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Topic: Paclitaxel

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Chemotherapy

Microtubule

	MedlinePlus Drug Information: Paclitaxel
		Paclitaxel is in a class of drugs known as taxanes.
		Paclitaxel has been used to treat head and neck cancer, non-small cell lung cancer, small cell lung cancer, and bladder cancer.
		The most common side effect of paclitaxel is a decrease of blood cells.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a698035.html (543 words)

	Paclitaxel - Wikipedia, the free encyclopedia
		Paclitaxel (Taxol®) is a drug used in the treatment of cancer.
		Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents (Heldman et al 2001).
		Paclitaxel is an effective treatment for aggressive cancers because it adversely affects the process of cell division by preventing this restructuring.
	en.wikipedia.org /wiki/Paclitaxel (1035 words)

	Biolyse Pharma Corporation - Paclitaxel for Injection (Site not responding. Last check: 2007-10-13)
		Paclitaxel is a chemotherapeutic agent that is currently prescribed worldwide to treat the most aggressive forms of ovarian, lung and breast cancer, as well as AIDS related Kaposi's sarcoma.
		Paclitaxel is considered by the scientific and medical community as a 'first line of defense' in the treatment of cancer.
		Paclitaxel is an anti-cancer compound originally obtained from the bark of the Pacific yew tree, Taxus brevifolia.
	www.biolyse.ca /paclitaxel.asp (792 words)

	Paclitaxel Injection quality control, 21CEC
		Paclitaxel is a white to off-white crystalline powder and is highly lipophilic, insoluble in water, and melts at around 216-217°C. Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization.
		In five patients administered a 225 or 250 mg/m2 dose of radio-labeled paclitaxel as a 3 hour infusion, a mean of 71% of the radioactivity was excreted in the feces in 120 hours, and 14% was recovered in the urine.
		Paclitaxel remained active in patients who had developed resistance to platinum-containing therapy (defined as tumor progression while on, or tumor relapse within 6 months from completion of, platinum containing regimen) with response rate of 14% in the Phase 3 study and 31% in the Phase 1 and 2 clinical studies.
	www.21cecpharm.com /px/pxinj.htm (1845 words)

	Paclitaxel (Taxol) mechanism of action, 21CEC
		Paclitaxel has activity against a broad band of tumour types, including breast, ovarian, lung, head and neck cancers.
		Paclitaxel also has activity in other malignancies that are refractory to conventional chemotherapy, including previously-treated lymphoma and small cell lung cancers and oesophageal, gastric endometrial, bladder and germ cell tumours.
		The Paclitaxel molecule shows a T-shaped or butterfly structure is optimized within the beta-tubulin and exhibits functional similarity to a portion of the B9-B10 loop in the alpha-tubulin.
	www.21cecpharm.com /px/action.htm (747 words)

	New designed paclitaxel analog kills more cancer cells than natural product
		Paclitaxel, a natural compound from yew trees, is the world's best-selling anticancer drug.
		One problem that paclitaxel and all its analogs share, however, is that they are all highly complex compounds, and cannot be prepared synthetically in a commercially viable way.
		Paclitaxel consists of a rigid ring system attached to a flexible side chain, but the exact arrangement of the side chain in space is not known.
	www.eurekalert.org /pub_releases/2004-06/vt-ndp062104.php (739 words)

	Paclitaxel And Cancer
		Paclitaxel is salvage therapy for patients with advanced ovarian cancer and for patients with metastatic breast cancer who failed to response to prior chemotherapy with standard agents.
		Paclitaxel, the first organic compound with a taxane ring that has been demonstrated to possess antineoplastic activity, was isolated in 1967 from the bark of the Western yew, Taxus brevifolia.
		Paclitaxel promotes the assembly and stabilization of microtubules which are intracellular structures vital to mitosis and other critical cell functions.
	articlesrightnow.com /Article/Paclitaxel-And-Cancer/76768 (515 words)

	Paclitaxel (Taxol®) : CancerBACUP
		Paclitaxel (pronounced pak li tax el) is chemotherapy that is given as a treatment for some types of cancer.
		Numbness or tingling in hands or feet This is due to the effect of paclitaxel on nerves and is known as peripheral neuropathy.
		While paclitaxel is being given, it can cause pain at the place where the injection is given, or along the vein.
	www.cancerbacup.org.uk /Treatments/Chemotherapy/Individualdrugs/Paclitaxel (1236 words)

	paclitaxel news articles (Site not responding. Last check: 2007-10-13)
		The balloon is coated with paclitaxel, which is used in the treatment of breast and other cancers and also one of the drugs used to coat stents.
		Paclitaxel is a chemotherapy agent that is commonly used in the treatment of breast cancer.
		Prolonged Paclitaxel therapy lengthens the recurrence-free interval, with increased neurotoxicity.
	www.mongabay.com /drugs/drugs/paclitaxel.html (9870 words)

	Synergistic Interaction of Lovastatin and Paclitaxel in Human Cancer Cells -- Holstein and Hohl 1 (2): 141 -- Molecular ...
		paclitaxel binds to and stabilizes microtubules (14, 15).
		The effects of paclitaxel alone as well as in combination with lovastatin in two different fixed ratios are shown.
		K562 cells were treated for 24 h with lovastatin (lov) and/or paclitaxel (tax) and/or mevalonate (mev), followed by PI staining of the nuclei and analysis by flow cytometry.
	mct.aacrjournals.org /cgi/content/full/1/2/141 (4666 words)

	Taxol (Paclitaxel) drug description - prescription drugs and medications at RxList (Site not responding. Last check: 2007-10-13)
		(paclitaxel) Injection should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents.
		In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, it is recommended that frequent peripheral blood cell counts be performed on all patients receiving TAXOL.
		Paclitaxel is a white to off-white crystalline powder with the empirical formula C
	www.rxlist.com /cgi/generic/paclitaxel.htm (403 words)

	Timeline of Paclitaxel Disputes
		There are special issues related to paclitaxel that may seriously complicate the approval process for generic versions of paclitaxel.
		Paclitaxel is to be made available to all women in England and Wales with ovarian cancer following the long awaited ruling by the National Institute for Clinical Excellence, which advises the NHS in England and Wales on the clinical and cost effectiveness of medicines.
		According to the British Medical Journal, the recommendation is expected to cost the NHS an additional 7m ($11.2m) a year to treat the 1000 patients each year who have been denied paclitaxel because their health authorities have refused to pay the 7000 for a course of treatment.
	www.cptech.org /ip/health/taxol/taxol-timeline2001.html (9338 words)

	Paclitaxel
		Paclitaxel is a natural (though quite toxic) substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug.
		In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 grams of glutamine four times daily along with the chemotherapy.
		In another study, patients receiving high-dose paclitaxel and melphalan had significantly fewer episodes of oral ulcers and bleeding when they took 6 g of glutamine four times daily along with the chemotherapy.
	www.gianteagle.com /healthnotes/Drug/Paclitaxel.htm (2987 words)

	Paclitaxel (Taxol®) : Cancerbackup
		Paclitaxel (pronounced pak-li-tax-el) is a chemotherapy drug that is given as a treatment for some types of cancer.
		This information describes paclitaxel, how it is given and some of its possible side effects.
		Contraception It is not advisable to become pregnant or father a child while taking paclitaxel, as the developing foetus may be harmed.
	www.cancerbackup.org.uk /Treatments/Chemotherapy/Individualdrugs/Paclitaxel (1353 words)

	Paclitaxel (Taxol), Best quality, Large quantity, Lowest price in the world, 21CEC
		To be the Exclusive Agent for EU generic Paclitaxel Injection in your country.
		Today, Paclitaxel is the No. 1 Anti-cancer Drug in the battle of we humans against cancer.
		Pure Paclitaxel is a white to off-white crystalline powder and is highly lipophilic, insoluble in water, and melts at around 216-217°C. Paclitaxel success is largely due to its unique mechanism of action -
	www.21cecpharm.com /px (486 words)

	A beta -Tubulin Leucine Cluster Involved in Microtubule Assembly and Paclitaxel Resistance -- Gonzalez-Garay et al. 274 ...
		Paclitaxel is the prototype for a novel class of agents that inhibit cells in mitosis by promoting and stabilizing microtubule
		of paclitaxel (0.2 µg/ml) that is lethal to wild-type cells.
		The total resistant cell population was then trypsinized and replated for 24 h in medium without tetracycline or paclitaxel before processing for immunofluorescence with an antibody specific for the HA tag.
	www.jbc.org /cgi/content/full/274/34/23875 (6117 words)

	Lung Cancer, Non-Small Cell
		Paclitaxel pharmacokinetics in patients with non-small cell lung cancer: compartmental and non-compartmental analyses
		The weekly paclitaxel and carboplatin regimen was designed to optimize the radiosensitizing properties of paclitaxel and carboplatin during the concurrent phase of treatment.
		Paclitaxel (P) and Gemcitabine (G) are active drugs in NSCLC and have different mechanims of action and side effects.
	www.rosoncoweb.ru /cure/taxol/thes22.htm (11638 words)

	Cyberbotanica: Paclitaxel (Taxol) & Docetaxel (Taxotere) (Site not responding. Last check: 2007-10-13)
		Paclitaxel is given intravenously (it irritates skin and mucous membranes on contact), and is most effective against ovarian carcinomas and advanced breast carcinomas.
		Slightly less than half of the patients receiving paclitaxel during clinical trials developed an allergic reaction to it, which resulted in problems ranging from rashes or a mild drop in blood pressure to major breathing problems, hives and/or fluid buildup around the heart.
		Like paclitaxel, it prevents the mitotic spindle from being broken down by stabilizing the microtubule bundles, but clinical trials indicate it's about twice as effective as paclitaxel in doing so.
	biotech.icmb.utexas.edu /botany/tax.html (347 words)

	Estrogen Inhibits Paclitaxel-Induced Apoptosis via the Phosphorylation of Apoptosis Signal-Regulating Kinase 1 in Human ...
		the induction of apoptosis by paclitaxel is mediated by the
		Relative densitometric units of the phospho-c-Jun bands are shown in A (panel ii), the upper panels of B, and C (panel ii), with the density of the control bands set arbitrarily at 1.0.
		paclitaxel is not always the same as that of cisplatin.
	endo.endojournals.org /cgi/content/full/145/1/49 (5615 words)

	ZD1839 Modulates Paclitaxel Response in Renal Cancer by Blocking Paclitaxel-Induced Activation of the Epidermal Growth ...
		RCC cells were treated with the complex (ZD1839, paclitaxel) indicated for 48 h, and cell cycle progression and apoptotic cell death were analyzed by flow cytometry (A) and/or fragmented DNA ELISA (B) as described in the "Materials and Methods." Experiments were repeated three times with similar results.
		paclitaxel for 12 h, and cell lysates were analyzed by Western blot analysis using specific antibodies (Abs).
		to paclitaxel was predominantly mediated by EGFR activation
	clincancerres.aacrjournals.org /cgi/content/full/10/2/794 (4051 words)

	(Taxol) Paclitaxel (Site not responding. Last check: 2007-10-13)
		It works by stopping the cancers cells separating into two new cells, so it blocks the growth of the cancer.
		The treatment plan for paclitaxel depends on which cancer you are being treated for.
		While you are having the chemotherapy, paclitaxel may leak from the drip or injection site and damage the body tissues in that area.
	www.cancerhelp.org.uk /help/default.asp?page=4016 (1182 words)

	Clinical Evidence for Topotecan-Paclitaxel Non-Cross-Resistance in Ovarian Cancer -- Gore et al. 19 (7): 1893 -- ...
		The incidence of grade 4 neutropenia with paclitaxel was
		McGuire WP, Hoskins WJ, Brady MF, et al: Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer.
		Thigpen JT, Blessing JA, Ball H, et al: Phase II trial of paclitaxel in patients with progressive ovarian carcinoma after platinum-based chemotherapy: A Gynecologic Oncology Group study.
	www.jco.org /cgi/content/full/19/7/1893 (4352 words)

	Vascular Endothelial Growth Factor Immunoneutralization Plus Paclitaxel Markedly Reduces Tumor Burden and Ascites in ...
		Administration of paclitaxel (20 µg/g body weight) was twice weekly in the first week and increased to three times weekly for the last 5 weeks.
		Administration of paclitaxel (20 µg/g body weight) was three times weekly for 6 weeks.
		Paclitaxel (20 µg/g body weight) was administered three times weekly for 4 weeks.
	ajp.amjpathol.org /cgi/content/full/161/5/1917 (4631 words)

	Preoperative Twice-Weekly Paclitaxel With Concurrent Radiation Therapy Followed by Surgery and Postoperative ...
		Conclusion: Twice-weekly paclitaxel with concurrent RT is a
		Buzdar AU, Singletary SE, Theriault RL, et al: Prospective evaluation of paclitaxel versus combination chemotherapy with fluorouracil, doxorubicin, and cyclophosphamide as neoadjuvant therapy in patients with operable breast cancer.
		Lau D, Ryu J, Gandara D, et al: Concurrent twice-weekly paclitaxel and thoracic irradiation for stage III non-small cell lung cancer.
	www.jco.org /cgi/content/full/21/5/864 (4221 words)

	TopSearch10 - Search Results - paclitaxel and solid tumors (Site not responding. Last check: 2007-10-13)
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	paclitaxel-and-solid-tumors.tbl.sytes.net (70 words)

	Disputes involving Paclitaxel, a cancer drug sold under different brand names, including Taxol.
		Disputes involving Paclitaxel, a cancer drug sold under different brand names, including Taxol.
		July 21, 2000, ivax.com, Ivax Paclitaxel approval in EU for Karposi Sarcoma
		May 13, 2000, The Pharmaceutical Journal, Paclitaxel should be standard therapy for ovarian cancer, says NICE
	www.cptech.org /ip/health/taxol (989 words)

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