| | Inhaled p38[alpha] Mitogen-activated Protein Kinase Antisense Oligonucleotide Attenuates Asthma in Mice American ... |
 | | A recent study showed that p38 MAPK activity in the lungs of asthmatic mice was significantly higher as compared with control mice (7). |
 | | It has also been shown that the p38 MAPK pathway is critically important for the activation of the IL-5 receptor and eotaxin receptors in eosinophils, resulting in survival, activation, degranulation, and chemotaxis of eosinophils (11-13). |
 | | A recent study revealed that the p38 MAPK inhibitor SB239063 markedly reduced ovalbumin (OVA)-induced pulmonary eosinophilia in animal models of asthma, suggesting that the p38 MAPK pathway can be a pharmacologie target for the treatment of allergic asthma (14). |
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