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Topic: PKR

In the News (Mon 28 Dec 09)

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Hugh Jackman

	BioCarta - Charting Pathways of Life
		PKR phosphorylation of I-kB kinase activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection.
		The PKR kinase is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR.
		Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis.
	www.biocarta.com /pathfiles/rnaPathway.asp (136 words)

	Double-Stranded RNA-Activated Protein Kinase (PKR) Is Negatively Regulated by 60S Ribosomal Subunit Protein L18 -- ... (Site not responding. Last check: 2007-09-18)
		PKR kinase assays were performed by using the protocol described elsewhere (58).
		PKR was originally characterized as a ribosomal protein that could be washed away with high-salt buffers (46, 51, 74).
		PKR is depicted as a monomer bound to and inhibited by ribosomal protein L18.
	mcb.asm.org /cgi/content/full/19/2/1116 (7170 words)

	The Direct Binding of the Catalytic Subunit of Protein Phosphatase 1 to the PKR Protein Kinase Is Necessary but Not ...
		is not a substrate for PKR in vitro.
		The kinase activity of affinity-purified PKR protein (0.15 µg) was assayed in the presence of GST or the indicated GST fusion (0.2 µg) as described above.
		The PKR protein is indicated by arrow; GST fusion proteins are indicated by an asterisk.
	www.jbc.org /cgi/content/full/277/39/36109 (5799 words)

	Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails -- ZHENG and BEVILACQUA ...
		PKR was incubated with 0.3 µM of C26, C83, and aptamer 2; 0.1 µM of 79-bp dsRNA; and 0.1 unit/µL heparin.
		PKR is not due to an inability to bind.
		Bevilacqua, P.C., George, C.X., Samuel, C.E., and Cech, T.R. Binding of the protein kinase PKR to RNAs with secondary structure defects: Role of the tandem A-G mismatch and noncontiguous helixes.
	www.rnajournal.org /cgi/content/full/10/12/1934 (7074 words)

	The Kinase Insert Domain of Interferon-induced Protein Kinase PKR Is Required for Activity but Not for Interaction with ...
		by PKR in vitro (9) and in vivo (10, 11).
		PKR proteins were immunoprecipitated with monoclonal antibody 71/10, and kinase assays were performed in the presence of purified eIF2 and either in the absence or presence of dsRNA.
		PKR constructs were co-transfected with Rous sarcoma virus-luciferase (50), luciferase activity was measured using a luminometer, and luciferase mRNA was measured by RNase-One (Promega) protection assay (data not shown).
	www.jbc.org /cgi/content/full/271/40/24526 (6468 words)

	Virology Journal \| Full text \| Involvement of PKR and RNase L in translational control and induction of apoptosis after ...
		In particular of these four kinases, PKR has been shown to be the key regulator of cell defence against viral infections, and mediates the antiviral and antiproliferative effects of interferon (IFN) [28].
		PKR induces apoptosis in response to activation by different stimuli, such as the accumulation of dsRNA as a by-product during virus replication [36], or when PKR is overexpressed in cells [56].
		Yu and co-workers [68] described that hepatic overexpression of PKR mRNA, and reduced expression of an RNase L inhibitor mRNA, are parameters that seem to contribute to an anti-HCV response.
	www.virologyj.com /content/2/1/81 (7720 words)

	The Florida Knee and Orthopedic Centers (Site not responding. Last check: 2007-09-18)
		A PKR implant is much smaller than a total knee implant and does not disturb the knee’s healthy tissues.
		For a PKR, a 3" incision is made, rather than the 12" incision required for total knee replacement.
		PKR implants save more bone so that future total knee replacement procedures can be more easily performed, if necessary.
	www.fla-ortho.com /frames/news/pkr/b_pkr.php3 (734 words)

	PKR Poker Review (Site not responding. Last check: 2007-09-18)
		PKR is the first site to take online poker to the next level.
		PKR is not for hard core poker players, it's for online players who like to have some fun while playing, instead of just being a blinking light at an oval table.
		You send the PKR tech team two pictures of yourself, and they are able to scan your body to create a perfect replica of yourself on PKR.
	www.3dpokersource.com /pkrreview.htm (1074 words)

	Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is ...
		Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue -- Peel et al.
		Low to moderate levels of active PKR was detected in normal human caudate (A), putamen (C) and globus pallidus (E), and to a much greater degree in corresponding areas from HD brain (B, D, F).
		PKR in normal brain, particularly in neurons, is not unanticipated.
	hmg.oxfordjournals.org /cgi/content/full/10/15/1531 (4721 words)

	Site-specific modification and RNA crosslinking of the RNA-binding domain of PKR -- Spanggord and Beal 28 (9): 1899 -- ...
		Native gel mobility shifts for the wild-type PKR RBD and PKR RBD (E29C) binding to a 92 nt RNA ligand.
		Structure of the PKR RBD (amino acids 1–179) showing the three amino acids selected for mutagenesis along with the structure of the photocrosslinking reagent TFPAM-3 used to modify the different cysteine residues.
		PKR RBD was manually infused on a Micromass Quattro II triple quadrupole mass spectrometer and molecular masses were calculated using MassLynx software.
	nar.oxfordjournals.org /cgi/content/full/28/9/1899 (4020 words)

	PKR 3D Poker Review PKR.com Bonus Code & Download
		PKR is packed with features like designing your own avatar from head to toe, performing chip tricks and more.
		PKR has effectively launched a poker site with graphics and playability like a Play Station Video game but with real money up for grabs.
		PKR is a new site, but interest has been high and it won't remain a small site for very long.
	www.4kingpoker.com /pkr_poker_review.php (385 words)

	Malaysia Today: MT-Kongres PKR: Sunday, December 19, 2004
		Parti Keadilan Rakyat (PKR) Saturday reiterated its stand on wanting to work with the government to eradicate corruption and abuse of power but hoped that the government would act on all reports on the matter.
		PKR President Datin Seri Dr Wan Azizah Wan Ismail pointed out that PKR Adviser Datuk Seri Anwar Ibrahim and PKR Youth leader Ezam Mohd Nor had lodged numerous reports on corruption with the police.
		The PKR is the result of a merger between Parti Keadilan Nasional and PRM.
	www.malaysia-today.net /PKR/2004_12_19_MT_PKR_archive.htm (1264 words)

	A PKR-like eukaryotic initiation factor 2{alpha} kinase from zebrafish contains Z-DNA binding domains instead of dsRNA ...
		PKR induces proinflammatory genes by activating the NF-
		The residues that are autophosphorylated in PKR and the analogous residues in PKZ are boxed in light blue.
		This activity is the same as that of PKR in mammalian cells.
	www.pnas.org /cgi/content/full/102/5/1602 (3955 words)

	Role of Double-Stranded RNA-Activated Protein Kinase R (PKR) in Deoxynivalenol-Induced Ribotoxic Stress Response -- ...
		PKR contributes to the subsequent induction of apoptosis by
		Goh, K. C., deVeer, M. J., and Williams, B. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.
		Wong, M. L., and Yen, Y. Protein synthesis in pseudorabies virus-infected cells: Decreased expression of protein kinase PKR, and effects of 2-aminopurine and adenine.
	toxsci.oxfordjournals.org /cgi/content/full/74/2/335 (4545 words)

	Role of the protein kinase PKR in the inhibition of varicella-zoster virus replication by beta interferon and gamma ...
		Role of the protein kinase PKR in the inhibition of varicella-zoster virus replication by beta interferon and gamma interferon -- Desloges et al.
		Role of the protein kinase PKR in the inhibition of varicella-zoster virus replication by beta interferon and gamma interferon
		Blots were reacted with antiserum against PKR (PKR), PKR phosphorylated at Thr-446/451 (PKR-P) and the IE63 protein (IE63) to confirm infection of the cells.
	vir.sgmjournals.org /cgi/content/full/86/1/1 (2512 words)

	Profound Knowledge Resources - Learn More About PKR Systems & Philosophy (Site not responding. Last check: 2007-09-18)
		PKR, Inc. is in the business of translating theory into practice for organizations that want to improve.
		At PKR, Inc. we specialize in customized training materials and services for a variety of organizations in the public and private sectors in both the United States and Canada.
		PKR, Inc. and its Network of colleagues are committed to learning, staying at the leading edge of developments in organization design and improvement.
	www.pkrnet.com /about2.html (198 words)

	Involvement of PKR in the Regulation of Myogenesis -- Kronfeld-Kinar et al. 10 (3): 201 -- Cell Growth & Differentiation
		Involvement of PKR in the Regulation of Myogenesis -- Kronfeld-Kinar et al.
		PKR was able to protect the cells from this event (17, 18).
		Tanaka H., Samuel C. Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.
	cgd.aacrjournals.org /cgi/content/full/10/3/201 (5745 words)

	PKR Consulting, Inc. - Construction Management and Litigation Support
		PKR Consulting offers a variety of construction consulting services, including schedule delay and cost overrun analysis, and project management support.
		PKR Consulting is skilled at presenting its findings at project meetings, settlement negotiations, mediations, dispute review boards, arbitrations, and trial.
		PKR Consulting provides the highest standard of construction consulting
	www.pkrconsultinginc.com /default.html (103 words)

	PKR Poker - www.PKR.com bonus review
		PKR is set to change online poker and take it into the next generation.
		PKR.com is set to launch at the end of May 2006 but are currently having beta testers while the software is in the final stages of development.
		PKR is looking like it is going to close the gap between video game graphics and online poker!
	www.pokerchatforum.com /pkr.php (157 words)

	The Polycystic Kidney Research (PKR) Foundation has changed its name to the PKD Foundation. (Site not responding. Last check: 2007-09-18)
		The Polycystic Kidney Research (PKR) Foundation has changed its name to the PKD Foundation.
		If you are trying to locate the PKR Foundation, please click here to be directed to the official PKD Foundation website.
		The PKD Foundation is exactly the same organization as the PKR Foundation.
	www.pkrfoundation.org (135 words)

	RNA-Dependent Protein Kinase PKR Is Required for Activation of NF-{{kappa}}B by IFN-{{gamma}} in a STAT1-Independent ...
		PKR activity was assayed after immunoprecipitation with equal amounts of PKR (200 µg) and anti-human monoclonal PKR Ab followed by autophosphorylation assay monitored by incorporation of [
		B, Quantitation and comparison of activity of PKR by phosphorimager and luciferase activity from the same sample are shown in A.
		B by dsRNA is PKR dependent (17, 20, 21, 22).
	www.jimmunol.org /cgi/content/full/166/10/6170 (5248 words)

	PKR Poker Bonus Code (Site not responding. Last check: 2007-09-18)
		Existing PKR players are still eligible, just scroll down.
		PKR has finally finished their beta testing and has launched real money play to the public.
		Unfortunately, due to the "online gambling issue" in the US, PKR will not be launching real money play in the US until this issue is decided.
	www.3dpokersource.com /pkrbonuscodes.htm (210 words)

	PKR Nation - For PKR Poker Players - Powered by vBulletin
		Welcome to the PKR Nation - For PKR Poker Players.
		The PKR Logo is the trademark of PKR Limted.
		PKR Nation is dedicated to bringing you up to date information on PKR, PKR online poker room,, Crunchy Frog, Crunchy Frog poker, poker, online poker, 3d poker, poker tournaments, internet poker, Texas hold'em, free online poker, PKR freerolls, PKR Nation, poker strategy.
	www.pkrnation.com (203 words)

	SDSC: A National Laboratory for Computational Science and Engineering (Site not responding. Last check: 2007-09-18)
		The workshop, organized by the SDSC-based Protein Kinase Resource (PKR – http://pkr.sdsc.edu), will feature more than 30 scientists who will present the latest findings on kinases and phosphatases, that play key roles in cellular regulation.
		The workshop will offer the opportunity to hear from renowned experts in kinase research and provide a forum for discussing the ideas and needs related to the development of bioinformatics resources in protein phosphorylation.
		PKR wants to be a service tailoredto the specific requirements of protein phosphorylation research and this workshop provides researchers from academia and industry with the opportunity to communicate their needs to the PKR developers.” said R. Hannes Niedner, technical lead and project manager of the PKR.
	www.sdsc.edu /Press/03/100603_PKR.html (396 words)

	Need help extracting files with the .pkr extension - FILExt FAQ and Forum
		According to filext.com, pkr is a,,Public Keyring'' file.
		I used keywords like,,pkr files", or,,extract pkr files'', etc., but I only found Dragon Unpacker, which is useless in this case, since it doesn't recognize all file formats.
		I also found Unpkr, but that doesn't work either, because it's designed for THPS (although the two games use the same file extension).
	filext.com /info/showthread.php?p=2089 (267 words)

	PKR \| internet - Home (via CobWeb/3.1 planetlab2.cs.unc.edu) (Site not responding. Last check: 2007-09-18)
		PKR Internet is a full-service web consulting firm that offers effective software and hosting solutions.
		We are experts at building web-based, multilingual content management systems, using Linux, Java, and Open Source tools to deliver superior results.
		We offer web hosting plans with an emphasis on security and personal support.
	pkrinternet.com.cob-web.org:8888 (249 words)

	PKR - Freeroll poker tournaments and tournament promotions
		PKR - Freeroll poker tournaments and tournament promotions
		Below, youâll find a huge schedule of freerolls at PKR, and they offer the perfect chance to play some risk-free poker with a shot at a real money prize.
		Use this guide to convert GMT times (along the top) to your local time.
	www.pkr.com /poker-tournaments/freerolls-and-promotions.cfm (65 words)

	PKR Rake Club, PKR Rake, PKR Bonus, RakeRebate, Poker Rake
		Welcome to the PKR Rake Club, your number one resource for rakeback at PKR.com.
		At the PKR Rake Club service is the first and only priority.
		By providing our players with comprehensive monthly reports, fast and easy payments and a dedicated service team the PKR Rake Club is an industry leader in offering rakeback to new PKR.com players.
	www.pkrrakeclub.com (280 words)

	PKR MUSIC (Site not responding. Last check: 2007-09-18)
		PKR - the new label focusing on dance music with a twist, ranging from electronic to acoustic sounds.
		We intend to provide music lovers of all influences with a distinct sonic flavour, having one consistent element: a PHAT GROOVE!
		PKR will supply original material from live bands, singers and electronic artists.
	www.pkrmusic.com (75 words)

	Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR -- Fasciano et al. 272 (6): ... (Site not responding. Last check: 2007-09-18)
		Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR -- Fasciano et al.
		Identification of the heparin-binding domains of the interferon-induced protein kinase, PKR
		In contrast to dsRNA-induced activation of PKR, heparin-dependent
	content.febsjournal.org /cgi/content/abstract/272/6/1425 (277 words)

	Ericsson PKR series MacroDens standard
		The PKR series covers a power range of 3W to 15W with single and dual outputs providing a complete program for low power applications.
		Combining the proven electrical topology and components used in the PKF series products with innovative open frame design the PKR series products offer a cost competitive and highly reliable alternative in Internetworking, fixed and mobile communication systems as well as in Industrial process equipment.
		The PKR series products comply with the European RoHS directive and the requirements in high temperature lead-free reflow soldering processes and thereby also offer drop-in replacement products with identical electrical performances and mechanical footprint and pin-out as the PKF series products.
	www.ericsson.com /products/hp/PKR_series_MacroDens_standard_pos.shtml (137 words)

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