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Topic: Pancytopenia

In the News (Sat 20 Oct 18)

  Two patients presented with pancytopenia due to two different causes...   (Site not responding. Last check: 2007-11-04)
Pancytopenia from bone marrow failure is also an important feature of acute leukaemias, the later stages of chronic leukaemias, myeloproliferative disorders, and myelodysplasias.
Pancytopenia is commonly caused by Hepatitis B and C viruses, occasionally by cytomegalovirus, Epstein - Barr Virus, HIV, and rarely by Hepatitis A virus.
Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis.
www.indegene.com /Onc/FeatArt/indOncFeatArt14.html   (2089 words)

 Bone Marrow Examination in Cases of Pancytopenia   (Site not responding. Last check: 2007-11-04)
The mechanism by which pancytopenia develops appears to be either associated with decrease in hematopoietic cell production as a result of destruction of the marrow tissue by toxins, replacement by abnormal or malignant tissue, or perhaps suppression of normal growth and differentiation.
A full-blown case of AIDS presented with pancytopenia and the marrow was hypoplastic with the presence of large number of lymphocytes, plasma cells, and evidence of vascular proliferation.
Pancytopenia occurs late in the course of HIV infection1.
www.indegene.com /Ped/FeatArt/indPedFeatArt8.html   (1118 words)

 Med Bull   (Site not responding. Last check: 2007-11-04)
Pancytopenia is a rare hematological manifestation of enteric fever.
Pancytopenia was attributed to the infection associated hemophagocytosis.
Pancytopenia, a rare manifestation of enteric fever may be due to hemophagocytosis.
www.istanbul.edu.tr /istanbultip/mecmua/medmecmua/med-99-1/12.htm   (669 words)

This study was done to describe the etiology, presentation and outcome of patients with pancytopenia presenting in a general medical ward.
All admitted patients with pancytopenia were studied and a total of 100 adult patients were selected for the study by non-probability convenient sampling.
Pancytopenia is not an uncommon hematological problem encountered in our clinical practice and should be suspected on clinical grounds when a patient presents with unexplained anemia, prolonged fever and tendency to bleed.
www.ayubmed.edu.pk /JAMC/PAST/16-1/Osama.htm   (1496 words)

Aplastic anemia is a condition of bone marrow failure that arises from injury to or abnormal expression of the stem cell.
Pancytopenia in the presence of a normocellular bone marrow
All the causes of aplastic anemia and pancytopenia may cause neutropenia.
www.geocities.com /dreamerica/07anae.htm   (473 words)

 Pancytopenia after a single intradermal infiltration of methotrexate Journal of Drugs in Dermatology - Find Articles
We report a woman with hypertensive renal disease who was receiving hemodialysis and developed pancytopenia following a single intradermal infiltration of 25 mg of methotrexate.
Caution should be exercised when considering the use of either systemic or intralesional methotrexate therapy in patients with risk factors that have been implicated in the development of adverse hematologic side effects: renal dysfunction, possible drug interactions, and advanced age.
In patients with rheumatoid arthritis who are treated with methotrexate, the estimated prevalence of drug-associated hematologic toxicity is 3% and the incidence of pancytopenia in these individuals is approximately 1.4%.
www.findarticles.com /p/articles/mi_m0PDG/is_5_4/ai_n15396472   (844 words)

 "Parvovirus-B19-Related Pancytopenia in Children with HIV Infection"
B19 can be considered the cause of pancytopenia in HIV-positive children, independent of the hemophagocytic syndrome, write Giovanni Nigro et al.
Dr. Muir and colleagues (Lancet-May 9) report parvovirus-B19-related pancytopenia and hemophagocytosis in two patients with hereditary spherocytosis, indicating that hemophagocytis could account for the leucopenia and thrombocytopenia linked with parvovirus B19 infection.
analyzed serum samples from four children with vertically-transmitted HIV infection and pancytopenia for IgM and IgG antibodies against parvovirus B19, by means of two enzyme immunoassays with synthetic peptide or recombinant protein and subsequent detection of serum B19-DNA with polymerase chain reaction.
www.aegis.com /news/ads/1992/AD921504.html   (473 words)

Thus, the clinical impression was hepatosplenomegaly with pancytopenia (in view of fever, petechiae and pallor) with CCF to rule out megaloblastic anemia (dietary deficiency) or leukemia.
Her investigations showed Hb of 4.5 gm/dl, WBC count of 6,100/cumm (ANC=976/cumm) and platelet count of 32,000/cumm suggestive of pancytopenia.
Peripheral smear was suggestive of hypopolychromasia, Howell Jolly bodies, poikilocytosis with presence of macrocytes and basophilic stippling.
www.pediatriconcall.com /fordoctor/casereports/megaloblastic.asp   (811 words)

 Haematologica 2004;89(96):ecr38   (Site not responding. Last check: 2007-11-04)
Bone marrow failure is the principal cause of early mortality with an additional predisposition to malignancy and fatal pulmonary complications.
The patient was born as the third child of the family after an uneventful pregnancy at 39 weeks of gestation, with slightly intrauterine growth retardation (weight 2400 gram, length 44 cm and head circumference 32 cm).
Magnetic resonance imaging of the brain was performed because of the developmental delay and revealed hypoplasia of the cerebellum and cerebellar vermis (Figure 2).
www.haematologica.org /online/e-cases/2004/9/ECR38   (2111 words)

 Aplastic Anemia
Pancytopenia and hypocellular marrow due to paroxysmal nocturnal hemoglobinuria
Pancytopenia and hypocellular marrow due to FA or dyskeratosis congenita
Patients with severe pancytopenia with maturation arrest due to antiprogenitor cell or stem cell antibodies; bone marrow aspirate is usually cellular
members.tripod.com /enotes/anemia-aplastic.htm   (1327 words)

 PakMediNet - View Abstract
Pancytopenia is a condition in which there is deficiency of all the cellular elements of blood.
A definitive diagnosis of etiology of pancytopenia was reached in 28 out of 30 patients.
In two patients the cause of pancytopenia could not be determined.
www.pakmedinet.com /view.php?id=5098   (313 words)

 Result Content View   (Site not responding. Last check: 2007-11-04)
Cytomegalovirus (CMV) PCR was performed in all cases of fever, or pancytopenia.
There was no difference in the liklihood of developing cytopenias in terms of age, sex or dose of alemtuzumab and the pancytopenia never heralded disease recurrence.
While prolonged lymphopenia is expected, pancytopenia is unexpected since neither haematopoietic stem cells (CD34+) nor more mature myeloid or erythroid cells or megakaryocytes express CD52.
www.abstracts2view.com /hem_sandiego2004/view.php?nu=HEM4L1_5242   (551 words)

The chronic severe form of canine monocytic ehrlichiosis (CME) is characterized by severe pancytopenia, and carries a grave prognosis despite treatment.
A three-year old male weimaraner dog was referred to the Hebrew University Veterinary Teaching Hospital with chief complaints of exercise intolerance for the last 3 months, fever, and a history of tick infestation.
CBC revealed severe pancytopenia (Table 1), severe anemia (RBC - 2.48x106/mm3), and no evidence of RBC regeneration in peripheral blood smears (reticulocyte count was 0%).
www.isrvma.org /article/56_2_7.htm   (843 words)

 Leflunomide-Associated Pancytopenia With or Without Methotrexate -- Chan et al. 38 (7): 1206 -- The Annals of ...
of new-onset mild pancytopenia: hemoglobin (Hb) 8.7 g/dL with
pancytopenia, and an Escherichia coli urinary tract infection;
Mofredj A, Baraka D, Charoud A. Comment: severe pancytopenia associated with methotrexate therapy for rheumatoid arthritis (letter).Ann Pharmacother 2002;36:1295.
www.theannals.com /cgi/content/full/38/7/1206   (2147 words)

 Quinine-induced Pancytopenia and Coagulopathy -- Schmitt and Tomford 120 (1): 90 -- Annals of Internal Medicine
Quinine-induced Pancytopenia and Coagulopathy -- Schmitt and Tomford 120 (1): 90 -- Annals of Internal Medicine
1991 with fever, mild renal insufficiency, and pancytopenia.
Recurrent pancytopenia, coagulopathy, and renal failure associated with multiple quinine-dependent antibodies.
www.annals.org /cgi/content/full/120/1/90-a   (519 words)

 The Fluoroquinolone Toxicity Research Foundation
Presuming that the pancytopenia was drug related and since the patient had become afebrile and his jaundice had subsided, both drugs were stopped.
His blood counts continued to be low, however, and he developed gingival bleed and purpuric spots on the right cubital fossa, left forearm and thigh over the next week.
In one case, pancytopenia was observed only 2 days after use of ciprofloxacin, while in the other case, bleeding symptoms started
www.fqresearch.org /rip_17.htm   (1372 words)

 Medical Dictionary: Pancytopenia - WrongDiagnosis.com
Pancytopenia: an abnormal deficiency in all blood cells (red blood cells and white blood cells and platelets); usually associated with bone marrow tumor or with aplastic anemia
Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
The following list attempts to classify Pancytopenia into categories where each line is subset of the next.
www.wrongdiagnosis.com /medical/pancytopenia.htm   (225 words)

 eMedicine - Bone Marrow Failure : Article by Emmanuel C Besa, MD
Morbidity and mortality from pancytopenia are caused by low levels of mature blood cells.
Severe pancytopenia is a medical emergency, requiring rapid institution of definitive therapy (ie, early determination of supportive care and bone marrow transplant candidates).
Constitutional aplastic anemia is associated with chronic bone marrow failure, congenital anomalies, familial incidence, or thrombocytopenia at birth.
www.emedicine.com /med/topic235.htm   (4248 words)

 Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years -- Lim et al. 44 ...
pancytopenia at the Norfolk and Norwich University Hospital
side-effects as pancytopenia can be a late manifestation.
Methotrexate induced pancytopenia is rare and concern for it should not limit its use
rheumatology.oxfordjournals.org /cgi/content/abstract/44/8/1051   (399 words)

 [No title]
Such deficiencies, which are known to result in megaloblastic anaemia at a late stage, may also influence the granulocyte and platelet lines, but pancytopenia rarely occurs.
We report 3 cases of pancytopenia associated with folate and/or vitamin B12 deficiency in elderly patients.
In two of these patients bone marrow examination showed a misleading "pseudo-leukaemia" due to a significant proportion of strongly dystrophic young cells.
jesuswasavegetarian.7h.com /leuk.html   (946 words)

 Definition: Primary deficiency of stem cells resulting in aplasia and pancytopenia   (Site not responding. Last check: 2007-11-04)
Primary deficiency of stem cells resulting in aplasia and pancytopenia.
Blood smear shows pancytopenia with reticulocytopenia; MCV is normal or increased.
Bone marrow showing severe hypocellularity with absence of all cell lines and replacement of marrow by fat is diagnostic.
intmedweb.wfubmc.edu /blurbs/ho/aplastic.html   (257 words)

 Anemia, Fanconi's
The disorder is characterized by deficiency of all bone marrow elements including red blood cells, white blood cells, and platelets (pancytopenia).
Hairy Cell Leukemia is a rare malignant disease characterized by the presence in the blood of abnormal "hairy-like" cells (mononuclear) and abnormally low levels of all the cellular elements of the blood including red blood cell, white blood cells, and platelets (pancytopenia).
Dyskeratosis Congenita is a rare disorder characterized by darkening and/or unusual absence of skin color (hyper/hypopigmentation), abnormal changes in the nails (dystrophy), and progressive degenerative changes of the mucous membranes (leukoplakia) in the anus, urethra, lips, mouth and/or eyes.
hw.healthdialog.com /kbase/nord/nord84.htm   (2622 words)

 [No title]
Pancytopenia Defintion: A pancytopenia is when the white blood cells are low, the red blood cells are low and the thrombocytes are low.
This is a serious problem because one is anemic (low red blood cells), and one does not have the ability to have their blood clot (thrombocytopenia) and one cannot defend themselves against attacks by bacteria, fungus or virus (low white blood cells).
After the bone marrow is obtained, then the therapy of giving whole blood and platelets is started.
www.swcp.com /~tanman/ho/Pancytopenia.txt   (180 words)

 - Letter
In addition, rare cases of pancytopenia, including aplastic anemia, some with a fatal outcome, have been reported in patients with rheumatoid arthritis who have received ENBREL therapy.
Although the majority of patients who have developed pancytopenia on ENBREL therapy had recent or concurrent exposure to other anti-rheumatic medications known to be associated with myelosuppression (e.g., methotrexate, leflunomide, azathioprine, and cyclophosphamide), some patients had no recent or concurrent exposure to such therapies.
Cases of pancytopenia occurred as early as 2 weeks after initiating ENBREL therapy.
www.fda.gov /medwatch/SAFETY/2000/enbrel2.htm   (735 words)

 bmj.com Rapid Responses for Konstantopoulou et al., 330 (7487) 350-351
Thiopurine Methyl Transferase, TPMT levels (Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase M Konstantopoulou, A Belgi, K D Griffiths, J R C Seale, A W Macfarlane BMJ  2005;330:350-351, doi:10.1136/ bmj.330.7487.350)are the result of gene expression.
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase.
Azathioprine-induced pancytopenia in a patient thiopurine methyltransferase with pompholyx and deficiency of erythrocyte BMJ 2005;330;350-351 2.
www.bmj.com /cgi/eletters/330/7487/350   (5964 words)

 eMedicine - Hairy Cell Leukemia : Article by Emmanuel C Besa, MD
Symptoms of pancytopenia are related to anemia (fatigue and weakness), thrombocytopenia (bleeding or easy bruising), and neutropenia (infections).
A positive TRAP stain in conjunction with a characteristic bone marrow biopsy is essentially diagnostic of HCL.
Histologic Findings: The findings of pancytopenia and splenomegaly in the presence of circulating cells that are TRAP-positive and a dry bone marrow aspirate with biopsy material showing infiltration with a mononuclear cells that have a fried-egg appearance are diagnostic.
www.emedicine.com /med/topic937.htm   (3100 words)

 Aplastic anemia
Aplastic anemia is a serious condition defined as pancytopenia with an "empty" bone marrow (hypoplastic or aplastic).
Other causes of pancytopenia include: malignancy (leukemia or other cancer replacing bone marrow), megaloblastic hematopoiesis, viral infection, paroxysmal nocturnal hematuria and myelodysplastic syndrome.
Definitive diagnosis is made with bone marrow biopsy, but the workup for pancytopenia should include an evaluation for all possible causes of pancytopenia as well as an investigation into the etiologies of aplastic anemia.
pedclerk.bsd.uchicago.edu /aplasticanemia.html   (320 words)

 Clinical Study: 86-H-0088, Lymphocytapheresis of Patients with Pancytopenia   (Site not responding. Last check: 2007-11-04)
Aplastic anemia is a condition in which the cells normally found in blood are greatly decreased.
However, low levels of blood cells make it difficult to collect specialized white blood cells (mononuclear cells) for research studies.
This study was designed to collect lymphocytes from patients with low levels of all blood cells (pancytopenia) for use in research.
clinicalstudies.info.nih.gov /cgi/detail.cgi?A_86-H-0088.html   (337 words)

 Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by ...
Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor -- Basser et al.
Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
From the Centre for Developmental Cancer Therapeutics, Ludwig Institute for Cancer Research, Department of Haematology and Medical Oncology, Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital; Walter and Eliza Hall Institute for Medical Research; Department of Haematology and Medical Oncology, Western Hospital, Parkville, Victoria, Australia; Amgen Australia, Kew; and Amgen, Thousand Oaks, CA.
www.bloodjournal.org /cgi/content/full/99/7/2599   (2605 words)

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