /library/docfree.asp?DOCID=1G1:135181434&ctrlInfo=Round16:Mode16c:DocG:Result&ao= (4463 words)

	Oxyntomodulin
		Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs.
		Oxyntomodulin appears to inhibit food intake both prior to the onset of dark phase, as well as in fasted rats in the am.
		Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial.
	www.glucagon.com /oxyntomodulin.htm (793 words)

	Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled ... (Site not responding. Last check: 2007-10-10)
		Oxyntomodulin treatment resulted in weight loss and a change in the levels of adipose hormones consistent with a loss of adipose tissue.
		Oxyntomodulin is a peptide product of the proglucagon gene released from the L-cells of the small intestine in response to food ingestion (5).
		Oxyntomodulin has been reported to reduce food intake by 19.3% during an intravenous infusion administered to normal-weight humans, an effect that continues for >12 h after infusion (6).
	highbeam.com /library/docfree.asp?DOCID=1G1:135181434&... (4463 words)

	Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double-Blind, Randomized, Controlled ...
		After oxyntomodulin injection, there was a small but significant rise in preprandial insulin (***day 2, P = 0.0004; day 29, P = 0.0008).
		long-term efficacy of oxyntomodulin as an antiobesity therapy.
		The use of oxyntomodulin for the treatment of obesity is the
	diabetes.diabetesjournals.org /cgi/content/full/54/8/2390 (3972 words)

	APOLLOlipids.org -- News -- Gut hormone injections aid weight loss in obese
		Fourteen of the volunteers were randomized in a blinded fashion to self-administered subcutaneous injections of oxyntomodulin 400 nmol, injected 30 minutes before eating, three times a day for 4 weeks.
		Wynne and colleagues report that participants receiving oxyntomodulin therapy lost an average of 2.3 kg, compared with 0.5 kg among control participants, an average additional weight loss of 0.45 kg/week in the active- versus the placebo-treated individuals.
		Indeed, patients taking oxyntomodulin ate around 170 fewer calories than they usually would during the first 3 days of the study, with this figure increasing to 250 fewer calories by week 4.
	www.apollolipids.org /cms/templates/article.aspx?articleid=5261&zoneid=1 (366 words)

	Saga Health News - Jab stops hunger (Site not responding. Last check: 2007-10-10)
		The jabs boost existing levels of oxyntomodulin, which are normally released from the small intestine as food is consumed and signal to the brain that the body is full and has had enough to eat.
		Oxyntomodulin was randomly assigned to 14 of the participants, while the remaining 12 formed a control group using saline shots.
		By the end of the trial, the oxyntomodulin group had dropped an average of 5 lbs and cut calories by an average of 170 kcal after the first injection, rising to 250 kcal at the end of the four weeks.
	www.saga.co.uk /health/pages/article.asp?bhjs=0&articleid=3CF96928-0530-4640-949A-9F79648113DE (463 words)

	Injection of natural hormone promotes weight loss (Site not responding. Last check: 2007-10-10)
		Bloom, of Hammersmith Hospital in London, and colleagues note in the journal Diabetes that oxyntomodulin is one of several gut hormones that have been found to modulate appetite.
		To investigate further, the researchers conducted a study involving 26 overweight or obese volunteers who were randomly assigned to inject oxyntomodulin or inactive saline subcutaneously three times a day, 30 minutes before each meal for 4 weeks.
		The oxyntomodulin group showed changes in levels of the fat-related hormones leptin and adiponectin that indicated a loss of fat.
	www.leadingthecharge.com /stories/news-0063880.html (340 words)

	THIAKIS I News (Site not responding. Last check: 2007-10-10)
		Thiakis is the exclusive licensee from Imperial Innovations of 4 patent families relating to use of the gut hormones oxyntomodulin and PYY 3-36 for the treatment of obesity and associated conditions, based on original research conducted by Professor Steve Bloom and his colleagues at Imperial College London.
		Oxyntomodulin is a hormone naturally produced by specialized cells in the gut in proportion to the calorie content of a meal and is structurally related to glucagon and GLP-1.
		Oxyntomodulin is believed be involved in regulation of the appetite circuits in the hypothalamus.
	www.thiakis.com /news.html (2272 words)

	Daily Health Report (Site not responding. Last check: 2007-10-10)
		Increasing levels of the hormone oxyntomodulin found in the gut could help reduce appetite and increase physical activity in overweight and obese people, new research suggests.
		Increasing the blood level oxyntomodulin, a hormone occurring naturally in the digestive tract, appears to reduce appetite and increase metabolic activity in the overweight.
		They found that after the first meal, the volunteers given oxyntomodulin ate on average 128 kcal or 17.4 percent less, while activity related energy expenditure increased by an average of 143 kcal or 26.2 percent.The researchers also found a reduction in body weight by an average of 0.5 percent.
	www.dhreport.com /archives/m2.html (519 words)

	Imperial College London - Hormone found to decrease appetite and increase activity
		"Oxyntomodulin could work by letting the brain know it has an adequate energy supply and that it can afford to do productive things rather than concentrate solely on food seeking or conserving energy.
		Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial, International Journal of Obesity..
		Consistently rated in the top three UK university institutions, Imperial College London is a world leading science-based university whose reputation for excellence in teaching and research attracts students (11,000) and staff (6,000) of the highest international quality.
	www.ic.ac.uk /P7717.htm (629 words)

	Hormone Injection Curbs Appetite; Leads to Weight Loss - Elites TV - Your Elite News Source
		A study showed that those using oxyntomodulin lost an average of five pounds over a four week period as compared to a loss on only one pound over four weeks for those on placebos.
		Oxyntomodulin is released by the body as food is ingested.
		Those using oxyntomodulin had a lower appetite than those using the saline but they also noticed that their enjoyment of food was not reduced by the injections.
	www.elitestv.com /pub/2005/Jul/EEN42e52f8c07de8.html (367 words)

	BBC NEWS \| Health \| Gut hormone jab aids weight loss
		Oxyntomodulin is normally released from the small intestine as food is consumed.
		In addition to seeing greater weight loss, the group taking oxyntomodulin also had a reduced appetite, but they saw no change in their enjoyment of food.
		Levels of leptin, a protein known to be responsible for regulating the body's energy expenditure, and adipose hormones, which encourage the build up of a type of tissue where fat cells are stored, were also found to be lower in the group having hormone injections.
	news.bbc.co.uk /2/hi/health/4707923.stm (500 words)

	Hormone Shot May Help Weight Loss
		Oxyntomodulin is one of several hormones made by the body that are thought to regulate satiety, or feeling full.
		For four days, each participant injected his or her abdomen with oxyntomodulin or salt water (placebo) before meals.
		Bloom is involved in two patent applications related to oxyntomodulin, the journal states.
	www.webmd.com /content/article/121/114338?src=RSS_PUBLIC (582 words)

	New jab may help people slim down
		Oxyntomodulin, is released from the small intestine as a person eats.
		The study found that after four weeks, the group taking oxyntomodulin reduced their weight by an average of 2.3kg compared to around 0.3kg in the control group.
		They also found that the daily calorie intake in the test group was reduced by an average of 170 calories after the first injection, and by 250 calories at the end of the trial.
	archive.thisiswiltshire.co.uk /2005/7/25/81427.html (404 words)

	RedOrbit - Health - Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double-Blind, ... (Site not responding. Last check: 2007-10-10)
		This study investigated the effect of subcutaneously administered oxyntomodulin on body weight in healthy overweight and obese volunteers.
		Oxyntomodulin has been reported to reduce food intake by 19.3% during an intravenous infusion administered to normal- weight humans, an effect that continues for >12 h after infusion (6).
		The self-administration of subcutaneous oxyntomodulin was well- tolerated by the subjects, and good compliance rates were achieved.
	www.redorbit.com /news/display?id=204195&source=r_healt (4662 words)

	Hormone Oxyntomodulin May Provide the Solution to Obesity \| Weight Loss and Obesity Issues
		An article published in Diabetes, the world's top diabetes research journal, a team from Imperial College London and Hammersmith Hospitals NHS Trust has used injections of oxyntomodulin, a naturally occurring digestive hormone found in the small intestine, to reduce body weight and calorific intake in overweight volunteers.
		The researchers found that over four weeks, injections of oxyntomodulin three times a day in 14 volunteers reduced their body weight by an average of 2.3kg.
		They also found that daily energy intake by the test group was reduced by an average of 170kcal after the first injection, to 250kcal at the end of four weeks.
	www.weight-watch.biz /archives/2005/08/hormone_oxyntom.html (570 words)

	The Albuquerque Tribune: Science
		The hormone, found in the small intestine, is normally released as food is consumed to signal the brain to stop eating.
		Patients with higher levels of oxyntomodulin have also been found to have reduced levels of the appetite hormone leptin and other hormones that encourage the body to store energy as fat.
		"Oxyntomodulin could work by letting the brain know that it has an adequate energy supply and that it can afford to do productive things rather than concentrate on food-seeking or conserving energy," he explained.
	www.abqtrib.com /albq/nw_science/article/0,2668,ALBQ_21236_4657759,00.html (666 words)

	BBC NEWS \| Health \| New way to treat obesity heralded
		Boosting oxyntomodulin limits appetite and raises activity levels at the same time - leading to speedy but healthy weight loss rates, a UK study suggests.
		The fact that oxyntomodulin was naturally found in the body was also an advantage as it was unlikely to have unpleasant side-effects, he said.
		And there do not appear to be any harmful effects of having high levels of oxyntomodulin, he said pointing to some medical conditions that produce this.
	news.bbc.co.uk /2/low/health/4946574.stm (609 words)

	Oxyntomodulin (Site not responding. Last check: 2007-10-10)
		Oxyntomodulin (OXM) is a circulating gut hormone released post prandially from cells of the gastrointestinal mucosa in proportion to energy intake.
		Only Oxyntomodulin and GLP-1 have proven biological activity; Oxyntomodulin probably interacts with GLP-1 and glucagon receptors, although with lower affinity than GLP-1 itself, to effect a reduction in food intake.
		A 4-week subcutaneous adminstration of Oxyntomodulin three times a day in obese and overweight subjects in a randomised controlled double blind study was shown to reduce food intake with a decrease in body weight by
	www.guthormones.co.uk /Oxyntomodulin.htm (423 words)

	billingsgazette.com
		Despite the short trial length, he said, the hormone - called oxyntomodulin - is promising because it appears to lack the side effects seen in other anti-obesity drugs.
		Oxyntomodulin is naturally produced in the human intestine and is released when the stomach becomes full.
		For example, Bloom has previously found that oxyntomodulin levels in the blood are above normal in patients who have undergone gastric bypass surgery.
	www.billingsgazette.com /newdex.php?display=rednews/2005/07/25/build/health/40-obesity-test.inc (402 words)

	Life Extension Daily News
		The injections boost the body's existing levels of oxyntomodulin, which is normally released as food is consumed, signalling to the brain that the body is full and has had enough to eat.
		A total of 26 volunteers took part in the four-week trial, with 14 given oxyntomodulin jabs and a control group of 12 given saline injections.
		The researchers found that after four weeks, the group taking oxyntomodulin reduced their weight by an average of 2.3kg, compared to around 0.3kg in the control group.
	www.lef.org /news/LefDailyNews.htm?NewsID=2500&Section=NUTRITION (316 words)

	Pharmacy Times: Hormone Injection May Facilitate Weight Loss
		Researchers randomly injected oxyntomodulin or placebo before meals to 26 obese and overweight patients 3 times a day, 30 minutes prior to mealtime for 4 weeks.
		In the oxyntomodulin group, body weight decreased by 5 lb versus 1 lb in the placebo group.
		The oxyntomodulin group ate less, but their perception of their meals did not change.
	www.pharmacytimes.com /article.cfm?ID=2791 (157 words)

	Nubella - Solution to Obesity in Stomach?
		But his study suggests that boosting the hormone oxyntomodulin would create a double whammy: limiting appetite while raising the urge to get physically active.
		"Oxyntomodulin could work by letting the brain know it has an adequate energy supply and that it can afford to do productive things rather than concentrate solely on seeking food or conserving energy," Bloom said.
		Bloom's findings back up earlier studies that showed oxyntomodulin decreased appetite, but his research was the first link to increased physical activity - a critical factor in weight loss and long-term management.
	www.nubella.com /content/view/1870/44 (632 words)

	Health News
		The team gave injections of oxyntomodulin to 15 overweight but healthy volunteers aged 23 to 49, and monitored how this affected their food intake and levels of activity.
		The volunteers completed three separate four-day study sessions, where they self-administered either saline or oxyntomodulin according to a randomised protocol.
		They found that after the first meal, the volunteers given oxyntomodulin ate on average 128 kcal or 17.4 percent less, while activity related energy expenditure increased by an average of 143 kcal or 26.2 percent.
	www.sutterdelta.org /health/healthinfo/reutershome_top.cfm?fx=article&id=29020 (605 words)

	eMedicine News
		Researchers at Imperial College London believe the treatment, an injection of a natural digestive hormone called oxyntomodulin that is released in the small intestine, could help to stem the world's growing obesity epidemic.
		Oxyntomodulin injections were associated with "transient mild nausea" in 3 percent of occasions, compared with 0.2 percent with placebo injections.
		Bloom and his colleagues, who reported their findings in the journal Diabetes, said it was still early and more research needs to be done.
	www.emedicine.com /cgi-bin/foxweb.exe/newsitem@/em/news?name=20050725elin021.xml (454 words)

	National Library for Health - News & RSS Article
		The objective was to investigate the effect of regular injections of oxyntomodulin on body weight in healthy overweight and obese individuals.
		Healthy male and female volunteers, aged between 18 and 55 years, were randomised to self-administer either oxyntomodulin (400nmol/dose) or saline injections three times daily 30 minutes prior to every meal.
		Those receiving injections of oxyntomodulin reduced their body weight by an average of 2.3kg compared to 0.5kg in the control group.
	www.library.nhs.uk /rss/newsAndRssArticle.aspx?uri=http://www.library.nhs.uk/resources/?id=95315 (755 words)

	Feeding effects of the gut hormones ghrelin, peptide YY3-36 and oxyntomodulin in lean and obese mice
		The gastric hormone ghrelin stimulates feeding whereas the intestinal hormones peptide YY) and oxyntomodulin inhibit feeding.
		Oxyntomodulin also inhibited food intake in lean and obese fasted mice.
		Thus the stimulatory feeding effect of ghrelin appears to be lost in dietary-induced obesity in the mouse whereas the inhibitory effects of PYY
	www.endocrine-abstracts.org /ea/0009/ea0009oc24.htm (328 words)

	Imperial College London - New treatment that boosts the stomach's 'full' signal offers new way of tackling growing ... (Site not responding. Last check: 2007-10-10)
		The injections boost existing levels of oxyntomodulin, normally released from the small intestine as food is consumed, signalling to the brain that the body is full and has had enough to eat.
		The treatment group of 14 self administered oxyntomodulin 30 minutes before each meal, three times a day, over a period of four weeks.
		Subcutaneous oxyntomodulin reduces body-weight in overweight and obese subjects: a double blind randomised controlled trial.
	www.imperial.ac.uk /P6704.htm (737 words)

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