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Topic: Paracrine


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  Paracrine signalling - Wikipedia, the free encyclopedia
Paracrine signalling is a form of cell signalling in which the target cell is close to ("para" = alongside of or next to, but this strict prefix definition is not meticulously followed here) the signal releasing cell, and the signal chemical is broken down too quickly to be carried to other parts of the body.
Some paracrine agents also have autocrine or endocrine actions as well.
muscle growth), and in a paracrine manner to stimulate spermatogenesis in the adjacent seminiferous tubules.
en.wikipedia.org /wiki/Paracrine_signalling   (280 words)

  
 [No title]
The use of chemical messengers to transfer information from cell to cell within a single tissue is called paracrine communication, and the chemicals involved are called paracrine factors.
Paracrine factors enter the circulation, but the concentrations are usually so low that distant cells and tissues are not affected.
However, some paracrine factors, including several of the prostaglandins and related chemicals, have primary effects in their tissues of origin and secondary effects in other tissues and organs.
www.angelo.edu /faculty/cadkins/endocrine.doc   (1739 words)

  
 Transforming Growth Factor {beta}1 Is a Paracrine Inhibitor of Prolactin Gene Expression -- Abraham et al. 139 (12): ...
TGFß1 is a paracrine inhibitor of PRL gene expression.
the intercellular inhibition of PRL gene expression by a paracrine
pituitary as a paracrine inhibitor of PRL release and gene expression.
endo.endojournals.org /cgi/content/full/139/12/5174   (4757 words)

  
 ApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effects -- Dove et al. 288 ...
Theoretical basis for the separation of autocrine and paracrine effects of apolipoprotein E (apoE) on cholesterol efflux.
Effects of apoE that depend on the relative concentration in the extracellular distribution volume are paracrine.
Stochastic model of autocrine and paracrine signals in cell culture assays.
ajpcell.physiology.org /cgi/content/full/288/3/C586   (3695 words)

  
 Paracrine mitogenic effect of human endothelial progenitor cells: role of interleukin-8 -- He et al. 289 (2): H968 -- ...
Paracrine mitogenic effect of human endothelial progenitor cells: role of interleukin-8 -- He et al.
Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2.
Implication in autocrine and paracrine regulation of angiogenesis.
ajpheart.physiology.org /cgi/content/full/289/2/H968   (2363 words)

  
 Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission ...
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias -- Dias et al.
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias
we assessed the relative contribution of paracrine and autocrine
www.pnas.org /cgi/content/full/98/19/10857   (4369 words)

  
 Autocrine and Paracrine Apoptosis Are Mediated by Differential Regulation of Fas Ligand Activity in Two Distinct Jurkat ...
Autocrine and Paracrine Apoptosis Are Mediated by Differential Regulation of Fas Ligand Activity in Two Distinct Jurkat T Cell Populations -- Su et al.
Autocrine and Paracrine Apoptosis Are Mediated by Differential Regulation of Fas Ligand Activity in Two Distinct Jurkat T Cell Populations
Apoptosis mediated by a paracrine pathway in GFP
www.jimmunol.org /cgi/content/full/160/11/5288   (4228 words)

  
 Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma -- Bisping et al. 101 ...
Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma -- Bisping et al.
Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma
Expression of the angiogenesis-inducing molecules VEGF and bFGF in multiple myeloma and its regulation by paracrine interactions between tumor cells and stromal bone marrow cells [abstract].
www.bloodjournal.org /cgi/content/full/101/7/2775   (6491 words)

  
 Evidence for Paracrine Signaling Between Macrophages and Bovine Adrenal Chromaffin Cell Ca2+ Channels -- Currie et al. ...
Evidence for Paracrine Signaling Between Macrophages and Bovine Adrenal Chromaffin Cell Ca2+ Channels -- Currie et al.
Paracrine signaling within the adrenal gland is likely to be a complex web of interactions.
Nussdorfer, G. Paracrine control of adrenal cortical function by medullary chromaffin cells.
jn.physiology.org /cgi/content/full/83/1/280   (5126 words)

  
 Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation -- DeLeve et al. ...
Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation -- DeLeve et al.
paracrine and autocrine regulation of the SEC phenotype.
is essential to the paracrine effect seen in the coculture model.
ajpgi.physiology.org /cgi/content/full/287/4/G757   (4599 words)

  
 AUTOCRINE AND PARACRINE MECHANISMS IN THE EVOLUTION OF KAPOSI'S SARCOMA
Supernatants of cultured KS-derived cells could stimulate the growth of endothelial cells (paracrine stimulation) as well as of KS cells themselves (autocrine stimulation).
Although the model needs to be validated, the local triggering and perpetuation of such a specific cytokine cascade by the spindle cells of the KS lesions could provide a common denominator in the pathogenesis of the various forms of KS.
The pathogenic mechanism(s) responsible for the initial triggering of the spindle cells is not clear, but initial observations indicate that a factor(s) produced by retrovirus-activated T cells can selectively stimulate the outgrowth of spindle cells, which may develop pleiotropic, paracrine, and autocrine effects in the tissues.
www.aegis.com /aidsline/1992/may/M9250962.html   (580 words)

  
 Interplay between paracrine signaling and gap junctional communication in ovarian follicles -- Gittens et al. 118 (1): ...
Interplay between paracrine signaling and gap junctional communication in ovarian follicles -- Gittens et al.
Interplay between paracrine signaling and gap junctional communication in ovarian follicles
Paracrine actions of growth differentiation factor-9 in the mammalian ovary.
jcs.biologists.org /cgi/content/full/118/1/113   (6892 words)

  
 Conversion from a Paracrine to an Autocrine Mechanism of Androgen-stimulated Growth during Malignant Transformation of ...
Conversion from a Paracrine to an Autocrine Mechanism of Androgen-stimulated Growth during Malignant Transformation of Prostatic Epithelial Cells -- Gao et al.
Conversion from a Paracrine to an Autocrine Mechanism of Androgen-stimulated Growth during Malignant Transformation of Prostatic Epithelial Cells
paracrine pathways may be involved in the regulation of the
cancerres.aacrjournals.org /cgi/content/full/61/13/5038   (6248 words)

  
 Connective Tissue Growth Factor Expression in the Human Corpus Luteum: Paracrine Regulation by Human Chorionic ...
Expression of CTGF in cultures and cocultures of luteinized granulosa cells and ovarian fibroblast-like cells.
paracrine molecules, and this is not affected by the presence
investigation of the paracrine role of cytokines is therefore
jcem.endojournals.org /cgi/content/full/90/9/5366   (7752 words)

  
 Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions -- Williams et ...
Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions -- Williams et al.
paracrine growth effects of IGF-I in vivo are not defined.
Autocrine and paracrine actions of intestinal fibroblast-derived insulin-like growth factors.
ajpgi.physiology.org /cgi/content/full/283/4/G875   (6250 words)

  
 Nitric Oxide Synthases and Cardiac Muscle : Autocrine and Paracrine Influences -- Balligand and Cannon 17 (10): 1846 -- ...
Paracrine and autocrine influences of NO produced by endothelial NO synthase (eNOS) in cardiac muscle.
Endothelial cell eNOS activated by shear stress and various agonists exerts paracrine influences on platelets to inhibit aggregation, on vascular smooth muscle cells to induce relaxation and inhibit proliferation, and on cardiac myocytes to increase diastolic relaxation and decrease O
Paracrine and autocrine influences of NO produced by inducible NO synthase (iNOS) in cardiac muscle.
atvb.ahajournals.org /cgi/content/full/17/10/1846   (6271 words)

  
 Paracrine activation of the HIV-1 LTR promoter by the viral Tat protein is mechanistically similar to trans-activation ...
Paracrine activation of the HIV-1 LTR promoter by the viral Tat protein is mechanistically similar to trans-activation within a cell.
Tat can also activate the LTR promoter in a paracrine or inter-cellular manner by a yet unknown mechanism.
One possibility is that Tat protein itself is secreted by cells and taken up by other cells.
www.aegis.com /aidsline/1997/mar/M9731164.html   (511 words)

  
 Autocrine/Paracrine Secreted Frizzled-related Protein 2 Induces Cellular Resistance to Apoptosis: A POSSIBLE MECHANISM ...
To assay the paracrine activity of SFRP2, the media from MPG-F2 cells stably expressing SFRP2 were added to the NMG cells.
Paracrine activity of SFRP2 on the neighboring normal cells.
Paracrine SFRP2 induces tumorous transformation and inhibits apoptosis in neighboring normal cells.
www.jbc.org /cgi/content/full/279/15/14602   (4837 words)

  
 Adrenomedullin: An Autocrine/Paracrine Factor for Cardiorenal Protection -- Tsuruda and Burnett 90 (6): 625 -- ...   (Site not responding. Last check: 2007-10-21)
To date, the role of AM as an autocrine or paracrine factor
paracrine factor but mainly in in vitro environments.
Autocrine and paracrine pathways for endogenous AM actions in the vasculature.
circres.ahajournals.org /cgi/content/full/90/6/625   (1878 words)

  
 A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor ...
A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor {alpha} -- Suganami et al.
to identify the paracrine signals between adipocytes and macrophages.
paracrine mediator of inflammation in macrophages because of
atvb.ahajournals.org /cgi/content/full/25/10/2062   (4026 words)

  
 Integrating multiple paracrine regulators of renal microvascular dynamics -- Navar 274 (3): 433 -- AJP - Renal ...
The single most important criterion for a paracrine mediator of the TGF mechanism is that a change in distal flow leads to
There is growing accord for the presence of a variety of paracrine systems in macula densa cells (Fig.
This brief consideration of the myriad of potential paracrine signals that regulate renal microvascular tone emphasizes the
ajprenal.physiology.org /cgi/content/full/274/3/F433   (6436 words)

  
 Induction of a Potential Paracrine Angiogenic Loop between Human THP-1 Macrophages and Human Microvascular Endothelial ...
Induction of a Potential Paracrine Angiogenic Loop between Human THP-1 Macrophages and Human Microvascular Endothelial Cells during Bartonella henselae Infection -- Resto-Ruiz et al.
This secreted VEGF functions in a paracrine manner and acts as an endothelial cell mitogen.
Paracrine angiogenic loop between head-and-neck squamous-cell carcinomas and macrophages.
iai.asm.org /cgi/content/full/70/8/4564   (4485 words)

  
 Viral G Protein-coupled Receptor and Kaposi's Sarcoma: A Model of Paracrine Neoplasia? -- Cesarman et al. 191 (3): 417 ...
T or NK cells in the lesions express KSHV GPCR and overexpress VEGF (triangles), inducing angiogenesis and spindle cell proliferation in a paracrine fashion.
These cells, according to the data from the CD2 promoter KSHV GPCR transgenic mice, upregulate VEGF secretion and have the potential for paracrine induction of spindle cell proliferation and angiogenesis.
Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis
www.jem.org /cgi/content/full/191/3/417   (4088 words)

  
 Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia -- ...
Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia -- Frolkis et al.
Articles by Frolkis, I. Articles by Mohr, R. Interaction between paracrine tumor necrosis factor-alpha and paracrine angiotensin II during myocardial ischemia
This paracrine release of TNF-alpha is correlated with the postischemic
content.onlinejacc.org /cgi/content/full/37/1/316   (3321 words)

  
 Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in ...
Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in Rat Model of Myocardial Infarction -- Tang et al.
Paracrine Action Enhances the Effects of Autologous Mesenchymal Stem Cell Transplantation on Vascular Regeneration in Rat Model of Myocardial Infarction
analysis was used to assay the paracrine factors and proapoptotic
ats.ctsnetjournals.org /cgi/content/abstract/80/1/229   (570 words)

  
 Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo -- Wang et al. 104 ...
Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo -- Wang et al.
Inhibition of paracrine VEGFR-2 pathway reduces growth of established lymphoma xenografts in NOD/SCID mice and correlates with decreased tumor angiogenesis.
Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.
www.bloodjournal.org /cgi/content/full/104/9/2893   (6153 words)

  
 Paracrine Immunotherapy with Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain ...
Paracrine Immunotherapy with Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain Tumors -- Sampath et al.
Paracrine Immunotherapy with Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain Tumors
Pardoll D. Paracrine cytokine adjuvants in cancer immunotherapy.
cancerres.aacrjournals.org /cgi/content/full/59/9/2107   (5096 words)

  
 Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1alpha and its dual ...
Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1alpha and its dual block by ovarian steroids -- Singer et al.
Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1
Collagenase production by endometrial fibroblasts depends on paracrine interactions and is repressed by ovarian steroids.
www.pnas.org /cgi/content/full/94/19/10341   (3997 words)

  
 paracrine - definition of paracrine in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and ...   (Site not responding. Last check: 2007-10-21)
paracrine - definition of paracrine in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia.
Relating to the release of locally acting substances from endocrine cells.
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
medical-dictionary.thefreedictionary.com.cob-web.org:8888 /paracrine   (82 words)

  
 Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins ...
Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins -- Hussein et al.
Paracrine factors secreted by the oocyte regulate a broad range
Proposed model by which the paracrine network of BMP/GDF-9 growth factors and their binding proteins interact to regulate apoptosis in the COC microenvironment.
jcs.biologists.org /cgi/content/full/118/22/5257   (7352 words)

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