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Topic: Parafollicular cell

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	NationMaster - Encyclopedia: Parafollicular cell
		Parafollicular cells also called C cells, are cells in the thyroid which produce and secrete calcitonin.
		Contribution of proliferation and hypertrophy of the epitheliocytes to the growth and regeneration of the rat parathyroid glands was estimated using organo- and cytometry, cytophotometry of DNA content in the nuclei and determination of mitotic index.
		We have studied the contribution of proliferation and hypertrophy of glandular cells to the ontogenetic growth of adrenal chromaffin tissue using several methods (organometry, cytometry, cytophotometric quantitation of DNA in the nuclei, radioautographic analysis of 3H- thymidine incorporation, calculation of the mitotic index and proportion of binuclear cells, as well as stereological analysis).
	www.nationmaster.com /encyclopedia/Parafollicular-cell (267 words)

	Visual Histology Text Book
		An example of this sort of cells of the anterior pituitary sit in front of the hypothalamic regulation of endocrine function is described in detail in the text of Plate 19-4.
		Finally, the Thyroid Hormone is released from the base of the epithelial cells into nearby blood or lymph capillaries, from whence it is distributed to the tissues of the body.
		Parafollicular Cells are neurosecretory cells that release the hormone Calcitonin, which inhibits bone resorption by osteoclasts and has the effect of lowering blood calcium levels.
	www.visualhistology.com /Visual_Histology_Atlas/VHA_Chpt19_The_Endocrine_System.html (3414 words)

	A Study of Granule Formation in the Bat Parafollicular Cell -- NUNEZ et al. 5 (2): 531 -- Journal of Cell Science
		A Study of Granule Formation in the Bat Parafollicular Cell -- NUNEZ et al.
		A Study of Granule Formation in the Bat Parafollicular Cell
		parafollicular cells undergo a series of intracellular changes
	jcs.biologists.org /cgi/content/abstract/5/2/531 (330 words)

	Department of Histology (Yaroslavl State Medical Academy): Research
		Contribution of proliferation and hypertrophy of the epitheliocytes to the growth and regeneration of the rat parathyroid glands was estimated using organo- and cytometry, cytophotometry of DNA content in the nuclei and determination of mitotic index.
		Relatively not high proliferative activity of parafollicular cells might be due to their pronounced polyfunctional character and their participation in complex paracrine interactions with other cell elements of the thyroid gland.
		We have studied the contribution of proliferation and hypertrophy of glandular cells to the ontogenetic growth of adrenal chromaffin tissue using several methods (organometry, cytometry, cytophotometric quantitation of DNA in the nuclei, radioautographic analysis of 3H- thymidine incorporation, calculation of the mitotic index and proportion of binuclear cells, as well as stereological analysis).
	gw.yma.ac.ru /books/hist/en/info/scien.htm (1651 words)

	Calcium Receptor-Induced Serotonin Secretion by Parafollicular Cells: Role of Phosphatidylinositol 3-Kinase-Dependent ...
		PF cells were infected with adenoviral vectors at 20-50 pfu per cell for 17 hr.
		Infection of PF cells with the adenovirus encoding dominant-negative
		PF cells were infected with an adenovirus containing a DN form of p85 that consists of a regulatory subunit of PI3-K lacking the p110-interaction domain.
	www.jneurosci.org /cgi/content/full/23/6/2049 (5440 words)

	Endocrine System (Site not responding. Last check: 2007-10-11)
		The oxyphil cells are large, have condensed chromatin in a small round nucleus, their cytoplasm stains very light pink, and their cells margin are usually observed.
		The cells of the zona glumerulosa present as smaller cells with an eosinophilic cytoplasm.
		The cells of this zone are arranged in a reticular (not very regular) cords with cells having a round nucleus and an eosinophilic cytoplasm containing lipofuscin granules.
	anatomy.iupui.edu /courses/histo_D502/D502f04/Labs.f04/Lab16/Lab16endof03.html.txt (1918 words)

	ENDOCRINE SYSTEM
		This is the parafollicular cell which may be found as single cells in the epithelial lining of the follicle or in groups in the connective tissue between follicles.
		Cells of the zona reticularis are arranged in a network of cords no longer arranged in parallel as in the zona fasiculata.
		Cells in the medulla are arranged in groups or cords, clustered around capillaries and venules.
	www.cvm.okstate.edu /instruction/mm_curr/histology/HistologyReference/HREndo.htm (2423 words)

	Hyperplastic and neoplastic changes in ultimobranchial remnants and in parafollicular (C) cells in bulls: a histologic ...
		In addition, differentiated light and cytoplasm-rich cells were scattered in the walls of the thyroid follicles, ultimobranchial follicles, cysts and tubules as well as in the solid component.
		They corresponded to light cytoplasm-rich cells seen in the ultimobranchial lesions that were argyrophilic and harbored material reactive with antibodies against calcitonin and/or somatostatin.
		The changes observed in the parafollicular cell system resembled lesions seen in human thyroid glands with the familial variant of medullary carcinoma as well as those reported in thyroid glands of patients with longstanding hypercalcemia.
	www.ihop-net.org /UniPub/iHOP/gp/4936032.html (283 words)

	Calcium receptor-active molecules - Patent 5763569 (Site not responding. Last check: 2007-10-11)
		Other cells in the body, specifically the osteoclast in bone, the juxtaglomerular, proximal tubule cells in the kidney, the keratinocyte in the epidermis, the parafollicular cell in the thyroid, intestinal cells, and the trophoblast in the placenta, have the capacity to sense changes in Ca.sup.2+ !.
		The postulated calcium receptor on the parathyroid cell is therefore promiscuous because it detects a variety of extracellular di- and trivalent cations.
		A typical procedure is to load cells with fura-2 and then divide the cell suspension in two; most of the cells are used for measurement of Ca.sup.2+ !.sub.i and the remainder are incubated with molecules to assess their effects on cyclic AMP and PTH secretion.
	www.freepatentsonline.com:9003 /5763569.html (15161 words)

	CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential ...
		NK cells and T cells are thought to be the critical immunoregulatory lymphocytes of innate and adaptive immunity, respectively.
		NK cells are the primary NK subset present in lymph nodes: trafficking or differentiation.
		Increased Susceptibility to Apoptosis of CD56dimCD16+ NK Cells Induces the Enrichment of IFN-{gamma}-Producing CD56bright Cells in Tuberculous Pleurisy
	www.bloodjournal.org /cgi/content/full/101/8/3052 (4987 words)

	Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride ...
		Thyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane
		Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York.
		cells by opening a chloride channel associated with the granule membrane.
	www.jcb.org /cgi/content/abstract/107/6/2137 (564 words)

	Somatostatin Receptor Subtypes 2 and 5 Differentially Affect Proliferation in Vitro of the Human Medullary Thyroid ...
		cells that are characterized by the presence of a TGC to TGG
		Cells were incubated in 96-well plates for 48 h in a culture medium supplemented with SRIF analogs at various concentrations (10
		TT cell proliferation was measured as absorbance at 490 n
	jcem.endojournals.org /cgi/content/full/86/5/2161 (4416 words)

	Laboratory Sixteen: Endocrine System
		The glomerulosa cells are smaller and less vacuolated (therefore, stain with eosin) than the cells of the zone fasciculata, and are arranged in small round clusters.
		The predominant cell type in the medulla is the chromaffin cell (see FIGURE 07 on the next page) which appears either white or light blue on your slides.
		The squamous cells are presumed to be less active that the cuboidal cells.
	medinfo.ufl.edu /year1/histo/review/lab16.html (1243 words)

	Endocrine System (Site not responding. Last check: 2007-10-11)
		The uneven staining appearance of the pars distalis is attributed to the varying concentrations of the different cell types throughout this region.
		In humans and rodents, the B (insulin) cells tend to be located centrally in the islet while other cells, A (glucagon), D (somatostatin) lie in the periphery.
		The nuclei of the major cell types (A, B, and D) are large, circular to oval in shape.
	www.complab.nymc.edu /Histology/EndocrineSystem/Endocrine.htm (944 words)

	Dr. Koop - Fosamax Patient Info
		Parafollicular cell (thyroid) adenomas were increased in high-dose male rats (p= 0.003) in a 2-year oral carcinogenicity study at doses of 1 and 3.75 mg/ kg body weight.
		Alendronate was not genotoxic in the in vitro microbial mutagenesis assay with and without metabolic activation, in an in vitro mammalian cell mutagenesis assay, in an in vitro alkaline elution assay in rat hepatocytes, and in an in vivo chromosomal aberration assay in mice.
		In an in vitro chromosomal aberration assay in Chinese hamster ovary cells, however, alendronate gave equivocal results.
	www.drkoop.com /druglibrary/43/fosamax-patient_info_3.html (534 words)

	Serotonin-storing secretory granules from thyroid parafollicular cells -- Barasch et al. 7 (12): 4017 -- Journal of ...
		Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
		parafollicular cell granules may be analogous to the synaptic vesicles of
		Ca2+-Evoked Serotonin Secretion by Parafollicular Cells: Roles in Signal Transduction of Phosphatidylinositol 3'-kinase, and the gamma and zeta Isoforms of Protein Kinase C
	www.jneurosci.org /cgi/content/short/7/12/4017 (357 words)

	AEGiS-10CROI: SDF-1 Production by Dendritic Cells.
		METHODS: Characterization of SDF-1 producing cells in paraffin-embedded and frozen sections in normal tonsils and lymph nodes from HIV-infected patients at different clinical stages was analyzed by immunohistochemistry and in situ hybridization techniques, using specific antibodies against SDF-1, CD1a, and dendritic cells antigens.
		) in tonsil cripts and in the parafollicular compartment of lymph nodes.
		CONCLUSIONS: These results suggest that the presence of SDF-1 producing cells in the parafollicular T-cell region and the SDF expression in endothelial and dendritic cells could account for the low propagation of X4 HIV strains in early stages of infection in which lymphoid organs structure is still conserved.
	www.aegis.com /conferences/croi/2003/480.html (363 words)

	Somatostatin production by a human medullary thyroid carcinoma cell line -- Gagel et al. 118 (4): 1643 -- Endocrinology
		cells derived from a human medullary thyroid carcinoma.
		isolated from the TT cells hybridized to a specific bovine fetal pancreatic
		Northern transfer of TT cell cytoplasmic RNA and
	endo.endojournals.org /cgi/content/abstract/118/4/1643 (342 words)

	Immunocytochemical Localization of Prohormone Convertases PC1 and PC2 in the Mouse Thyroid Gland and Respiratory Tract ...
		PC1-positive cells are visible in the tracheal epithelium (a, large and small arrows) and the duct of the tracheal gland (b, small arrow).
		Immunoelectron micrographs showing parafollicular cells labeled with immunogold particles of different sizes (in parentheses): PC1 (20 nm) and calcitonin (5 nm) (a,b), PC1 (10 nm) and PC2 (15 nm) (c), and PC1 (10 nm) and CGRP (15 nm) (d).
		Kameda Y (1971) The occurrence and distribution of the parafollicular cells in the thyroid, parathyroid IV and thymus IV in some mammals.
	www.jhc.org /cgi/content/full/50/7/903 (3778 words)

	Thyroid Transcription Factor 1 Is Calcium Modulated and Coordinately Regulates Genes Involved in Calcium Homeostasis ...
		neural cells in the hippocampus, and anterior pituitary cells
		TTF-1 mRNA (fl coloration) is observed in the perinuclear area of thyroid follicular epithelium (thin arrows) and parafollicular C cells (thick arrows); calcitonin protein is seen as a brown coloration (arrowheads) of the cytoplasm of parafollicular C cells.
		cells, the CaSR is the critical extracellular Ca -sensing component of parathyroid cells (11).
	mcb.asm.org /cgi/content/full/18/12/7410 (8913 words)

	Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign ...
		VEGF secretion of cell lines derived from primary and metastatic thyroid tumors were similar.
		The higher levels of VEGF expression in differentiated thyroid cancers of follicular cell origin suggests a role in oncogenesis.
		The VEGF mRNA levels were higher in the thyroid cancer cell lines than in primary cultures of normal thyroid cells, and higher in thyroid cancers of follicular than those of parafollicular cell origin.
	www.ihop-net.org /UniPub/iHOP/gp/1217326.html (255 words)

	AEGiS-9CROI: Expression of CXCR4 and SDF-1 in Lymphocytes and Dendritic Cells
		Characterization of SDF-1-producing cells in paraffin-embedded sections in normal tonsils and of lymph nodes from HIV-infected patients at different clinical stages was analyzed with inmunohistochemistry and in situ hybridization techniques, using specific antibodies against SDF-1, CD1a and dendritic cells antigens.
		In contrast, SDF-1 was widely expressed in endothelial cells and also in dendritic cells (CD1a+) in the parafollicular compartment of lymph nodes.
		The presence of SDF-1 producing cells in the parafollicular T-cell region could account for the low propagation of X4 HIV strains in early stages of infection, in which lymph node structure is still conserved.
	www.aegis.com /conferences/CROI/2002/256-T.html (345 words)

	Role for p300 in Pax 8 Induction of Thyroperoxidase Gene Expression -- De Leo et al. 275 (44): 34100 -- Journal of ...
		HeLa cells were transiently transfected with TPO-pGL3 plasmid and were co-transfected with the vectors encoding the indicated factors as described under "Experimental Procedures." The relative luciferase activity of the cells transfected with TPO-pGL3 only was normalized to 1, and the other activities are expressed relative to this.
		The relative luciferase activity of the cells transfected with the GAL 4-Luc plasmid only was normalized to 1, and the other activities are expressed relative to this.
		We have found that the same strong band, shown in lanes 1 and 3, is also present in a band-shift assay performed with oligo C and a cell extract of HeLa cells (data not shown); therefore we consider this complex as unspecific and not related to Pax 8.
	www.jbc.org /cgi/content/full/275/44/34100 (4156 words)

	Naturally occurring parafollicular cell carcinoma of the thyroid in dogs. A histological and ultrastructural study -- ...
		Naturally occurring parafollicular cell carcinoma of the thyroid in dogs.
		Seven cases of parafollicular cell carcinoma in dogs were seen.
		canine thyroid parafollicular cell carcinoma, even when there is no
	www.vetpathology.org /cgi/content/abstract/14/6/556 (128 words)

	Vascular Endothelial Growth Factor Expression Is Higher in Differentiated Thyroid Cancer than in Normal or Benign ...
		cells and is secreted by the cancer cells (7, 8, 9, 10).
		Cell lines derived from primary tumor and cell lines derived from metastases (C vs.
		Note stronger staining in follicular thyroid cancer (K), papillary thyroid cancer (L), and Hürthle cell cancer (M) compared with medullary thyroid cancer (N), adjacent normal thyroid tissue of follicular thyroid cancer (J), and benign thyroid disease such as follicular adenoma (O) and Graves’ thyroid (P).
	jcem.endojournals.org /cgi/content/full/82/11/3741 (3563 words)

	Mixed Medullary and Follicular Carcinoma of the Thyroid : On the Search for Its Histogenesis -- Matias-Guiu 155 (5): ...
		for determination of clonal derivation of cell populations.
		mimic clonal derivation of cells in a nonneoplastic polyclonal
		to the proliferation of Schwann cells in maturing neuroblastomas,
	ajp.amjpathol.org /cgi/content/full/155/5/1413 (4140 words)

	Pathology Seminars, SGPGI: Classification of Primary Thyroid Tumors (Site not responding. Last check: 2007-10-11)
		The major modifications in the revised classification (Table 1) include the removal of subtypes of undifferentiated (anaplastic) carcinoma of thyroid, including its small cell type; the deletion of squamous cell carcinoma as a major tumour type; a revision of the nonepithelial and miscellaneous tumours; and the addition of malignant lymphoma as a major separate entity.
		Some newly described prognostically important variants of papillary carcinoma like diffuse follicular variant, and tall cell and columnar variants are also not emphasized in the revised WHO classification.
		Inclusion of oncocytic (Hurthle cell) tumours under follicular tumours is not accepted by some workers who consider oncocytic carcinoma as a distinct entity because of its greater propensity for nodal metastasis.
	www.sgpgi.ac.in /path/seminars/thyclass.html (880 words)

	Parafollicular Cell Cancer Related Definition
		Nutrtion Guide Home > NCI Cancer Thesaurus > Parafollicular Cell
		To search for Parafollicular Cell on the web, just click the search button below.
		Click on a letter to find infomation NCI Cancer and related disease terms starting with that letter.
	www.thenutritionguide.com /nci/30372.html (41 words)

	Hyperplastic and neoplastic changes in ultimobranchial remnants and in parafollicular (C) cells in bulls: a histologic ...
		Hyperplastic and neoplastic changes in ultimobranchial remnants and in parafollicular (C) cells in bulls: a histologic and immunohistochemical study -- Ljungberg and Nilsson 22 (2): 95 -- Veterinary Pathology
		differentiated light and cytoplasm-rich cells were scattered in the walls
		diffuse or multifocal hyperplasia of the parafollicular (C) cells that was
	www.vetpathology.org /cgi/content/abstract/22/2/95 (271 words)

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