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Platelet-derived growth factor - Wikipedia, the free encyclopedia Platelet-derived growth factor (PDGF) is one of the numerous proteins that regulate cell growth and division. PDGF was one of the first growth factors characterized, and has led to an understanding of the mechanism of many growth factor signaling pathways. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand-induced receptor dimerization and autophosphorylation. en.wikipedia.org /wiki/Platelet-derived_growth_factor   (362 words)

PDGF Signaling Group The aim of the work in the PDGF signaling group is to elucidate the mechanism of signal transduction downstream of the receptors for platelet-derived growth factor (PDGF), and to connect the individual signaling pathways activated with the cellular effects of PDGF, i.e. The T-cell phosphatase preferentially dephosphorylates pY1021 of the PDGF ß receptor. PDGF receptor signaling is implicated in various cancer associated processes, including autocrine stimulation of growth, stimulation of tumor fibroblasts and promotion of tumor angiogenesis. www.licr.uu.se /groups/PDGF/index.html   (1671 words)

Expression of Platelet-Derived Growth Factor (PDGF) in the Epididymis and Analysis of the Epididymal Development in ... of PDGF A- and B-chain and PDGF receptor (PDGFR) testis, mRNAs for PDGF A- and B-chain and PDGFR RT-PCR of PDGF and PDGFR mRNA expression in postnatal mouse epididymis. www.biolreprod.org /cgi/content/full/70/1/168   (4943 words)

PDGF Receptor Protein Tyrosine Kinase Expression in the Balloon-Injured Rat Carotid Artery -- Panek et al. 17 (7): 1283 ...   (Site not responding. Last check: 2007-10-08) Autophosphorylation of the PDGF ß receptor tyrosine kinase PDGF receptors were immunoprecipitated with PDGF receptor polyclonal antibodies directed against the ß receptor isoform and Western blotted with anti-rat PI-3 kinase polyclonal antibody. PDGF receptors immunoprecipitated from injured rat carotid arteries atvb.ahajournals.org /cgi/content/full/17/7/1283   (4168 words)

PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries -- Dobrian et al. 276 ... PDGF-A expression correlates with blood pressure and remodeling in 1K1C hypertensive rat arteries -- Dobrian et al. Bands corresponding to PDGF-A (305 bp) and GAPDH (171 bp) were quantified by densitometry, and results were expressed as ratios of relative optical density (OD) ± SE. PDGF ligand and receptor gene expression during repair of arterial injury. ajpheart.physiology.org /cgi/content/full/276/6/H2159   (4693 words)

Expression of Platelet-Derived Growth Factor-A (PDGF-A), PDGF-B, and PDGF Receptor-{alpha} and -{beta} during Human ... A- and B-chains and of the PDGF receptor (PDGFR) In the 20-wk-old fetal testis the PDGF A-chain immunoreactivity PDGFs and PDGFRs in infancy and puberty, we speculate that the jcem.endojournals.org /cgi/content/full/87/5/2310   (6365 words)

Leydig Cell Loss and Spermatogenic Arrest in Platelet-derived Growth Factor (PDGF)-A-deficient Mice -- Gnessi et al. ... PDGF-A, a high-affinity ligand for the receptor tyrosine kinase At E17.5 PDGF-A expression is seen in the tubular epithelium in the testis and in the epididymis (asterisk), but not in the interstitial mesenchyme (A, low magnification view; C, high magnification view of the testicular section shown in A). PDGF-A staining is localized in the seminiferous epithelium of all the testicular tubules at P18 (A) and in a subset of tubules (spermatogenic stages IX-X) and some interstitial cells at P42 (B). www.jcb.org /cgi/content/full/149/5/1019   (4427 words)

PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase -- Liu et al. 274 (5): 702 -- ... Although PDGF is considered to be a major mitogen for mesenchymal tissues, it regulates a variety of other biological processes. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Phospholipase C- 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. ajplung.physiology.org /cgi/content/full/274/5/L702   (5418 words)

Involvement of PDGF in pressure-induced mesangial cell proliferation through PKC and tyrosine kinase pathways -- Kato ... Quiescent MC were subjected to a pressure of 80 mmHg for 1 h in absence or presence of indicated concentration of a neutralizing antibody against PDGF (10, 100, and 1,000 ng) (left) or bFGF (10, 100, and 1,000 ng) (right). Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically-mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. ajprenal.physiology.org /cgi/content/full/277/1/F105   (4426 words)

Upregulation of the PDGF-alpha Receptor Precedes Asbestos-induced Lung Fibrosis in Rats -- LASKY et al. 157 (5): 1652 ... PDGF isoforms are potent mitogens (4) and chemoattractants Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Lipopolysacharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms. ajrccm.atsjournals.org /cgi/content/full/157/5/1652   (4009 words)

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-{alpha}{alpha} and ... Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-{alpha}{alpha} and -{alpha}{beta} receptors -- CAO et al. Soriano, P. (1997) The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. The Role of PDGF Receptor Inhibitors and PI3-Kinase Signaling in the Pathogenesis of Corneal Neovascularization www.fasebj.org /cgi/content/full/16/12/1575   (5753 words)

Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level -- ... Pirfenidone inhibits PDGF isoforms in bleomycin hamster model of lung fibrosis at the translational level -- Gurujeyalakshmi et al. Human recombinant PDGF-A, PDGF-B, and BALF samples were electrophoresed on 4-20% Tris-glycine gels and electroblotted onto polyvinylidene difluoride membrane. mRNAs and PDGF isoforms are elevated in BL-treated hamster lungs. ajplung.physiology.org /cgi/content/full/276/2/L311   (4675 words)

Bradykinin B1 receptor blocks PDGF-induced mitogenesis by prolonging ERK activation and increasing p27Kip1 -- Dixon et ... It demonstrates that stimulation with PDGF produced a more rapid mobility band characteristic of the phosphorylated active form of Cdk2 and this was blocked by treatment with DABK (30). Cdk2 is constitutively present in cells and depends on an increase in cyclin E and cyclin A for its activation. PDGF or DABK tended to decrease expression of p27Kip1, and this ajpcell.physiology.org /cgi/content/full/283/1/C193   (7121 words)

Platelet-derived Growth Factor (PDGF) Receptor-{alpha}-activated c-Jun NH2-terminal Kinase-1 Is Critical for ... After 16 h of transfection, cells were cultured in serum-free medium for 36 h and then treated with 0 (A and D) and 25 ng/ml PDGF AA (B and E) or 25 ng/ml of PDGF BB (C and F) for 3 h. After 16 h of transfection, cells were serum-deprived for 36 h and treated with 25 ng/ml PDGF AA or PDGF BB for 3 h. After 16 h of transfection, cells were cultured in serum-free medium for 36 h and treated with 0 or 25 ng/ml PDGF BB for 3 h. www.jbc.org /cgi/content/full/278/49/49582   (4613 words)

Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF {beta}-receptor null mice -- ... PDGF is a potent stimulant of mesenchymal cell proliferation, PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. www.bloodjournal.org /cgi/content/full/97/7/1990   (4814 words)

Functional Properties of Hyalocytes under PDGF-Rich Conditions -- Noda et al. 45 (7): 2107 -- Investigative ... PDGF receptor expression by cultured hyalocytes and its activation In contrast, autophosphorylation of PDGF receptor ß reached its maximum level within 2 minutes and declined thereafter. To confirm the protein levels of PDGF receptors, the membrane was reprobed with antibodies against PDGF receptors. www.iovs.org /cgi/content/full/45/7/2107   (4164 words)

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas ... PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo of an autocrine loop comprising of PDGF and its receptors (Guha Hart, I.K., Richardson, W.D., Heldin, C.H., Westermark, B., and Raff, M.C. PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage. www.genesdev.org /cgi/content/full/15/15/1913   (7106 words)

PDGF Mediates Cardiac Microvascular Communication -- Edelberg et al. 102 (4): 837 -- Journal of Clinical Investigation PDGF AB neutralization in vivo was performed by the embryonic injection of antibody similar to the previously described injection Cardiac myocyte induction of endothelial PDGF B. The potential for PDGF to be involved in the induction of cardiac microvascular gene expression was explored in vitro. PDGF B expression by cardiac microvascular endothelial cells is induced in the presence of cardiac myocytes. www.jci.org /cgi/content/full/102/4/837   (4080 words)

Human Cytokine Data Sheets (Platelet Derived Growth Factor BB) available through RDI Divison of Fitzgerald Industries ... The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. www.researchd.com /cytokines/rdi114.htm   (693 words)

Retina-Specific Expression of PDGF-B Versus PDGF-A: Vascular Versus Nonvascular Proliferative Retinopathy -- Mori et ... Retina-Specific Expression of PDGF-B Versus PDGF-A: Vascular Versus Nonvascular Proliferative Retinopathy -- Mori et al. In rho/PDGF-A mice, increased expression of PDGF-A in photoreceptors (1992) PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage Development 115,535-551 www.iovs.org /cgi/content/full/43/6/2001   (4101 words)

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall -- Lindblom et al. ... Klinghoffer, R.A., Mueting-Nelsen, P.F., Faerman, A., Shani, M., and Soriano, P. The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. LaRochelle, W.J., May-Siroff, M., Robbins, K.C., and Aaronson, S.A. A novel mechanism regulating growth factor association with the cell surface: Identification of a PDGF retention domain. Pietras, K., Rubin, K., Sjoblom, T., Buchdunger, E., Sjoquist, M., Heldin, C.-H., and Östman, A. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. www.genesdev.org /cgi/content/full/17/15/1835   (3726 words)

Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors ...   (Site not responding. Last check: 2007-10-08) PDGF-A can be alternatively spliced and carries two stop codons resulting in proteins of 198 and 211 amino acid residues. PDGF-A and -B. The motifs are identified as proteolytic cleavage Raines EW, Lane TF, Iruela-Arispe ML, Ross R and Sage EH (1992) The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF) -AB and – BB and inhibits the binding of PDGF to its receptors. content.febsjournal.org /cgi/content/full/272/22/5723   (9060 words)

In vivo chemotactic properties and spatial expression of PDGF in developing mesenteric microvascular networks -- Zeller ... The PDGF family of growth factors consists of homodimers (PDGF-AA and PDGF-BB) or heterodimers (PDGF-AB) that are synthesized The purpose of this study was to investigate the potential role of PDGF in mediating perivascular cell recruitment during Kamiyama, K, Iguchi I, Wang X, and Imanishi J. Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. ajpheart.physiology.org /cgi/content/full/280/5/H2116   (5225 words)

Angiotensin-Converting Enzyme Inhibition Abolishes Medial Smooth Muscle PDGF-AB Biosynthesis and Attenuates Cell ...   (Site not responding. Last check: 2007-10-08) PDGF-A peptides in injured and uninjured carotid arteries of animals treated with perindopril or vehicle. PDGF-A and PDGF-B mRNA expression in injured vessels (Fig 9 Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-ß. circ.ahajournals.org /cgi/content/full/96/5/1631   (5611 words)

Human Cytokine Data Sheets (PDGF-AB ) Platelet Derived Growth Factor AB from RDI Divison of Fitzgerald Industries Intl Description: Platelet Derived Growth Factor (PDGF) is a potent mitogen for a wide range of cell types including fibroblasts, smooth muscle and connective tissue. PDGF, which is composed of a dimer of two chains termed the A chain and B chain, can be present as AA or BB homodimers or as an AB heterodimer. Human PDGF-AB is a 25.5 kDa homodimer protein consisting of 13.3 kDa A chain and 12.2 B chain. www.researchd.com /cytokines/rdi1000.htm   (369 words)

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors -- Li et al. ... Benjamin, L.E., Hemo, I., and Keshet, E. A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF- B and VEGF. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. www.jci.org /cgi/content/full/115/1/118   (5854 words)

PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis ... PDGF-C is a new protease-activated ligand for the PDGF-a receptor. PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle. Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts. www.bloodjournal.org /cgi/content/full/104/10/3198   (4898 words)

Platelet-derived Growth Factor (PDGF)-induced Ca2+ Signaling in the CG4 Oligodendroglial Cell Line and in Transformed ... PDGF is mitogenic and chemotactic for several cell types, that the oscillatory Ca response induced by PDGF is a peculiarity of oligodendroglia. PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors www.jbc.org /cgi/content/full/272/7/4351   (5066 words)

Induction of the Lung Myofibroblast PDGF Receptor System by Urban Ambient Particles from Mexico City -- Bonner et al. ... Induction of the Lung Myofibroblast PDGF Receptor System by Urban Ambient Particles from Mexico City -- Bonner et al. Induction of the Lung Myofibroblast PDGF Receptor System by Urban Ambient Particles from Mexico City Platelet-derived growth factor (PDGF) is a major mitogen and chemoattractant for cells of mesenchymal origin that has been ajrcmb.atsjournals.org /cgi/content/full/19/4/672   (4289 words)

Epigallocathechin-3 Gallate Selectively Inhibits the PDGF-BB-induced Intracellular Signaling Transduction Pathway in ...   (Site not responding. Last check: 2007-10-08) Beckman, M.P., Betzholz, C., Heldin, C.-H., Westermark, B., DiMarco, E., DiFiore, P.P., Robbins, K.C., and Aaronson, S.A. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Hoppe, J., Weich, H.A., and Eichner, W. Preparation of biologically active PDGF type BB from a fusion protein expressed in Escherichia coli. Imai, K., and Nakachi, K. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. www.molbiolcell.org /cgi/content/full/10/4/1093   (5691 words)

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