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	Press release : NICOX CompanynewsGroup
		PAOD is associated with a high level of morbidity with an estimated 30% of patients expected to die within five years of PAOD diagnosis.
		Chronic PAOD is a marker of widespread atherosclerosis, and patients with intermittent claudication must be considered a high-risk population for the development of clinical manifestations of cardiovascular diseases.
		In fact, the principal symptom of PAOD is leg pain during walking (intermittent claudication) due to a reduction of blood flow in lower limb arteries leading to cyclic episodes of ischemia during walking followed by reperfusion during rest.
	www.companynewsgroup.com /communique.asp?co_id=97032&l=9 (609 words)

	Development of new peripheral arterial occulsive disease in patients with type 2 diabetes during a mean follow-up of 11 ... (Site not responding. Last check: 2007-10-21)
		Of the 21 patients with PAOD at baseline, 11 were deceased (52%), and progression was seen in 4 of the remaining 10 patients (19%).
		PAOD was bilateral in 13 of 21 patients (62%) at baseline.
		Objectively verified PAOD was seen in 59% of the 22 patients reporting claudication, whereas a history of claudication was reported by 62% of 21 patients with verified PAOD.
	highbeam.com /library/docfree.asp?DOCID=1G1:100192812&... (3153 words)

	Peripheral artery occlusive disease - Wikipedia, the free encyclopedia
		In medicine (vascular surgery), peripheral artery occlusive disease (PAOD, also known as peripheral vascular disease or PVD) is a collator for all disease caused by the obstruction of large peripheral arteries, which can result from atherosclerosis, inflammatory processes leading to stenosis, an embolism or thrombus formation.
		Upon suspicion of PAOD, the first-line test is the ankle brachial pressure index (ABPI/ABI) which is a measure of the fall in blood pressure in the arteries supplying the legs.
		Many PAOD patients also have angina pectoris or have had myocardial infarction.
	en.wikipedia.org /wiki/Peripheral_vascular_disease (585 words)

	ADVANCE for LPNs Online \| Editorial
		PAOD is characterized by stenosis or occlusion of a peripheral artery by an atherosclerotic plaque, resulting in inadequate muscle perfusion and ischemia.
		Patients with PAOD may be as physically limited as patients with class II or III heart failure.
		Dyslipidemia is as prevalent in patients with PAOD as in patients with coronary artery disease.
	lpn.advanceweb.com /common/editorial/editorial.aspx?CC=35863 (2260 words)

	Exercise Daily
		PAOD is characterized by atherosclerotic plaques in the arteries of the leg that can slowly starve muscle of needed nutrients and oxygen.
		The researchers will follow such markers as the growth of new capillaries in leg muscles, the occurrence of programmed cell death (apoptosis) within leg muscle, and blood levels of vascular progenitor cells, which are produced in the bone marrow and are responsible for blood vessel repair.
		Patients who are interested in enrolling in the PAOD trial should contact Leslie Kelly, recruitment coordinator, at (919) 660-6739 or Kelly045@mc.duke.edu.
	www.exercisedaily.org /cgi-bin/details.pl?article_id=534 (818 words)

	VasoCare Therapy Approved In Europe For Blocked Peripheral Arteries (Site not responding. Last check: 2007-10-21)
		PAOD is a serious cardiovascular condition that affects millions of people in Europe and North America.
		Therapies for PAOD have been limited to marginally-effective drugs and surgical intervention in the form of bypass surgery, angioplasty or amputation in later stages.
		PAOD is the leading cause of approximately 200,000 lower limb amputations performed in Europe and North America each year.
	www.docguide.com /dg.nsf/PrintPrint/FEDB789086232CE18525659B0052E35A (409 words)

	NCX 4016 - Peripheral Arterial Obstructive Disease (PAOD)
		Normally, the first symptom of PAOD is intermittent claudication, a disabling pain on walking which can be relieved by rest.
		The disease is believed to be caused by atherosclerosis and diabetes, which leads to the dysfunction of the endothelium in the lower limbs and decreases the ability of the arteries to adequately supply the increased demand for oxygen that occurs in the muscles during exercise.
		The primary objective of the study was to evaluate the clinical efficacy of NCX 4016 in PAOD and the primary endpoint was the change in maximal treadmill walking distance (absolute claudication distance) after six months, where NCX 4016 showed a non-significant advantage over placebo (p=0.276).
	www.nicox.com /update/NCX_4016.html (1032 words)

	eMedicine - Peripheral Arterial Occlusive Disease : Article by Vincent Lopez Rowe, MD
		PAOD is most common with the distal superficial femoral artery (located just above the knee joint), which corresponds to claudication in the calf muscle area (the muscle group just distal to the arterial disease).
		The risk factors for PAOD are the same as those for coronary artery disease or cerebrovascular disease and include diabetes, hypertension, hyperlipidemia, family history, sedentary lifestyle, and tobacco use.
		Palpation of pulses should be attempted from the abdominal aorta to the foot, with auscultation for bruits in the abdominal and pelvic regions.
	www.emedicine.com /med/topic391.htm (3674 words)

	PRESS RELEASE NicOx announces results of a phase 2 trial for NCX 4016 in PAOD (Site not responding. Last check: 2007-10-21)
		The disease is believed to be caused by atherosclerosis and dysfunction of the endothelium in the lower limbs, which decreases the ability of the arteries to adequately supply the increased demand for oxygen that occurs in the muscles during exercise.
		These results are a disappointment for PAOD patients, as current therapies are associated with only modest efficacy and there is a clear need for more effective drugs.
		However, PAOD is known to be an extremely challenging area for clinical development, due to the high variability in the course of the disease and the marked placebo effect that is expected in any study."
	www.marketwire.com /mw/release_html_b1?release_id=101091 (937 words)

	Lower-Extremity Peripheral Arterial Disease among Patients with End-Stage Renal Disease -- O’Hare and Johansen 12 ...
		PAOD are at increased risk for hospital admission (7), death
		Intermittent claudication, the earliest symptom of PAOD, is
		of PAOD among patients with incident ESRD was 14.9% (3).
	jasn.asnjournals.org /cgi/content/full/12/12/2838 (6071 words)

	Ostomy Wound Management - Topics in Wound Care
		Fifty-four patients with various stages of PAOD were evaluated; ICCs were as follows: 0.98 (same observer/same day measures), 0.89 (same observer/measures separated by 1 week), 0.92 (different observers/same day measures), and 0.87 (different observers/measures separated by 1 week).
		The ABI is not always reliable in individuals with PAOD who have distal lower extremity arterial calcification.8,13 High cuff pressures are required to occlude calcified vessels during ankle systolic pressure evaluation.
		Early PAOD detection with the noninvasive vascular tests may be valuable for preventive purposes.
	www.o-wm.com /article/81 (3187 words)

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	uk.geocities.com /sex969otc/paod-and-birth-control-pills.htm (378 words)

	Noninvasive Vascular Laboratory for Evaluation of Peripheral Arterial Occlusive Disease: Part II--Clinical ...
		of PAOD at or proximal to the pneumatic cuff of the extremity
		waveform to infer the absence of upstream PAOD in arterial segments
		The depressed toe brachial index of 0.32 is indicative of severe PAOD, although the absolute second toe pressure of 46 mm Hg would suggest probable adequate vascular supply to heal the skin ulcer.
	www.jvir.org /cgi/content/full/11/10/1257 (10029 words)

	Development of New Peripheral Arterial Occlusive Disease in Patients With Type 2 Diabetes During a Mean Follow-Up of 11 ...
		RESULTS— PAOD was diagnosed in 21 (16%) patients at baseline.
		At baseline, 21 of 130 patients (16%) had PAOD (Table 1).
		Baseline PAOD was strongly associated with cardiovascular mortality
	care.diabetesjournals.org /cgi/content/full/26/4/1241 (2825 words)

	Preclinical models of human peripheral arterial occlusive disease: implications for investigation of therapeutic agents ...
		of PAOD is impaired perfusion to the lower extremity.
		The primary pathophysiology of PAOD is impaired perfusion to
		In humans, PAOD is largely a bilateral disease (23, 24).
	jap.physiology.org /cgi/content/full/97/2/773 (5435 words)

	Dyslipoproteinemia and Peripheral Arterial Occlusive Disease -- Kröger 55 (2): 135 -- Angiology
		Peripheral arterial occlusive disease (PAOD) is common in older
		PAOD is associated with an increased risk of vascular events
		associated with PAOD are improved by this treatment.
	ang.sagepub.com /cgi/content/abstract/55/2/135 (154 words)

	Effects of Exercise and Ischemia on Mobilization and Functional Activation of Blood-Derived Progenitor Cells in ... (Site not responding. Last check: 2007-10-21)
		Amount of CPCs in blood samples of training (circles) and control (triangles) patients with ischemic PAOD (A), patients with nonischemic PAOD (B), and patients with CAD (C) was analyzed weekly after resting period of at least 72 hours.
		Improvement in functional capacity of CPCs after ET was demonstrated in patients with ischemic PAOD (A), patients with nonischemic PAOD (B), and patients with CAD (C).
		Level of VEGF in blood samples of training (circles) and control (triangles) patients with ischemic PAOD (A), patients with nonischemic PAOD (B), and patients with CAD (C) was analyzed weekly after resting period of at least 72 hours.
	circ.ahajournals.org /cgi/content/full/111/25/3391 (4709 words)

	Soluble Fas is a marker of peripheral arterial occlusive disease in haemodialysis patients -- Masse et al. 17 (3): 485 ...
		PAOD was defined by the presence of either lower-extremity vascular
		The association between prevalence of PAOD and sFas was assessed
		associated with the presence of PAOD on univariate analysis.
	ndt.oxfordjournals.org /cgi/content/full/17/3/485 (3274 words)

	Serum Hepatocyte Growth Factor in Patients with Peripheral Arterial Occlusive Disease -- Yoshitomi et al. 84 (7): 2425 ...
		Serum HGF concentrations in control subjects (n = 40) and patients with PAOD (n = 37).
		The source of circulating HGF was not determined in this study.
		Thus, HGF may serve as a marker for PAOD.
	jcem.endojournals.org /cgi/content/full/84/7/2425 (2568 words)

	International Union of Angiology: scientific society for the advancement of research in angiology. (Site not responding. Last check: 2007-10-21)
		Apart from the scientific meetings, staff physicians of the Department of Vascular Diseases at the University of Ljubljana Medical Center have held regular educational courses on the essentials of vascular medicine (PAOD, venous thrombosis, antiplatelet and anticoagulation treatment) for physicians specializing in family medicine.
		At present, in Slovenia the essentials of vascular medicine are taught to residents in internal medicine as part of their ìcommon trunkî training in the second year, and later in more detail as part of the cardiology- vascular medicine training.
		In 2002, the Slovenian Society for Vascular Diseases has collected data clearly showing that patients with PAOD are undertreated in Slovenia.
	www.i.u.angiology.org /anglais/news.html (8824 words)

	Role of Hemostatic Risk Factors for Restenosis in Peripheral Arterial Occlusive Disease After Transluminal Angioplasty ...
		to the severity of PAOD, independent of the outcome.
		Repeated Measurements of Hemostatic Variables in Relation to the Severity of PAOD
		and the severity of PAOD were taken together as categorical
	atvb.ahajournals.org /cgi/content/full/17/11/3208 (3788 words)

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