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Topic: Pancreatic carcinoma

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	Crippa S, et al. Pancreaticoduodenectomy for Pancreatic Metastases from Breast Carcinoma. JOP. J Pancreas (Online) ...
		In all cases, the pancreatic metastases were solitary lesions located in the head of the pancreas and the intervals between the primary breast carcinoma and the pancreatic metastases were 3, 5 and 7 years.
		Unlike primary pancreatic carcinoma, metastatic lesions to the pancreas are uncommon and account for approximately 2% of pancreatic malignancies [1].
		Jaundice in patients with breast carcinoma is most likely to be the result of diffuse metastases of the liver and the onset of jaundice is a sign associated with a mean survival of only 1 month [17, 18].
	www.joplink.net /prev/200409/05.html (2451 words)

	eMedicine - Pancreatic Cancer : Article by Richard A Erickson, MD, FACP, FACG
		Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail.
		Interestingly, amylase and lipase are infrequently elevated in pancreatic carcinoma unless the patient is presenting with acute pancreatitis secondary to the pancreatic cancer.
		Hematoxylin and eosin stain of a pancreatic carcinoma.
	www.emedicine.com /med/topic1712.htm (7789 words)

	s020313a - Pancreatic Adenocarcinoma - CA-19-9 Marker
		The level of CA 19-9 was increased with the development of early pancreatic cancer and this elevation steadily continued with the progression of the cancer.
		A total of 156 consecutive patients with clinical suspicion of pancreatic cancer or for confirmation and follow-up of their chronic pancreatitis disease were included: 84 patients presenting a pancreatic mass (group 1) and 72 patients without a pancreatic mass (group 2).
		Elevated levels of TPS were detected in 100% of patients with pancreatic carcinoma and in 22% of patients with chronic pancreatitis.
	www.emory.edu /WHSCL/grady/amreport/litsrch01/s020313a.html (2686 words)

	Pancreatic carcinoma (Disease) - Detroit, Michigan
		Pancreatic cancer is the 4th leading cause of death from cancer in the U.S. The disease is slightly more common in men than in women, and risk increases with age.
		Patients with pancreatic cancer that can be removed successfully with surgery should consider enrollment in a clinical trial (a medical research study to determine the best treatment).
		For patients with pancreatic cancer that cannot be removed completely with surgery or cancer that has spread beyond the pancreas, cure is not currently possible.
	www.henryfordhealth.org /13231.cfm (598 words)

	MedlinePlus Medical Encyclopedia: Pancreatic carcinoma
		Pancreatic carcinoma is a malignancy (cancer) of the pancreas.
		This surgery for pancreatic cancer should be done at centers that perform the procedure frequently.
		For pancreatic cancer that cannot be removed completely with surgery, or cancer that has spread beyond the pancreas, cure is not currently possible and the average survival is usually less than 1 year.
	www.nlm.nih.gov /medlineplus/ency/article/000236.htm (709 words)

	Archives of Pathology & Laboratory Medicine: Splenic Rupture: A Rare Presentation of Pancreatic Carcinoma
		In 3 of these cases, the pancreatic carcinoma grossly invaded the spleen at the time of resection.
		Carcinoma of the pancreas is generally associated with nonspecific symptoms that suggest a wide range of differential diagnoses.
		Splenic rupture is a very rare presenting sign of pancreatic carcinoma, and to our knowledge only 4 cases have been reported previously.6-9 Regardless of etiology, clinical signs of splenic rupture include pain, tenderness, and muscle guarding in the left upper quadrant of the abdomen, as well as shoulder pain, nausea, vomiting, dizziness, and syncope.1,10
	www.findarticles.com /p/articles/mi_qa3725/is_200410/ai_n9454794 (1348 words)

	PET Imaging Pancreatic Carcinoma
		Pancreatic ductal adenocarcinoma was noted at the pancreatico-jejunostomy anastomosis corresponding to the PET and CT soft tissue abnormalities.
		In summary, FDG PET is useful in staging and determination of resectability of pancreatic cancer at the time of initial diagnosis as well as in re-evaluation of patients after therapy and in differentiating malignancy from chronic pancreatitis.
		Overexpression of glucose transporter 1 and increased FDG uptake in pancreatic carcinoma.
	brighamrad.harvard.edu /Cases/jpnm/hcache/1097/full.html (693 words)

	Molecular Cancer \| Full text \| Genetic alterations in pancreatic carcinoma
		In sporadic pancreatic cancer BRCA2 is inactivated in 7 to 10% and lately the biallelic inactivation in a high-grade duct lesion was demonstrated, so that it is assumed that BRCA2 mutation occur late in the neoplastic progression in the pancreas [56].
		Pancreatic cancers occurring in context of the Lynch syndrome are different compared to sporadic pancreatic carcinomas in terms of the superior clinical course, histopathology and distinct molecular genetic profiles, including retention of wildtyp RAS [72-74].
		Pancreatic cancer is a genetic disease, but the transition between cancer and non-cancer is not regulated by a simple switch activated by a single gene.
	www.molecular-cancer.com /content/2/1/15 (4234 words)

	eMedicine - Ampullary Carcinoma : Article by Vivek K Mehta, MD
		Background: Carcinoma of the ampulla of Vater is defined as a malignant tumor arising in the last centimeter of the common bile duct where it passes through the wall of the duodenum and ampullary papilla.
		Carcinomas originating in the ampulla of Vater by gross inspection can arise from 1 of 4 epithelial types, (1) terminal common bile duct, (2) duodenal mucosa, (3) pancreatic duct, or (4) ampulla of Vater.
		It often is elevated in pancreatic malignancies and might have a role in assessing response to therapy, predicting tumor recurrence, or both.
	www.emedicine.com /med/topic123.htm (3788 words)

	Clinical Experience With Gemcitabine in Pancreatic Carcinoma (Site not responding. Last check: 2007-09-06)
		Pancreatic adenocarcinoma is the number five cause of cancer mortality in North America, with an estimated 27,600 new cases in 1997.[1] Only 20% of patients present with localized, and thus potentially resectable, disease.
		If the pancreatic mass was smaller but less well-defined, a partial response was declared if, according to the reference radiologist, there was a “substantial reduction in the mass effect,” and the radiologic findings were accompanied by clinical improvement.
		Studies of gemcitabine in advanced pancreatic carcinoma have demonstrated a benefit in terms of both disease palliation and survival.
	www.cancernetwork.com /journals/oncology/o9711b.htm (6419 words)

	Pancreatic cancer
		John TG, Greig JD, Carter DC, et al.: Carcinoma of the pancreatic head and periampullary region: tumor staging with laparoscopy and laparoscopic ultrasonography.
		The operative mortality rate for a radical pancreatic resection is less than 10%.[1,2] For suitable patients post-pancreatectomy, fluorouracil plus regional radiation appears to offer a survival advantage.
		Pain associated with unresectable pancreatic cancer may be palliated with radiation therapy, with or without chemotherapy,[1,3-5] or with chemical splanchnicectomy with 50% alcohol at the time of surgical exploration.[6] Celiac nerve blocks and local neurosurgical procedures to relieve pain can be considered.[7]
	www.meds.com /pdq/pancreatic_pro.html (2796 words)

	News - Adding Cisplatin To Gemcitabine Improves Outcomes In Pancreatic Carcinoma
		Median times to disease progression and overall response rates in patients with advanced pancreatic adenocarcinoma are significantly better with cisplatin plus gemcitabine than with gemcitabine alone.
		The objective response rate, overall survival rate and toxicity patterns of patients in the two treatment arms were evaluated as secondary end points.
		Patients with measurable, locally advanced and/or metastatic pancreatic adenocarcinoma were randomised to receive gemcitabine (n=54) or a combination of gemcitabine and cisplatin (n=53).
	docguide.com /news/content.nsf/news/852569780017887A85256B680075F6F0 (620 words)

	Pancreatic Carcinoma versus Chronic Pancreatitis: Dynamic MR Imaging -- Johnson and Outwater 212 (1): 213 -- Radiology
		In c, the dilated pancreatic duct appears as a beaded low-signal-intensity structure in the parenchyma of the body and tail.
		CT pancreatogram in carcinoma of the pancreas and chronic pancreatitis.
		Root of the superior mesenteric artery in pancreatitis and pancreatic carcinoma: evaluation with CT. Radiology 1991; 180:659-662.
	radiology.rsnajnls.org /cgi/content/full/212/1/213 (3598 words)

	Stromelysin 3 is overexpressed in human pancreatic carcinoma and regulated by retinoic acid in pancreatic carcinoma ...
		Stromelysin 3 is overexpressed in human pancreatic carcinoma and regulated by retinoic acid in pancreatic carcinoma cell lines -- von Marschall et al.
		Stromelysin 3 is overexpressed in human pancreatic carcinoma and regulated by retinoic acid in pancreatic carcinoma cell lines
		STR-3 expression was examined by immunohistochemistry in 21 human pancreatic carcinomas.
	gut.bmjjournals.com /cgi/content/abstract/43/5/692 (396 words)

	Pancreatic Carcinoma Treatment Information, OnTumor.com
		The signs of pancreatic cancer are like many other illnesses, and there may be no signs in the first stages.
		A doctor should be seen if there are any of the following symptoms: nausea, loss of appetite, weight loss without trying to lose weight, pain in the upper or middle of the abdomen, or yellowing of the skin (jaundice).
		The use of biological therapy (using the body's immune system to fight cancer) is being tested in clinical trials for pancreatic cancer.
	www.cancerlinksusa.com /pancreas/nci_patient.htm (1967 words)

	K-ras Mutations in DNA Extracted From the Plasma of Patients With Pancreatic Carcinoma: Diagnostic Utility and ... (Site not responding. Last check: 2007-09-06)
		K-ras Mutations in DNA Extracted From the Plasma of Patients With Pancreatic Carcinoma: Diagnostic Utility and Prognostic Significance -- Castells et al.
		K-ras mutations in the plasma of patients with pancreatic carcinoma.
		Probability of survival of pancreatic adenocarcinoma patients with the wild-type (solid line) or the mutant-type (dashed line) K-ras gene in plasma DNA samples, considering both the whole series (top) and only those cases in which the primary tumor exhibited K-ras mutations (bottom).
	www.jco.org /cgi/content/full/17/2/578 (4485 words)

	IngentaConnect Human Pancreatic Carcinoma Cells Activate Maspin Expression Throu... (Site not responding. Last check: 2007-09-06)
		This activation of maspin expression in pancreatic carcinoma cells was linked to demethylated promoters and hyperacetylation of the associated H3 and H4 histones.
		-deoxycytidine treatments activated maspin expression in the two maspin-negative pancreatic carcinoma cell lines, suggesting a causal role for cytosine methylation in the maintenance of a transcriptionally silent maspin gene.
		Thus, human pancreatic carcinoma cells acquire maspin expression through epigenetic derepression of the maspin locus, and in so doing appear to co-opt a normal cellular mechanism for the regulation of this gene.
	www.ingentaconnect.com /content/neo/neo/2003/00000005/00000005/art00006 (229 words)

	Pancreatic Carcinoma (Site not responding. Last check: 2007-09-06)
		The intrapancreatic, tubular shaped, hypoechoic structure is a dilated pancreatic duct.
		Although the appearance of the duct may be similar in these conditions, most patients with chronic pancreatitis have glandular calcifications, while patients with acute pancreatitis have an enlarged, sonolucent (edematous) gland and peripancreatic effusions.
		Other images obtained during this examination revealed extrahepatic bile duct dilatation and a small mass in the head of the pancreas, which was subsequently proven to be pancreatic carcinoma.
	brighamrad.harvard.edu /Cases/bwh/hcache/27/full.html (260 words)

	MIR Teaching file case pt009
		FDG whole body PET imaging demonstrates markedly increased FDG accumulation in the pancreatic head (on the anterior image) and in the left adrenal gland (on the posterior image).
		The CT images demonstrate a soft tissue mass in the head of the head of the pancreas and a nodule in the left adrenal gland.
		The metastatic adrenal adenocarcinoma is likely from the bronchogenic carcinoma in this patient, although it could be from pancreatic carcinoma.
	gamma.wustl.edu /pt009te173.html (487 words)

	Genetic Progression and Divergence in Pancreatic Carcinoma -- Yamano et al. 156 (6): 2123 -- American Journal of ...
		Molecular studies of pancreatic carcinoma have advanced recently.
		pancreatic ductal carcinoma were obtained from 166 cases of
		Caldas C, Hahn SA, Hruban RH, Redston MS, Yeo CJ, Kern SE: Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
	ajp.amjpathol.org /cgi/content/full/156/6/2123 (5119 words)

	Molecular Analysis of Microdissected Tumors and Preneoplastic Intraductal Lesions in Pancreatic Carcinoma -- ...
		Molecular Analysis of Microdissected Tumors and Preneoplastic Intraductal Lesions in Pancreatic Carcinoma -- Heinmöller et al.
		DPC4, and p53 genes occurring early in carcinogenesis of pancreatic carcinoma.
		Bocsi J, Zalatnai A: Establishment and long-term xenografting of human pancreatic carcinomas in immunosuppressed mice: changes and stability in morphology, DNA ploidy and proliferation activity.
	ajp.amjpathol.org /cgi/content/full/157/1/83 (5982 words)

	ENLmedical.com: Conditions And Concerns: Medical Encyclopedia: Pancreatic carcinoma
		Pancreatic cancer is the 4th most common cancer causing death in the U.S. The disease is more common in men especially those between 60 and 70 years.
		Over- or under-production of hormones from any of these glands is associated with many different types of disease.
		A CT scan of the upper abdomen showing a tumor (pancreas carcinoma) in the head of the pancreas, seen here in the middle of the picture.
	www.enlmedical.com /article/000236.htm (304 words)

	Tumor Stroma Interactions Induce Chemoresistance in Pancreatic Ductal Carcinoma Cells Involving Increased Secretion and ...
		Tumor Stroma Interactions Induce Chemoresistance in Pancreatic Ductal Carcinoma Cells Involving Increased Secretion and Paracrine Effects of Nitric Oxide and Interleukin-1{beta} -- Müerköster et al.
		Tumor Stroma Interactions Induce Chemoresistance in Pancreatic Ductal Carcinoma Cells Involving Increased Secretion and Paracrine Effects of Nitric Oxide and Interleukin-1ß
		Pancreatic ductal carcinoma is characterized by a profound chemoresistance.
	cancerres.aacrjournals.org /cgi/content/abstract/64/4/1331 (539 words)

	pancreas \| pancreas directory (Site not responding. Last check: 2007-09-06)
		It makes pancreatic juices, which contain enzymes that aid in digestion, and it produces several hormones, including insulin.
		The Adult Kidney and Pancreas Transplant Program at Stanford was established in 1991 when Dr. Donald Dafoe, former Chief of the Division of Transplantation at the University of Pennsylvania, came...
		The human pancreas is an amazing organ with two main functions: [1] to produce pancreatic endocrine...
	www.ultimate-cancer-breakthroughs.com /cancer1/pancreas (2003 words)

	RedNova News - Health - Pancreatic Panniculitis Due to Pancreatic Carcinoma (Site not responding. Last check: 2007-09-06)
		A 52-year-old woman had a 3-month history of multiple red-brown, tender subcutaneous nodules confined to the lower extremities and associated with a 15-kg weight loss.
		A skin incisional biopsy specimen revealed lymphocytic panniculitis with necrosis of fat cells, some appearing as ghostlike cells, consistent with pancreatic panniculitis.
		The serum lipase level was 2910 U/L. Computed tomography of the abdomen showed what appeared to be a tumor thrombus in the portal vein.
	www.rednova.com /news/display?id=155448&source=r_health (266 words)

	AllRefer Health - Pancreas - Pancreatic Carcinoma Pictures & Images (Cancer - Pancreas, Pancreatic Cancer)
		AllRefer Health - Pancreas - Pancreatic Carcinoma Pictures and Images (Cancer - Pancreas, Pancreatic Cancer)
		You are here : AllRefer.com > Health > Diseases and Conditions > Pancreatic Carcinoma > Pictures and Images: Pancreas
		The pancreas is an elongated, tapered gland that is located behind the stomach and secretes digestive enzymes and the hormones insulin and glucagon.
	health.allrefer.com /health/pancreatic-carcinoma-pancreas-1.html (280 words)

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