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	Progressive Multifocal Leukoencephalopathy Information Page: National Institute of Neurological Disorders and Stroke ...
		The symptoms of PML are the result of an infection that causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain.
		Typical symptoms associated with PML are diverse, since they are related to the location and amount of damage in the brain, and evolve over the course of several days to several weeks.
		A positive diagnosis of PML can be made on brain biopsy, or by combining observation of a progressive course of the disease, consistent white matter lesions visible on a magnetic resonance image (MRI) scan, and the detection of the JC virus in spinal fluid.
	www.ninds.nih.gov /disorders/pml/pml.htm (602 words)

	Progressive multifocal leukoencephalopathy
		Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells (oligodendrocytes and astrocytes) by the JC virus (JCV).
		PML is an opportunistic infection associated with AIDS and certain cancers.
		In PML, the JCV infects and kills the cells (oligodendrocytes) that produce myelin, which is needed to form the sheath that surrounds and protects nerves.
	www.healthatoz.com /healthatoz/Atoz/ency/progressive_multifocal_leukoencephalopathy.jsp (550 words)

	eReader.com: Palm Markup Language
		PML commands start with a backslash, "\", and usually consist of a single character after that.
		PML is not meant to be an industrial-strength markup language, but it is easy to understand, easy to parse, and creates high-quality electronic books.
		Any text or PML placed after the first footnote or sidebar is ignored as part of the book text.
	www.ereader.com /dropbook/pml (1510 words)

	Project Inform: Progressive Multifocal Leukoencephalopathy (PML) [ HIV / AIDS Treatment Information ]
		PML is a rare AIDS-related condition of the brain, caused by the JC virus.
		After a presumptive diagnosis of PML is made and whether or not a person elects to have a brain biopsy, it seems advisable to start or change to a new potent anti-HIV regimen including a protease inhibitor.
		PML is a rare condition affecting the brain, caused by the JC virus.
	www.projinf.org /fs/pml.html (2374 words)

	Definition of PML
		PML is a demyelinating disease, in which the myelin sheath covering the axons of nerve cells is gradually destroyed, impairing the transmission of nerve impulses.
		PML is similar to another demyelinating disease, multiple sclerosis, but since it destroys the cells that produce myelin (unlike MS, in which myelin itself is attacked but can be replaced), it progresses much more quickly.
		PML is diagnosed by testing for JC virus DNA in cerebrospinal fluid or in a brain biopsy specimen.
	www.wordiq.com /definition/PML (349 words)

	PML (Psychogeographical Markup Language)
		PML is a set of keywords lifted from various sources that can be used to capture meaningful psychogeographical [meta]data about urban space.
		PML is a unified system of psychogeonamic classification that lurks behind the psychogeogram: the diagrammatic representation of psychogeographically experienced space.
		PML is definitely in need of an abundance of concepts to name & identify different types of space, while PML data is by definition subjective data, PML does not cater for aesthetic judgements.
	www.socialfiction.org /psychogeography/PML.html (745 words)

	Cover Pages: Procedural Markup Language (PML)
		PML is a markup language written in XML that allows the content designer to encode domain knowledge in an intuitive and flexible manner by specifying the knowledge structures, the underlying physical media, and the relationship between them using cognitive media roles.
		We propose a new markup language called PML (Procedural Markup Language) which allows the content to be represented in a flexible manner by specifying the knowledge structures, the underlying physical media, and the relationships between them using cognitive media roles.
		The PML description can then be translated into different presentations depending on such factors as the context, goals, presentation preferences, and expertise of the user.
	xml.coverpages.org /pml.html (686 words)

	Electric car motors, electric boat motors, 12 volt brushless motors
		PML Flightlink will be showing the revolutionary Mini QED at DSEi, Europe’s premier defence show, held at London’s Excel centre this month.
		Last summer, PML exhibited the new Mini QED hybrid motor car with its unique Hi-Pa Drive at the British Motor Show in London.
		PML Flightlink Ltd, Newman Lane, Riverwey Industrial Park, Alton, Hants, GU34 2QW, UK.
	www.pmlflightlink.com (222 words)

	eMedicine - HIV-1 Associated Opportunistic Infections: PML : Article by Niranjan N Singh
		Progressive multifocal leukoencephalopathy (PML) is characterized by widespread demyelinative lesions due to infection of oligodendrocytes by a human papovavirus.
		PML is caused by reactivation of the endemic JC papovavirus (ie, polyomavirus).
		Whether PML develops when resident virus in the brain is reactivated or when the virus is reactivated and seeds the brain via blood lymphocytes or in free form is unclear.
	www.emedicine.com /neuro/topic450.htm (2114 words)

	Inference Web Overview
		PML may be used to support applications that need to interoperate and provide access information to components that require justifications for answers.
		PML has been used in a number of government and corporate projects to encode justification collections.
		With PML, collections of justifications can be encoded in the interlingua, and then be shared for interoperation and information integration among heterogeneous distributed applications especially for question answering systems.
	iw.stanford.edu /2005/wd-pml-primer/pml-primer-20051128.htm (1921 words)

	The GENEVA Report: Update on Neurology: Opportunistic Infections of the Nervous System (Site not responding. Last check: )
		PML declined from 1.6% to 1.0% during the same period.
		In addition, worldwide, there are no effective prophylactic agents for PML or for primary CNS lymphoma, and as the survival rates for individuals with advanced HIV infection lengthen, the prevalence of these conditions may actually increase.
		Case series of PML response to cidofovir have appeared in recent months and were expanded upon by Al-Shahi and colleagues [Abstract 32193].
	www.hopkins-aids.edu /geneva/hilites_mcar_opp.html (670 words)

	Porsche Market Letter Main Page - close to 1,000 Porsches For Sale in Each Issue!!
		* The October issue of PML** will mail 10/10/07.
		- William Agnew (PML Technical Editor)
		PML is not affiliated in any way with Dr. Ing.
	www.pmletter.com (60 words)

	PML Flightlink
		PML Flightlink will be showing the revolutionary Mini QED at DSEi next month.
		The Mini QED (which showcases PML’s Hi-Pa Drive in-wheel motors) will be on stand 1123.
		One application of PML’s technology is being unveiled to the world by a major car company at September’s International Motor Show in Frankfurt.
	www.pmlflightlink.com /news.html (358 words)

	Public Health Advisory: Suspended marketing of Tysabri (natalizumab)
		Any suspect cases of PML should be reported immediately to Biogen Idec or to the FDA MedWatch program, as described at the end of this advisory.
		PML is a rare, serious, progressive neurologic disease, usually occurring in immunosuppressed patients, often resulting in irreversible neurologic deterioration and death.
		No cases of PML were observed during the clinical trials performed prior to approval of Tysabri.
	www.fda.gov /cder/drug/advisory/natalizumab.htm (678 words)

	[No title]
		The PML compiler prints a warning to this effect when an abstraction declaration is encountered for the first time.
		PML supports arbitrary-precision ("big") integers, so integer operations never overflow.
		Several other pre-defined structures are available in PML, providing other commonly used functions on the basic types, together with functions and variables for controlling the behaviour of the PML system.
	www.cs.bham.ac.uk /research/projects/poplog/src/master/S.pcwnt/pml/help/features (845 words)

	PML Holdings Group Company Profile - PR.com
		PML offers through employee leasing and peo payroll services "top of the line" benefits packages with a number of health insurance options, complete payroll services, personalized reporting, administrative services, plus, PML works closely WITH our clients in keeping costs down for the employee leasing and peo payroll company AND our clients.
		PML maintains a "minimal" administrative, sales and marketing staff in order to keep overall costs down, and in turn, "employee leasing costs" to their clients has remained consistently lower than their major national competitors in the employee leasing and peo industry, without services being affected.
		PML's philosophy is somewhat different than most companies involved in this field; it is PML's goal to continue slow, but stable growth in order to continue its unique, "personalized" service, and, to control the costs that normally increase as the employee leasing and peo's size increases.
	www.pr.com /company-profile/overview/1262 (385 words)

	ASHP Website : News Article
		Both deaths were attributed to progressive multifocal leukoencephalopathy (PML) caused by the reactivation of a previously latent JC virus infection.
		According to a Dear Healthcare Professional letter (PDF) from Genentech, 23 cases of PML have been recorded in patients who received infusions of the drug for the treatment of blood cancers.
		The document states that in both cases, PML was diagnosed within a year of the patients' last rituximab infusion, and rituximab was the "last treatment" administered before PML was detected.
	www.ashp.org /news/ShowArticle.cfm?cfid=17566452&CFToken=19389144&id=17960 (592 words)

	AEGiS OI: Progressive Multifocal Leukoencephalopathy
		PML is caused by the JC virus (JCV).
		PML is generally a "late stage" disease that shows up only with a severely damaged immune system.
		Once PML begins, it is usually quite aggressive and fatal.
	www.aegis.com /topics/oi/oi-pml.html (305 words)

	Cellular Localization, Expression, and Structure of the Nuclear Dot Protein 52 -- Sternsdorf et al. 138 (2): 435 -- The ...
		the mAb C8A2 cross-reacts with PML or Sp100.
		PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
		The acute promyelocytic leukaemia-associated PML gene is induced by interferon.
	www.jcb.org /cgi/content/full/138/2/435 (7511 words)

	National MS Society \| Tysabri
		PML (progressive multifocal leukoencephalopathy) is a brain disease that occurred in three people (two of whom died) who had been in clinical trials of Tysabri.
		The Black Box Warning for Tysabri warns of the increased risk of PML and the importance of monitoring patients using the drug for any new sign or symptoms that may be suggestive of PML.
		If the risk for PML or other serious adverse events were to significantly rise in clinical use, we would advocate that the FDA take immediate and appropriate action.
	www.nationalmssociety.org /Research-TysabriQ&A.asp (3324 words)

	Green Left - `Absolute tyranny' in Pakistan
		The PML's coalition partners have deserted the government in the National Assembly, the Senate and all the provincial assemblies.
		In Sindh province, the PML provincial government is trying to negotiate with independent MPs to maintain its majority.
		While the PML can muster enough assembly members' support to pass the bill, it is not clear whether the government can secure the two-thirds majority in the Senate required to pass the bill.
	www.greenleft.org.au /1998/332/20410 (1118 words)

	Progressive Multifocal Leukoencephalopathy - PML
		PML is caused by a papovavirus, usually the JC strain.
		Prior to the onset of HIV and AIDS in the 1980s, PML was extremely rare.
		Reactivation of the JC virus and development of PML has rarely been associated with lymphoproliferative disorders, tuberculosis, sarcoidosis, prolonged immunosuppression (organ transplant or cancer patients), chronic steroid therapy, and rare inherited immunodeficiencies.
	www.upmc.com /healthmanagement/ManagingYourHealth/HealthReference/procedures/?chunkiid=102904 (394 words)

	PR Leap: PML Worldwide, Inc. is up and running!
		PML Worldwide, Inc. is in the process of registering and licensing in several other states in the east, south and Midwest and will eventually license in the southwest and western states.
		Programming, exclusive to PML and its affiliates is also nearing completion for online access to a comprehensive client/broker lead system, client quoting system to handle all states and a client/employee website designed exclusively for PML and its affiliates nationwide.
		PML has attracted a lot of very positive attention nationally; many contacts have developed that will prove to be essential to a quality and well structured growth, benefiting not only the current base of leasing companies, but future merger partners and affiliates nationally.
	www.prleap.com /pr/16265 (465 words)

	Multiple sclerosis drug to return with caveats : National-World : Albuquerque Tribune
		PML, the apparent side effect, is caused by a common virus that usually lies dormant.
		Karl Kieburtz of the University of Rochester, who chaired the FDA advisory committee, cautioned that there are complicating factors: Clinical trials of Tysabri have included fairly young people whose MS wasn't too severe.
		And PML's symptoms are hard to distinguish from those of an MS relapse, because the two diseases both attack the coating of nerve cells.
	www.abqtrib.com /news/2006/mar/09/multiple-sclerosis-drug-to-return-with-caveats (707 words)

	News: Biogen Idec and Alnylam Form Alliance to Discover and Develop Therapeutics for the Potential Treatment of ...
		PML is caused by infection of the central nervous system with a virus called "JC virus" and can occur in certain immune-suppressed patients, including those receiving immunomodulatory therapies.
		PML is an opportunistic viral infection of the brain that usually leads to death or severe disability.
		Alnylam is honored to be the "emerging/mid-cap" company recipient of the 2006 James D. Watson Helix Award, the biotechnology industry's award for outstanding corporate achievement.
	www.genengnews.com /news/bnitem.aspx?name=5806707&chid=2&taxid=15 (856 words)

	About PML (Site not responding. Last check: )
		Owning and publishing PML provides the perfect environment to utilize Phil's Porsche background.
		PML's approach has been to present a "picture" of the US market for Porsche.
		PML is not affiliated in any way with Dr. Ing.
	www.pmletter.com /aboutpml.html (189 words)

	RealMoney.com: Biogen Idec Says What's Known Is Known
		Rastetter spent part of the meeting using the emotional approach to the Tysabri discussion by reading aloud quotes from patients who considered the drug their "last hope," and he touted the treatment as a "much heralded, much desired" treatment for MS.
		Though little is known about the sometimes fatal brain disease, experts do know PML is extremely rare in the generally healthy population, but it has been known to occur in patients with impaired immune systems, like those with HIV or on drugs that suppress the immune system.
		PML is not a death sentence if it's discovered early, the company said after consulting with specialists.
	www.thestreet.com /p/stocks/altheachang/10226541.html (465 words)

	NERC - Life's a beach
		The Plymouth Marine Laboratory (PML) is an independent multidisciplinary marine research centre.
		PML's research programme feeds into national strategies to deliver knowledge and solutions for both government and other public sector bodies.
		The PML Innovation and Partnerships programme is aimed at exploiting our knowledge, know-how and research outputs for the wider community and industry.
	www.nerc.ac.uk /press/releases/2004/27-beach.asp (475 words)

	PML at Drives and Controls: News from PML FlightLinK
		PML is exhibiting an exciting new range of electric motors and drives at Drives and Controls on stand D132, Hall 9.
		Slimline and compact, the new brushless pancake motors from PML are ideal for applications where precise speed control, space saving designs and a long maintenance free life are essential.
		PML joysticks also enjoy a reputation for being robust, high quality man-machine interfaces that benefit vehicle, motion control, construction and mobility sectors.
	www.processingtalk.com /news/pml/pml100.html (458 words)

	News: Biogen Idec and Alnylam Form Collaboration to Discovery and Develop PML Therapeutics. Genetic Engineering News - ...
		News: Biogen Idec and Alnylam Form Collaboration to Discovery and Develop PML Therapeutics.
		Biogen Idec and Alnylam formed a collaboration to discover and develop RNAi therapeutics for the potential treatment of progressive multifocal leukoencephalopathy (PML).
		PML is caused by infection of the central nervous system with the JC virus and can occur in certain immune-suppressed patients, including those receiving immunomodulatory therapies.
	www.genengnews.com /news/bnitem.aspx?name=5855612&chid=4&taxid=30 (175 words)

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