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Topic: P-glycoprotein

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Glycoprotein - Wikipedia, the free encyclopedia Glycoproteins are often used in proteins that are at least in part located in extracellular space (that is, outside the cell). Glycoproteins are important for immune cell recognition, especially in mammals. Soluble glycoproteins often show a high viscosity, for example, in egg white and blood plasma. en.wikipedia.org /wiki/Glycoprotein   (208 words)

Pfam 18.0 : Glycoprotein_B This family of proteins are the surface glycoprotein of various herpesviruses.The glycoprotein is anchored to the lipid envelope of the virus by a transmembrane region. pfam.wustl.edu /cgi-bin/getdesc?name=Glycoprotein_B   (33 words)

Characterization of the rabbit homolog of human MUC1 glycoprotein isolated from bladder by affinity chromatography on immobilized jacalin -- Higuchi et al. 10 (7): 659 -- Glycobiology Devaraj,N., Devaraj,H. and Bhavanandan,V.P. (1992) Purification of mucin glycoproteins by density gradient centrifugation in cesium trifluoroacetate. Erickson,D.R., Mast,S., Ordille,S. and Bhavanandan,V.P. (1996) Urinary epitectin (MUC-1 glycoprotein) in the menstrual cycle and interstitial cystitis. The radiolabeled glycoprotein was purified to homogeneity by glycob.oxfordjournals.org /cgi/content/full/10/7/659   (4768 words)

Glycoprotein main page The glycoprotein hormones are a family of cystine rich proteins consisting of an alpha and beta subunit. The glycoprotein hormones are characterised by there heavy glycosylation and are cystine rich molecules with 5 conserved disulphides in alpha and 6 in beta. The structure of hCG was first determined in Glasgow at 3.0Ang resolution and is described in the paper 'Crystal Structure of Chorionic Gonadotropin'. www.chem.gla.ac.uk /protein/glyco/GPH.html   (377 words)

Invitrogen - Molecular Probes - Proteomics and Protein Biochemistry Products - Detect Glycoproteins Directly in Gels or on Blots Glycoproteins and molecular weight markers stained with Pro-Q Emerald 300 glycoprotein stain (left) or SYPRO Ruby protein gel stain (right), shown before (lanes 2, 4 and 6, respectively) and after treatment with glycosidases (lanes 3, 5 and 7, respectively). 1-acidic glycoprotein (40% carbohydrate), glucose oxidase 12% carbohydrate) and avidin (7% carbohydrate). Pro-Q Emerald stain detects glycoproteins more easily and reliably than mobility–shift assays, which only detect glycoproteins susceptible to specific deglycosylating enzymes and which can only be used in 1-D gels. probes.invitrogen.com /lit/catalog/1/sections/1143.html   (546 words)

Post-Translational Modifications Some glycoproteins are tethered to the membrane by a lipid linkage: the protein is attached to the carbohydrate through phosphatidylethanolamine (PE) linkage, and the carbohydrate is in turn attached to the membrane via linkage to phosphatidylinositol (PI), which anchors the structure within the membrane. Glycoproteins on cell surfaces are important for communication between cells, for maintaining cell structure and for self-recognition by the immune system. The distinction between proteoglycans and glycoproteins resides in the level and types of carbohydrate modification. web.indstate.edu /thcme/mwking/protein-modifications.html   (3571 words)

Envelope Glycoprotein Determinants of Increased Fusogenicity in a Pathogenic Simian-Human Immunodeficiency Virus (SHIV-KB9) Passaged In Vivo -- Etemad-Moghadam et al. 74 (9): 4433 -- The Journal of Virology 225) gp120 glycoprotein was indistinguishable from that of Numbering of envelope glycoprotein residues is according to current convention (33). Luciferase activity in the lysate was calculated and normalized to that observed for the 89.6 envelope glycoproteins. jvi.asm.org /cgi/content/full/74/9/4433   (5193 words)

Carbohydrate deficient Glycoprotein Syndrome Type Ia Carbohydrate-deficient Glycoprotein Syndrome Type Ia (CDG1A) is an extremely rare inherited metabolic disorder belonging to a group of diseases known as Carbohydrate-deficient Glycoprotein Syndromes (CDGS).** These disorders are characterized by the presence of abnormal oligosaccharides, or "sugar chains," on many glycoproteins (e.g., transferrin). Glycoproteins are compounds in which oligosaccharides are "attached" to certain proteins. It is possible that the main title of the report Carbohydrate deficient Glycoprotein Syndrome Type Ia is not the name you expected. my.webmd.com /hw/health_guide_atoz/nord1071.asp   (492 words)

Human Herpesvirus 8 Glycoprotein B (gB), gH, and gL Can Mediate Cell Fusion -- Pertel 76 (9): 4390 -- The Journal of Virology Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments. Glycoprotein 110, the Epstein-Barr virus homolog of herpes simplex virus glycoprotein B, is essential for Epstein-Barr virus replication in vivo. Unidirectional complementation between glycoprotein B homologues of pseudorabies virus and bovine herpesvirus 1 is determined by the carboxy-terminal part of the molecule. jvi.asm.org /cgi/content/full/76/9/4390   (8175 words)

Glycoprotein definition - Medical Dictionary definitions of popular medical terms A glycopeptide is similar in structure to a glycoprotein but has a shorter chain of amino acids. For instance, in the immune system almost all of the key molecules involved in the immune response are glycoproteins. Glycoprotein: A molecule that consists of a carbohydrate plus a protein. www.medterms.com /script/main/art.asp?articlekey=16842   (253 words)

Early Assembly Step of a Retroviral Envelope Glycoprotein: Analysis Using a Dominant Negative Assay -- Rosenberg et al. 145 (1): 57 -- The Journal of Cell Biology of the mutated glycoproteins: 21 of the 22 glycoproteins incapable In a cell that coexpresses the wt glycoprotein and an assembly-competent mutant, three dimer combinations are possible: homodimers of wt precursor subunits, homodimers of mutant precursor subunits, and heterodimers consisting of both subunit types. of the glycoprotein is sufficient to impair precursor assembly. www.jcb.org /cgi/content/full/145/1/57   (7366 words)

InterPro: IPR002551 Coronavirus S1 glycoprotein The type I glycoprotein S of coronavirus, trimers of which constitute the typical viral spikes, is assembled into virions through noncovalent interactions with the M protein. The spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 and S2 Both chimeric S proteins appeared to cause cell fusion when expressed individually, suggesting that they were biologically fully active [ 2 ]. The spike is a type I membrane glycoprotein that possesses a conserved transmembrane anchor and an unusual cysteine-rich (cys) domain that bridges the putative junction of the anchor and the cytoplasmic tail [ 3 ]. www.ebi.ac.uk /interpro/DisplayIproEntry?ac=IPR002551   (2775 words)

The Signal Peptide of the Junin Arenavirus Envelope Glycoprotein Is Myristoylated and Forms an Essential Subunit of the Mature G1-G2 Complex -- York et al. 78 (19): 10783 -- The Journal of Virology A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure. The glycoprotein precursor gene of the attenuated Junin virus vaccine strain (Candid #1). glycoprotein oligomers in the stabilization of the fusion pore jvi.asm.org /cgi/content/full/78/19/10783   (6593 words)

Alpha 1 Acid Glycoprotein antibody (ab440) datasheet Alpha 1 Acid Glycoprotein (AGP) is an acute phase plasma protein synthesized by the liver. If Alpha 1 Acid Glycoprotein antibody (ab440) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund. The protein is believed to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, also regulates the extravasation of the cells during infection and inflammation. www.abcam.com /?datasheet=440   (445 words)

Biosynthesis and role of filoviral glycoproteins -- Feldmann et al. 82 (12): 2839 -- Journal of General Virology The transmembrane glycoprotein GP is anchored into the lipid membrane by a hydrophobic domain (FD in part A) at the carboxy terminus of GP is attached to GP by a intramolecular disulphide bond probably involving cysteine residue 53. Filoviral glycoproteins are encoded by gene 4 (GP gene) of the The type I transmembrane glycoprotein GP carries three hydrophobic domains (grey boxes): a signal peptide (SP) at the amino-terminal end, a fusion domain (FD) and a transmembrane domain (TD) at the carboxy-terminal end. vir.sgmjournals.org /cgi/content/full/82/12/2839   (5591 words)

Organizational Diversity among Distinct Glycoprotein Endoplasmic Reticulum-associated Degradation Programs -- Cabral et al. 13 (8): 2639 -- Molecular Biology of the Cell Hebert, D.N., Foellmer, B., and Helenius, A. Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum. Sousa, M.C., Ferro-Garcia, M.A., and Parodi, A.J. Recognition of the oligosaccharide and protein moieties of glycoproteins by the UDP-glc:glycoprotein glucosyltransferase. Cannon, K.S., and Helenius, A. Trimming and re-addition of glucose to N-linked oligosaccharides determines calnexin association of a substrate glycoprotein in living cells. www.molbiolcell.org /cgi/content/full/13/8/2639   (6969 words)

NEJM -- Inhibition of Platelet Glycoprotein IIb/IIIa with Eptifibatide in Patients with Acute Coronary Syndromes Distinct yet complementary mechanisms of heparin and glycoprotein IIb/IIIa inhibitors on platelet activation and aggregation: implications for restenosis during percutaneous coronary intervention. Is glycoprotein IIb/IIIa antagonism as effective in women as in men following percutaneous coronary intervention?: Lessons from the ESPRIT study. Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty. content.nejm.org /cgi/content/abstract/339/7/436   (6940 words)

Cloning and characterization of mammalian UDP-glucose glycoprotein: glucosyltransferase and the development of a specific substrate for this enzyme -- Tessier et al. 10 (4): 403 -- Glycobiology Sousa,M.C., Ferrero Garcia,M.A. and Parodi,A.J. (1992) Recognition of the oligosaccharide and protein moieties of glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase. Hebert,D.N., Foellmer,B. and Helenius,A. (1995) Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum. Trombetta,S.E., Bosch,M. and Parodi,A.J. (1989) Glucosylation of glycoproteins by mammalian, plant, fungal and trypanosomatid protozoa microsomal membranes. glycob.oxfordjournals.org /cgi/content/full/10/4/403   (6181 words)

Intestinal P Glycoprotein Acts as a Natural Defense Mechanism against Listeria monocytogenes -- Neudeck et al. 72 (7): 3849 -- Infection and Immunity glycoprotein or the lack of P glycoprotein on the apical surface P glycoprotein (Caco-2/MDR) was derived and an in vitro invasion Intestinal P Glycoprotein Acts as a Natural Defense Mechanism against Listeria monocytogenes -- Neudeck et al. iai.asm.org /cgi/content/full/72/7/3849   (3642 words)

Evaluation of Three Glycoprotein G2-Based Enzyme Immunoassays for Detection of Antibodies to Herpes Simplex Virus Type 2 in Human Sera -- Eis-Hübinger et al. 37 (5): 1242 -- Journal of Clinical Microbiology Comparison of the Western immunoblot assay and a glycoprotein G enzyme immunoassay for detection of serum antibodies to herpes simplex virus type 2 in patients with AIDS. Evaluation of a test based on baculovirus-expressed glycoprotein G for detection of herpes simplex virus type-specific antibodies. Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with neonatal herpes. jcm.asm.org /cgi/content/full/37/5/1242   (3627 words)

Amino Acids 270 to 510 of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Are Required for Interaction with Receptor -- Babcock et al. 78 (9): 4552 -- The Journal of Virology Conformational changes in the spike glycoprotein of murine coronavirus are induced at 37°C either by soluble murine CEACAM1 receptors or by pH 8. glycoprotein in the presence of increasing concentrations of normal (circles) or SARS convalescent-phase (squares) human serum. Proteolytic cleavage of the E2 glycoprotein of murine coronavirus: host-dependent differences in proteolytic cleavage and cell fusion. jvi.asm.org /cgi/content/full/78/9/4552   (5341 words)

The serum protein {alpha}2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification -- Schäfer et al. 112 (3): 357 -- Journal of Clinical Investigation Serum glycoproteins in cancer patients: first report of correlations with in vitro and in vivo parameters of cellular immunity. Gorgani, N.N., Smith, B.A., Kono, D.H., and Theofilopoulos, A.N. Histidine-rich glycoprotein binds to DNA and Fc gamma RI and potentiates the ingestion of apoptotic cells by macrophages. Demetriou, M., Binkert, C., Sukhu, B., Tenenbaum, H.C., and Dennis, J.W. Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist. www.jci.org /cgi/content/full/112/3/357   (5958 words)

Myelin-associated glycoprotein (Siglec-4) expression is progressively and selectively decreased in the brains of mice lacking complex gangliosides -- Sun et al. 14 (9): 851 -- Glycobiology Trapp, B.D., Andrews, S.B., Cootauco, C., and Quarles, R. (1989) The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. Myelin-associated glycoprotein (Siglec-4) expression is progressively and selectively decreased in the brains of mice lacking complex gangliosides -- Sun et al. Yin, X., Crawford, T.O., Griffin, J.W., Tu, P., Lee, V.M., Li, C., Roder, J., and Trapp, B.D. (1998) Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. glycob.oxfordjournals.org /cgi/content/full/14/9/851   (3885 words)

Human cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: identification of a novel subgroup, geographical distribution and evidence of positive selective pressure -- Pignatelli et al. 84 (3): 647 -- Journal of General Virology Glycoprotein B genotype correlates with cell tropism in vivo of human cytomegalovirus infection. Gilbert, C., Handfield, J., Tome, E., Lalonde, R., Bergeron, M. and Boivin, G. Human cytomegalovirus glycoprotein gB genotypes in blood of AIDS patients: lack of association with either the viral DNA load in leukocytes or presence of retinitis. Human cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: identification of a novel subgroup, geographical distribution and evidence of positive selective pressure -- Pignatelli et al. vir.sgmjournals.org /cgi/content/full/84/3/647   (3946 words)

Products - Glycoprotein Carbohydrate Estimation Kit carbohydrate in the glycoprotein under analysis ca be estimated. Estimates the percent carbohydrate content of a glycoprotein when run against a set of glycoprotein standards with known carbohydrate content Glycoprotein carbohydrate content estimation has never been easier www.piercenet.com /Products/Browse.cfm?fldID=02020107&Format=Print   (191 words)

Intracellularly Located Misfolded Glycoprotein Hormone Receptors Associate with Different Chaperone Proteins than Their Cognate Wild-Type Receptors -- Mizrachi and Segaloff 18 (7): 1768 -- Molecular Endocrinology Ou W-J, Cameron PH, Thomas DY, Bergeron JM 1993 Association of folding intermediates of glycoproteins with calnexin during protein maturation. Trombetta ES, Helenius A 1998 Lectins as chaperones in glycoprotein folding. of the glycoprotein hormone receptors are mediated by the monoglucosylated mend.endojournals.org /cgi/content/full/18/7/1768   (6296 words)

Histidine-rich Glycoprotein (HRG) Histidine-rich glycoprotein (HRG) is a relatively abundant plasma glycoprotein (1-2 µM in humans) whose function is still matter of debate. It contains about 15% carbohydrate and an unusually high proportion of histidine and proline (see below), hence its name (we think that the name of histidine-proline-rich glycoprotein better reflects the amino acid composition bias). The aminoacid sequence of human and rabbit HRG have been deduced from the cDNA sequence. cctr.umkc.edu /user/dborza/hrg.html   (180 words)

glycoprotein - OneLook Dictionary Search Phrases that include glycoprotein: variable surface glycoprotein, p glycoprotein, a1-acid glycoprotein, a1 acid glycoprotein, alpha2-heremans-schmid glycoprotein, more... Glycoprotein (gp) : Drug Discovery and Development [home, info] Tip: Click on the first link on a line below to go directly to a page where "glycoprotein" is defined. www.onelook.com /?w=glycoprotein   (211 words)

Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease? -- Ho et al. 52 (5): 759 -- Gut Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. The percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisolone. gut.bmjjournals.com /cgi/content/full/52/5/759   (5420 words)

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor -- Nakabayashi et al. 109 (11): 1445 -- Journal of Clinical Investigation Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor -- Nakabayashi et al. Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor glycoprotein hormone was named as thyrostimulin based on its www.jci.org /cgi/content/abstract/109/11/1445   (442 words)

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