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Topic: Paraldehyde

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	DEA Briefs & Background, Drugs and Drug Abuse, Drug Descriptions, Paraldehyde
		DEA Briefs and Background, Drugs and Drug Abuse, Drug Descriptions, Paraldehyde
		This drug is not used by injection because of tissue damage, and taken orally, it can be irritating to the throat and stomach.
		One of the signs of paraldehyde use is a strong, characteristic smell to the breath.
	www.usdoj.gov /dea/concern/paraldehyde.html (98 words)

	Paraldehyde - LoveToKnow 1911
		PARALDEHYDE, in medicine, a clear colourless liquid (for the chemistry see Aldehydes), soluble in i in 10 of water and freely in alcohol.
		Paraldehyde is a powerful hypnotic, giving a refreshing quiet sleep which is not followed by unpleasant after effects.
		As it does not depress the heart when used in medicinal doses, it may be given to patients suffering from cardiac disease.
	www.1911encyclopedia.org /Paraldehyde (141 words)

	Data Sheet
		Paraldehyde may be effective in reducing the anxiety associated with withdrawal from drugs such as narcotics or barbiturates, as well as in the management of acute agitation or delirium tremens due to alcohol withdrawal.
		Paraldehyde should not be used for obstetric anaesthesia, as the drug diffuses across the placenta and has been known to cause respiratory depression in neonates.
		Paraldehyde Injection is contraindicated in patients with bronchopulmonary disease, as unmetabolised paraldehyde (11 to 28%) is excreted via exhalation.
	www.medsafe.govt.nz /Profs/Datasheet/p/Paraldehydeinj.htm (1552 words)

	Paraldehyde Injection, SPC from the eMC
		Paraldehyde should not be administered to patients with gastric disorders or patients receiving disulfiram.
		Paraldehyde should be used with extreme caution in patients with bronchopulmonary disease or hepatic impairment.
		Paraldehyde readily crosses the placental barrier and appears in the foetal circulation and is also found in breast milk.
	emc.medicines.org.uk /emc/assets/c/html/displaydoc.asp?DocumentID=649 (500 words)

	AllRefer.com - paraldehyde (Pharmacology) - Encyclopedia (Site not responding. Last check: 2007-10-13)
		A colorless flammable liquid with a disagreeable odor, paraldehyde produces sleep for up to 12 hr.
		Paraldehyde is also used in the manufacture of synthetic resins, as a preservative, and in preparing leather.
		It is produced by treating acetaldehyde with a small amount of sulfuric acid.
	reference.allrefer.com /encyclopedia/P/paraldeh.html (198 words)

	Indian Pediatrics - Editorial
		Although paraldehyde has been advocated as an effective anticonvulsant drug in the newborn(1), it is sparingly used in neonates because of its various toxic effects(2), short shelf life (decomposes on prolonged storage), and tendency to react with plastics(3).
		Paraldehyde (Hindustan Pharma-ceuticals, Barauni) is used from a fresh ampoule each time using a disposable (Doctor®) 1 ml polypropylene syringe with 26-gauge needle, intramuscularly in the anterolateral thigh.
		Paraldehyde is an effective anticonvulsant drug and is rapidly absorbed when administered by oral, rectal, or parenteral route, but is irritating to soft tissue.
	www.indianpediatrics.net /feb2001/feb-209-210.htm (875 words)

	PARALDEHYDE (ACETALDEHYDE, TRIMER)
		Paraldehyde (also called paracetaldehyde), colourless highly flammable, disagreeable taste and pungent odored liquid, is a cyclic trimer of acetaldehyde contains a six-membered ring of alternating carbon and oxygen atoms with a hydrogen atom and a methyl group attached to each carbon atom.
		Paraldehyde is available on prescription only; paraldehyde should be used with caution in people with disease of the airways or lungs.
		Paraldehyde is commercially prepared the polymerization of acetaldehyde with a small amount of sulfuric acid; then neutralization with calcium carbonate and purifying by fractional distillation are followed.
	www.chemicalland21.com /arokorhi/industrialchem/solalc/PARALDEHYDE.htm (420 words)

	PARALDEHYDE - Online Information article about PARALDEHYDE
		Paraldehyde is a powerful hypnotic, giving a refreshing quiet See also:
		DELIRIUM (a Latin medical term for madness, from delirare, to be mad, literally to wander from the lira, or furrow)
		When taken in an overdose paraldehyde kills by producing See also:
	encyclopedia.jrank.org /PAI_PAS/PARALDEHYDE.html (307 words)

	Acetaldehyde - Polymers of Acetaldehyde
		Paraldehyde is produced from acetaldehyde in the presence of acid catalysts, such as sulfuric acid, phosphoric acid, hydrochloric acid, or acid cation exchangers.
		Paraldehyde is used in chemical synthesis as a source of acetaldehyde whereby resin formation and other secondary reactions are largely eliminated.
		Ingested paraldehyde partly is metabolized to carbon dioxide and water and partly is exhaled unchanged.
	www.mindfully.org /Plastic/Monomers/Acetaldehyde-Polymers.htm (1757 words)

	Paraldehyde
		Paraldehyde is an anti-epileptic medicine belonging to a group of medicines called barbiturates.
		Paraldehyde is thought to act mainly by preventing chemicals from passing through openings on the nerve cells.
		Paraldehyde also has a sedative action, that is, it has a calming efect, relieving anxiety and tension.
	www.netdoctor.co.uk /medicines/100002011.html (698 words)

	Indian Pediatrics - Reader's forum
		Paraldehyde has been in clinical use since 1882 for the treatment of status epilepticus in children as well as adults.
		Reports of incompatibility of paraldehyde with disposable plastic syringes have been published as early as 1959 where the authors noted that paraldehyde dissolved a plastic syringe made of polystyrene within a relatively short period of time(1).
		An experiment involving the exposure of plastic disposable syringes to paraldehyde for a five-minute period showed increased resistance to injection, hairline fractures of the shaft and plunger in two minutes, and breaks in the shaft(2).
	www.indianpediatrics.net /april2000/april-448.htm (356 words)

	NW Newborn Drug Protocol - Paraldehyde Pharmacology
		Paraldehyde is a hypnotic and sedative with anticonvulsant effects.
		The drug is used to control seizures in infants, including those refractory to phenobarbitone and phenytoin, and is as effective as phenobarbitone in the emergency treatment of convulsions in children.
		Adult metabolism of paraldehyde involves 80% conversion to acetaldehyde, which is oxidised by aldehyde dehydrogenase to acetic acid.
	www.adhb.govt.nz /newborn/DrugProtocols/ParaldehydePharmacology.htm (312 words)

	Paraldehyde Drug Information
		Use of paraldehyde during labor may cause breathing problems in the newborn infant.
		Children—Although there is no specific information comparing use of paraldehyde in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		There is no specific information comparing use of paraldehyde in the elderly with use in other age groups.
	www.drugs.com /cons/Paraldehyde.html (1888 words)

	Study of Death Due to Combined Action of Alcohol and Paraldehyde in Man (Site not responding. Last check: 2007-10-13)
		Paraldehyde is similar to alcohol in its pharmacologic behavior, but it is a more powerful sedative.
		It is generally agreed that under most conditions paraldehyde is a relatively innocuous drug, and it has been called one of the safest of the hypnotics.
		In an attempt to evaluate the relative hazard of the administration of paraldehyde to animals already intoxicated with alcohol, studies on mice were performed.
	rcm-medicine.upr.clu.edu /publications/sidney_kaye/Study-of-Death-Due.html (1215 words)

	MedlinePlus Drug Information: Paraldehyde (Systemic) (Site not responding. Last check: 2007-10-13)
		Paraldehyde (par-AL-de-hyde) is used to treat certain convulsive disorders.
		It also has been used in the treatment of alcoholism and in the treatment of nervous and mental conditions to calm or relax patients who are nervous or tense and to produce sleep.
		Children—Although there is no specific information comparing use of paraldehyde in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202440.html (1529 words)

	InteliHealth:
		Paraldehyde (par-AL-de-hyde) is used to treat certain convulsive disorders.
		It also has been used in the treatment of alcoholism and in the treatment of nervous and mental conditions to calm or relax patients who are nervous or tense and to produce sleep.
		Paraldehyde will cause your breath to have a strong unpleasant odor.
	www.intelihealth.com /IH/ihtIH/WSBOS000/408/4631/8240.html (989 words)

	Paraldehyde (Systemic)
		Paraldehyde has not been reported to cause problems in nursing babies.
		Although there is no specific information comparing use of paraldehyde in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		The dose of paraldehyde will be different for different patients.
	allnutritionals.com /drugs/p/paraldehyde-systemic.shtml (1529 words)

	Acetaldehyde
		Paraldehyde has historically been used as a stabile and less volatile form of acetaldehyde in a wide array of chemical reactions.
		The diethyl acetal of acetaldehyde, commonly known as acetal, may be generated from acetaldehyde or paraldehyde, ethanol, and calcium chloride.
		Acetaldehyde and paraldehyde have also been used for the protection of diols as their ethylidene acetals.
	www.wiley.com /legacy/wileychi/eros/acetaldehyde.html (818 words)

	Epilepsy Action: Drugwatch - latest epilepsy medication news
		We have become aware of problems with the availability of paraldehyde, which is used to treat status epilepticus.
		The manufacturer of paraldehyde, Mayne Pharma, has confirmed that they are not able to produce the drug at present.
		They cannot say when they expect to be able to begin producing paraldehyde again, but this is unlikely to be until late 2007.
	www.epilepsy.org.uk /news/drugwatch/index.html (1244 words)

	Paraldehyde Review
		If you spend just a few minutes on this summary site, you will find extremely well organized Paraldehyde information and special resources, which will definitely answer nearly any questions you have on the topic.
		Drug Rehabilitation Center Paraldehyde Overview 1.800.468.6933 Drug Rehabilitation Center Drug Rehabilitation Assistance If you or someone you know is addicted to drugs and alcohol, we can...
		Paraldehyde (ParalÂ®) is a Schedule IV depressant used most frequently in...
	www.chemicalsbuyer.com /Paraldehyde.html (308 words)

	Drugs of Abuse Publication, Chapter 6
		A notable exception to this is a relatively recent drug of abuse, gamma hydroxybutyric acid (GHB).
		Choral hydrate and paraldehyde are two of the oldest pharmaceutical depressants still in use today.
		The oldest of the hypnotic (sleep inducing, depressants, chloral hydrate was first synthesized in 1832.
	www.dea.gov /pubs/abuse/6-depress.htm (2264 words)

	paraldehyde — FactMonster.com
		A colorless flammable liquid with a disagreeable odor, paraldehyde produces sleep for up to 12 hr.
		Paraldehyde is also used in the manufacture of synthetic resins, as a preservative, and in preparing leather.
		It is produced by treating acetaldehyde with a small amount of sulfuric acid.
	www.factmonster.com /ce6/sci/A0837581.html (123 words)

	paraldehyde -- Encyclopædia Britannica (Site not responding. Last check: 2007-10-13)
		It is most useful for recalcitrant cases and is an older drug for treatment of acute alcoholic…
		Their major toxic effect is depression of the central nervous system, which results in muscular incoordination and slurred speech (Table 3).
		For sleeping pills containing barbiturates, chloral hydrate, paraldehyde, and meprobamate, however, the...
	www.britannica.com /eb/article-9058394?tocId=9058394 (354 words)

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