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Topic: PI3k

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	PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration -- ...
		PI3K, v-P3k or Myr-P3k, was sufficient to induce actin filament
		of PI3K in the reorganization of actin filaments and the induction
		PI3K is sufficient to induce actin filament remodeling.
	ajpcell.physiology.org /cgi/content/full/286/1/C153 (5943 words)

	Activities of Phosphoinositide Kinase-3 (PI3K)
		PI3K is inhibited by wortmannin, a fungal metabolite, which is an inhibitor of the lipid and protein kinase activities of the heterodimeric enzyme.
		PI3K was fond to coprecipitate with Ras, which suggests that PI3K could be acting either as an affector or as a regulator of Ras.
		PI3K is thought to down regulate cell apoptosis by effecting Protein Kinase B activity which is believed to be the cell signaler that inhibits apoptosis.
	wwwchem.csustan.edu /chem4400/SJBR/angel99.htm (2271 words)

	PI3K signaling in the murine kidney inner medullary cell response to urea -- Zhang et al. 278 (1): 155 -- AJP - Renal ...
		PI3K signaling in the murine kidney inner medullary cell response to urea -- Zhang et al.
		PI3K signaling in the murine kidney inner medullary cell response to urea
		Phosphatidylinositol-3 kinase (PI3K), a phosphoinositide kinase, is a heterodimer comprising regulatory (p85) and catalytic
	ajprenal.physiology.org /cgi/content/full/278/1/F155 (5515 words)

	Phosphatidylinositol 3-Kinase Is a Negative Regulator of Cellular Differentiation -- Ptasznik et al. 137 (5): 1127 -- ...
		The activity of PI3K was inversely correlated with the hepatocyte
		We measured DNA synthesis in fetal ICCs cultured in the presence of the PI3K inhibitors.
		PI3K inhibitor-treated cells is not secondary to nonspecific blockade
	www.jcb.org /cgi/content/full/137/5/1127 (5821 words)

	Transformation by v-Src: Ras-MAPK and PI3K-mTOR Mediate Parallel Pathways -- Penuel and Martin 10 (6): 1693 -- ...
		PI3K phosphorylates inositol lipids at the D-3 position of the inositol ring (Liscovitch and Cantley, 1994
		Scanning densitometry indicated that LY294002 reduced the level of phospho-Akt to 47% (lane 5) or 60% (lane 6) of the level in untreated cells expressing empty vector (lane 1) (mean of two determinations).
		MEK and mTOR as Downstream Mediators of Ras and PI3K
	www.molbiolcell.org /cgi/content/full/10/6/1693 (6505 words)

	Phosphoinositide 3-Kinase Activation Regulates Cell Division Time by Coordinated Control of Cell Mass and Cell Cycle ...
		PI3K is an enzyme that transfers phosphate to the 3-position
		NIH 3T3 cell lines, stably transfected as indicated, were cultured in DMEM with 10% CS and harvested, and cell diameter and volume were measured using a particle size counter.
		PI3K regulates the TSC complex and TOR (7, 30–32),
	www.jbc.org /cgi/content/full/278/29/26466 (4880 words)

	The Class II Phosphoinositide 3-Kinase PI3K-C2alpha Is Concentrated in the Trans-Golgi Network and Present in ...
		Since it is widely considered that the class IA PI3K enzymes are intimately involved in signal transduction at the plasma
		The class II PI3K isozymes are distinguished by the presence of two adjacent domains in their carboxyl terminus.
		Identification of PI3K isozymes responsible for driving vesicular traffic from the mammalian TGN has proved somewhat elusive.
	www.jbc.org /cgi/content/full/275/16/11943 (5358 words)

	Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial ...
		Transfectants were grown in methyl cellulose for 3 wk in the absence or presence of PI3K inhibitor.
		PI3K activity is increased in tumor cells as a result of aberrant signaling from cell–ECM and cell–growth factor receptor interactions.
		by, up-regulation of the PI3K antagonist, PTEN (Fig.
	www.jcb.org /cgi/content/full/164/4/603 (6058 words)

	Retinoic Acid Induces Selective Expression of Phosphoinositide 3-Kinase {{gamma}} in Myelomonocytic U937 Cells -- Baier ...
		correlated with an increase of PI3K lipid kinase
		Thereafter, the cells were harvested and lysed by ultrasonication in lysis buffer, as described in "Materials and Methods." A, ATRA enhances total PI3K activity after 24 h in an in vitro kinase assay.
		RA; RAR, RA receptor; PI3K, phosphoinositide 3-kinase; MAPK,
	cgd.aacrjournals.org /cgi/content/full/10/6/447 (4832 words)

	SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation -- Poser et al. 19 (18): 4955 -- ... (Site not responding. Last check: 2007-11-06)
		(PI3K) is a central regulator of mitosis, apoptosis and oncogenesis.
		PI3K signaling is required for growth factor-stimulated c-fos transcription.
		PI3K activity was blocked by cotransfection with a 3-fold excess (125 ng/well) of the dominant-negative regulatory subunit of PI3K (DN p85) DNA or pretreatment with 100 nM wortmannin (Wort).
	embojournal.npgjournals.com /cgi/content/full/19/18/4955 (6844 words)

	Cbl, IRS-1, and IRS-2 Mediate Effects of Rosiglitazone on PI3K, PKC-{lambda}, and Glucose Transport in 3T3/L1 ...
		Inc.) PI3K activity was determined as described previously (19).
		Effects of rosiglitazone on basal and insulin-stimulated IRS-1-dependent (A and B) and IRS-2-dependent (C and D) PI3K activity in 3T3/L1 adipocytes.
		PI3K were not increased by simple rosiglitazone treatment.
	endo.endojournals.org /cgi/content/full/143/5/1705 (5595 words)

	Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors -- Arcaro ...
		Class II PI3K enzymes are distinguished by a carboxy-terminal C2 (CalB) domain (47).
		The samples were assayed for PI3K in the presence of Ca and the radioactive phosphoinositide products were separated by TLC (A).
		EGF stimulation of PI3K activity has been described for a large number of primary cells and cell lines.
	mcb.asm.org /cgi/content/full/20/11/3817 (7388 words)

	Inhibition of receptor-localized PI3K preserves cardiac {beta}-adrenergic receptor function and ameliorates pressure ...
		(d) Basal ßARK1-associated PI3K activity in the LV of WT (n = 6) and 180-fold overexpressing transgenic mice (n = 6); 4 mg of cytosolic extract was used for immunoprecipitation with ßARK1 mAb.
		to the translocation of inactive PI3K by ßARK1 to
		PI3K activity was measured from the myocardial lysates of WT and PI3K
	www.jci.org /cgi/content/full/112/7/1067 (5824 words)

	Essential Role of Phosphoinositide 3-Kinase {delta} in Neutrophil Directional Movement -- Sadhu et al. 170 (5): 2647 -- ...
		PI3K assay was performed according to Chantry et al.
		Structure of IC87114 (a) and activity profiles of class I PI3Ks in the presence of the PI3K inhibitors IC87114 (b) and LY294002 (c).
		PI3Ks were assayed in the presence of the inhibitors according to the protocol described in Materials and Methods and the data are presented as the residual activity compared with the activity in the absence of any inhibitor.
	www.jimmunol.org /cgi/content/full/170/5/2647 (4791 words)

	The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival -- Cooray 85 (5): 1065 -- ...
		The PI3K inhibitors Wortmannin and LY294002 are used to study PI3K–Akt signalling.
		A schematic representation is shown of the association of different viral proteins with the adaptor or enzyme subunits of PI3K and the proposed requirement of PI3K signalling in different types of infection.
		with the catalytic subunit of PI3K and elevates phosphorylation
	vir.sgmjournals.org /cgi/content/full/85/5/1065 (6991 words)

	Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent ...
		Ectopic expression of the class I PI3K affects organ size, while ectopic expression of the class II PI3K affects patterning.
		The extracts were immunoprecipitated with an antibody to the Myc (9E10) epitope and assayed for PI3K activity with PI as a substrate.
		For each sample the equivalent of 0.5 or 2 female flies were used for the immunoblot (from extracts) and for the PI3K assay (from immunoprecipitations), respectively.
	mcb.asm.org /cgi/content/full/24/2/796 (9219 words)

	Activation of PI3K Is Indispensable for Interleukin 7-mediated Viability, Proliferation, Glucose Use, and Growth of T ...
		Activation of PI3K Is Indispensable for Interleukin 7-mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells -- Barata et al.
		Articles by Barata, J. Articles by Boussiotis, V. Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells
		PI3K signaling was also required for cell size increase,
	www.jem.org /cgi/content/abstract/200/5/659 (330 words)

	PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells -- Goncharova et al. ...
		PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells -- Goncharova et al.
		PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells
		IA PI3K (p110*-CA) was sufficient to induce DNA synthesis (mitotic
	ajplung.physiology.org /cgi/content/abstract/283/2/L354 (704 words)

	Phosphatidylinositol 3-Kinase Signaling Controls Levels of Hypoxia-inducible Factor 1 -- Jiang et al. 12 (7): 363 -- ...
		for the catalytic subunit of PI3K is amplified in cervical and
		The PI3K inhibitors LY294002 and wortmannin were added at the indicated concentration 30 min before the addition of 20 ng/ml EGF.
		The PI3K inhibitor LY294002 was added at the indicated concentration 30 min before the addition of insulin and EGF, followed by incubation in the absence (-) or presence (+) of 200 n
	cgd.aacrjournals.org /cgi/content/full/12/7/363 (5058 words)

	N-WASP activation by a {beta}1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by ...
		PI3K was essential for Cdc42, Rac1 and N-WASP activation and
		PI3K is suggested to act as an upstream effector
		PI3K in MDA MB 231 cells was evident through their ability to stimulate
	jcs.biologists.org /cgi/content/full/115/4/699 (7639 words)

	Insulin-Sensitive Phospholipid Signaling Systems and Glucose Transport. Update II -- Farese 226 (4): 283 -- ... (Site not responding. Last check: 2007-11-06)
		PI3K (5), perhaps for translocation of Rho and ARF (6) or activation
		the activation of G3PAT is not dependent upon PI3K (5).
		and an activation of the p110 subunit of PI3K (1).
	www.ebmonline.org /cgi/content/full/226/4/283 (6214 words)

	Inhibition of receptor-localized PI3K preserves cardiac {beta}-adrenergic receptor function and ameliorates pressure ...
		Inhibition of receptor-localized PI3K preserves cardiac {beta}-adrenergic receptor function and ameliorates pressure overload heart failure -- Nienaber et al.
		Inhibition of receptor-localized PI3K preserves cardiac ß-adrenergic receptor function and ameliorates pressure overload heart failure
		PI3K activity represents a novel therapeutic approach to restore
	www.jci.org /cgi/content/abstract/112/7/1067 (559 words)

	Cellular survival: a play in three Akts -- Datta et al. 13 (22): 2905 -- Genes and Development
		PI3K was first implicated in the suppression of apoptosis in a study by Yao and Cooper (1995)
		PI3K activity was subsequently found to be required for the GF-dependent survival of a wide variety of cultured cell types
		Only a subset of the lipid products generated by PI3K may be capable of promoting cell survival in certain cell types.
	www.genesdev.org /cgi/content/full/13/22/2905 (7763 words)

	The Prognostic Significance of Phosphatidylinositol 3-Kinase Pathway Activation in Human Gliomas -- Chakravarti et al. ...
		PI3K pathway members were correlated with histology, markers
		The PI3K pathway, in particular, appears to be one of the most
		that PI3K family members are involved in suppression of apoptosis.
	www.jco.org /cgi/content/full/22/10/1926 (3386 words)

	Compound Inhibits One Critical Pathway In Breast Cancer Growth
		Now, after five years of painstaking, sophisticated tests, scientists at the University of Virginia Health System have discovered that a compound, derived...
		Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway (December 31, 2004) -- Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for...
		Protein Inhibits Cell Growth, May Play Role In Breast Cancer (February 23, 2004) -- A protein known as cdk6 inhibits proliferation of some cell types and may play a role in the development of breast cancer, according to a report by researchers at National Jewish Medical and Research...
	www.sciencedaily.com /releases/2005/03/050310174650.htm (854 words)

	p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK ... (Site not responding. Last check: 2007-11-06)
		Lysates were prepared from MCF7 cells after mitomycin C treatment for 0 and 24 h with or without the PI3K inhibitor, LY294002.
		Immunoblot analysis was performed using antibodies against p53, phospho-Akt and Akt.
		as the PI3K inhibitor, LY294002, were purchased from Calbiochem.
	embojournal.npgjournals.com /cgi/content/full/20/8/1931 (5139 words)

	Multi-layered Representation for Cell Signaling Pathways -- Paek et al. 3 (10): 1009 -- Molecular & Cellular Proteomics
		that PDGF receptor "sends a signal to" PI3K, but fails to indicate
		2A, a signaling event from PDGF receptor to PI3K is shown
		PDGF receptor to PI3K and provides information on the features
	www.mcponline.org /cgi/content/full/3/10/1009 (4176 words)

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