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Topic: Pain and nociception

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pijncentrum Research in the field of nociception and pain is thus imperative for the continued development (and existence!) of anaesthesiology as an academic speciality — and to permit much-needed progress in the management of diseases associated with pain, or whose treatment is associated with pain. Nociception and pain are now being recognised to be a key contributor to pathological processes in an extraordinarily wide range of diseases. The management of nociception and pain and its consequences is the central therapeutic area of anaesthesiology and all of its subspecialties (anaesthesia, intensive care, pain medicine, emergency medicine). www.umcn.nl /scientist/afdelingen/pijncentrum   (2561 words)

Nociception If a dissociation between nociception and pain appraisal occurs, the experience of pain would not bear on behavior, as the affect is missing. The neuronal mechanism of nociception and pain perception have been treated. Nociception is the term commonly used to refer to the perception of pain. serendip.brynmawr.edu /bb/neuro/neuro98/202s98-paper3/Pernar3.html   (1620 words)

Nociception, Mechanoreception and Proprioception ... What's the Difference and What Do They Have to Do with Subluxation? David R. Seaman, DC, MS, DABCN Clearly, the clinical importance of pain and nociception should not be minimized. Nociception, mechanoreception, and proprioception are all intimately associated with the normal and abnormal function of vertebral joints. Nociception is the process by which nociceptive receptors receive tissue damaging stimuli that is then carried into the CNS by nociceptive axons (A-delta and C fibers). www.chiroweb.com /archives/12/24/16.html   (594 words)

Nociception Receptors and signalling mechanisms involved in neurotrophin-produced modulation of nociception are areas of intensive current research and represent novel avenues for pharmacological intervention in chronic pain states. Nociceptive activity can be modulated at several peripheral and central relay points in pain pathways. The NMDA subtype of glutamate receptors are key mediators of chronic nociceptive phenomena in the spinal cord and the thalamus. encref.springer.de /mp/0002.htm   (1965 words)

Spinal mediators involved in nociception NMDA receptors are found as autoreceptors in terminals of primary afferent fibers, where they can facilitate the transmission of inputs to the spinal cord by increasing the release of neurotransmitters from the primary afferent terminals SP released from primary afferents stimulates NK-1 receptors and is believed to play a major role in pain transmission. Glutamate can act on receptors such as NMDA and AMPA and is involved in various functions other than processing of nociception such as development of opioid tolerance and nitric oxide (NO) synthesis. Three types of opioid receptors are found in pain transmission pathways and are involved in spinal and supraspinal analgesia. www.geocities.com /mahindakommalage/spinal_mediators.html   (353 words)

noc.html Nociception is carried by A-delta and C fibers (slow), whereas mechanoreception is carried by A-beta fibers (fast). Because of the different pathways for nociception and mechanoreception, damage to the right half of the spinal cord will disrupt mechanoreception from the right side of the body and nociception from the opposite side of the body. Nociception crosses to the contralateral side of the nervous system in the spinal cord, whereas mechanoreception crosses to the contralateral side in the medulla. www.vancouver.wsu.edu /fac/morgan/lecture/noc.html   (487 words)

Nociception and Subluxation David R. Seaman, DC, MS, DABCN A major misconception, held by BOOPers and non-BOOPers, is the presumption that nociception equates with pain. A basic point to understand is that pain is merely one possible outcome of nociception. If you are a BOOPer or a non-BOOPer and have not investigated the topic of nociception and subluxation, then here is a chance for both sides to agree on a basic tenet of chiropractic -- nerve (nociception) irritation -- and approach it from the science of the 1990s. www.chiroweb.com /archives/12/20/11.html   (936 words)

Chemical nociception in the jejunum induced by capsaicin -- Schmidt et al. 53 (8): 1109 -- Gut Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Chemical nociception in the jejunum induced by capsaicin -- Schmidt et al. nociception was mediated by mucosal receptors, by receptors gut.bmjjournals.com /cgi/content/full/53/8/1109   (4950 words)

Untitled Document Distinct from other sensations, nociception is responsive to a diversity of stimulus that may arise from any origin, while being able to distinguish them between being nocuous and innocuous. Intermixed together, these neurons project their axons into the spinal cord and transmit their signals into the brain for the interpretation of pain. The initial perception of pain occurs at the site of so-called nociceptors, a set of neurons that are specialized in detection of harmful events. www.smbs.buffalo.edu /CENTERS/csmb/Qin/research_nociception.htm   (257 words)

PainOnline Evidently, whether motor or sensory, the influence of the cerebellum on many nociceptive phenomena cannot be treated with skepticism, but should rather be considered as yet another magnifying glass through which new dimensions of pain may be revealed, and as an alarm against scientific dogmatism and distortion. In fact, when stimulated, the superficial cells of the cerebellum (Purkinje cells) tended to heighten the sensitivity of neurons in the spinal cord pathway that relay visceral nociception (similar to the pathway that relays visceral pain in humans) to noxious colorectal distension. In this study, the aim was to correlate the event of nociception in the rat with the areas in the brain that are more active than the baseline, i.e. www.painonline.org /LittleBrain.htm   (1137 words)

July/August 1996- Resource Reviews, part 2- Peripheral Neurons in Nociception This is a useful reference volume for those who want to review the physiology and pharmacology of nociception and pain states induced by peripheral nerve lesions. John Loeser is professor of neurological surgery and anesthesiology and director of the Multidisciplinary Pain Center at the University of Washington, Seattle. July/August 1996- Resource Reviews, part 2- Peripheral Neurons in Nociception www.ampainsoc.org /pub/bulletin/jul96/resrev2.htm   (242 words)

Groups II and III Metabotropic Glutamate Receptors Differentially Modulate Brief and Prolonged Nociception in Primate STT Cells -- Neugebauer et al. 84 (6): 2998 -- Journal of Neurophysiology Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase. transmission and in prolonged nociception evoked by intradermal Neugebauer V, Vanegas H, Nebe J, Rümenapp P, and Schaible H-G. Effects of N- and L-type calcium channel antagonists on the responses of nociceptive spinal cord neurons to mechanical stimulation of the normal and the inflamed knee joint. jn.physiology.org /cgi/content/full/84/6/2998   (8273 words)

Comparison of Antiepileptic Drugs Tiagabine, Lamotrigine, and Gabapentin in Mouse Models of Acute, Prolonged, and Chronic Nociception -- Laughlin et al. 302 (3): 1168 -- Journal of Pharmacology And Experimental Therapeutics pain (acute phase) and tonic nociception involving central sensitization Coderre TJ and Melzack R (1992) The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. Enhancement of GABA neurotransmission may provide an approach to diminish the level of nociception in various pain states. jpet.aspetjournals.org /cgi/content/full/302/3/1168   (4847 words)

Capsaicin Induced Muscle Nociception The knowledge of the actions and mechanisms behind the effects of capsaicin will contribute to the further progress in the biology of nociception and for the development of novel analgesic strategies. In this study the role of TRPV1 in mediating nociceptive responses produced by capsaicin injections intramuscularly will be assessed and the presence of TRPV1 in muscle afferent neurons in the trigeminal ganglia (TG) will be investigated. Conclusion: This study provides an evidence for the involvement of TRPV1 in mediating nociceptive responses caused by craniofacial muscle pain. iadr.confex.com /iadr/2004Hawaii/techprogram/abstract_45363.htm   (332 words)

Pain - Wikipedia, the free encyclopedia Nociception is a neurophysiologic term and denotes the activity in the nerve pathways. Nociception is the physiological sense for perception of physiological pain. Interestingly, the brain itself is devoid of nociceptive tissue, and hence cannot experience pain (thus a headache is not pain in the brain itself). en.wikipedia.org /wiki/Nociception   (1801 words)

March/April 1996 - Resource Reviews, part 1 - Pain and the Brain: From Nociception to Cognition March/April 1996 - Resource Reviews, part 1 - Pain and the Brain: From Nociception to Cognition The symposium was a satellite of the International Association for the Study of Pain (IASP) Congress in Paris, and many of the participants had presented their research at that and prior congresses and other meetings. This volume derives from the symposium, "From Nociception to Pain," which was held August 27-29, 1993, in Beaune, France. www.ampainsoc.org /pub/bulletin/mar96/resrev1.htm   (573 words)

P2X Receptors and Nociception -- Chizh and Illes 53 (4): 553 -- Pharmacological Reviews Bland-Ward PA and Humphrey PP (1997) Acute nociception mediated by hindpaw P2X receptor activation in the rat. to directly evoke pain or nociceptive behavior, both ATP and Hamilton SG, Wade A and McMahon SB (1999) The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. pharmrev.aspetjournals.org /cgi/content/full/53/4/553   (6720 words)

Pain in the Trigeminal System: from Orofacial Nociception to Neural Network Modeling -- Woda 82 (10): 764 -- Journal of Dental Research trigeminal nucleus • nociception • oralis subnucleus • orofacial pain Superficial and deep convergent nociceptive neurons are differentially affected by N-methyl-D-aspartate applied on the brainstem surface of the rat medullary dorsal horn. Properties of nociceptive and non-nociceptive neurons in trigeminal subnucleus oralis of the rat. jdr.iadrjournals.org /cgi/content/full/82/10/764   (2980 words)

Module 10: Overview and Assessment of Cancer Pain The definition of pain may be clarified by distinguishing nociception, pain, and suffering (Figure: Distinctions and interactions between nociception, pain, and suffering). Failure to address these other factors while targeting therapy at sources of nociception can lead to a poor outcome, in which the focus of tissue damage is ameliorated but the pain continues. Nociception is the activity produced in the nervous system by noxious (potentially tissue-damaging) stimuli. www.ama-cmeonline.com /pain_mgmt/module10/04defin   (261 words)

British Journal of Pharmacology - Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice All experiments were carried out in accordance with current guidelines for the care of laboratory animals and ethical guidelines for investigations of experimental pain in conscious animals (Zimmermann, 1983). To explore the relationship between the in vitro and in vivo BK nociceptive effect, we have performed experiments with cyclooxygenase blocking and found that i.pl. injection of ibuprofen was not able to reduce BK-induced nociception. Likewise, BK-induced overt nociception was decreased by lipoxygenase (LOX) inhibition. www.nature.com /bjp/journal/v141/n5/full/0705546a.html   (5204 words)

IASP Newsletter Technical Corner: Pain, Its Perception and Pain Imaging Although nociception may give rise to the experience of pain, pain may arise in the absence of nociception. The descending connections of the anterior cingulate cortex to the medial thalamic nuclei and to the peri-aqueductal gray in the brain stem suggest that this system may also be involved in the modulation of reflex responses to noxious stimuli. Nociception is the response to excitation of nociceptors. www.iasp-pain.org /TC97MayJune.html   (2375 words)

Journal of Circadian Rhythms Full text Daily rhythm of nociception in rats Nociception was investigated by Eddy's hot plate method, tail immersion method, and tail clip method. Nociception was evaluated by Eddy's hot plate method, tail immersion method, and tail clip method. Understanding of the daily rhythmicity in nociception is important for the standardization of studies of analgesic drugs. www.jcircadianrhythms.com /content/2/1/2   (678 words)

Nat' Academies Press, (NAS Colloquium) The Neurobiology of Pain (1999) In contrast, lesions within the anterior cingulate cortex have no effect on innocuous or nociceptive somesthetic discriminative functions, but impair the recognition of the noxious or aversive quality of the stimulus in animals and the perceived affective quality of pain in humans (4, 5). The broad range of environmental influences, such as attention, fear, and the placebo effect on the perception of pain suggests that cortical association areas and their subcortical connections are critical participants in mediating the cognitive aspects of pain. The structures most consistently activated across genders and during contact heat pain, cold pain, cutaneous laser pain or intramuscular pain were the contralateral insula and anterior cingulate cortex, the bilateral thalamus and premotor cortex, and the cerebellar vermis. www.nap.edu /books/0309065488/html/42.html   (1356 words)

Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice -- Kamp et al. 284 (3): 434 -- AJP - Gastrointestinal and Liver Physiology Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen. Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice -- Kamp et al. ajpgi.physiology.org /cgi/content/full/284/3/G434   (6754 words)

How Might Thoughts and Diet Influence Nociception and Subluxation? David R. Seaman, DC, MS, DABCN Figure A demonstrates a proposed mechanism by which nociception can result in pain, autonomic symptoms, vasoconstriction and muscle spasm. The DIP is known to descend down the dorsolateral funiculus and cause a pre-synaptic inhibition of the primary nociceptive neurons and a post-synaptic inhibition of preganglionic sympathetic neurons. Sympathetic hyperactivity may be involved in the pathogenesis of various visceral disorders such as neurogenic pulmonary edema, peptic ulcers and pancreatitis.1 In the upper left hand corner of Figure A there is a sagital section of the brain, and projecting from it is the serotonergic descending inhibitory pathway (DIP). www.chiroweb.com /archives/12/22/14.html   (1236 words)

Pain disaggregation theory--statistical nonsense or a pointer to a paradigm for quantum nociception? -- Conacher et al. 91 (2): 279 -- British Journal of Anaesthesia The values represent changes in nociception from background/baseline (at rest) to when the two stresses (arm movement and cough) are activated and compared. by, shoulder-tip pain resulting from predominance of nociception of nociception being conducted along the phrenic and vagus nerves, bja.oxfordjournals.org /cgi/content/full/91/2/279   (1438 words)

Animal Models of Nociception -- Le Bars et al. 53 (4): 597 -- Pharmacological Reviews of nociception and/or pain in other species can be found in the In this review, we describe and critically analyze the most commonly used behavioral tests of nociception in animals (Fig. The term nociceptive refers to the potential of a stimulus to produce a tissue lesion and a reaction from the organism. pharmrev.aspetjournals.org /cgi/content/full/53/4/597   (9702 words)

Attenuation of thermal nociception and hyperalgesia by VR1 blockers -- García-Martínez et al. 99 (4): 2374 -- Proceedings of the National Academy of Sciences The role of VR1 channels in nociception and pain perception has been a matter of intense investigation. Mechanical nociception was evaluated using von Frey hairs as described (25). Adult male ICR mice were habituated to the test environment for 24 h in Plexiglas chambers prior the nociception assays. www.pnas.org /cgi/content/full/99/4/2374   (4413 words)

Herman, Ola, Molecular mechanisms of nociception in the rat brain The pontine parabrachial nucleus (PB) is a major recipient of fibers from nociceptive (pain-responsive) spinal and trigeminal dorsal horn neurons. Following nociceptive stimulation of the neck, tail, and hindlimb, most of the FOS was found in the dorsal and the superior lateral subnuelei of PB. Therefore, the expression of active, phosphorylated, CREB was investigated in PB after nociceptive stimulation and was found to be present in the majority of the ppENK-expressing neurons in K-F and the internal lateral subnucleus. www.bibl.liu.se /liupubl/disp/disp97/med514s.htm   (852 words)

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