| | PPH Cure Foundation - Internet Journal - Volume 2 Issue 1 |
 | | This classification is increasingly falling out of favor due to the similar clinical path of many forms of SPH with PPH, overlapping histopathological features among the two classifications, and correlations of PPH occurrence with certain other diseases and exogenous ingested substances, even if the precise cause remains unclear. |
 | | In other words, it is now believed that PPH is not really distinct from much of SPH, at least as far as the pathophysiology and treatment of pulmonary hypertension is concerned. |
 | | "To determine whether the endothelial cell proliferation in plexiform lesions in PPH is monoclonal or polyclonal, we assessed the methylation pattern of the human androgen-receptor gene (HUMARA) in proliferated endothelial cells in plexiform lesions from female PPH patients (n=4) compared to secondary pulmonary hypertension (SPH) (n=4). |
| www.pphcure.org /journals/issues/9801.htm (913 words) |