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Topic: P27

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	Center News - 5/20/04 - Cancer protein p27 may alter cell migration
		p27 initially earned its greatest fame among cancer biologists for its effects on cell division, which is also a key function that is disrupted in tumors.
		The p27 protein was originally identified as a tumor suppressor, a type of protein that normally acts to prevent cells from dividing.
		He observed that p27 interacts with a key controller of a cell’s microscopic skeleton, or cytoskeleton, which is repeatedly broken down and reassembled as a cell inches along its path to a new destination.
	www.fhcrc.org /pubs/center_news/2004/may20/sart2.html (859 words)

	Thyrotropin and Serum Regulate Thyroid Cell Proliferation through Differential Effects on p27 Expression and ...
		p27 shuttles between the nucleus and cytoplasm (38, 39).
		B, p27 localization in quiescent cells stimulated with TSH (T), serum (CS), or TSH/serum (T/CS) for 15 h in the same experiment as panel A. DAPI staining of the same fields is shown (left panels).
		export of p27 from the nucleus temporally preceded its degradation.
	mend.endojournals.org /cgi/content/full/18/9/2321 (5668 words)

	Constitutive MEK/MAPK Activation Leads to p27Kip1 Deregulation and Antiestrogen Resistance in Human Breast Cancer Cells ...
		by phosphorylation of p27 on threonine 187 (Thr-187) by cyclin
		gene are uncommon (9, 10), p27 degradation is increased in
		A and B, the 2D-IEF patterns of immunoprecipitated p27 (A) or cyclin E1-bound p27 (B) were assayed in MCF-7 and LY-2 cells after 48 h of treatment with ICI, and in LY-2 cells after 48 h treatment with both ICI and UO126.
	www.jbc.org /cgi/content/full/276/44/40888 (6263 words)

	Early Cycling-independent Changes to p27, Cyclin D2, and Cyclin D3 in Differentiating Mouse Embryonal Carcinoma Cells ...
		The effect of cell density on the expression of p27 in nondifferentiated EC cells.
		was focused on the phenomenon of coexpression of p27 and D-type
		The effect of overexpression of p27 on the level of cyclin (cyc) D3 and vice versa in EC cells.
	cgd.aacrjournals.org /cgi/content/full/13/9/421 (6358 words)

	p21 Functions to Maintain Quiescence of p27-deficient Hepatocytes -- Kwon et al. 277 (44): 41417 -- Journal of ...
		Expression of p21 and p27 in livers of wild-type mice and mice deficient for p21 or p27.
		Tyramide-amplified indirect immunostaining was used to examine p27 and p21 expression in livers of adult male mice.
		Reproducible increases in Cdk2 and PCNA protein levels were detected in extracts from livers of mice deficient for p27.
	www.jbc.org /cgi/content/full/277/44/41417 (4261 words)

	An Adenovirus Expressing Mutant p27 Showed More Potent Antitumor Effects Than Adenovirus-p27 Wild Type -- Park et al. ...
		Lung cancer cells transduced with ad-p27wt and ad-p27mt produced large amounts of p27 proteins that were indistinguishable by the p27 antibody.
		The p27 monoclonal antibody was specific for the NH portion of p27 that was unchanged in p27mt.
		that mutation of Thr-187 to Val of p27
	cancerres.aacrjournals.org /cgi/content/full/61/16/6163 (4478 words)

	Loss of p16 Contributes to p27 Sequestration by Cyclin D1-Cyclin-dependent Kinase 4 Complexes and Poor Prognosis in ...
		of p27 in hepatocellular carcinoma (HCC), we immunohistochemically
		that p27 is a promising adverse prognostic factor (2).
		Analysis of p27 expression in HCCs by immunohistochemical staining in representative tissue samples and by Western blot.
	clincancerres.aacrjournals.org /cgi/content/full/9/9/3389 (4223 words)

	Expression of Phosphorylated p27Kip1 Protein and Jun Activation Domain-Binding Protein 1 in Human Pituitary Tumors -- ...
		Detection of Jab1 (lane 1), p27 (lane 2), and P-p27 (lane 3) in whole-tissue extract from a pituitary adenoma (38.5 kDa, Jab1; 27 kDa, p27).
		p27 staining was observed in the nuclei of the pituitary cells.
		shuttles p27 from the nucleus to the cytoplasm.
	jcem.endojournals.org /cgi/content/full/87/6/2635 (5920 words)

	Anomalous High p27/KIP1 Expression in a Subset of Aggressive B-Cell Lymphomas Is Associated With Cyclin D3 ...
		p27 cyclin-dependent kinase inhibitor downregulation is essential for transition to the S phase of the cell cycle.
		Cyclin D3 expression in benign lymph nodes and reactive tonsils was mainly observed in large lymphocytes, either in the germinal center or in the interfollicular area (Fig 1B).
		An association between high p27 expression and overexpression of cyclin D3 is the main result of this study.
	www.bloodjournal.org /cgi/content/full/94/2/765 (5465 words)

	p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers -- Lloyd et ...
		The cells were homogenized and analyzed for p27 by Western blotting using a monoclonal antibody (Transduction Laboratories, Lexington, KY) and enhanced chemiluminescence (Amersham, Arlington Heights, IL).
		C: Normal and neoplastic breast tissue with strong staining for p27 in normal mammary ducts whereas the invasive carcinoma cells are mostly negative.
		Poon RY, Toyoshima H, Hunter T: Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.
	ajp.amjpathol.org /cgi/content/full/154/2/313 (7213 words)

	ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR -- Kullmann et al. 16 (23): 3087 -- Genes ...
		A p27 IRES in a mouse macrophage cDNA
		This decline is paralleled by an increase in p27
		Millard, S.S., Vidal, A., Markus, M., and Koff, A. A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.
	www.genesdev.org /cgi/content/full/16/23/3087 (7046 words)

	Epstein-Barr Virus Nuclear Antigen 3C Regulates Cyclin A/p27 Complexes and Enhances Cyclin A-Dependent Kinase Activity ...
		p27 coimmunoprecipitated strongly with cyclin A from the lysates
		BJAB cells and BJAB cells stably expressing EBNA3C were lysed, precleared with normal rabbit serum and protein A beads, and then immunoprecipitated with antibody reactive to p27.
		Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.
	jvi.asm.org /cgi/content/full/78/4/1981 (6080 words)

	Melissa's Knit Dishcloth Pattern (Site not responding. Last check: 2007-11-01)
		Row 50: (WS) K4 then P27, then K4 Rows 51-57: Garter Stitch (Knit all rows) binding off on Row 57.
		Row 18: (WS) K4, then P27 then K4 Row 19: K4 then K7, P2, K1, P2, K2, P2, K1, P3, K7 then K4.
		Row 27: K4 then K6, P13, K8 then K4 Row 28: (WS) K4, then P27 then K4.
	home.earthlink.net /~oscarsdotter/id2.html (4201 words)

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