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Topic: P53

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	P53 - Wikipedia, the free encyclopedia
		p53, also known as tumor protein 53 (TP53), is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor.
		Tetramerization greatly increases the activity of p53 in vivo.
		The p53 gene was first cloned in 1983 by Moshe Oren (Weizmann Institute).
	en.wikipedia.org /wiki/P53 (1239 words)

	P53 (Protein 53 kDa) (Site not responding. Last check: 2007-10-13)
		P53 is mutated in 30% of breast cancers; preferentially observed in advanced and aggressive forms; probably a late event; hotspots at codons 175, 248, and 273.
		P53 is mutated in 50% of oesophagus cancers (70% in squamous cell carcinoma and 45% of adenocarcinoma); probably an early event; hotspots at codons 175, 248 and 273.
		The p53 pathway is inactivated by the E6 protein that binds and inactivates the p53 protein.
	www.infobiogen.fr /services/chromcancer/Genes/P53ID88.html (1397 words)

	[4] p53
		The major regulator of p53 is Mdm2, which can trigger the degradation of p53 by the ubiquitin system.
		p53 is a transcriptional activator, regulating the expression of Mdm2 (for its own regulation) and the genes involved in growth arrest, DNA repair and apoptosis.
		The roles of p53 in growth arrest and apoptosis are illustrated in Figure 4-H-6.
	www.web-books.com /MoBio/Free/Ch4Hp53.htm (605 words)

	[No title] (Site not responding. Last check: 2007-10-13)
		In fact, p53 mutations that inactivate its function is associated with about 50% of colon cancers and at least 30% of all other cancers.
		News suggesting that p53 is not one but a series of slightly different proteins (same shirt but different colors) will actually help in cancer treatment.
		To think that p53 and thousands of others have such power is neat- for lack of a better word.
	www.aloismd.com /archives/2005/08/p53.php (692 words)

	Molecule of the Year: p53 (Site not responding. Last check: 2007-10-13)
		When a mutation in the p53 gene results in the substitution of one amino acid for another, p53 loses its ability to block abnormal cell growth.
		Almost 50% of human cancers contain a p53 mutation -- including cancers of the breast, cervix, colon, lung, liver, prostate, bladder, and skin -- and these cancers are more aggressive, more apt to metastasize, and more often fatal.
		Since p53 is part of a fundamental pathway in human cell growth, researchers are looking for ways to use it for the diagnosis, prevention, and cure of cancers associated with p53 mutations.
	agham.asti.dost.gov.ph /3rd/inside/extras/p53_mole.html (300 words)

	p53 (Site not responding. Last check: 2007-10-13)
		The gene for p53 is located on the short arm of chromosome 17 at 17p13.105-p12.
		The structure of p53 consists of a large beta-sandwich which encompasses 3 loop-based elements and is composed of 2 anti-parallel beta-sheets encompassing 4 and 5 beta-strands, respectively.
		In the June 1, 1996 issue of The Journal of Immunology, Boehme et al described that T cell blasts derived from mice containing a germ-line deficiency of the p53 tumor suppressor gene were susceptible to TCR-induced apoptosis to the same degree as the wild-type T cells.
	www.bioscience.org /news/scientis/p53.htm (586 words)

	p53 - tumor suppressor protein
		If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood.
		However, mutations in p53 are found in most tumor types, and so contribute to the complex network of molecular events leading to tumor formation.
		Mutant p53 can no longer bind DNA in an effective way, and as a consequence the p21 protein is not made available to act as the 'stop signal' for cell division.
	www.ncbi.nlm.nih.gov /disease/p53.html (288 words)

	p53, "Molecule of the Year" (Site not responding. Last check: 2007-10-13)
		The p53 gene was originally discovered in 1979 by Arnold Levine of Princeton University (now a member of HHMI's Scientific Review Board in Genetics), David Lane of the University of Dundee, Scotland (now an HHMI International Research Scholar), and William Old of the Memorial Sloan-Kettering Cancer Center in New York City.
		In its normal form, p53 acts to stop cell division whenever it senses that a cell's DNA is damaged, thus giving the cell a chance to repair the DNA before its errors are duplicated and passed on to daughter cells.
		The p53 found in normal cells acts as a transcription factor, a protein that binds to a particular DNA sequence and regulates its expression, Vogelstein reported, but the mutant forms of p53 seen in colorectal cancers have lost this function.
	www.hhmi.org /annual95/b140.html (1098 words)

	p53: Keeping Cancer in Check (Site not responding. Last check: 2007-10-13)
		The p53 protein is a tumor suppressor encoded by a gene whose disruption is associated with approximately 50 to 55 percent of human cancers.
		The p53 protein acts as a checkpoint in the cell cycle, either preventing or initiating programmed cell death.
		The p53 tumor suppressor and its surrounding molecules are now the focus of thousands of studies in laboratories around the world.
	www.rockefeller.edu /pubinfo/p53.html (233 words)

	Tumor Suppressors (Site not responding. Last check: 2007-10-13)
		However, the wild-type p53 protein suppresses the activity of mutant alleles of p53 which are the oncogenic forms of p53.
		The mutant p53 proteins were shown to be altered in stability and conformation as well as binding to hsp70.
		Sequences at the N-terminus of the p53 protein function as a transcription activator indicating the role of p53 in the transcription of genes involved in suppression of cell growth.
	web.indstate.edu /thcme/mwking/tumor-suppressors.html (3447 words)

	Aberrant p53 Expression Correlates With Expression of Vascular Endothelial Growth Factor mRNA and Interleukin-8 mRNA ...
		exons 5 to 8 of the p53 gene
		Sigal A, Rotter V: Oncogenic mutation of the p53 tumor suppressor: the demons of the guardian of the genome.
		Carbone DP, Mitsudomi T, Chiba I, et al: p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer: A preliminary report of LCSG 871.
	www.jco.org /cgi/content/full/20/4/900 (6574 words)

	Expanding complexity of p53 (Site not responding. Last check: 2007-10-13)
		While further research is needed to delineate how the various p53 isoforms affect p53 tumor suppressor activity, the scientists did establish that some p53 isoforms can modulate p53 transcriptional activity and p53-induced cell death.
		Lane and colleagues observed that p53 isoforms are abnormally expressed in breast tumors presenting no mutation of the p53 gene.
		David Lane and Jean-Christophe Bourdon, group leader in David Lane's laboratory, consider the discovery of p53 isoforms to be "a major breakthrough in the understanding of cancer formation.
	www.eurekalert.org /pub_releases/2005-08/cshl-eco082905.php (199 words)

	PUMA protein coordinates the cell-suicide activities of p53 in the nucleus and cytoplasm
		PUMA travels from the nucleus to the cytoplasm to free p53 from the grip of Bcl-xL, allowing p53 to trigger signaling on mitochondria that leads to cell death, according to St. Jude
		The accumulation of p53 in the cytoplasm and nucleus each contribute to apoptosis, but until this finding, scientists did not know these contributions were linked.
		After p53 is liberated, it triggers a series of signals on the cell's mitochondria-tiny membrane-bound capsules of enzymes that produce the energy-rich molecules required for cellular activities.
	www.eurekalert.org /pub_releases/2005-09/sjcr-ppc090805.php (933 words)

	Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following ...
		Expression of exogenous p53 mRNA and p53-targeted gene mRNA (p21, MDM2, Noxa, and p53AIP1) 24 h after Ad-p53 infection in vitro was measured by the real-time quantitative PCR assay.
		Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer.
		The 1993 Walter Hubert Lecture: the role of the p53 tumor-suppressor gene in tumorigenesis.
	mct.aacrjournals.org /cgi/content/full/3/1/93 (4408 words)

	Control of p53 Ubiquitination and Nuclear Export by MDM2 and ARF -- Zhang and Xiong 12 (4): 175 -- Cell Growth & ...
		ARF reversed the inhibition of p53 acetylation by MDM2 and induced
		MDM2 in the nucleolus, releasing p53 from MDM2 inhibition (Refs.
		Notably, p53 colocalized with the PODs in response to oncogenic
	cgd.aacrjournals.org /cgi/content/full/12/4/175 (8679 words)

	p53-Independent Functions of MDM2 -- Ganguli and Wasylyk 1 (14): 1027 -- Molecular Cancer Research
		The tumor suppressor p53 is inactivated by overexpression of
		The p53 protective function after UV irradiation in the basal layer is unaltered.
		Blattner, C., Sparks, A., and Lane, D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53.
	mcr.aacrjournals.org /cgi/content/full/1/14/1027 (5530 words)

	Pfam 19.0 : P53 (Site not responding. Last check: 2007-10-13)
		This domain is found in p53 transcription factors, where it is responsible for DNA-binding.
		These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis PUBMED:12826037.
		The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex PUBMED:11780147.
	pfam.wustl.edu /cgi-bin/getdesc?name=P53 (133 words)

	P53 Oncoprotein antibodies from RDI Divison of Fitzgerald Industries Intl
		In man the p53 gene is located on the small arm of chromosome 17.
		Alterations to the p53 tumour suppressor gene are a common feature of human malignancies, a normal function which, is to induce apoptosis after DNA damage and so its inactivation can permit the survival of cells that have sustained genetic damage.
		CBL 773 reacts with the human form of p53 protein at an epitope within the core region between amino acids 250 and 270 which is located between conserved domain IV and V on an exposed turn of the protein structure.
	www.researchd.com /tumorabs/cbl240x.htm (1266 words)

	Adenovirus E1-transformed cells grow despite the continuous presence of transcriptionally active p53 -- Löber et ...
		a significant proportion of p53 molecules is not inhibited in
		Chen, J., Lin, J. and Levine, A. Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene.
		Lin, J., Chen, J., Elenbaas, B. and Levine, A. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
	vir.sgmjournals.org /cgi/content/full/83/8/2047 (6339 words)

	Regulation of the p53 Tumor Suppressor Protein -- Oren 274 (51): 36031 -- Journal of Biological Chemistry
		As described later, induction of the p53 response upon stress occurs largely through alterations in the p53 protein.
		The p53 protein binds to the mdm2 gene and activates its transcription.
		Finally, both p53 and Mdm2 may also be subject to other types of modifications.
	www.jbc.org /cgi/content/full/274/51/36031 (4183 words)

	p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA ...
		Miller,S.D., Moses,K., Jayaraman,L. and Prives,C. (1997) Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA.
		Jin,S., Martinek,S., Joo,W.S., Wortman,J.R., Mirkovic,N., Sali,A., Yandell,M.D., Pavletich,N.P., Young,M.W. and Levine,A.J. (2000) Identification and characterization of a p53 homologue in Drosophila melanogaster.
		Ko,L.J., Shieh,S.Y., Chen,X., Jayaraman,L., Tamai,K., Taya,Y., Prives,C. and Pan,Z.Q. (1997) p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
	carcin.oxfordjournals.org /cgi/content/full/22/6/851 (7383 words)

	IARC TP53 DATABASE - Welcome
		The database is meant to be a source of information on TP53 mutations for a broad range of scientists and clinicians who work in different areas:
		The next p53 meeting will be held in New York, May 20-24 2006.
		The p53 Knowledgebase has been launched in October 2005.
	www-p53.iarc.fr (247 words)

	ScienceDaily: PUMA Protein Coordinates The Cell-suicide Activities Of p53 In The Nucleus And Cytoplasm (Site not responding. Last check: 2007-10-13)
		ScienceDaily: PUMA Protein Coordinates The Cell-suicide Activities Of p53 In The Nucleus And Cytoplasm
		Proof That PUMA Stalks Cancer Cells Solves Long-standing Mystery Of The Anti-cancer Role Of P53 (November 3, 2003) -- A team of scientists led by investigators at St. Jude Children's Research Hospital has demonstrated that the p53 gene, long considered to be a central conductor of the process by which abnormal cells...
		CK2 Protein Sustains Colon Cancer Cells By Sabotaging Ability To Commit Suicide (March 4, 2005) -- A protein called CK2 plays a deadly role in colorectal carcinoma by blocking the ability of these tumors to activate a natural self-destruct mechanism that would clear this cancer from the...
	www.sciencedaily.com /releases/2005/09/050909074827.htm (1384 words)

	Genetics Glossary P (Site not responding. Last check: 2007-10-13)
		P53 is involved in regulating the activity of some other genes (eg.
		P53 levels are increased after DNA is damaged by UV and ionizing radiation and cells are arrested in cell division until either the damage is repaired or they die by apoptosis (programmed cell death).
		The site on the ribosome occupied by the peptidyl-tRNA just before peptide bond formation.
	helios.bto.ed.ac.uk /bto/glossary/p.htm (2512 words)

	p53
		Hirata H, Cadet JL.: Methamphetamine-induced serotonin neurotoxicity is attenuated in p53 knockout mice.
		The p53 targeting vector was constructed by insertion of the 3.7-kb
		The first one, vector pCPR3.1 used to generate clone R72 was created by ligation of a
	www.bioscience.org /knockout/p53.htm (374 words)

	p53 Soussi Mutation Database Cancer
		the p53 database section has been temporarily closed
		GO DIRECTLY TO THE UMD SITE (p53 ONLINE ANALYSIS TOOLS)
		Everything you always wanted to know about p53 but were afraid to ask....
	p53.free.fr (31 words)

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